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The map label for this gene is kinA [H]

Identifier: 108763801

GI number: 108763801

Start: 5527707

End: 5529260

Strand: Direct

Name: kinA [H]

Synonym: MXAN_4465

Alternate gene names: 108763801

Gene position: 5527707-5529260 (Clockwise)

Preceding gene: 108760999

Following gene: 108761117

Centisome position: 60.48

GC content: 70.53

Gene sequence:

>1554_bases
TTGCGTACAAGCGGTTGCCTCCGCCATGCTCGTCACATGGAAACACCCGTGCCGCTCGCCCAACTGCTCCAGGCCGTGGA
GGCAGGGGACCTGACGGCCGCGCGAACAGCGGCGGCGGCGCTGCAACGTGCGGGAGCGCACACCTCTCAGCTGGCGGCGG
AGGTGCTGCACGAGCTGCGACAACCGCTGCTCGGCGTGAAGGCCTACGCCCAACTCCTCGCGGAGGACGGCGCCGCCCCC
GGGCCCCTGCGCCTGCTGCTGGCCCAGGTGGAGCGGATGGAGCAGATCGTCTCCGACTTCATCCGCCTGTCGAGCGAGCG
ACCGGCGTCCCAACAGCGCCTCTCCCTGGCGGCCCCCATCTGGGCGGCGGCGAAGCACTTCAGCATCAACCCGGACTCCT
CGCGCATCTCCCTGGAGGTGGAAGCCCCGGAGGACATCACCATCCAGGGCAACGCGCGCCTCATTGAACAGCTCACCCTG
AACCTGCTCAACAACGCGCGCGACGCCATGGCGGGGCGCGGCCGGGTGAAGGTGGTGCTCACGATGGAGGGCCCCTCCCC
TGCCCTCTACGTGGCGGACTGGGGTCCGGGCATCCCCGAGGAGCTGCGAGCGCGCATCTTCGAGCCCTACATCACCGCCA
ACAATCGAGGCACCGGACTGGGCTTGTCGGTGTGCCAGCGCATCGCCCGCGAGCACCACGCGCGCCTCGAGCTGGCCCCG
CAGGGCGTCATTCGCGACGTCCCGCCCCCGGCCACCGTGTTCCGCGTGCTCTTCCCCGCGACGGACGCGCCGCCCACGCA
GAAGCACCGGGTCCTGGTGGTGGATGACGAAATCATCATCCGCATGGTCTTCCGCGACCTGATGGGCAAGGAGTGCGAGA
TCATCGAAGCGGCAAGCGGCGAGGAGGCCCTGGACCTGCTGCAACAGGCGCCGGTGGACCTCATCGTCACCGACAAGAAC
CTGCCCGGCATGTCCGGCCTGGAGCTGGCGCAGCAGGCGCGGCGGCGGCACACGGACTCGCGCGTCATCCTGATGACGGG
CTACCCGTCGCTGGTGACGACACAGCAGGCGCTGGAGCTGGGCGTGGTGGACTACCTGCTCAAGCCCTTCGACGACATCC
GCGAGGTGCGCGCCCTGCTGCGCTCCACGCTGGCCCGGAAGCCCGCCCCCGCGCCGCTGGAGACGAACCCCGCGATGCGC
CGGGTGGACGTGCTGGAGGACAACCCGGCGGCGGCGGCGCAAATCACCCACGCCCTGTCCCTGGTGGGACTGGAGGCGCG
CATCCTGACGACGACGGAGCTGGCCGCGCTGGAGCCGCCCGCGGGCGTGGTGGTGAGCTGGGACTTCACGCCCGCCTACG
GGCGCAAGGCGCTGGAGCTGGGCAAGGCGCTGGCCCAGGGCGCTCCCTTCGTCGTGCTGGCCGAGCACCTCACCATGGAG
ACGGCGCTGGAGTCCCTCCGTGCGGGCGCCGCCGCGTGCCTCCCCAAGCTGATGTCCGACGCCTCGGCGCTCAGCCGAGA
GTTGAACCGCGCATTCAAACGAGAGACCCCATGA

Upstream 100 bases:

>100_bases
AGGCCGGTGTCGCGATATCCGGATTTCCGGACGGTGCGATGAGAACGCGGCCAGCATCCGTGCCGGCACGGTCCGGGTCA
ACGGATTCCCTCCAGGTGCG

Downstream 100 bases:

>100_bases
GACTCGCGCTCCTGTCCGTCCTGCTGTTGGGTGTTGCTTGCTCCTCCGACAAGCCGCCGATGCAGGACGGGCCGGACGCG
GGCCGTGGCGACGCGGGCAC

Product: sensor histidine kinase/response rgulator

Products: NA

Alternate protein names: Stage II sporulation protein F; Stage II sporulation protein J [H]

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MRTSGCLRHARHMETPVPLAQLLQAVEAGDLTAARTAAAALQRAGAHTSQLAAEVLHELRQPLLGVKAYAQLLAEDGAAP
GPLRLLLAQVERMEQIVSDFIRLSSERPASQQRLSLAAPIWAAAKHFSINPDSSRISLEVEAPEDITIQGNARLIEQLTL
NLLNNARDAMAGRGRVKVVLTMEGPSPALYVADWGPGIPEELRARIFEPYITANNRGTGLGLSVCQRIAREHHARLELAP
QGVIRDVPPPATVFRVLFPATDAPPTQKHRVLVVDDEIIIRMVFRDLMGKECEIIEAASGEEALDLLQQAPVDLIVTDKN
LPGMSGLELAQQARRRHTDSRVILMTGYPSLVTTQQALELGVVDYLLKPFDDIREVRALLRSTLARKPAPAPLETNPAMR
RVDVLEDNPAAAAQITHALSLVGLEARILTTTELAALEPPAGVVVSWDFTPAYGRKALELGKALAQGAPFVVLAEHLTME
TALESLRAGAAACLPKLMSDASALSRELNRAFKRETP

Sequences:

>Translated_517_residues
MRTSGCLRHARHMETPVPLAQLLQAVEAGDLTAARTAAAALQRAGAHTSQLAAEVLHELRQPLLGVKAYAQLLAEDGAAP
GPLRLLLAQVERMEQIVSDFIRLSSERPASQQRLSLAAPIWAAAKHFSINPDSSRISLEVEAPEDITIQGNARLIEQLTL
NLLNNARDAMAGRGRVKVVLTMEGPSPALYVADWGPGIPEELRARIFEPYITANNRGTGLGLSVCQRIAREHHARLELAP
QGVIRDVPPPATVFRVLFPATDAPPTQKHRVLVVDDEIIIRMVFRDLMGKECEIIEAASGEEALDLLQQAPVDLIVTDKN
LPGMSGLELAQQARRRHTDSRVILMTGYPSLVTTQQALELGVVDYLLKPFDDIREVRALLRSTLARKPAPAPLETNPAMR
RVDVLEDNPAAAAQITHALSLVGLEARILTTTELAALEPPAGVVVSWDFTPAYGRKALELGKALAQGAPFVVLAEHLTME
TALESLRAGAAACLPKLMSDASALSRELNRAFKRETP
>Mature_517_residues
MRTSGCLRHARHMETPVPLAQLLQAVEAGDLTAARTAAAALQRAGAHTSQLAAEVLHELRQPLLGVKAYAQLLAEDGAAP
GPLRLLLAQVERMEQIVSDFIRLSSERPASQQRLSLAAPIWAAAKHFSINPDSSRISLEVEAPEDITIQGNARLIEQLTL
NLLNNARDAMAGRGRVKVVLTMEGPSPALYVADWGPGIPEELRARIFEPYITANNRGTGLGLSVCQRIAREHHARLELAP
QGVIRDVPPPATVFRVLFPATDAPPTQKHRVLVVDDEIIIRMVFRDLMGKECEIIEAASGEEALDLLQQAPVDLIVTDKN
LPGMSGLELAQQARRRHTDSRVILMTGYPSLVTTQQALELGVVDYLLKPFDDIREVRALLRSTLARKPAPAPLETNPAMR
RVDVLEDNPAAAAQITHALSLVGLEARILTTTELAALEPPAGVVVSWDFTPAYGRKALELGKALAQGAPFVVLAEHLTME
TALESLRAGAAACLPKLMSDASALSRELNRAFKRETP

Specific function: Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. It also autophosphorylates in the presence of ATP [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=237, Percent_Identity=26.5822784810127, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1790436, Length=199, Percent_Identity=32.1608040201005, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1790551, Length=199, Percent_Identity=31.1557788944724, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1788713, Length=436, Percent_Identity=22.0183486238532, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1787487, Length=157, Percent_Identity=30.5732484076433, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI87081816, Length=400, Percent_Identity=25.25, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI48994928, Length=371, Percent_Identity=25.3369272237197, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790300, Length=235, Percent_Identity=28.0851063829787, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790299, Length=120, Percent_Identity=37.5, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789808, Length=210, Percent_Identity=27.6190476190476, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790863, Length=121, Percent_Identity=32.2314049586777, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=35.7798165137615, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR013655
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF08447 PAS_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56056; Mature: 56056

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTSGCLRHARHMETPVPLAQLLQAVEAGDLTAARTAAAALQRAGAHTSQLAAEVLHELR
CCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
QPLLGVKAYAQLLAEDGAAPGPLRLLLAQVERMEQIVSDFIRLSSERPASQQRLSLAAPI
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
WAAAKHFSINPDSSRISLEVEAPEDITIQGNARLIEQLTLNLLNNARDAMAGRGRVKVVL
HHHHHCCCCCCCCCEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
TMEGPSPALYVADWGPGIPEELRARIFEPYITANNRGTGLGLSVCQRIAREHHARLELAP
EECCCCCEEEEECCCCCCCHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHCEEEECC
QGVIRDVPPPATVFRVLFPATDAPPTQKHRVLVVDDEIIIRMVFRDLMGKECEIIEAASG
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCEEEEECCCC
EEALDLLQQAPVDLIVTDKNLPGMSGLELAQQARRRHTDSRVILMTGYPSLVTTQQALEL
HHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHH
GVVDYLLKPFDDIREVRALLRSTLARKPAPAPLETNPAMRRVDVLEDNPAAAAQITHALS
HHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHH
LVGLEARILTTTELAALEPPAGVVVSWDFTPAYGRKALELGKALAQGAPFVVLAEHLTME
HHCCCEEEEEHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHH
TALESLRAGAAACLPKLMSDASALSRELNRAFKRETP
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRTSGCLRHARHMETPVPLAQLLQAVEAGDLTAARTAAAALQRAGAHTSQLAAEVLHELR
CCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
QPLLGVKAYAQLLAEDGAAPGPLRLLLAQVERMEQIVSDFIRLSSERPASQQRLSLAAPI
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
WAAAKHFSINPDSSRISLEVEAPEDITIQGNARLIEQLTLNLLNNARDAMAGRGRVKVVL
HHHHHCCCCCCCCCEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
TMEGPSPALYVADWGPGIPEELRARIFEPYITANNRGTGLGLSVCQRIAREHHARLELAP
EECCCCCEEEEECCCCCCCHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHCEEEECC
QGVIRDVPPPATVFRVLFPATDAPPTQKHRVLVVDDEIIIRMVFRDLMGKECEIIEAASG
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCEEEEECCCC
EEALDLLQQAPVDLIVTDKNLPGMSGLELAQQARRRHTDSRVILMTGYPSLVTTQQALEL
HHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHH
GVVDYLLKPFDDIREVRALLRSTLARKPAPAPLETNPAMRRVDVLEDNPAAAAQITHALS
HHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHH
LVGLEARILTTTELAALEPPAGVVVSWDFTPAYGRKALELGKALAQGAPFVVLAEHLTME
HHCCCEEEEEHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHH
TALESLRAGAAACLPKLMSDASALSRELNRAFKRETP
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2104615; 2509430; 9384377 [H]