Click here to switch to the map view.

The map label for this gene is pcoA [H]

Identifier: 108757506

GI number: 108757506

Start: 3981829

End: 3983151

Strand: Direct

Name: pcoA [H]

Synonym: MXAN_3425

Alternate gene names: 108757506

Gene position: 3981829-3983151 (Clockwise)

Preceding gene: 108757703

Following gene: 108761493

Centisome position: 43.57

GC content: 66.82

Gene sequence:

>1323_bases
ATGGACCGCAGACAGTTCATTCAGCTCGGCGCGCTCGCTGGGGGCACGCTGGTCGCAAGCCAAGCCCTCGCGCAAGGACA
GTCCCACGCCGTGCCTTCCGCTCCCGTCAGCGCACGCGCCAGGACGCCGAGCATCGTCGCTCCGGGCGGGCAGGTGGCCG
TCACCACGCCCAACGGCTCCACGCTACCCTGGAGGAAGGTGGGGGGCGTGAAGGTGGGCCACCTGGTGGCCATGCCTGTG
AAGCACACCTTCGCCCCTGGGCTGGAGGTGGAAGCGTGGGGCTACAACGGCTCGACGCCAGGGCCCACCATCGAGGCGGT
GGAGGGAGAGCGCCTTCGCATCTACGTCACCAACCGGCTGCCTGAGCCGACCACCGTGCACTGGCACGGGCTCATCATTC
CCAATGGCATGGATGGCGTGTCCGGGCTGAACCAGCGCCCCATCGCCCCCGGAGAAACGTTCGCCTACGAGTTCACGCTG
AACCAGCCGGGCACGTACATGTATCACCCGCACTACGACGAGATGACCCAGATGGCGCTGGGGATGATGGGCATGTTCAT
CGTCCATCCGAAGCGTCCGCGCGGCCCGAAGGTGGTCCGCGACTTCGCGCTGATGACGCACGAGTGGAAGGTGCTTCCAG
GCATGCGCCGGCCGGACCCCAACGCGATGAGCGACTTCAATGTCCTCACGTTCAACTCCAAGGCCTTCCCGGCCACCGAG
CCGCTCGTCATCGGACGCAGGGAGCGGGTGCGCATCCGCCTGGGGAATCTGTCCGCCATGGACCACCACCCCATTCACCT
GCATGGCCTGTCCTTCGAAATGACGGGGACGGATGGGGGCTTCGTCCCCGAGTCCGCCCGCTACCCGGAGACTTCGATCC
TGGTGCCGGTGGGGAGCACCCGGGTCATCGAGTTCGTCGCGGACGAACCGGGTGACTGGGCCATGCACTGCCACATGACC
CACCACGTGATGAACCAGATGGGACACGCGGGTCCGGTGACGCTGGGCGCTGACGCACGGGCCATCGACCGGCGGGTGCA
GGCGCTGGTGCCGGGGTACATGACGATGGGGCAGGATGGCATGGGCGGCATGGAAGAGATGGGCATGCCAATGCCGGCCA
ACAGCATTCCCATGAAGGGCGGAAAGGGGCCCTTCGGCCCCATCGACATGGGCGGCATGTTCACGCTCCTCAAGGTGCGC
GAGAACCCGGACACCGAGGATGGGAGCGGCTGGTACGTGCACCCGAAGGGGACGGTGGCGGAAAAGGCCGACCCGGTGCG
CATGGACGCGGACGGCATCAATCCGGACGTGCGCTTTGGTTGA

Upstream 100 bases:

>100_bases
CGCGTTTCGTCGATGAGCGCGAGCTCCGGTCCAGCCGCCGCGGCGGACGCGCACTGACCTTCGCATTCACGGCACTTCGA
CATTGAGAGGACACACCACC

Downstream 100 bases:

>100_bases
TGGCGAAGGGGGCAGAGGACGGCTTGCACCAGGTCCTCTGTCCCTGTACCTGAACGGCATGAGCGACATGAATCAGGGAG
CGGGTGCGGAGAGCGATGGC

Product: multicopper oxidase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MDRRQFIQLGALAGGTLVASQALAQGQSHAVPSAPVSARARTPSIVAPGGQVAVTTPNGSTLPWRKVGGVKVGHLVAMPV
KHTFAPGLEVEAWGYNGSTPGPTIEAVEGERLRIYVTNRLPEPTTVHWHGLIIPNGMDGVSGLNQRPIAPGETFAYEFTL
NQPGTYMYHPHYDEMTQMALGMMGMFIVHPKRPRGPKVVRDFALMTHEWKVLPGMRRPDPNAMSDFNVLTFNSKAFPATE
PLVIGRRERVRIRLGNLSAMDHHPIHLHGLSFEMTGTDGGFVPESARYPETSILVPVGSTRVIEFVADEPGDWAMHCHMT
HHVMNQMGHAGPVTLGADARAIDRRVQALVPGYMTMGQDGMGGMEEMGMPMPANSIPMKGGKGPFGPIDMGGMFTLLKVR
ENPDTEDGSGWYVHPKGTVAEKADPVRMDADGINPDVRFG

Sequences:

>Translated_440_residues
MDRRQFIQLGALAGGTLVASQALAQGQSHAVPSAPVSARARTPSIVAPGGQVAVTTPNGSTLPWRKVGGVKVGHLVAMPV
KHTFAPGLEVEAWGYNGSTPGPTIEAVEGERLRIYVTNRLPEPTTVHWHGLIIPNGMDGVSGLNQRPIAPGETFAYEFTL
NQPGTYMYHPHYDEMTQMALGMMGMFIVHPKRPRGPKVVRDFALMTHEWKVLPGMRRPDPNAMSDFNVLTFNSKAFPATE
PLVIGRRERVRIRLGNLSAMDHHPIHLHGLSFEMTGTDGGFVPESARYPETSILVPVGSTRVIEFVADEPGDWAMHCHMT
HHVMNQMGHAGPVTLGADARAIDRRVQALVPGYMTMGQDGMGGMEEMGMPMPANSIPMKGGKGPFGPIDMGGMFTLLKVR
ENPDTEDGSGWYVHPKGTVAEKADPVRMDADGINPDVRFG
>Mature_440_residues
MDRRQFIQLGALAGGTLVASQALAQGQSHAVPSAPVSARARTPSIVAPGGQVAVTTPNGSTLPWRKVGGVKVGHLVAMPV
KHTFAPGLEVEAWGYNGSTPGPTIEAVEGERLRIYVTNRLPEPTTVHWHGLIIPNGMDGVSGLNQRPIAPGETFAYEFTL
NQPGTYMYHPHYDEMTQMALGMMGMFIVHPKRPRGPKVVRDFALMTHEWKVLPGMRRPDPNAMSDFNVLTFNSKAFPATE
PLVIGRRERVRIRLGNLSAMDHHPIHLHGLSFEMTGTDGGFVPESARYPETSILVPVGSTRVIEFVADEPGDWAMHCHMT
HHVMNQMGHAGPVTLGADARAIDRRVQALVPGYMTMGQDGMGGMEEMGMPMPANSIPMKGGKGPFGPIDMGGMFTLLKVR
ENPDTEDGSGWYVHPKGTVAEKADPVRMDADGINPDVRFG

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=244, Percent_Identity=25, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323703, Length=98, Percent_Identity=46.9387755102041, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6321067, Length=110, Percent_Identity=40, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI18859919, Length=125, Percent_Identity=35.2, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24650186, Length=115, Percent_Identity=34.7826086956522, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574104, Length=125, Percent_Identity=37.6, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 47697; Mature: 47697

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.6 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.6 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRRQFIQLGALAGGTLVASQALAQGQSHAVPSAPVSARARTPSIVAPGGQVAVTTPNGS
CCHHHEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCC
TLPWRKVGGVKVGHLVAMPVKHTFAPGLEVEAWGYNGSTPGPTIEAVEGERLRIYVTNRL
CCCHHHCCCEEEEEEEEECCHHHCCCCCEEEEECCCCCCCCCEEEECCCCEEEEEEECCC
PEPTTVHWHGLIIPNGMDGVSGLNQRPIAPGETFAYEFTLNQPGTYMYHPHYDEMTQMAL
CCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEECCCHHHHHHHHH
GMMGMFIVHPKRPRGPKVVRDFALMTHEWKVLPGMRRPDPNAMSDFNVLTFNSKAFPATE
HHHCEEEECCCCCCCHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCEEEEECCCCCCCCC
PLVIGRRERVRIRLGNLSAMDHHPIHLHGLSFEMTGTDGGFVPESARYPETSILVPVGST
CEEECCCEEEEEEECCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCEEEEECCCC
RVIEFVADEPGDWAMHCHMTHHVMNQMGHAGPVTLGADARAIDRRVQALVPGYMTMGQDG
EEEEEEECCCCCEEEEEEHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCCHHCCCCCC
MGGMEEMGMPMPANSIPMKGGKGPFGPIDMGGMFTLLKVRENPDTEDGSGWYVHPKGTVA
CCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCEEEECCCCCCC
EKADPVRMDADGINPDVRFG
CCCCCEEECCCCCCCCCCCC
>Mature Secondary Structure
MDRRQFIQLGALAGGTLVASQALAQGQSHAVPSAPVSARARTPSIVAPGGQVAVTTPNGS
CCHHHEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCC
TLPWRKVGGVKVGHLVAMPVKHTFAPGLEVEAWGYNGSTPGPTIEAVEGERLRIYVTNRL
CCCHHHCCCEEEEEEEEECCHHHCCCCCEEEEECCCCCCCCCEEEECCCCEEEEEEECCC
PEPTTVHWHGLIIPNGMDGVSGLNQRPIAPGETFAYEFTLNQPGTYMYHPHYDEMTQMAL
CCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEECCCHHHHHHHHH
GMMGMFIVHPKRPRGPKVVRDFALMTHEWKVLPGMRRPDPNAMSDFNVLTFNSKAFPATE
HHHCEEEECCCCCCCHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCEEEEECCCCCCCCC
PLVIGRRERVRIRLGNLSAMDHHPIHLHGLSFEMTGTDGGFVPESARYPETSILVPVGST
CEEECCCEEEEEEECCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCEEEEECCCC
RVIEFVADEPGDWAMHCHMTHHVMNQMGHAGPVTLGADARAIDRRVQALVPGYMTMGQDG
EEEEEEECCCCCEEEEEEHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCCHHCCCCCC
MGGMEEMGMPMPANSIPMKGGKGPFGPIDMGGMFTLLKVRENPDTEDGSGWYVHPKGTVA
CCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCEEEECCCCCCC
EKADPVRMDADGINPDVRFG
CCCCCEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]