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The map label for this gene is lysC [H]

Identifier: 108563596

GI number: 108563596

Start: 1235752

End: 1236969

Strand: Direct

Name: lysC [H]

Synonym: HPAG1_1171

Alternate gene names: 108563596

Gene position: 1235752-1236969 (Clockwise)

Preceding gene: 108563595

Following gene: 108563597

Centisome position: 77.41

GC content: 45.48

Gene sequence:

>1218_bases
GTGTTAATCGTTCAAAAATACGGCGGCACGAGCATGGGCAGCGTGGAAAGGATCCACAATGTCGCTCAAAGGGTTTTAGA
AAGCGTTAAATTAGGGCATCAGGTGGTGGTAGTGGTTTCGGCGATGAGCGGCGAAACCGACAGGCTTTTAGAATTTGGCA
AGAATTTTAGCCATAACCCCAACAAGCGAGAGATGGACAGGATTGTAAGCGTGGGGGAATTGGTTTCAAGCGCGGCTTTG
AGCATGGCGTTAGAGAGGTATGGGCATAGAGCCATTTCCTTGAGCGGGAAAGAAGCGGGCATTTTAACCAGTTCGCATTT
TCAAAACGCCGTGATCCAATCCATTGACACCAAACGCATCACAGAGCTTTTAGAAAAAAACTACATTGTGGTGATCGCTG
GGTTTCAAGGCGCTGACATTCAAGGCGAAACAACGACTTTAGGGCGTGGGGGGAGCGATTTGAGCGCGGTCGCTTTGGCC
GGGGCTTTAAAAGCGCATTTGTGCGAAATCTATACGGATGTGGATGGCGTTTATACCACCGATCCGCGCATTGAAGAAAA
GGCTCAAAAAATCGCACAAATCAGCTATGATGAAATGCTTGAACTGGCTTCTATGGGGGCTAAAGTTTTATTAAACCGCT
CGGTGGAATTAGCCAAAAAACTCAGCGTGAAGTTAGTGACTCGCAATTCGTTTAACCATAGCGAAGGCACGCTCATTGTG
GCTGAAAAAGACTTTAAAGGAGAACGCATGGAAACCCCTATAGTGAGTGGGATCGCATTGGATAAAAATCAGGCTCGTGT
GAGCATGGAGGGCGTGGAAGACAGGCCAGGCATTGCCGCTGAAATCTTTGGCGCTTTAGCGGAGTATCGCATTAATGTGG
ATATGATCGTCCAAACGATCGGCAGAGACGGCAAAACCGATTTGGATTTTACGATCGTTAAAACCCAAATAGAAGAAACC
AAGCAAGCCTTAAAGCCTTTTTTAGCGCAAATGGATTCCATTGATTATGATGAAAATATCGCTAAAGTTTCCATAGTGGG
CGTGGGCATGAAGTCGCATTCTGGGGTAGCGAGTATCGCTTTTAAAGCCCTAGCCAAAGACAATATCAATATCATGATGA
TTTCTACAAGCGAGATTAAAATTTCGGTTTTGATTGACATTAAATACGCTGAATTAGCCGTTAGAACTTTGCATGCGGTG
TATCAATTAGATCAATGA

Upstream 100 bases:

>100_bases
TTCATCCATCTTAAGGATTTGCTTAAAAAAATCGTTCCCTTTAAGCGTCAGGTGTACCGCCAAGTCATCGCTTATTTCAA
AAGAGAGGGGTATTTATAGG

Downstream 100 bases:

>100_bases
AAAATTTCTACGACTGGATCAAAGAATTTGTGCGTGATCAGGGGGAATTTATCGCCCAGCAAAGCGGGTGGCTGGAATTA
GAGCGATCAAGCTATGCAAA

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MLIVQKYGGTSMGSVERIHNVAQRVLESVKLGHQVVVVVSAMSGETDRLLEFGKNFSHNPNKREMDRIVSVGELVSSAAL
SMALERYGHRAISLSGKEAGILTSSHFQNAVIQSIDTKRITELLEKNYIVVIAGFQGADIQGETTTLGRGGSDLSAVALA
GALKAHLCEIYTDVDGVYTTDPRIEEKAQKIAQISYDEMLELASMGAKVLLNRSVELAKKLSVKLVTRNSFNHSEGTLIV
AEKDFKGERMETPIVSGIALDKNQARVSMEGVEDRPGIAAEIFGALAEYRINVDMIVQTIGRDGKTDLDFTIVKTQIEET
KQALKPFLAQMDSIDYDENIAKVSIVGVGMKSHSGVASIAFKALAKDNINIMMISTSEIKISVLIDIKYAELAVRTLHAV
YQLDQ

Sequences:

>Translated_405_residues
MLIVQKYGGTSMGSVERIHNVAQRVLESVKLGHQVVVVVSAMSGETDRLLEFGKNFSHNPNKREMDRIVSVGELVSSAAL
SMALERYGHRAISLSGKEAGILTSSHFQNAVIQSIDTKRITELLEKNYIVVIAGFQGADIQGETTTLGRGGSDLSAVALA
GALKAHLCEIYTDVDGVYTTDPRIEEKAQKIAQISYDEMLELASMGAKVLLNRSVELAKKLSVKLVTRNSFNHSEGTLIV
AEKDFKGERMETPIVSGIALDKNQARVSMEGVEDRPGIAAEIFGALAEYRINVDMIVQTIGRDGKTDLDFTIVKTQIEET
KQALKPFLAQMDSIDYDENIAKVSIVGVGMKSHSGVASIAFKALAKDNINIMMISTSEIKISVLIDIKYAELAVRTLHAV
YQLDQ
>Mature_405_residues
MLIVQKYGGTSMGSVERIHNVAQRVLESVKLGHQVVVVVSAMSGETDRLLEFGKNFSHNPNKREMDRIVSVGELVSSAAL
SMALERYGHRAISLSGKEAGILTSSHFQNAVIQSIDTKRITELLEKNYIVVIAGFQGADIQGETTTLGRGGSDLSAVALA
GALKAHLCEIYTDVDGVYTTDPRIEEKAQKIAQISYDEMLELASMGAKVLLNRSVELAKKLSVKLVTRNSFNHSEGTLIV
AEKDFKGERMETPIVSGIALDKNQARVSMEGVEDRPGIAAEIFGALAEYRINVDMIVQTIGRDGKTDLDFTIVKTQIEET
KQALKPFLAQMDSIDYDENIAKVSIVGVGMKSHSGVASIAFKALAKDNINIMMISTSEIKISVLIDIKYAELAVRTLHAV
YQLDQ

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=351, Percent_Identity=33.048433048433, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI1790455, Length=455, Percent_Identity=27.032967032967, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1790376, Length=172, Percent_Identity=29.6511627906977, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44147; Mature: 44147

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIVQKYGGTSMGSVERIHNVAQRVLESVKLGHQVVVVVSAMSGETDRLLEFGKNFSHNP
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHCCCCCCCC
NKREMDRIVSVGELVSSAALSMALERYGHRAISLSGKEAGILTSSHFQNAVIQSIDTKRI
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEEHHHHHHHHHHHCCHHHH
TELLEKNYIVVIAGFQGADIQGETTTLGRGGSDLSAVALAGALKAHLCEIYTDVDGVYTT
HHHHHCCEEEEEECCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEC
DPRIEEKAQKIAQISYDEMLELASMGAKVLLNRSVELAKKLSVKLVTRNSFNHSEGTLIV
CCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHCCHHHHHHCEEEEEEECCCCCCCCEEEE
AEKDFKGERMETPIVSGIALDKNQARVSMEGVEDRPGIAAEIFGALAEYRINVDMIVQTI
EECCCCCCCCCCCCCCCEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
GRDGKTDLDFTIVKTQIEETKQALKPFLAQMDSIDYDENIAKVSIVGVGMKSHSGVASIA
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCHHHHH
FKALAKDNINIMMISTSEIKISVLIDIKYAELAVRTLHAVYQLDQ
HHHHHCCCCEEEEEECCCEEEEEEEEEHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLIVQKYGGTSMGSVERIHNVAQRVLESVKLGHQVVVVVSAMSGETDRLLEFGKNFSHNP
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHCCCCCCCC
NKREMDRIVSVGELVSSAALSMALERYGHRAISLSGKEAGILTSSHFQNAVIQSIDTKRI
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEEHHHHHHHHHHHCCHHHH
TELLEKNYIVVIAGFQGADIQGETTTLGRGGSDLSAVALAGALKAHLCEIYTDVDGVYTT
HHHHHCCEEEEEECCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEC
DPRIEEKAQKIAQISYDEMLELASMGAKVLLNRSVELAKKLSVKLVTRNSFNHSEGTLIV
CCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHCCHHHHHHCEEEEEEECCCCCCCCEEEE
AEKDFKGERMETPIVSGIALDKNQARVSMEGVEDRPGIAAEIFGALAEYRINVDMIVQTI
EECCCCCCCCCCCCCCCEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
GRDGKTDLDFTIVKTQIEETKQALKPFLAQMDSIDYDENIAKVSIVGVGMKSHSGVASIA
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCHHHHH
FKALAKDNINIMMISTSEIKISVLIDIKYAELAVRTLHAVYQLDQ
HHHHHCCCCEEEEEECCCEEEEEEEEEHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]