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The map label for this gene is lpxB

Identifier: 108761680

GI number: 108761680

Start: 5913292

End: 5914443

Strand: Direct

Name: lpxB

Synonym: MXAN_4718

Alternate gene names: 108761680

Gene position: 5913292-5914443 (Clockwise)

Preceding gene: 108761669

Following gene: 108762457

Centisome position: 64.7

GC content: 70.23

Gene sequence:

>1152_bases
ATGACGAATCCACCCCGCATCCTCGTCGTCGCCGGCGAGGCGTCAGGCGATACCCACGCCGCCGAGCTCGTCGCCGCCCT
CCGGGCCCGCCGTCCCGACCTCACCTTCTTTGGCATGGGCGGTGCCCGCCTGGCCGCCCAGGGAGTGGAGCTGCTCTTCG
ACGCCCGGGAGGTGTCCGTCATGGGCATCACCGAGGTCCTGCCCCGGATTCCCCGCATCCTTCAAATCCTGAAGGGCCTG
GCCGAGGCCGCCGCCGAGCGCAAACCGGACGTCGCCATCCTGGTGGACATCCCTGACTTCAACCTGCGCCTGGCCAAGAA
ACTCAAGGCGCTGGGGGTCCCCGTCGCCTACTACGTGTCGCCCATGATCTGGGCCTGGCGCCGGGGTCGGGTGCGCACCA
TCAAACGGTTGGTGGACCGGATGCTCTGCATCCTCCCGTTCGAGGAAGACTTCTACCGGGAGGCCGGCGTCAGCGCTCGC
TACGTCGGCAGCCCGGTGGTGGAGCAGGTTCCCTCACCGGATACGGCCACGGCCTTCCGCGAGCGGCTGGGGCTGTCGAA
GGACGCCCCCACACTCGCGCTGCTGCCCGGCAGCCGGATGGGCGAAATCCGCCGTCTGCTTCCCGACATGGTGGAGGCGG
CGAAACGCCTCTCCGCCGAGCGGCCCGGACTCCAGGTCGTCGTCCCCCTCGCGCCCACCATCGACCGGGAGGAAATCACG
TCCCGCTTCGAAGGCAGTGGCGTGACGCCCATCCTGGTAGAGGGACGGGCACCCGAGGTCGTGGGCGCCAGTGACGCCGC
GGTGGTGGCCTCCGGTACCGCCGTCCTGGAAGCCGGGCTGATGCAGCGCCCCCTGGTGGTCGTCTACCGTGTGTCACTCA
TCACGTACTGGGTGGGCCGGTTGATGCTGAAGGTGGCCTTCGTGTCCCTCATCAACCTGCTGGCGGGCCGACGCGTCGTC
CCCGAGCTGCTCCAGGGGGAGATGACGCCCGAGCGCATCGCCGAGGAGGTCCGCCGCGTCTGGATACCCGGTGCTCCCCG
GGAGGAGATGCTCCAGGGGTTGGCGGAGATGCGCGGCCGGCTGGGCGAGACGGGCGCGGCCACCCGGGCGGCGGAGTCCG
TACTGGAGCTGCTGCCCCCGGGCCGCGTTTAG

Upstream 100 bases:

>100_bases
AGCGTGGGGGGATGGCTCTCGGCGAGCAGAAGCGTCTTCAAGGGGGCCACAGTCTACACCTTCACCCGCGCCCGCATCAG
GTACGATGCGCGACTCTCAC

Downstream 100 bases:

>100_bases
GGTATGTCGGCCGGGTCATGAACCCAGCCCTGGTCTGCATCCCCACGTACAACGAGCGGGAAAACATCGAGGCCATCGTC
CAGGCGGTGCTGGAGACCGA

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MTNPPRILVVAGEASGDTHAAELVAALRARRPDLTFFGMGGARLAAQGVELLFDAREVSVMGITEVLPRIPRILQILKGL
AEAAAERKPDVAILVDIPDFNLRLAKKLKALGVPVAYYVSPMIWAWRRGRVRTIKRLVDRMLCILPFEEDFYREAGVSAR
YVGSPVVEQVPSPDTATAFRERLGLSKDAPTLALLPGSRMGEIRRLLPDMVEAAKRLSAERPGLQVVVPLAPTIDREEIT
SRFEGSGVTPILVEGRAPEVVGASDAAVVASGTAVLEAGLMQRPLVVVYRVSLITYWVGRLMLKVAFVSLINLLAGRRVV
PELLQGEMTPERIAEEVRRVWIPGAPREEMLQGLAEMRGRLGETGAATRAAESVLELLPPGRV

Sequences:

>Translated_383_residues
MTNPPRILVVAGEASGDTHAAELVAALRARRPDLTFFGMGGARLAAQGVELLFDAREVSVMGITEVLPRIPRILQILKGL
AEAAAERKPDVAILVDIPDFNLRLAKKLKALGVPVAYYVSPMIWAWRRGRVRTIKRLVDRMLCILPFEEDFYREAGVSAR
YVGSPVVEQVPSPDTATAFRERLGLSKDAPTLALLPGSRMGEIRRLLPDMVEAAKRLSAERPGLQVVVPLAPTIDREEIT
SRFEGSGVTPILVEGRAPEVVGASDAAVVASGTAVLEAGLMQRPLVVVYRVSLITYWVGRLMLKVAFVSLINLLAGRRVV
PELLQGEMTPERIAEEVRRVWIPGAPREEMLQGLAEMRGRLGETGAATRAAESVLELLPPGRV
>Mature_382_residues
TNPPRILVVAGEASGDTHAAELVAALRARRPDLTFFGMGGARLAAQGVELLFDAREVSVMGITEVLPRIPRILQILKGLA
EAAAERKPDVAILVDIPDFNLRLAKKLKALGVPVAYYVSPMIWAWRRGRVRTIKRLVDRMLCILPFEEDFYREAGVSARY
VGSPVVEQVPSPDTATAFRERLGLSKDAPTLALLPGSRMGEIRRLLPDMVEAAKRLSAERPGLQVVVPLAPTIDREEITS
RFEGSGVTPILVEGRAPEVVGASDAAVVASGTAVLEAGLMQRPLVVVYRVSLITYWVGRLMLKVAFVSLINLLAGRRVVP
ELLQGEMTPERIAEEVRRVWIPGAPREEMLQGLAEMRGRLGETGAATRAAESVLELLPPGRV

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=377, Percent_Identity=40.053050397878, Blast_Score=259, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_MYXXD (Q1D393)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_632880.1
- ProteinModelPortal:   Q1D393
- STRING:   Q1D393
- GeneID:   4104078
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_4718
- TIGR:   MXAN_4718
- eggNOG:   COG0763
- HOGENOM:   HBG584837
- OMA:   EFAFICS
- PhylomeDB:   Q1D393
- ProtClustDB:   CLSK946302
- BioCyc:   MXAN246197:MXAN_4718-MONOMER
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 41693; Mature: 41561

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPPRILVVAGEASGDTHAAELVAALRARRPDLTFFGMGGARLAAQGVELLFDAREVSV
CCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
MGITEVLPRIPRILQILKGLAEAAAERKPDVAILVDIPDFNLRLAKKLKALGVPVAYYVS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHHHH
PMIWAWRRGRVRTIKRLVDRMLCILPFEEDFYREAGVSARYVGSPVVEQVPSPDTATAFR
HHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEECCCHHHHHCCCCCHHHHHH
ERLGLSKDAPTLALLPGSRMGEIRRLLPDMVEAAKRLSAERPGLQVVVPLAPTIDREEIT
HHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHH
SRFEGSGVTPILVEGRAPEVVGASDAAVVASGTAVLEAGLMQRPLVVVYRVSLITYWVGR
HHHCCCCCCEEEECCCCCCCCCCCCCHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LMLKVAFVSLINLLAGRRVVPELLQGEMTPERIAEEVRRVWIPGAPREEMLQGLAEMRGR
HHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LGETGAATRAAESVLELLPPGRV
CCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TNPPRILVVAGEASGDTHAAELVAALRARRPDLTFFGMGGARLAAQGVELLFDAREVSV
CCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
MGITEVLPRIPRILQILKGLAEAAAERKPDVAILVDIPDFNLRLAKKLKALGVPVAYYVS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHHHH
PMIWAWRRGRVRTIKRLVDRMLCILPFEEDFYREAGVSARYVGSPVVEQVPSPDTATAFR
HHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEECCCHHHHHCCCCCHHHHHH
ERLGLSKDAPTLALLPGSRMGEIRRLLPDMVEAAKRLSAERPGLQVVVPLAPTIDREEIT
HHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHH
SRFEGSGVTPILVEGRAPEVVGASDAAVVASGTAVLEAGLMQRPLVVVYRVSLITYWVGR
HHHCCCCCCEEEECCCCCCCCCCCCCHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LMLKVAFVSLINLLAGRRVVPELLQGEMTPERIAEEVRRVWIPGAPREEMLQGLAEMRGR
HHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LGETGAATRAAESVLELLPPGRV
CCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA