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The map label for this gene is tetA [H]

Identifier: 108760370

GI number: 108760370

Start: 4008179

End: 4009381

Strand: Direct

Name: tetA [H]

Synonym: MXAN_3444

Alternate gene names: 108760370

Gene position: 4008179-4009381 (Clockwise)

Preceding gene: 108759411

Following gene: 108763982

Centisome position: 43.85

GC content: 71.99

Gene sequence:

>1203_bases
GTGCAGCGACGGGTACGGGCGCTCGTCTTCGTCACGGTGTTCCTGGACCTGGTGGGCTTCGGCCTCATCATCCCGTTGCT
GCCGTTCTACGTGGAGTCCATGGGCGGGACGGCCACGACGGCGGGTGTGCTGCTGGCGTTGTTCTCCTTCGCGCAGCTCG
TCGCCTCGCCGGTGCTGGGGCGGCTGTCGGACCGGGTGGGGCGCCGCCCCGTCATCCTGCTGAGCCTGCTGGGCAACGCG
ATTTCCATGGCCCTGTTCGCGTACTCCACCCACGTCCAATGGCTGCCGTGGTTGTTCGCGTCGCGGCTGCTCGCGGGAGC
CACCGCGGGAAACCTGGCGGCGTGTCAGGCGGCGGTGGCGGACGTCACGGACGAGAGTGGGCGGGCAGCGGGCATGGGGC
TCGTCGGCGCGGGCATTGGCCTGGGCATGGTGCTGGGGCCCGTCATTGGCAGCCTCCTCCATGTGCATGGCGCCTGGGCG
CCACCGCTGGCGGGCGCGGTGATGGCGGCGGCGGCGATGCTCGGCGTGCTCTTCTTCTTTCCGGAGACACACCGCCCGCA
GGCGGAGCGGCACCAGGAGCCAGGCCGTCCCCGGGTGCGGCTGTCCGACGTCCTGGCCCGGCCCGGGCTGGGCGCGGTGC
TGGCTTTGACGTTCCTGGTGTTCATCGGGATGACGAACCTCCAGGTGTCGCTGGGGCTGCTGGCCCAGGCGCGCTTCGGC
TGGGGCGAACAGGAGATCGGGCGGCTCTTCGCGTTGATGGGCCTGGTCACCTTCGTGCTTCAGGCCTTCGTCATCGGCTG
GCTGACGAGCCGGGTCCGGGACACGACATTGGTGCTGGTGGGCGCCGCGTGCATGGGGGCCGGGCTCACGTGCATCGCCG
CTGCGGGCCACGGTGCCATGTTGGTGCTGGCCATGGTGCTGGTGGGCTCGGGGACGGGCCTGTTGCAGCCGCTGATGGCC
AGCCTGGCCTCCGGGTTCGCGGGGCGCGAGCTGCGTGGCGGGGTGCTGGGCGTGGTGCAGTCGGCGGGCGGGCTCGCGCG
CGTGGTGGGGCCGGTGTGGAGCGGCTTCCTCTACTCACGGCTGGGGCCTGGTGCGCCCTTCACCAGTGGGGCGGTGGCGG
CGGGCGTCGCGCTGTTGGTGGGGGCTTCGCTCCTGCGGCGGCGCGTTCCGGACGCGCCGCCGCAGTCGACCTTGAAAGTC
TGA

Upstream 100 bases:

>100_bases
GCGGCAGAGCCGGATGCGAAACCTGTTCCCCTGGCGGGCGGGGCCGTCAATCATCTGGCGCATGCCCCCGCCATCATGGA
CTTCTCCCGTGCCCCGGAAT

Downstream 100 bases:

>100_bases
GCGCGGGGCCGCTTACAGACAGTACTGCGCGAACGTCGGGCTGCTGCACAGGCTCTGGAAGGCCGCCAGGTTGCAGGTGT
CGGCGCCGGGACCGACGTTG

Product: putative multidrug resistance protein

Products: NA

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MQRRVRALVFVTVFLDLVGFGLIIPLLPFYVESMGGTATTAGVLLALFSFAQLVASPVLGRLSDRVGRRPVILLSLLGNA
ISMALFAYSTHVQWLPWLFASRLLAGATAGNLAACQAAVADVTDESGRAAGMGLVGAGIGLGMVLGPVIGSLLHVHGAWA
PPLAGAVMAAAAMLGVLFFFPETHRPQAERHQEPGRPRVRLSDVLARPGLGAVLALTFLVFIGMTNLQVSLGLLAQARFG
WGEQEIGRLFALMGLVTFVLQAFVIGWLTSRVRDTTLVLVGAACMGAGLTCIAAAGHGAMLVLAMVLVGSGTGLLQPLMA
SLASGFAGRELRGGVLGVVQSAGGLARVVGPVWSGFLYSRLGPGAPFTSGAVAAGVALLVGASLLRRRVPDAPPQSTLKV

Sequences:

>Translated_400_residues
MQRRVRALVFVTVFLDLVGFGLIIPLLPFYVESMGGTATTAGVLLALFSFAQLVASPVLGRLSDRVGRRPVILLSLLGNA
ISMALFAYSTHVQWLPWLFASRLLAGATAGNLAACQAAVADVTDESGRAAGMGLVGAGIGLGMVLGPVIGSLLHVHGAWA
PPLAGAVMAAAAMLGVLFFFPETHRPQAERHQEPGRPRVRLSDVLARPGLGAVLALTFLVFIGMTNLQVSLGLLAQARFG
WGEQEIGRLFALMGLVTFVLQAFVIGWLTSRVRDTTLVLVGAACMGAGLTCIAAAGHGAMLVLAMVLVGSGTGLLQPLMA
SLASGFAGRELRGGVLGVVQSAGGLARVVGPVWSGFLYSRLGPGAPFTSGAVAAGVALLVGASLLRRRVPDAPPQSTLKV
>Mature_400_residues
MQRRVRALVFVTVFLDLVGFGLIIPLLPFYVESMGGTATTAGVLLALFSFAQLVASPVLGRLSDRVGRRPVILLSLLGNA
ISMALFAYSTHVQWLPWLFASRLLAGATAGNLAACQAAVADVTDESGRAAGMGLVGAGIGLGMVLGPVIGSLLHVHGAWA
PPLAGAVMAAAAMLGVLFFFPETHRPQAERHQEPGRPRVRLSDVLARPGLGAVLALTFLVFIGMTNLQVSLGLLAQARFG
WGEQEIGRLFALMGLVTFVLQAFVIGWLTSRVRDTTLVLVGAACMGAGLTCIAAAGHGAMLVLAMVLVGSGTGLLQPLMA
SLASGFAGRELRGGVLGVVQSAGGLARVVGPVWSGFLYSRLGPGAPFTSGAVAAGVALLVGASLLRRRVPDAPPQSTLKV

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI225703104, Length=369, Percent_Identity=28.1842818428184, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI225703102, Length=369, Percent_Identity=28.1842818428184, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI217416366, Length=441, Percent_Identity=25.8503401360544, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI39753965, Length=363, Percent_Identity=24.2424242424242, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI94721311, Length=400, Percent_Identity=24.25, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI22749525, Length=155, Percent_Identity=30.3225806451613, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI166064062, Length=402, Percent_Identity=25.1243781094527, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI166064060, Length=402, Percent_Identity=25.1243781094527, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI87081738, Length=405, Percent_Identity=26.1728395061728, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17551570, Length=353, Percent_Identity=26.628895184136, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71996331, Length=361, Percent_Identity=23.2686980609418, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71985371, Length=367, Percent_Identity=22.6158038147139, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17738085, Length=342, Percent_Identity=27.7777777777778, Blast_Score=108, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41201; Mature: 41201

Theoretical pI: Translated: 11.78; Mature: 11.78

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure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CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]