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The map label for this gene is mazG [H]

Identifier: 108762913

GI number: 108762913

Start: 5940472

End: 5941662

Strand: Direct

Name: mazG [H]

Synonym: MXAN_4741

Alternate gene names: 108762913

Gene position: 5940472-5941662 (Clockwise)

Preceding gene: 108759158

Following gene: 108757146

Centisome position: 65.0

GC content: 69.44

Gene sequence:

>1191_bases
ATGGCGGACACGACGCTGACCCCCGGGGCGGAGCTGGAGCGACTGGTCGACATCATGCGGAAGCTGCGCGCTGAAGGCGG
CTGCCCGTGGGATCGCGAACAAGACCTGCGCTCGCTGCGGCCCTACCTCCTGGAAGAGGCCTTCGAGGTCTTGGAGGAGA
TGGACCGGGTCGCCTACGGTGGCTCCTGGCGGACCTTCTGCGAAGAGCTGGGAGACCTGCTTTTCCAGATTGTCTTCCAC
GCCCAGCTCGCCTCGGAGCTTGGAGAGTTCTCCCTGGCTGACGTGGCGAAGGCCATTGGCGACAAGCTGGTCAGCCGGCA
TCCCCATGTCTTCGGCAACGGCCAGCGAATGGAAGGCGCCGAGCAGGTCCTGGACAACTGGGCCAAGCTGAAGGCCGCGG
AGAAGAAGCGCAAGACGGGCCGGGAGGGCTCGGTGCTGGACGGCGTCCCCGTCGCCGCCCCGGCGCTGATGCGCGCCGAG
CGGCTCACGGAGAAGGCCAGCCGCATCGGCTTCGACTGGCCGGACGTCGCCAGCGTGCGCGCCAAGCTGACGGAGGAGTT
GGGGGAGCTGGACGAGGCCATCGCCGCGAATGATCGGGATGCCATCGAGCACGAGCTGGGGGACGTGCTGTTCTCGCTCG
CCAACCTCGCGCGCTTCGTCGGAGCCCCCGCCGAGGACGCGCTGCGGATGGCCATCCGCCGCTTCACCGCCCGCTTCCAG
CACATCGAGTCCGCCCTCCGCGCCGAGGGTGTCGCCCTGGGGGACGCCACCCTGGAACACATGGAGCGTCACTGGCAGGA
GGCCAAGGCGCGCGAAAAGGCCCTGCCATCTCCGACGTGGGTTCCGCGCGCGCCCGTCACCACGCTGAGGCTGGGCGTGG
CGGATCTTCCCGCGCAGCGCGCCTTCTGGGACGTCCTGGCTCCGCGGCTGGGGTGGATCACCCGACGGGCTCCGGCGGCG
GATCAGGCCCGCTATGAGGACGGGGGCATCCTGATCGCCTTCGAAGCGGCAGGGACGCCCACAACGGGCCTGCGGCTGAG
CCTGACGGCCCCCTCCCTGGCGGCGGTGGAGCGACTCCCCGGCATCCTCGCGGAGATTCCGGGGAGTCGGCTGATCCAGC
ACCAGGCCGGCCGGCTCACCTTTCAAGATCCCGCGGGGCTGGTGTGGGAATATACGACTTCGGTAGAGTGA

Upstream 100 bases:

>100_bases
AGGCGACCCAGGGCCAAGCGCGAAAACGAACGCCAGCCTGGCTGCCCACCTGCCGCGTTTGCCGGACAGCACCAGACCCG
TGCGTGCTACAGGAACGTGC

Downstream 100 bases:

>100_bases
TTTTCCTCGCAGGTGCCCTCGGCGGGGCGTCCAGAGCCCGGAAATCCCGGCTGGAGGCCCACACCCGCCTTGACGCCTGC
GAGGCGTCGCAGTAAGGACG

Product: MazG family protein

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MADTTLTPGAELERLVDIMRKLRAEGGCPWDREQDLRSLRPYLLEEAFEVLEEMDRVAYGGSWRTFCEELGDLLFQIVFH
AQLASELGEFSLADVAKAIGDKLVSRHPHVFGNGQRMEGAEQVLDNWAKLKAAEKKRKTGREGSVLDGVPVAAPALMRAE
RLTEKASRIGFDWPDVASVRAKLTEELGELDEAIAANDRDAIEHELGDVLFSLANLARFVGAPAEDALRMAIRRFTARFQ
HIESALRAEGVALGDATLEHMERHWQEAKAREKALPSPTWVPRAPVTTLRLGVADLPAQRAFWDVLAPRLGWITRRAPAA
DQARYEDGGILIAFEAAGTPTTGLRLSLTAPSLAAVERLPGILAEIPGSRLIQHQAGRLTFQDPAGLVWEYTTSVE

Sequences:

>Translated_396_residues
MADTTLTPGAELERLVDIMRKLRAEGGCPWDREQDLRSLRPYLLEEAFEVLEEMDRVAYGGSWRTFCEELGDLLFQIVFH
AQLASELGEFSLADVAKAIGDKLVSRHPHVFGNGQRMEGAEQVLDNWAKLKAAEKKRKTGREGSVLDGVPVAAPALMRAE
RLTEKASRIGFDWPDVASVRAKLTEELGELDEAIAANDRDAIEHELGDVLFSLANLARFVGAPAEDALRMAIRRFTARFQ
HIESALRAEGVALGDATLEHMERHWQEAKAREKALPSPTWVPRAPVTTLRLGVADLPAQRAFWDVLAPRLGWITRRAPAA
DQARYEDGGILIAFEAAGTPTTGLRLSLTAPSLAAVERLPGILAEIPGSRLIQHQAGRLTFQDPAGLVWEYTTSVE
>Mature_395_residues
ADTTLTPGAELERLVDIMRKLRAEGGCPWDREQDLRSLRPYLLEEAFEVLEEMDRVAYGGSWRTFCEELGDLLFQIVFHA
QLASELGEFSLADVAKAIGDKLVSRHPHVFGNGQRMEGAEQVLDNWAKLKAAEKKRKTGREGSVLDGVPVAAPALMRAER
LTEKASRIGFDWPDVASVRAKLTEELGELDEAIAANDRDAIEHELGDVLFSLANLARFVGAPAEDALRMAIRRFTARFQH
IESALRAEGVALGDATLEHMERHWQEAKAREKALPSPTWVPRAPVTTLRLGVADLPAQRAFWDVLAPRLGWITRRAPAAD
QARYEDGGILIAFEAAGTPTTGLRLSLTAPSLAAVERLPGILAEIPGSRLIQHQAGRLTFQDPAGLVWEYTTSVE

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=265, Percent_Identity=41.1320754716981, Blast_Score=201, Evalue=5e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 43667; Mature: 43536

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTTLTPGAELERLVDIMRKLRAEGGCPWDREQDLRSLRPYLLEEAFEVLEEMDRVAYG
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GSWRTFCEELGDLLFQIVFHAQLASELGEFSLADVAKAIGDKLVSRHPHVFGNGQRMEGA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
EQVLDNWAKLKAAEKKRKTGREGSVLDGVPVAAPALMRAERLTEKASRIGFDWPDVASVR
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
AKLTEELGELDEAIAANDRDAIEHELGDVLFSLANLARFVGAPAEDALRMAIRRFTARFQ
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
HIESALRAEGVALGDATLEHMERHWQEAKAREKALPSPTWVPRAPVTTLRLGVADLPAQR
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHH
AFWDVLAPRLGWITRRAPAADQARYEDGGILIAFEAAGTPTTGLRLSLTAPSLAAVERLP
HHHHHHHHHHHHHHCCCCCHHHCCCCCCCEEEEEECCCCCCCCEEEEECCCHHHHHHHCC
GILAEIPGSRLIQHQAGRLTFQDPAGLVWEYTTSVE
HHHHHCCCHHHHHHHCCCEEECCCCCCEEEECCCCC
>Mature Secondary Structure 
ADTTLTPGAELERLVDIMRKLRAEGGCPWDREQDLRSLRPYLLEEAFEVLEEMDRVAYG
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GSWRTFCEELGDLLFQIVFHAQLASELGEFSLADVAKAIGDKLVSRHPHVFGNGQRMEGA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
EQVLDNWAKLKAAEKKRKTGREGSVLDGVPVAAPALMRAERLTEKASRIGFDWPDVASVR
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
AKLTEELGELDEAIAANDRDAIEHELGDVLFSLANLARFVGAPAEDALRMAIRRFTARFQ
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
HIESALRAEGVALGDATLEHMERHWQEAKAREKALPSPTWVPRAPVTTLRLGVADLPAQR
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHH
AFWDVLAPRLGWITRRAPAADQARYEDGGILIAFEAAGTPTTGLRLSLTAPSLAAVERLP
HHHHHHHHHHHHHHCCCCCHHHCCCCCCCEEEEEECCCCCCCCEEEEECCCHHHHHHHCC
GILAEIPGSRLIQHQAGRLTFQDPAGLVWEYTTSVE
HHHHHCCCHHHHHHHCCCEEECCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]