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The map label for this gene is czcC [H]

Identifier: 108757703

GI number: 108757703

Start: 3980325

End: 3981785

Strand: Direct

Name: czcC [H]

Synonym: MXAN_3424

Alternate gene names: 108757703

Gene position: 3980325-3981785 (Clockwise)

Preceding gene: 108756909

Following gene: 108757506

Centisome position: 43.55

GC content: 71.32

Gene sequence:

>1461_bases
ATGAAGACCTGGTCATCGTCACGCTGGAAGCGGCCCGCCGCAGGTACCCTCGTTGCATCCATGCTCACATTGGGGGGATG
CGTCACCGTTCCCCTGGCGAATGATGCGCGTGACGTGCACACGACGCTCAGCGCTCGTTGGACGCCTGGGGACCCGATGG
CCGGGCTCACCAGCGAGGCCCTCCGGGGAGAGGACGCGGACGCGGCAGTGCGGGCGCTGCTGGCCCAGCCGCTCACCGCC
GACACGGCCGTCCGCATCGCGCTGCTGAACAACCGCGACCTGCGCGCCGCGATGCACGCGCTGGGCATCGCCACTGGCAA
CCTGGTGCAGATGAGCCTTCCTCCCAATCCAGAGGTGGAACTGGAGATGCGAAAGCCCACCCGTGGCGGGCAGCCGCTGC
AAGGGGACATCGGGCTCGAGTACGACCTGTCCGAGCTCATCCTCCTGCCGCAGCGTCGCGGGGTGGCCCAGGCCGAGCGC
GCGGCTGAGCGCGCACTCACGGCGGGCGAGGTGCTGCATGTGGCCTACCGCACGCGCCTGGGCTTCTACGAGGTCCAGGC
CCGGCACCAGCAACTGGAACTGCGCAACCGGGCGCTGCAGGTCGCACAGGCGGGCTACGGCACGGCGGTGGAGCTGGAGA
AGGCGGGCAACGTCCGCGCACTGGAGGTGGCCACCGAGCGCTCCGCCGTGGAGTCCGCGCGCCTGGCCGTGGCCGAAGCC
GAGAACGCCCTGCTGGACTCGCGCGAGGCCCTCAATGTGTTGCTGGGCCTCTTCGGTCCCCGCACGCAGTGGACGGTGGA
TTCGCCGCTGGCCGACCCAGTCAACGACCTGGATTCGGGGGAGGGGCTGGAGGCGCGCGCCATCGAGGCGAGCCTCGACC
TGGCCGAGCTGCGCGGCCGCATGGAGGCCGCCGACCGGCGCCACAGGCTCGCGCGGACGGAGGGGTTTCTGCCCCACCTG
TCCGGCGGCTTCCACGGCGAGAAGGACGAGGACCGGTGGGAGATGGGGGCGCACCTCACGGTGGGGCTGCCGCTGTTCGA
CCGCAAGCAGGGCGTGCGCATGGCGGCCCTTTCTTCGCGTGAGTCCTTGAAGGCCCGTTACGAGGCCACGGCCACCGCAA
TCCGCGCCTCGCTGCGCCAGGCCAGCGGCCGAGTGGAGTCCACGGGGCGACGAGCGCGGCACGTCCGTGACGTGCTCCTG
CCGGCCCGGCGCCAGGTGCTCGACGAGACGGTGCTCCAGTACAACGCCATGCAGGTGGGCGTCTTCGAGGTGCTGCGTGC
CCAGGCCGCCGTGACGGACACGGCCAGCACCTACGTGGAGACGCTGCTCGACCACCACCGCGCCCGCTCGGCGCTGGAGC
AACTCCTGGCGGGCCGTCACCAAGGCTTGGAGTTGGGCTCCATCCGCGTTTCGTCGATGAGCGCGAGCTCCGGTCCAGCC
GCCGCGGCGGACGCGCACTGA

Upstream 100 bases:

>100_bases
GACACGGGGGGCACTCCGGTAGCGCCCCGGATGCCGGCAGTCCCGCCCCCAGCCACGACCATCACCAGCACTAGCCGCCC
GCGACGGAGAGAGAGGCACC

Downstream 100 bases:

>100_bases
CCTTCGCATTCACGGCACTTCGACATTGAGAGGACACACCACCATGGACCGCAGACAGTTCATTCAGCTCGGCGCGCTCG
CTGGGGGCACGCTGGTCGCA

Product: outer membrane efflux protein

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MKTWSSSRWKRPAAGTLVASMLTLGGCVTVPLANDARDVHTTLSARWTPGDPMAGLTSEALRGEDADAAVRALLAQPLTA
DTAVRIALLNNRDLRAAMHALGIATGNLVQMSLPPNPEVELEMRKPTRGGQPLQGDIGLEYDLSELILLPQRRGVAQAER
AAERALTAGEVLHVAYRTRLGFYEVQARHQQLELRNRALQVAQAGYGTAVELEKAGNVRALEVATERSAVESARLAVAEA
ENALLDSREALNVLLGLFGPRTQWTVDSPLADPVNDLDSGEGLEARAIEASLDLAELRGRMEAADRRHRLARTEGFLPHL
SGGFHGEKDEDRWEMGAHLTVGLPLFDRKQGVRMAALSSRESLKARYEATATAIRASLRQASGRVESTGRRARHVRDVLL
PARRQVLDETVLQYNAMQVGVFEVLRAQAAVTDTASTYVETLLDHHRARSALEQLLAGRHQGLELGSIRVSSMSASSGPA
AAADAH

Sequences:

>Translated_486_residues
MKTWSSSRWKRPAAGTLVASMLTLGGCVTVPLANDARDVHTTLSARWTPGDPMAGLTSEALRGEDADAAVRALLAQPLTA
DTAVRIALLNNRDLRAAMHALGIATGNLVQMSLPPNPEVELEMRKPTRGGQPLQGDIGLEYDLSELILLPQRRGVAQAER
AAERALTAGEVLHVAYRTRLGFYEVQARHQQLELRNRALQVAQAGYGTAVELEKAGNVRALEVATERSAVESARLAVAEA
ENALLDSREALNVLLGLFGPRTQWTVDSPLADPVNDLDSGEGLEARAIEASLDLAELRGRMEAADRRHRLARTEGFLPHL
SGGFHGEKDEDRWEMGAHLTVGLPLFDRKQGVRMAALSSRESLKARYEATATAIRASLRQASGRVESTGRRARHVRDVLL
PARRQVLDETVLQYNAMQVGVFEVLRAQAAVTDTASTYVETLLDHHRARSALEQLLAGRHQGLELGSIRVSSMSASSGPA
AAADAH
>Mature_486_residues
MKTWSSSRWKRPAAGTLVASMLTLGGCVTVPLANDARDVHTTLSARWTPGDPMAGLTSEALRGEDADAAVRALLAQPLTA
DTAVRIALLNNRDLRAAMHALGIATGNLVQMSLPPNPEVELEMRKPTRGGQPLQGDIGLEYDLSELILLPQRRGVAQAER
AAERALTAGEVLHVAYRTRLGFYEVQARHQQLELRNRALQVAQAGYGTAVELEKAGNVRALEVATERSAVESARLAVAEA
ENALLDSREALNVLLGLFGPRTQWTVDSPLADPVNDLDSGEGLEARAIEASLDLAELRGRMEAADRRHRLARTEGFLPHL
SGGFHGEKDEDRWEMGAHLTVGLPLFDRKQGVRMAALSSRESLKARYEATATAIRASLRQASGRVESTGRRARHVRDVLL
PARRQVLDETVLQYNAMQVGVFEVLRAQAAVTDTASTYVETLLDHHRARSALEQLLAGRHQGLELGSIRVSSMSASSGPA
AAADAH

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 52588; Mature: 52588

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTWSSSRWKRPAAGTLVASMLTLGGCVTVPLANDARDVHTTLSARWTPGDPMAGLTSEA
CCCCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHHEEECCCCCCCCCCHHHH
LRGEDADAAVRALLAQPLTADTAVRIALLNNRDLRAAMHALGIATGNLVQMSLPPNPEVE
HCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCEEEEECCCCCCEE
LEMRKPTRGGQPLQGDIGLEYDLSELILLPQRRGVAQAERAAERALTAGEVLHVAYRTRL
EEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GFYEVQARHQQLELRNRALQVAQAGYGTAVELEKAGNVRALEVATERSAVESARLAVAEA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHH
ENALLDSREALNVLLGLFGPRTQWTVDSPLADPVNDLDSGEGLEARAIEASLDLAELRGR
HHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHCCCCCCCCHHHHHHHCCHHHHHHH
MEAADRRHRLARTEGFLPHLSGGFHGEKDEDRWEMGAHLTVGLPLFDRKQGVRMAALSSR
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCEEEECCCCCCCCCCCCHHHHHHH
ESLKARYEATATAIRASLRQASGRVESTGRRARHVRDVLLPARRQVLDETVLQYNAMQVG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
VFEVLRAQAAVTDTASTYVETLLDHHRARSALEQLLAGRHQGLELGSIRVSSMSASSGPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCEEEECCCCCCCCC
AAADAH
CCCCCC
>Mature Secondary Structure
MKTWSSSRWKRPAAGTLVASMLTLGGCVTVPLANDARDVHTTLSARWTPGDPMAGLTSEA
CCCCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHHEEECCCCCCCCCCHHHH
LRGEDADAAVRALLAQPLTADTAVRIALLNNRDLRAAMHALGIATGNLVQMSLPPNPEVE
HCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCEEEEECCCCCCEE
LEMRKPTRGGQPLQGDIGLEYDLSELILLPQRRGVAQAERAAERALTAGEVLHVAYRTRL
EEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GFYEVQARHQQLELRNRALQVAQAGYGTAVELEKAGNVRALEVATERSAVESARLAVAEA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHH
ENALLDSREALNVLLGLFGPRTQWTVDSPLADPVNDLDSGEGLEARAIEASLDLAELRGR
HHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHCCCCCCCCHHHHHHHCCHHHHHHH
MEAADRRHRLARTEGFLPHLSGGFHGEKDEDRWEMGAHLTVGLPLFDRKQGVRMAALSSR
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCEEEECCCCCCCCCCCCHHHHHHH
ESLKARYEATATAIRASLRQASGRVESTGRRARHVRDVLLPARRQVLDETVLQYNAMQVG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
VFEVLRAQAAVTDTASTYVETLLDHHRARSALEQLLAGRHQGLELGSIRVSSMSASSGPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCEEEECCCCCCCCC
AAADAH
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]