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The map label for this gene is fabG [C]

Identifier: 108797025

GI number: 108797025

Start: 55218

End: 56030

Strand: Direct

Name: fabG [C]

Synonym: Mmcs_0044

Alternate gene names: 108797025

Gene position: 55218-56030 (Clockwise)

Preceding gene: 108797024

Following gene: 108797028

Centisome position: 0.97

GC content: 70.97

Gene sequence:

>813_bases
GTGACATTCGCGCAGAAGTACGGCCCGTGGGCCGTGGTGGCCGGCGCATCCGACGGTCTGGGCGCCGCCTTCGCCGAGCG
GATCGCAGAGAACGGCGTCAACGTGGTGCTGCTGGCCCGCAGGCAGTCCGTGCTCGACGACGTGGCCGCGGGCATCCGCG
ACCGCACGGGTGTCGAAACTCGCACGCTGGCAATCGACCTCACCGATCCGGCGGCCACCGGCGCCGTCGCCGACGCCACC
GACGACCTCGAAGTCGGGTTCCTGGTGTACTGCGCGGGCGCCGACCCGGCGTTCGAACCGTTCCTCGCGCAACCGATCGA
AGCCGCCGAGGCGATGGTGCAGCGCAACTGTGTGGCGCCGATGCGGCTGTGCCACCATTTCGCGCCGGCGATGGCCGCAC
GCGGGCGCGGCGGCCTCGTGATCTTCGGGTCGGGCGCCGGACTGGCCGGCGGCCCGAACATGGTGGCCTACGCCGCCACC
AAGGCGTTCGACATGGTGTTCGCCGAAGCCCTGTGGGCCGAACTGCACGATACGGGCGTCGACGTGCTCGGTCTGATCCT
CGGCAAGACCGACACCCCCGCACTGCGGACCCTGGAACACCGTCGCGGTCAGATCGCCTCGACGGAGCAGACGCCGCCCG
GCGCCGTCCCGGTCGCAGGCGTCGTCTCCGAGGCCTTCGACAACCTCGCCAACGGACCCACCTGGATCGTCGGGGAAGAT
CTGCGCGCCGCCACCCAGATGATGGGGTCGATCAGCCGCAGCGATGCGGTGCGGTTCATCGTCGAGGCGTCCCGCGACGC
GATGGGGCCGTAG

Upstream 100 bases:

>100_bases
TCGGCTTCTACGACGACGAACTGGTCCGCACCCCGGCCGGGTGGCGCATCGCGCGGCGCCGGTTCACCACCGTCCGGGTC
AGCCCCGTCGGAGGACAGTC

Downstream 100 bases:

>100_bases
CCTCAGGGCGCAGCGAAACAGCCTCAGGGCGCAGCGAAACCGTTGCGGCGCAACACCGTCTGCCCCGTCGTGCCGGTCAC
TGCCGCCAGGAACTGCCGCG

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MTFAQKYGPWAVVAGASDGLGAAFAERIAENGVNVVLLARRQSVLDDVAAGIRDRTGVETRTLAIDLTDPAATGAVADAT
DDLEVGFLVYCAGADPAFEPFLAQPIEAAEAMVQRNCVAPMRLCHHFAPAMAARGRGGLVIFGSGAGLAGGPNMVAYAAT
KAFDMVFAEALWAELHDTGVDVLGLILGKTDTPALRTLEHRRGQIASTEQTPPGAVPVAGVVSEAFDNLANGPTWIVGED
LRAATQMMGSISRSDAVRFIVEASRDAMGP

Sequences:

>Translated_270_residues
MTFAQKYGPWAVVAGASDGLGAAFAERIAENGVNVVLLARRQSVLDDVAAGIRDRTGVETRTLAIDLTDPAATGAVADAT
DDLEVGFLVYCAGADPAFEPFLAQPIEAAEAMVQRNCVAPMRLCHHFAPAMAARGRGGLVIFGSGAGLAGGPNMVAYAAT
KAFDMVFAEALWAELHDTGVDVLGLILGKTDTPALRTLEHRRGQIASTEQTPPGAVPVAGVVSEAFDNLANGPTWIVGED
LRAATQMMGSISRSDAVRFIVEASRDAMGP
>Mature_269_residues
TFAQKYGPWAVVAGASDGLGAAFAERIAENGVNVVLLARRQSVLDDVAAGIRDRTGVETRTLAIDLTDPAATGAVADATD
DLEVGFLVYCAGADPAFEPFLAQPIEAAEAMVQRNCVAPMRLCHHFAPAMAARGRGGLVIFGSGAGLAGGPNMVAYAATK
AFDMVFAEALWAELHDTGVDVLGLILGKTDTPALRTLEHRRGQIASTEQTPPGAVPVAGVVSEAFDNLANGPTWIVGEDL
RAATQMMGSISRSDAVRFIVEASRDAMGP

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG0300

COG function: function code R; Short-chain dehydrogenases of various substrate specificities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7705855, Length=178, Percent_Identity=33.1460674157303, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI226371731, Length=184, Percent_Identity=32.6086956521739, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4557649, Length=175, Percent_Identity=30.8571428571429, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1787335, Length=239, Percent_Identity=29.2887029288703, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25152911, Length=179, Percent_Identity=32.4022346368715, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6319635, Length=288, Percent_Identity=23.2638888888889, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24640442, Length=190, Percent_Identity=32.1052631578947, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24584748, Length=184, Percent_Identity=31.5217391304348, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI161076933, Length=184, Percent_Identity=31.5217391304348, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24584752, Length=185, Percent_Identity=33.5135135135135, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28574402, Length=188, Percent_Identity=31.3829787234043, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24584744, Length=188, Percent_Identity=30.8510638297872, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 28052; Mature: 27921

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFAQKYGPWAVVAGASDGLGAAFAERIAENGVNVVLLARRQSVLDDVAAGIRDRTGVET
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCCCCE
RTLAIDLTDPAATGAVADATDDLEVGFLVYCAGADPAFEPFLAQPIEAAEAMVQRNCVAP
EEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHCHHHHHHHHHHHCCHHH
MRLCHHFAPAMAARGRGGLVIFGSGAGLAGGPNMVAYAATKAFDMVFAEALWAELHDTGV
HHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCH
DVLGLILGKTDTPALRTLEHRRGQIASTEQTPPGAVPVAGVVSEAFDNLANGPTWIVGED
HHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCH
LRAATQMMGSISRSDAVRFIVEASRDAMGP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TFAQKYGPWAVVAGASDGLGAAFAERIAENGVNVVLLARRQSVLDDVAAGIRDRTGVET
CCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCCCCE
RTLAIDLTDPAATGAVADATDDLEVGFLVYCAGADPAFEPFLAQPIEAAEAMVQRNCVAP
EEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHCHHHHHHHHHHHCCHHH
MRLCHHFAPAMAARGRGGLVIFGSGAGLAGGPNMVAYAATKAFDMVFAEALWAELHDTGV
HHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCH
DVLGLILGKTDTPALRTLEHRRGQIASTEQTPPGAVPVAGVVSEAFDNLANGPTWIVGED
HHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCH
LRAATQMMGSISRSDAVRFIVEASRDAMGP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA