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The map label for this gene is rppH [H]

Identifier: 108563595

GI number: 108563595

Start: 1235283

End: 1235750

Strand: Direct

Name: rppH [H]

Synonym: HPAG1_1170

Alternate gene names: 108563595

Gene position: 1235283-1235750 (Clockwise)

Preceding gene: 108563594

Following gene: 108563596

Centisome position: 77.38

GC content: 42.31

Gene sequence:

>468_bases
ATGCTACATAAAAAATATCGTCCTAACGTTGCGGCCATTATCATGTCGCCAGACTACCCTAACACATGCGAAGTTTTTAT
CGCTGAGCGCATAGATATTGAAGGGGCGTGGCAATTCCCCCAAGGGGGCATTGATGAGGGCGAAACGCCTTTAGAAGCGC
TCCATAGAGAATTATTAGAAGAAATTGGCACGAATGAAATAGAGATTTTAGCGCAATACCCAAGGTGGATCGCCTATGAT
TTCCCAAGCAATATGGAGCATAAATTCTATGCGTTTGACGGGCAAAAGCAACGCTATTTTTTAGTGCGCCTAAAGCATGC
TAACAACATTGATTTGAACAAGCACACGCCAGAATTTAGAGCTTACCAATTCATCCATCTTAAGGATTTGCTTAAAAAAA
TCGTTCCCTTTAAGCGTCAGGTGTACCGCCAAGTCATCGCTTATTTCAAAAGAGAGGGGTATTTATAG

Upstream 100 bases:

>100_bases
TCTTAATTTTTGATTTTAATGGCGTTCTTAACCCTACTTAAAGCCAGCATACACTATAATACCATCTTAATCAAACAAGA
AAGAGCTAAAATAAAGACCT

Downstream 100 bases:

>100_bases
GGTGTTAATCGTTCAAAAATACGGCGGCACGAGCATGGGCAGCGTGGAAAGGATCCACAATGTCGCTCAAAGGGTTTTAG
AAAGCGTTAAATTAGGGCAT

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase [H]

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MLHKKYRPNVAAIIMSPDYPNTCEVFIAERIDIEGAWQFPQGGIDEGETPLEALHRELLEEIGTNEIEILAQYPRWIAYD
FPSNMEHKFYAFDGQKQRYFLVRLKHANNIDLNKHTPEFRAYQFIHLKDLLKKIVPFKRQVYRQVIAYFKREGYL

Sequences:

>Translated_155_residues
MLHKKYRPNVAAIIMSPDYPNTCEVFIAERIDIEGAWQFPQGGIDEGETPLEALHRELLEEIGTNEIEILAQYPRWIAYD
FPSNMEHKFYAFDGQKQRYFLVRLKHANNIDLNKHTPEFRAYQFIHLKDLLKKIVPFKRQVYRQVIAYFKREGYL
>Mature_155_residues
MLHKKYRPNVAAIIMSPDYPNTCEVFIAERIDIEGAWQFPQGGIDEGETPLEALHRELLEEIGTNEIEILAQYPRWIAYD
FPSNMEHKFYAFDGQKQRYFLVRLKHANNIDLNKHTPEFRAYQFIHLKDLLKKIVPFKRQVYRQVIAYFKREGYL

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789194, Length=151, Percent_Identity=35.7615894039735, Blast_Score=90, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 18507; Mature: 18507

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHKKYRPNVAAIIMSPDYPNTCEVFIAERIDIEGAWQFPQGGIDEGETPLEALHRELLE
CCCCCCCCCEEEEEECCCCCCHHEEEEEEECCCCCCEECCCCCCCCCCCHHHHHHHHHHH
EIGTNEIEILAQYPRWIAYDFPSNMEHKFYAFDGQKQRYFLVRLKHANNIDLNKHTPEFR
HHCCCCEEHEECCCCEEEECCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCCCCCCCHH
AYQFIHLKDLLKKIVPFKRQVYRQVIAYFKREGYL
HEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLHKKYRPNVAAIIMSPDYPNTCEVFIAERIDIEGAWQFPQGGIDEGETPLEALHRELLE
CCCCCCCCCEEEEEECCCCCCHHEEEEEEECCCCCCEECCCCCCCCCCCHHHHHHHHHHH
EIGTNEIEILAQYPRWIAYDFPSNMEHKFYAFDGQKQRYFLVRLKHANNIDLNKHTPEFR
HHCCCCEEHEECCCCEEEECCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCCCCCCCHH
AYQFIHLKDLLKKIVPFKRQVYRQVIAYFKREGYL
HEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA