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The map label for this gene is pheS

Identifier: 108763246

GI number: 108763246

Start: 4189082

End: 4190131

Strand: Direct

Name: pheS

Synonym: MXAN_3594

Alternate gene names: 108763246

Gene position: 4189082-4190131 (Clockwise)

Preceding gene: 108760663

Following gene: 108761050

Centisome position: 45.83

GC content: 69.33

Gene sequence:

>1050_bases
ATGCGGGATCGGTTGCTGGCGCTCGCGGAGTCCGCGAGGCGGGAGATTGGCGGCGCGTCGGAGCTGTCCGCGGTGGAAGC
ACTGCGGGTCCGCTACCTGGGCAAGAAGGGTGAGCTGTCCGGCGTGCTGGGCGGCATGGGCAAGCTGCCCCCGGACGAGC
GGCGCTCGCTGGGCGAGGTGGCCAACAGCGTGAAGGCGGAGCTGGAGAAGCTGCTCGCCGAGGCCGTGGAGCGCGCCGAG
GCGGCCGCGCTGGAGGCCCAGCTTCAGGGCCCGGGCCTGGACGTGACGCTGCCCGGACGCGGCGTGGCGCTGGGCAGCCG
GCACCCCGTGTCGCGGACGATGGAGGAGATTGTCCGGACCTTCTCGCGGCTCGGCTTCGACGTGGCCAGCGGCCCCGAGA
TCGAGCTGGACTACTTCAACTTCGAAGCGCTGAACCTGCCGAAGGACCACCCCGCGCGGGACATGCAGGACACCTTCTAC
GTGGACGAGGCCACGCTGGGCCACGCGAAGAAGGCGGACAGCTCCGCGCTGCTGCGCACGCACACGTCCCCGGTGCAGGT
GCGGTACATGCTCAACCGCAAGCCGCCCATCCGCGCGGTGATGCCGGGCCGGGTGTACCGGCGCGACTCGGACATCACGC
ACACGCCGATGTTCCACCAGGTGGAAGGCCTGCTGGTGGACAAGGGCGTGACGTTCGCCGAGCTGAAGGGCTCGTTGGCG
GCGTTCGTGACGGCGTTCTTCGGTTCGGACACGCGCACGCGCTTCCGCCCGTCCTTCTTCCCCTTCACGGAGCCCTCCGC
CGAGGTGGACATCACCTGCACGAACTGCGCGGGCAAGGGCTGCCGCATCTGCAAGCAGACGGGGTGGTTGGAGGTGCTGG
GCAGCGGCATGGTGCACCCCAACGTCTTCACCTCCGCCGGGTATGACCCGAACGAGGTGACGGGCTACGCGTTCGGCATG
GGCGTGGAGCGCATCGCCATGCTGCGCTACCGCATCGACGACCTGCGGATGATGTTCGAGAACGACGCGCGGTTCCTCGA
GCAGTTCTGA

Upstream 100 bases:

>100_bases
ACCCTGTCCGGATGTTTGAACGGGCTGCCTCTCTGGGGCGGCCCTTTTTTTTGCCTCGGCGCCAAGGGCGCGCGGGGAAC
TGGAACGGAGGCGGAAGTCC

Downstream 100 bases:

>100_bases
GATTCCAGGGGGCCGCTGGTGGGCCCCCGTGTTCCAGCCGATTGATGAAGAGGGTGGACCTGTGAAGATTTCGGTGAAGT
GGCTGGGCGATTACGTGGCG

Product: phenylalanyl-tRNA synthetase subunit alpha

Products: NA

Alternate protein names: Phenylalanine--tRNA ligase alpha chain; PheRS

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MRDRLLALAESARREIGGASELSAVEALRVRYLGKKGELSGVLGGMGKLPPDERRSLGEVANSVKAELEKLLAEAVERAE
AAALEAQLQGPGLDVTLPGRGVALGSRHPVSRTMEEIVRTFSRLGFDVASGPEIELDYFNFEALNLPKDHPARDMQDTFY
VDEATLGHAKKADSSALLRTHTSPVQVRYMLNRKPPIRAVMPGRVYRRDSDITHTPMFHQVEGLLVDKGVTFAELKGSLA
AFVTAFFGSDTRTRFRPSFFPFTEPSAEVDITCTNCAGKGCRICKQTGWLEVLGSGMVHPNVFTSAGYDPNEVTGYAFGM
GVERIAMLRYRIDDLRMMFENDARFLEQF

Sequences:

>Translated_349_residues
MRDRLLALAESARREIGGASELSAVEALRVRYLGKKGELSGVLGGMGKLPPDERRSLGEVANSVKAELEKLLAEAVERAE
AAALEAQLQGPGLDVTLPGRGVALGSRHPVSRTMEEIVRTFSRLGFDVASGPEIELDYFNFEALNLPKDHPARDMQDTFY
VDEATLGHAKKADSSALLRTHTSPVQVRYMLNRKPPIRAVMPGRVYRRDSDITHTPMFHQVEGLLVDKGVTFAELKGSLA
AFVTAFFGSDTRTRFRPSFFPFTEPSAEVDITCTNCAGKGCRICKQTGWLEVLGSGMVHPNVFTSAGYDPNEVTGYAFGM
GVERIAMLRYRIDDLRMMFENDARFLEQF
>Mature_349_residues
MRDRLLALAESARREIGGASELSAVEALRVRYLGKKGELSGVLGGMGKLPPDERRSLGEVANSVKAELEKLLAEAVERAE
AAALEAQLQGPGLDVTLPGRGVALGSRHPVSRTMEEIVRTFSRLGFDVASGPEIELDYFNFEALNLPKDHPARDMQDTFY
VDEATLGHAKKADSSALLRTHTSPVQVRYMLNRKPPIRAVMPGRVYRRDSDITHTPMFHQVEGLLVDKGVTFAELKGSLA
AFVTAFFGSDTRTRFRPSFFPFTEPSAEVDITCTNCAGKGCRICKQTGWLEVLGSGMVHPNVFTSAGYDPNEVTGYAFGM
GVERIAMLRYRIDDLRMMFENDARFLEQF

Specific function: Unknown

COG id: COG0016

COG function: function code J; Phenylalanyl-tRNA synthetase alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 1 subfamily

Homologues:

Organism=Homo sapiens, GI4758340, Length=267, Percent_Identity=31.4606741573034, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI5729820, Length=300, Percent_Identity=30, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI1788007, Length=345, Percent_Identity=51.0144927536232, Blast_Score=344, Evalue=5e-96,
Organism=Caenorhabditis elegans, GI32563657, Length=269, Percent_Identity=30.8550185873606, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17508957, Length=269, Percent_Identity=30.8550185873606, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI32566635, Length=262, Percent_Identity=32.0610687022901, Blast_Score=110, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6321087, Length=277, Percent_Identity=29.9638989169675, Blast_Score=129, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6325304, Length=338, Percent_Identity=26.3313609467456, Blast_Score=113, Evalue=4e-26,
Organism=Drosophila melanogaster, GI18858079, Length=308, Percent_Identity=29.2207792207792, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI17137424, Length=310, Percent_Identity=27.741935483871, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYFA_MYXXD (Q1D6E0)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_631783.1
- ProteinModelPortal:   Q1D6E0
- SMR:   Q1D6E0
- STRING:   Q1D6E0
- GeneID:   4107001
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_3594
- TIGR:   MXAN_3594
- eggNOG:   COG0016
- HOGENOM:   HBG284353
- OMA:   FRASYFP
- PhylomeDB:   Q1D6E0
- ProtClustDB:   PRK00488
- BioCyc:   MXAN246197:MXAN_3594-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00281
- InterPro:   IPR006195
- InterPro:   IPR004529
- InterPro:   IPR004188
- InterPro:   IPR022911
- InterPro:   IPR002319
- InterPro:   IPR010978
- PANTHER:   PTHR11538
- TIGRFAMs:   TIGR00468

Pfam domain/function: PF02912 Phe_tRNA-synt_N; PF01409 tRNA-synt_2d; SSF46589 tRNA_binding_arm

EC number: =6.1.1.20

Molecular weight: Translated: 38525; Mature: 38525

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDRLLALAESARREIGGASELSAVEALRVRYLGKKGELSGVLGGMGKLPPDERRSLGEV
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHH
ANSVKAELEKLLAEAVERAEAAALEAQLQGPGLDVTLPGRGVALGSRHPVSRTMEEIVRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEECCCCCCHHHHHHHHHHH
FSRLGFDVASGPEIELDYFNFEALNLPKDHPARDMQDTFYVDEATLGHAKKADSSALLRT
HHHCCCCCCCCCCEEEEEECEEEECCCCCCCCCCCCHHEEECCHHCCCCCCCCCCHHHHC
HTSPVQVRYMLNRKPPIRAVMPGRVYRRDSDITHTPMFHQVEGLLVDKGVTFAELKGSLA
CCCCEEEEEEECCCCCCEEECCCCCEECCCCCCCCCHHHHHCCEEEECCCCHHHHHHHHH
AFVTAFFGSDTRTRFRPSFFPFTEPSAEVDITCTNCAGKGCRICKQTGWLEVLGSGMVHP
HHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHCCHHHHHCCCCCCC
NVFTSAGYDPNEVTGYAFGMGVERIAMLRYRIDDLRMMFENDARFLEQF
CCCCCCCCCCCCCCEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRDRLLALAESARREIGGASELSAVEALRVRYLGKKGELSGVLGGMGKLPPDERRSLGEV
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHH
ANSVKAELEKLLAEAVERAEAAALEAQLQGPGLDVTLPGRGVALGSRHPVSRTMEEIVRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEECCCCCCHHHHHHHHHHH
FSRLGFDVASGPEIELDYFNFEALNLPKDHPARDMQDTFYVDEATLGHAKKADSSALLRT
HHHCCCCCCCCCCEEEEEECEEEECCCCCCCCCCCCHHEEECCHHCCCCCCCCCCHHHHC
HTSPVQVRYMLNRKPPIRAVMPGRVYRRDSDITHTPMFHQVEGLLVDKGVTFAELKGSLA
CCCCEEEEEEECCCCCCEEECCCCCEECCCCCCCCCHHHHHCCEEEECCCCHHHHHHHHH
AFVTAFFGSDTRTRFRPSFFPFTEPSAEVDITCTNCAGKGCRICKQTGWLEVLGSGMVHP
HHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHCCHHHHHCCCCCCC
NVFTSAGYDPNEVTGYAFGMGVERIAMLRYRIDDLRMMFENDARFLEQF
CCCCCCCCCCCCCCEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA