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The map label for this gene is nadC [H]

Identifier: 108563727

GI number: 108563727

Start: 1349202

End: 1350023

Strand: Reverse

Name: nadC [H]

Synonym: HPAG1_1302

Alternate gene names: 108563727

Gene position: 1350023-1349202 (Counterclockwise)

Preceding gene: 108563728

Following gene: 108563726

Centisome position: 84.57

GC content: 41.24

Gene sequence:

>822_bases
ATGGAGATTAAAACCTTTCTAAAACGCGCTTTAAAAGAAGATTTAGGGCATGGGGATTTGTTTGAAAGGGTGTTAGAAAA
AGATTTTAAAGCCACAGCGTTTGTTAGAGCTAAACAAGAGGGCGTGTTTTCAGGCGAAAAATACGCTTTGGAGTTGCTTC
AAATGACCGGCATTGAATGCACTCAAACCATTAAAGATAAAGAGCGTTTCAAGCCTAAAGACACTTTAATGGAGATTAGG
GGGGATTTTAGCATGCTTTTAAAGGTTGAACGCACCCTTTTAAACCTTTTGCAACACAGCAGCGGGATCGCTACTTTAAC
GAGTCGTTTTGTAGAAGCTTTAAATTCTCATAAGGTGCGTTTGTTGGACACACGAAAAACCAGACCCCTTTTAAGGATTT
TTGAAAAATATTCCGTGCTTAATGGGGGAGCGAGCAACCACCGATTAGGGCTAGATGACGCTTTAATGCTTAAAGACACG
CATTTAAAGCATGTCAAAGATCTCAAAAGCTTTTTAGCGCATGCCAGGAAAAATTTGCCTTTCACGGCTAAAATTGAAAT
TGAATGCGAGAGCTTTGAAGAGGCCAAAAACGCCATGAATGCGGGAGCGGATATTGTGATGTGCGATAACATGAGCGTTG
GAGAAACGAAAGAAATTGCCGCTTATAGAGATGCGCATTATCCTTTTGTTTTACTAGAAGCGAGCGGGAACATCTCGCTA
GAGAGCATCAACGCTTATGCTAAAAGCGGCGTGGATGCCATTAGTGTAGGGGCTTTAATCCATCAAGCCACTTTTATTGA
CATGCACATGAAAATGGCTTAA

Upstream 100 bases:

>100_bases
AAGCTTATAAAAACCACAGGGCTTATAATGCGGTTGAATTAAAAGATGAGGTGGCGCATTGGGCCAAACTCGCTTTAACC
AAAATGATGGAGTTATCTTA

Downstream 100 bases:

>100_bases
AAACTTTAAAAAAGGGGTTATTAGCATGCTAAAAGAATATTTAGAAGGCATTAAAGATCTGACGCTTGAAAGTAATGAAT
CCACGCACCGTCGCCCTTTA

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MEIKTFLKRALKEDLGHGDLFERVLEKDFKATAFVRAKQEGVFSGEKYALELLQMTGIECTQTIKDKERFKPKDTLMEIR
GDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVRLLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDT
HLKHVKDLKSFLAHARKNLPFTAKIEIECESFEEAKNAMNAGADIVMCDNMSVGETKEIAAYRDAHYPFVLLEASGNISL
ESINAYAKSGVDAISVGALIHQATFIDMHMKMA

Sequences:

>Translated_273_residues
MEIKTFLKRALKEDLGHGDLFERVLEKDFKATAFVRAKQEGVFSGEKYALELLQMTGIECTQTIKDKERFKPKDTLMEIR
GDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVRLLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDT
HLKHVKDLKSFLAHARKNLPFTAKIEIECESFEEAKNAMNAGADIVMCDNMSVGETKEIAAYRDAHYPFVLLEASGNISL
ESINAYAKSGVDAISVGALIHQATFIDMHMKMA
>Mature_273_residues
MEIKTFLKRALKEDLGHGDLFERVLEKDFKATAFVRAKQEGVFSGEKYALELLQMTGIECTQTIKDKERFKPKDTLMEIR
GDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVRLLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDT
HLKHVKDLKSFLAHARKNLPFTAKIEIECESFEEAKNAMNAGADIVMCDNMSVGETKEIAAYRDAHYPFVLLEASGNISL
ESINAYAKSGVDAISVGALIHQATFIDMHMKMA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=274, Percent_Identity=31.021897810219, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI1786299, Length=279, Percent_Identity=35.4838709677419, Blast_Score=149, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6321162, Length=275, Percent_Identity=34.1818181818182, Blast_Score=133, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30709; Mature: 30709

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKTFLKRALKEDLGHGDLFERVLEKDFKATAFVRAKQEGVFSGEKYALELLQMTGIEC
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHH
TQTIKDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVR
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEE
LLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLAHARKNLP
EEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
FTAKIEIECESFEEAKNAMNAGADIVMCDNMSVGETKEIAAYRDAHYPFVLLEASGNISL
EEEEEEEEHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHCCCCCEEEEECCCCEEH
ESINAYAKSGVDAISVGALIHQATFIDMHMKMA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MEIKTFLKRALKEDLGHGDLFERVLEKDFKATAFVRAKQEGVFSGEKYALELLQMTGIEC
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHH
TQTIKDKERFKPKDTLMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVR
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEE
LLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLAHARKNLP
EEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
FTAKIEIECESFEEAKNAMNAGADIVMCDNMSVGETKEIAAYRDAHYPFVLLEASGNISL
EEEEEEEEHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHCCCCCEEEEECCCCEEH
ESINAYAKSGVDAISVGALIHQATFIDMHMKMA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]