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The map label for this gene is nadA

Identifier: 108563728

GI number: 108563728

Start: 1350023

End: 1351033

Strand: Reverse

Name: nadA

Synonym: HPAG1_1303

Alternate gene names: 108563728

Gene position: 1351033-1350023 (Counterclockwise)

Preceding gene: 108563729

Following gene: 108563727

Centisome position: 84.63

GC content: 40.55

Gene sequence:

>1011_bases
ATGCCAACTGATAACGATTTAAAAACTTCTATTGTGGAATTGTTGCACGATTTAGACGCGCTTTTAGTGGCCCATTTCTA
TCAAAAAGATGAGATTGTAGAGTTAGCCCACCACACAGGCGATAGCTTGGAATTAGCCAAAATCGCAAGCCAAAGCGATA
AAAACCTCATCGTGTTTTGCGGGGTGCATTTCATGGGCGAGAGCGTGAAAGCCCTAGCCTTTGAAAAACAAGTGATCATG
CCCAAACTCTCATGCTGTTCTATGGCGAGGATGATTGATAGCCACTACTACGATAGAAGCGTTCATTTATTAAAAGAATG
CGGCGTTAAAGAATTTTACCCTATCACTTATATCAATTCTAACGCTGAAGTGAAAGCCAAAGTCGCTAAAGATGGTGGCG
TGGTTTGCACGAGCCGCAACGCTTCTAAAATCTTTAATCATGCCCTAAAACAAAATAAAAAAATCTTTTTTTTACCGGAT
AAATGCTTGGGGGAAAATCTAGCCCTAGAAAATGGCTTAAAAAGCGCGATTTTAGGCGTAAATAGCCCAGAAGAAATTAA
AAACGCTGATGTGGTTTGTTATAACGGCTTTTGCTCGGTGCATCAGCTTTTCAAATTAGAAGACATTGAATTTTACCGCC
AAAAATACCCGGATATTTTAATCGCTGTCCATCCAGAGTGCGAGCCTAGCGTGGTTTCTAACGCTGATTTTAGCGGATCA
ACGAGTCAAATCATAGAGTTTGTAGAAAAGCTAAGCCCTAATCAAAAAGTCGCCATAGGCACTGAAAGCCATTTAGTCAA
CCGCTTGAAAGCCAAGCGCCACCATCAAAACACTTTCATTCTCTCTAGCACGCTCGCCTTTTGTCCTACCATGAATGAAA
CGACTTTAAAAGATTTGTTTGAAGTCTTAAAAGCTTATAAAAACCACAGGGCTTATAATGCGGTTGAATTAAAAGATGAG
GTGGCGCATTGGGCCAAACTCGCTTTAACCAAAATGATGGAGTTATCTTAA

Upstream 100 bases:

>100_bases
TTTGAAATGGGCTCTACGATCGTTTTATTCATTCAAAACACCGCTTTTAAGGATTTGAAAGAAAAAAGCGTGAAGTTTGG
GGAAAGTATAGGGGAATTTC

Downstream 100 bases:

>100_bases
TGGAGATTAAAACCTTTCTAAAACGCGCTTTAAAAGAAGATTTAGGGCATGGGGATTTGTTTGAAAGGGTGTTAGAAAAA
GATTTTAAAGCCACAGCGTT

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MPTDNDLKTSIVELLHDLDALLVAHFYQKDEIVELAHHTGDSLELAKIASQSDKNLIVFCGVHFMGESVKALAFEKQVIM
PKLSCCSMARMIDSHYYDRSVHLLKECGVKEFYPITYINSNAEVKAKVAKDGGVVCTSRNASKIFNHALKQNKKIFFLPD
KCLGENLALENGLKSAILGVNSPEEIKNADVVCYNGFCSVHQLFKLEDIEFYRQKYPDILIAVHPECEPSVVSNADFSGS
TSQIIEFVEKLSPNQKVAIGTESHLVNRLKAKRHHQNTFILSSTLAFCPTMNETTLKDLFEVLKAYKNHRAYNAVELKDE
VAHWAKLALTKMMELS

Sequences:

>Translated_336_residues
MPTDNDLKTSIVELLHDLDALLVAHFYQKDEIVELAHHTGDSLELAKIASQSDKNLIVFCGVHFMGESVKALAFEKQVIM
PKLSCCSMARMIDSHYYDRSVHLLKECGVKEFYPITYINSNAEVKAKVAKDGGVVCTSRNASKIFNHALKQNKKIFFLPD
KCLGENLALENGLKSAILGVNSPEEIKNADVVCYNGFCSVHQLFKLEDIEFYRQKYPDILIAVHPECEPSVVSNADFSGS
TSQIIEFVEKLSPNQKVAIGTESHLVNRLKAKRHHQNTFILSSTLAFCPTMNETTLKDLFEVLKAYKNHRAYNAVELKDE
VAHWAKLALTKMMELS
>Mature_335_residues
PTDNDLKTSIVELLHDLDALLVAHFYQKDEIVELAHHTGDSLELAKIASQSDKNLIVFCGVHFMGESVKALAFEKQVIMP
KLSCCSMARMIDSHYYDRSVHLLKECGVKEFYPITYINSNAEVKAKVAKDGGVVCTSRNASKIFNHALKQNKKIFFLPDK
CLGENLALENGLKSAILGVNSPEEIKNADVVCYNGFCSVHQLFKLEDIEFYRQKYPDILIAVHPECEPSVVSNADFSGST
SQIIEFVEKLSPNQKVAIGTESHLVNRLKAKRHHQNTFILSSTLAFCPTMNETTLKDLFEVLKAYKNHRAYNAVELKDEV
AHWAKLALTKMMELS

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 3 subfamily

Homologues:

Organism=Escherichia coli, GI1786964, Length=352, Percent_Identity=28.4090909090909, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NADA_HELPH (Q1CRQ2)

Other databases:

- EMBL:   CP000241
- RefSeq:   YP_628044.1
- ProteinModelPortal:   Q1CRQ2
- SMR:   Q1CRQ2
- STRING:   Q1CRQ2
- GeneID:   4098451
- GenomeReviews:   CP000241_GR
- KEGG:   hpa:HPAG1_1303
- eggNOG:   COG0379
- HOGENOM:   HBG291157
- OMA:   SMARMID
- ProtClustDB:   PRK09375
- BioCyc:   HPYL357544:HPAG1_1303-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00569
- InterPro:   IPR003473
- TIGRFAMs:   TIGR00550

Pfam domain/function: PF02445 NadA

EC number: =2.5.1.72

Molecular weight: Translated: 37769; Mature: 37638

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: BINDING 25-25 BINDING 42-42 BINDING 117-117 BINDING 138-138 BINDING 224-224 BINDING 241-241

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTDNDLKTSIVELLHDLDALLVAHFYQKDEIVELAHHTGDSLELAKIASQSDKNLIVFC
CCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEE
GVHFMGESVKALAFEKQVIMPKLSCCSMARMIDSHYYDRSVHLLKECGVKEFYPITYINS
CHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
NAEVKAKVAKDGGVVCTSRNASKIFNHALKQNKKIFFLPDKCLGENLALENGLKSAILGV
CCEEEEEEECCCCEEEECCCHHHHHHHHHHCCCEEEEECHHHCCCCHHHHHCHHHHHCCC
NSPEEIKNADVVCYNGFCSVHQLFKLEDIEFYRQKYPDILIAVHPECEPSVVSNADFSGS
CCHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCC
TSQIIEFVEKLSPNQKVAIGTESHLVNRLKAKRHHQNTFILSSTLAFCPTMNETTLKDLF
HHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCHHHHHHHH
EVLKAYKNHRAYNAVELKDEVAHWAKLALTKMMELS
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PTDNDLKTSIVELLHDLDALLVAHFYQKDEIVELAHHTGDSLELAKIASQSDKNLIVFC
CCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEE
GVHFMGESVKALAFEKQVIMPKLSCCSMARMIDSHYYDRSVHLLKECGVKEFYPITYINS
CHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
NAEVKAKVAKDGGVVCTSRNASKIFNHALKQNKKIFFLPDKCLGENLALENGLKSAILGV
CCEEEEEEECCCCEEEECCCHHHHHHHHHHCCCEEEEECHHHCCCCHHHHHCHHHHHCCC
NSPEEIKNADVVCYNGFCSVHQLFKLEDIEFYRQKYPDILIAVHPECEPSVVSNADFSGS
CCHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCC
TSQIIEFVEKLSPNQKVAIGTESHLVNRLKAKRHHQNTFILSSTLAFCPTMNETTLKDLF
HHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCHHHHHHHH
EVLKAYKNHRAYNAVELKDEVAHWAKLALTKMMELS
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA