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The map label for this gene is hemD

Identifier: 108563591

GI number: 108563591

Start: 1232527

End: 1233207

Strand: Direct

Name: hemD

Synonym: HPAG1_1166

Alternate gene names: NA

Gene position: 1232527-1233207 (Clockwise)

Preceding gene: 108563590

Following gene: 108563592

Centisome position: 77.21

GC content: 37.74

Gene sequence:

>681_bases
ATGAGGGAGATTGTATGGGTGCATTCTCAAAGAATCGCCCCTTATAAGACTCTCATTTTAAATGAATTGCGCTACTATCC
TTTAGAATTGGATTTAACCCCTTTTAACGCCCTGATTTTCACTTCTAAAAATGCGGTGTTTTCCTTGCTAGAAACTCTAA
AAAACAGCCCCAAACTCAAAATTTTACAAAACATTCCTGCCTACGCTTTGAGCGAACCCACCGCAAAAACTTTACAAAAT
CACCATTTTAAAGTCGCCTTTATAGGGGAAAAAGCCCATGGCAAAGAGTTCGTTCAAGAAATCCTTCCTTTATTGGAAAA
AAAAAGCGTTTTGTATCTCAGGGCAAAAGAGATTGCCTCTTCTTTAGACACCATTCTTTTAGAGCATGGCATTGATTTCA
AACAAGCCGTTGTTTATGAAAACAAGCTCAAACATTTAACCTTAAGCGAACAAAACGCCCTAAAACCCAAAGAAAAGAGC
GTTCTTATTTTTACCGCCATAAGCCATGCAAAAGCCTTTTTGCACTATTTTGAATTTTTAGAAAATTACACCGCTATCAG
CATTGGCAACACGACCGCTCTTTATTTACAAGAACAAGGCATTCCAAGCCATATTGCCAAAAAGCCCTCCTTAGAAGCGT
GTTTAGAACTGGCTTTAAGTTTGAGAATTAAGGAATGTTAA

Upstream 100 bases:

>100_bases
TAGGCTATACGCCCTATTATTTAGAGGGCAATGTCTATGATTTTGAAAAATACGGCTTTAGAATGGTCTATGATGACACT
TGCGCTAAAAAAAACTAGGC

Downstream 100 bases:

>100_bases
AAACATCTCATTATAATGCTCTCAGTTATTTTGTTAAAGGATGACGCATGAATTTTGTCTTTTTATGGGCCGCTTTAGGG
GGGGCTATAGGGAGTTCGTT

Product: uroporphyrinogen-III synthase

Products: uroporphyrinogen III; H2O

Alternate protein names: Uroporphyrinogen-III Synthase HemD; Uroporphyrinogen-III Synthetase; Uroporphyrinogen III Cosynthase; Uroporphyrinogen III Cosynthase HemD

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MREIVWVHSQRIAPYKTLILNELRYYPLELDLTPFNALIFTSKNAVFSLLETLKNSPKLKILQNIPAYALSEPTAKTLQN
HHFKVAFIGEKAHGKEFVQEILPLLEKKSVLYLRAKEIASSLDTILLEHGIDFKQAVVYENKLKHLTLSEQNALKPKEKS
VLIFTAISHAKAFLHYFEFLENYTAISIGNTTALYLQEQGIPSHIAKKPSLEACLELALSLRIKEC

Sequences:

>Translated_226_residues
MREIVWVHSQRIAPYKTLILNELRYYPLELDLTPFNALIFTSKNAVFSLLETLKNSPKLKILQNIPAYALSEPTAKTLQN
HHFKVAFIGEKAHGKEFVQEILPLLEKKSVLYLRAKEIASSLDTILLEHGIDFKQAVVYENKLKHLTLSEQNALKPKEKS
VLIFTAISHAKAFLHYFEFLENYTAISIGNTTALYLQEQGIPSHIAKKPSLEACLELALSLRIKEC
>Mature_226_residues
MREIVWVHSQRIAPYKTLILNELRYYPLELDLTPFNALIFTSKNAVFSLLETLKNSPKLKILQNIPAYALSEPTAKTLQN
HHFKVAFIGEKAHGKEFVQEILPLLEKKSVLYLRAKEIASSLDTILLEHGIDFKQAVVYENKLKHLTLSEQNALKPKEKS
VLIFTAISHAKAFLHYFEFLENYTAISIGNTTALYLQEQGIPSHIAKKPSLEACLELALSLRIKEC

Specific function: Unknown

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.1.75

Molecular weight: Translated: 25758; Mature: 25758

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREIVWVHSQRIAPYKTLILNELRYYPLELDLTPFNALIFTSKNAVFSLLETLKNSPKLK
CCCEEEEECCCCCHHHHHHHHHHHHCEEEEECCCCEEEEEECCHHHHHHHHHHHCCCCEE
ILQNIPAYALSEPTAKTLQNHHFKVAFIGEKAHGKEFVQEILPLLEKKSVLYLRAKEIAS
EECCCCCHHCCCCHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHH
SLDTILLEHGIDFKQAVVYENKLKHLTLSEQNALKPKEKSVLIFTAISHAKAFLHYFEFL
HHHHHHHHCCCCHHHHHHHHHHHHEEEECCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHH
ENYTAISIGNTTALYLQEQGIPSHIAKKPSLEACLELALSLRIKEC
HCCEEEEECCEEEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MREIVWVHSQRIAPYKTLILNELRYYPLELDLTPFNALIFTSKNAVFSLLETLKNSPKLK
CCCEEEEECCCCCHHHHHHHHHHHHCEEEEECCCCEEEEEECCHHHHHHHHHHHCCCCEE
ILQNIPAYALSEPTAKTLQNHHFKVAFIGEKAHGKEFVQEILPLLEKKSVLYLRAKEIAS
EECCCCCHHCCCCHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHH
SLDTILLEHGIDFKQAVVYENKLKHLTLSEQNALKPKEKSVLIFTAISHAKAFLHYFEFL
HHHHHHHHCCCCHHHHHHHHHHHHEEEECCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHH
ENYTAISIGNTTALYLQEQGIPSHIAKKPSLEACLELALSLRIKEC
HCCEEEEECCEEEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: hydroxymethylbilane

Specific reaction: hydroxymethylbilane = uroporphyrinogen III + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA