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The map label for this gene is zraS [H]

Identifier: 108762891

GI number: 108762891

Start: 4206674

End: 4208824

Strand: Reverse

Name: zraS [H]

Synonym: MXAN_3606

Alternate gene names: 108762891

Gene position: 4208824-4206674 (Counterclockwise)

Preceding gene: 108756823

Following gene: 108762518

Centisome position: 46.05

GC content: 53.0

Gene sequence:

>2151_bases
ATGCTGACTGGCCCACTTTCTGGAAACGGCCTGCCTCAATCCTGCGCTAGTGTCACTCTCATGGCAACCCTGCAAGGGCA
GCACGTCTTTCGTCCTAGAGCTCGTGTCCTACGACTCCTCGGTGAAGAACTAATCAGCGACGAAACCATTGCCGTCGTCG
AGCTAGTCAGGAATGCATGGGACGCAGATGCGCTAAGCGTCAAGGTCGCATTTCACAATGCCCAAAATGCACTTGGCGGA
AGTCTTGACATCATTGATGACGGACACGGCATGTCGAAAGAGACCGTCCTTGGGTCATGGCTCCAACCTGCTACCCCGGA
CAAGAAACTTCGGCATGCATCTCCATCAGGACGGCCGCTTCTTGGCAAGAAGGGCATTGGTCGCTTTGCCGCTGATAAAC
TCGCTAGAAAGCTAGTACTCATCACAAAGAAAGAGGGAGAGACGACAGCAACAAGAGCGGTCGTCGACTGGAATCAGTTC
GACGATCCTATGAAGTTTCTCGACGAAATCCATCCACAGATTGACTCCCATCCAACCCCTGCCACTGGCCATGGCACCAG
TCTATTCCTCCAAGACCTCCGCAGCTCTTGGTCCGAAGACAGAATCGCCCATCTCAAATTAGAACTATTAAAGCTATTTC
CTCCATTCAGATCCACAGAAGTTCTGGGCAGCCCTGTGATACCTCCAGCGCTTGCCACGTTCCAGGTAAAGCTGGAGGTT
GATGGGATTTCCGAGGACATAGGCCATTTTCCGCAGTCACTCAGGACACTCTGTCCTTGGCGAGTGAGGGCTGTCGTTCG
CGCACACAGCCCAACCGAAGACGAAATTGCAATTGCAATCAATAATGAGCCCGAGCGCGTGCGACCCCTTGGCGGAGGAG
CAAAGGGAAAGAAGAGCGCAGCCGGCCATTTTGCCGTTGAAATCGACGTCTGGGTCAGAAGCGCAGAAGGACTGGCTGGT
ATTCGCGAGACACTGGATCTCTCGCTTCAAGAGGCCAGAGGACTGCTTGATAAGTGGTCGGGAATTTCAGTCTATAGAGA
CGGCTTCCGCGTCTTCCCTTATGGCGAACCAGGTAACGATTGGCTCGACCTCGACAAAGAGCGAATCAACACGCCCAAAG
AGAGGCTCAGCAACAGCCAAATCATTGGATGCATCTACCTAAGCGAGCAAGACAACCCAGAACTTCGCGATCAGACCAAT
CGCCAAGGCTTGGTAAACAATGACGCCTTCAACGATCTTCGCTCAGCGATCAGGCAGGTCATCAGAGAGATCGAAAACCG
AATACTCGTCGACAAGCCGACCACCAAGCAACGCCGATCCGGGAGGCGGCTCTTTGAACTGGAAAGTCTCAAGCGCTTGC
GGGAAATAGCGGAAACATCAAAATCAGTTGCAAGCACGCAAGTCCTCGCAATGATTGGCGCAGCAGAGGCAGAAAAATCG
TCCGCAGAAGAAACGATTTCGCAAGAAATTTCAAGATATCGTCGAATCCTAAGCCTATCAGTAGTAGCAACTCGGATGGC
TCATGAAATCAGGCAGCAGGTCGACATTATCCGCCGAGCGATAGACAATGGCCTCAAGCGCCTAGCAAAAGCCTCCGTCA
CTATTGTGGGTGTATCCGAAGCATTGGCACGTGCAGATGAATCGGCGGGCATCGTGGCTCGGGAAGTGCGCAGACTCCTT
CCGTTCACGCGCGCACGCAGAAAGATTGAGAAGATCGACCTCAGCAGGCTAGCCATCGACATCCAAAGCGATTTCACTGA
ACCAGCAAGCAAGAGAAACATTGAAATTAAATTTGCGTCACCGTCGAGTCCGGCAGAGGTCGAGGTAGACTATGGAGAGC
TATATCAAGCCGTTAGAAACCTCGTCGACAATGCCTTGTTCTGGAGTCCAGAAGGAGGGCAAGTAACTCTCTCTGTTTTC
GCAAAACACGGAAGTGCCTTCATAGCCGTCACCGACCAAGGACCCGGTGTGCCTACCGAGGATGAGGGCGTCATCTTCGA
GCCGTATTGGTCGACCAAGCCCAACGGCTCCGGATTGGGCCTGCCGATCGCGGGCGAAATCGCTGCCGATTACGGAGGGA
GTTTGAGCCTGAAGAAAAGTAGCACGATCGCTGGTGCATCATTTGAGATTGCAATTCCGCGTGCAAAATGA

Upstream 100 bases:

>100_bases
CTGCTCTCGCCCTCAAGGCGTCGTCAGCTCGGCACGTCAGCCGAGGCGACTTCTTCCCTGACCCAGGGGGGGGGTACATT
CCGACAGCGAGCCAAGTTAG

Downstream 100 bases:

>100_bases
AACCTACCGAAAGAATCCTGGTAATCGACGACGATTCAGCATACGGAGCAACGGTCAAGGAATCGCTGGAATTGGATGAC
TACGAGGTCCAAGTCCGTGA

Product: putative sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 716; Mature: 716

Protein sequence:

>716_residues
MLTGPLSGNGLPQSCASVTLMATLQGQHVFRPRARVLRLLGEELISDETIAVVELVRNAWDADALSVKVAFHNAQNALGG
SLDIIDDGHGMSKETVLGSWLQPATPDKKLRHASPSGRPLLGKKGIGRFAADKLARKLVLITKKEGETTATRAVVDWNQF
DDPMKFLDEIHPQIDSHPTPATGHGTSLFLQDLRSSWSEDRIAHLKLELLKLFPPFRSTEVLGSPVIPPALATFQVKLEV
DGISEDIGHFPQSLRTLCPWRVRAVVRAHSPTEDEIAIAINNEPERVRPLGGGAKGKKSAAGHFAVEIDVWVRSAEGLAG
IRETLDLSLQEARGLLDKWSGISVYRDGFRVFPYGEPGNDWLDLDKERINTPKERLSNSQIIGCIYLSEQDNPELRDQTN
RQGLVNNDAFNDLRSAIRQVIREIENRILVDKPTTKQRRSGRRLFELESLKRLREIAETSKSVASTQVLAMIGAAEAEKS
SAEETISQEISRYRRILSLSVVATRMAHEIRQQVDIIRRAIDNGLKRLAKASVTIVGVSEALARADESAGIVAREVRRLL
PFTRARRKIEKIDLSRLAIDIQSDFTEPASKRNIEIKFASPSSPAEVEVDYGELYQAVRNLVDNALFWSPEGGQVTLSVF
AKHGSAFIAVTDQGPGVPTEDEGVIFEPYWSTKPNGSGLGLPIAGEIAADYGGSLSLKKSSTIAGASFEIAIPRAK

Sequences:

>Translated_716_residues
MLTGPLSGNGLPQSCASVTLMATLQGQHVFRPRARVLRLLGEELISDETIAVVELVRNAWDADALSVKVAFHNAQNALGG
SLDIIDDGHGMSKETVLGSWLQPATPDKKLRHASPSGRPLLGKKGIGRFAADKLARKLVLITKKEGETTATRAVVDWNQF
DDPMKFLDEIHPQIDSHPTPATGHGTSLFLQDLRSSWSEDRIAHLKLELLKLFPPFRSTEVLGSPVIPPALATFQVKLEV
DGISEDIGHFPQSLRTLCPWRVRAVVRAHSPTEDEIAIAINNEPERVRPLGGGAKGKKSAAGHFAVEIDVWVRSAEGLAG
IRETLDLSLQEARGLLDKWSGISVYRDGFRVFPYGEPGNDWLDLDKERINTPKERLSNSQIIGCIYLSEQDNPELRDQTN
RQGLVNNDAFNDLRSAIRQVIREIENRILVDKPTTKQRRSGRRLFELESLKRLREIAETSKSVASTQVLAMIGAAEAEKS
SAEETISQEISRYRRILSLSVVATRMAHEIRQQVDIIRRAIDNGLKRLAKASVTIVGVSEALARADESAGIVAREVRRLL
PFTRARRKIEKIDLSRLAIDIQSDFTEPASKRNIEIKFASPSSPAEVEVDYGELYQAVRNLVDNALFWSPEGGQVTLSVF
AKHGSAFIAVTDQGPGVPTEDEGVIFEPYWSTKPNGSGLGLPIAGEIAADYGGSLSLKKSSTIAGASFEIAIPRAK
>Mature_716_residues
MLTGPLSGNGLPQSCASVTLMATLQGQHVFRPRARVLRLLGEELISDETIAVVELVRNAWDADALSVKVAFHNAQNALGG
SLDIIDDGHGMSKETVLGSWLQPATPDKKLRHASPSGRPLLGKKGIGRFAADKLARKLVLITKKEGETTATRAVVDWNQF
DDPMKFLDEIHPQIDSHPTPATGHGTSLFLQDLRSSWSEDRIAHLKLELLKLFPPFRSTEVLGSPVIPPALATFQVKLEV
DGISEDIGHFPQSLRTLCPWRVRAVVRAHSPTEDEIAIAINNEPERVRPLGGGAKGKKSAAGHFAVEIDVWVRSAEGLAG
IRETLDLSLQEARGLLDKWSGISVYRDGFRVFPYGEPGNDWLDLDKERINTPKERLSNSQIIGCIYLSEQDNPELRDQTN
RQGLVNNDAFNDLRSAIRQVIREIENRILVDKPTTKQRRSGRRLFELESLKRLREIAETSKSVASTQVLAMIGAAEAEKS
SAEETISQEISRYRRILSLSVVATRMAHEIRQQVDIIRRAIDNGLKRLAKASVTIVGVSEALARADESAGIVAREVRRLL
PFTRARRKIEKIDLSRLAIDIQSDFTEPASKRNIEIKFASPSSPAEVEVDYGELYQAVRNLVDNALFWSPEGGQVTLSVF
AKHGSAFIAVTDQGPGVPTEDEGVIFEPYWSTKPNGSGLGLPIAGEIAADYGGSLSLKKSSTIAGASFEIAIPRAK

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=234, Percent_Identity=25.6410256410256, Blast_Score=83, Evalue=7e-17,
Organism=Escherichia coli, GI1790861, Length=131, Percent_Identity=32.824427480916, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 78619; Mature: 78619

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTGPLSGNGLPQSCASVTLMATLQGQHVFRPRARVLRLLGEELISDETIAVVELVRNAW
CCCCCCCCCCCCHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
DADALSVKVAFHNAQNALGGSLDIIDDGHGMSKETVLGSWLQPATPDKKLRHASPSGRPL
CCCCEEEEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCHHHHCCCCCCCCC
LGKKGIGRFAADKLARKLVLITKKEGETTATRAVVDWNQFDDPMKFLDEIHPQIDSHPTP
CCCCCCCHHHHHHHHHEEEEEEECCCCCCHHEEEECCCCCCCHHHHHHHHCHHHCCCCCC
ATGHGTSLFLQDLRSSWSEDRIAHLKLELLKLFPPFRSTEVLGSPVIPPALATFQVKLEV
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCEEEEEEEEE
DGISEDIGHFPQSLRTLCPWRVRAVVRAHSPTEDEIAIAINNEPERVRPLGGGAKGKKSA
CCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCEEEEECCCCHHCCCCCCCCCCCCCC
AGHFAVEIDVWVRSAEGLAGIRETLDLSLQEARGLLDKWSGISVYRDGFRVFPYGEPGND
CCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEECCCCCCCC
WLDLDKERINTPKERLSNSQIIGCIYLSEQDNPELRDQTNRQGLVNNDAFNDLRSAIRQV
HHCCCHHHCCCCHHHCCCCCEEEEEEECCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHH
IREIENRILVDKPTTKQRRSGRRLFELESLKRLREIAETSKSVASTQVLAMIGAAEAEKS
HHHHHCCEEECCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAEETISQEISRYRRILSLSVVATRMAHEIRQQVDIIRRAIDNGLKRLAKASVTIVGVSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHH
ALARADESAGIVAREVRRLLPFTRARRKIEKIDLSRLAIDIQSDFTEPASKRNIEIKFAS
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCEEEEEECC
PSSPAEVEVDYGELYQAVRNLVDNALFWSPEGGQVTLSVFAKHGSAFIAVTDQGPGVPTE
CCCCCEEEECHHHHHHHHHHHHHHCEEECCCCCEEEEEEEECCCCEEEEEECCCCCCCCC
DEGVIFEPYWSTKPNGSGLGLPIAGEIAADYGGSLSLKKSSTIAGASFEIAIPRAK
CCCEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEECCCCCCCCEEEEECCCCC
>Mature Secondary Structure
MLTGPLSGNGLPQSCASVTLMATLQGQHVFRPRARVLRLLGEELISDETIAVVELVRNAW
CCCCCCCCCCCCHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
DADALSVKVAFHNAQNALGGSLDIIDDGHGMSKETVLGSWLQPATPDKKLRHASPSGRPL
CCCCEEEEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCHHHHCCCCCCCCC
LGKKGIGRFAADKLARKLVLITKKEGETTATRAVVDWNQFDDPMKFLDEIHPQIDSHPTP
CCCCCCCHHHHHHHHHEEEEEEECCCCCCHHEEEECCCCCCCHHHHHHHHCHHHCCCCCC
ATGHGTSLFLQDLRSSWSEDRIAHLKLELLKLFPPFRSTEVLGSPVIPPALATFQVKLEV
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCEEEEEEEEE
DGISEDIGHFPQSLRTLCPWRVRAVVRAHSPTEDEIAIAINNEPERVRPLGGGAKGKKSA
CCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCEEEEECCCCHHCCCCCCCCCCCCCC
AGHFAVEIDVWVRSAEGLAGIRETLDLSLQEARGLLDKWSGISVYRDGFRVFPYGEPGND
CCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEECCCCCCCC
WLDLDKERINTPKERLSNSQIIGCIYLSEQDNPELRDQTNRQGLVNNDAFNDLRSAIRQV
HHCCCHHHCCCCHHHCCCCCEEEEEEECCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHH
IREIENRILVDKPTTKQRRSGRRLFELESLKRLREIAETSKSVASTQVLAMIGAAEAEKS
HHHHHCCEEECCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAEETISQEISRYRRILSLSVVATRMAHEIRQQVDIIRRAIDNGLKRLAKASVTIVGVSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHH
ALARADESAGIVAREVRRLLPFTRARRKIEKIDLSRLAIDIQSDFTEPASKRNIEIKFAS
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCEEEEEECC
PSSPAEVEVDYGELYQAVRNLVDNALFWSPEGGQVTLSVFAKHGSAFIAVTDQGPGVPTE
CCCCCEEEECHHHHHHHHHHHHHHCEEECCCCCEEEEEEEECCCCEEEEEECCCCCCCCC
DEGVIFEPYWSTKPNGSGLGLPIAGEIAADYGGSLSLKKSSTIAGASFEIAIPRAK
CCCEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEECCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]