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The map label for this gene is nadB [H]

Identifier: 108761799

GI number: 108761799

Start: 5810654

End: 5812243

Strand: Direct

Name: nadB [H]

Synonym: MXAN_4629

Alternate gene names: 108761799

Gene position: 5810654-5812243 (Clockwise)

Preceding gene: 108758385

Following gene: 108760756

Centisome position: 63.58

GC content: 68.49

Gene sequence:

>1590_bases
ATGCCCCATCGGTTCGATTTCCTCGTCCTGGGAGGCGGCGTGGCGGGTCTTTCGTTCGCCCTCCAGGCGGCCCGCCATGG
CACGGTGGCCATCCTCACCAAGCGCGACCGTTTCGAAAGCAACACGGCCTATGCCCAGGGCGGCATCGCCAGCGTGCTCG
CGCCCCCTGACACCTTCGAGTCCCACATCGAGGACACGCTGGTGGCGGGTGCGGGGCTGTGCCACCGCGACGCGGTGGAA
GTCACGGTGAAGGAAGGCCCCAGCCGCGTGCAGGAGCTGGCGGACCTGGGCGCGGAGTTCAACCGCCGCATCACCGGCGA
ATTCGACCTCACCCGCGAGGGTGGCCACTCCGCGCGCCGCATCATCCATTCGGGCGACATCACCGGCCGCGAGGTGCAGC
GCGCGCTGCTCGCCGCGTGTGACGAAGCCCCCAACATCACCTTCTTCCCGCAGACGGCCGCCATCGACCTCATCCAGGAC
CGGCGCGTCCCCTCCCCTGGGGTCAGCCGCTGTCTGGGGGTCTACGCCCTGCTGGAAGACGGCGTCATCGAGCGCTTCCT
GGCCAAGGTGACGGTGCTGGCCACCGGCGGCGCTGGCAAGGTGTACCTCTACACATCCAACCCGGACGTGGCGACGGGTG
ACGGCGTGGCCATGGCGTACCGGGCGGGCGCGAAGGTGGCGAACATGGAGTTCTACCAGTTCCACCCCACGTGCCTTTAC
CACCCGGAGGCCAAGAGCTTCCTCATCAGTGAGGCGCTGCGCGGCGAGGGCGGCAAGCTGAAGCTCAAGAGCGGCGCGTC
CTTCATGGAGCGCTACCACCCCATGGGCGCGCTCGCGCCGCGTGACGTGGTGGCGCGTGCCATCGACGCGGAGATGAAGC
GCACGGGCGACGACTGCGTCTACCTGGACATGACGCACCTGGGACGCGCCTTCCTCGCCGAGCGCTTCCCCAACATCTAC
GCCACCTGCAAGGCGTTCAACATCGACATGGCGGTGCAGCCCATCCCCGTCGTCCCGGCGGCCCACTACATGTGCGGCGG
CGTGGTGACGGACCTGGAGGGACGCACCAACGTGCCCAGCCTGTACGCCATCGGAGAAGTCACCTGTACGGGCCTGCACG
GCGCCAACCGGCTCGCGTCCAACTCGCTGCTGGAAGGGCTCGTCTTCGGCCACCGCGCCGTGCAGGTGGCCGCCGAAGAA
GTGCGCGCCCAGCCCTCTCCCTCCGAGGACCCGCCGCCCTGGGATTCGGGCAGCGCGGTGGAGTCGGATGAGAGCGTCGT
CGTCACCCACAACTGGGACGAGATTCGCAGGCTCATGTGGAACTACGTCGGCATTGTCCGCACGGACAAGCGGCTGATGC
GCGCGCGGCGCCGGCTGGAACTGCTGCGCGAGGAGATTCGCGACTACTACTGGCGCTTCAAGGTGACTCGCGACGTCATC
GAGCTGCGGAACATCGCCGACGTCGCCTACCTCATCGTCGACTGCGCCAGCCGCCGCAAGGAGAGCCGCGGCCTCCACTA
CACGCTGGACTACCCGCACCCGGACGACCACCGCTGGTTGCGGGACACCGTCGTGTCCAGGGAGCCGTGA

Upstream 100 bases:

>100_bases
AATAGGCACGCATATCGGCCCACGAACCTTAGACATCCGCGGGAAAGTCCTCAAGAAAACGCCTTGTTTCCAGCACTTAC
AGTCGTTAAGGCTGCTCACC

Downstream 100 bases:

>100_bases
GCCCGAATGTCTTCCCGTCCACGACGCATTCTCGATGCACCCTCCTCCGCCTCGGGCGGTGAAGGCACCGGCGCGCAGCC
CCCTGGCTCACCCATGCCAG

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO; Quinolinate synthase B [H]

Number of amino acids: Translated: 529; Mature: 528

Protein sequence:

>529_residues
MPHRFDFLVLGGGVAGLSFALQAARHGTVAILTKRDRFESNTAYAQGGIASVLAPPDTFESHIEDTLVAGAGLCHRDAVE
VTVKEGPSRVQELADLGAEFNRRITGEFDLTREGGHSARRIIHSGDITGREVQRALLAACDEAPNITFFPQTAAIDLIQD
RRVPSPGVSRCLGVYALLEDGVIERFLAKVTVLATGGAGKVYLYTSNPDVATGDGVAMAYRAGAKVANMEFYQFHPTCLY
HPEAKSFLISEALRGEGGKLKLKSGASFMERYHPMGALAPRDVVARAIDAEMKRTGDDCVYLDMTHLGRAFLAERFPNIY
ATCKAFNIDMAVQPIPVVPAAHYMCGGVVTDLEGRTNVPSLYAIGEVTCTGLHGANRLASNSLLEGLVFGHRAVQVAAEE
VRAQPSPSEDPPPWDSGSAVESDESVVVTHNWDEIRRLMWNYVGIVRTDKRLMRARRRLELLREEIRDYYWRFKVTRDVI
ELRNIADVAYLIVDCASRRKESRGLHYTLDYPHPDDHRWLRDTVVSREP

Sequences:

>Translated_529_residues
MPHRFDFLVLGGGVAGLSFALQAARHGTVAILTKRDRFESNTAYAQGGIASVLAPPDTFESHIEDTLVAGAGLCHRDAVE
VTVKEGPSRVQELADLGAEFNRRITGEFDLTREGGHSARRIIHSGDITGREVQRALLAACDEAPNITFFPQTAAIDLIQD
RRVPSPGVSRCLGVYALLEDGVIERFLAKVTVLATGGAGKVYLYTSNPDVATGDGVAMAYRAGAKVANMEFYQFHPTCLY
HPEAKSFLISEALRGEGGKLKLKSGASFMERYHPMGALAPRDVVARAIDAEMKRTGDDCVYLDMTHLGRAFLAERFPNIY
ATCKAFNIDMAVQPIPVVPAAHYMCGGVVTDLEGRTNVPSLYAIGEVTCTGLHGANRLASNSLLEGLVFGHRAVQVAAEE
VRAQPSPSEDPPPWDSGSAVESDESVVVTHNWDEIRRLMWNYVGIVRTDKRLMRARRRLELLREEIRDYYWRFKVTRDVI
ELRNIADVAYLIVDCASRRKESRGLHYTLDYPHPDDHRWLRDTVVSREP
>Mature_528_residues
PHRFDFLVLGGGVAGLSFALQAARHGTVAILTKRDRFESNTAYAQGGIASVLAPPDTFESHIEDTLVAGAGLCHRDAVEV
TVKEGPSRVQELADLGAEFNRRITGEFDLTREGGHSARRIIHSGDITGREVQRALLAACDEAPNITFFPQTAAIDLIQDR
RVPSPGVSRCLGVYALLEDGVIERFLAKVTVLATGGAGKVYLYTSNPDVATGDGVAMAYRAGAKVANMEFYQFHPTCLYH
PEAKSFLISEALRGEGGKLKLKSGASFMERYHPMGALAPRDVVARAIDAEMKRTGDDCVYLDMTHLGRAFLAERFPNIYA
TCKAFNIDMAVQPIPVVPAAHYMCGGVVTDLEGRTNVPSLYAIGEVTCTGLHGANRLASNSLLEGLVFGHRAVQVAAEEV
RAQPSPSEDPPPWDSGSAVESDESVVVTHNWDEIRRLMWNYVGIVRTDKRLMRARRRLELLREEIRDYYWRFKVTRDVIE
LRNIADVAYLIVDCASRRKESRGLHYTLDYPHPDDHRWLRDTVVSREP

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=529, Percent_Identity=34.0264650283554, Blast_Score=233, Evalue=2e-61,
Organism=Escherichia coli, GI1788928, Length=518, Percent_Identity=52.5096525096525, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI1786942, Length=559, Percent_Identity=34.7048300536673, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1790597, Length=540, Percent_Identity=34.0740740740741, Blast_Score=249, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17550100, Length=528, Percent_Identity=33.7121212121212, Blast_Score=231, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17505833, Length=525, Percent_Identity=32.1904761904762, Blast_Score=228, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI71986328, Length=471, Percent_Identity=27.3885350318471, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6322701, Length=569, Percent_Identity=32.5131810193322, Blast_Score=237, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6322416, Length=569, Percent_Identity=33.9191564147627, Blast_Score=236, Evalue=8e-63,
Organism=Drosophila melanogaster, GI24663005, Length=557, Percent_Identity=32.1364452423698, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI17137288, Length=529, Percent_Identity=32.8922495274102, Blast_Score=227, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24655642, Length=529, Percent_Identity=32.8922495274102, Blast_Score=227, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24655647, Length=529, Percent_Identity=32.8922495274102, Blast_Score=227, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 58438; Mature: 58307

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHRFDFLVLGGGVAGLSFALQAARHGTVAILTKRDRFESNTAYAQGGIASVLAPPDTFE
CCCCEEEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEECCCCHHHH
SHIEDTLVAGAGLCHRDAVEVTVKEGPSRVQELADLGAEFNRRITGEFDLTREGGHSARR
HHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHCCHHHCCEECCCEEECCCCCHHHHH
IIHSGDITGREVQRALLAACDEAPNITFFPQTAAIDLIQDRRVPSPGVSRCLGVYALLED
EEECCCCCHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
GVIERFLAKVTVLATGGAGKVYLYTSNPDVATGDGVAMAYRAGAKVANMEFYQFHPTCLY
HHHHHHHHHEEEEEECCCCEEEEEECCCCCCCCCCEEEEECCCCCEECEEEEEECCEEEE
HPEAKSFLISEALRGEGGKLKLKSGASFMERYHPMGALAPRDVVARAIDAEMKRTGDDCV
CCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEE
YLDMTHLGRAFLAERFPNIYATCKAFNIDMAVQPIPVVPAAHYMCGGVVTDLEGRTNVPS
EEEHHHHHHHHHHHHCCCCEEEEEEEEECEECCCCCCCCHHHHHHCCEEECCCCCCCCCC
LYAIGEVTCTGLHGANRLASNSLLEGLVFGHRAVQVAAEEVRAQPSPSEDPPPWDSGSAV
EEEECCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
ESDESVVVTHNWDEIRRLMWNYVGIVRTDKRLMRARRRLELLREEIRDYYWRFKVTRDVI
CCCCCEEEEECHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELRNIADVAYLIVDCASRRKESRGLHYTLDYPHPDDHRWLRDTVVSREP
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
PHRFDFLVLGGGVAGLSFALQAARHGTVAILTKRDRFESNTAYAQGGIASVLAPPDTFE
CCCEEEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEECCCCHHHH
SHIEDTLVAGAGLCHRDAVEVTVKEGPSRVQELADLGAEFNRRITGEFDLTREGGHSARR
HHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHCCHHHCCEECCCEEECCCCCHHHHH
IIHSGDITGREVQRALLAACDEAPNITFFPQTAAIDLIQDRRVPSPGVSRCLGVYALLED
EEECCCCCHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
GVIERFLAKVTVLATGGAGKVYLYTSNPDVATGDGVAMAYRAGAKVANMEFYQFHPTCLY
HHHHHHHHHEEEEEECCCCEEEEEECCCCCCCCCCEEEEECCCCCEECEEEEEECCEEEE
HPEAKSFLISEALRGEGGKLKLKSGASFMERYHPMGALAPRDVVARAIDAEMKRTGDDCV
CCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEE
YLDMTHLGRAFLAERFPNIYATCKAFNIDMAVQPIPVVPAAHYMCGGVVTDLEGRTNVPS
EEEHHHHHHHHHHHHCCCCEEEEEEEEECEECCCCCCCCHHHHHHCCEEECCCCCCCCCC
LYAIGEVTCTGLHGANRLASNSLLEGLVFGHRAVQVAAEEVRAQPSPSEDPPPWDSGSAV
EEEECCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
ESDESVVVTHNWDEIRRLMWNYVGIVRTDKRLMRARRRLELLREEIRDYYWRFKVTRDVI
CCCCCEEEEECHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELRNIADVAYLIVDCASRRKESRGLHYTLDYPHPDDHRWLRDTVVSREP
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7737518; 10984043; 7961421 [H]