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The map label for this gene is yhfN [H]

Identifier: 108563435

GI number: 108563435

Start: 1063947

End: 1065170

Strand: Direct

Name: yhfN [H]

Synonym: HPAG1_1010

Alternate gene names: 108563435

Gene position: 1063947-1065170 (Clockwise)

Preceding gene: 108563433

Following gene: 108563436

Centisome position: 66.65

GC content: 39.54

Gene sequence:

>1224_bases
ATGCTTGACATATGGATAGATATGATAATTTGTATTTTTTATTTGCTCTTTTTTACGACTCCTTACATTGTAGGCGATAT
TTTGCAATTGAACTTTATCCGTCAAAAGCTCTGCGAGAAGCCTGTTTTACTCCCACAAAAGGATTATGAGGAAGCGGGAA
ATTATGCCATTAGGAAAATGCAATTATCCATTATTTCTCAAATTTTAGACGGGATAATCTTTGCTGGTTGGGTCTTTTTT
GGTTTGACGCATTTAGAAGATTTGACGCATTATTTAAACCTTTCTGAAACGCTAGGTGACTTGGTGTTTGCCTTGTTGTT
TTTAGCGATTCAAAGCGTTTTATCCTTACCCATTAGCTACTACACCACCATGCATTTGGATAAGGAATTTGGCTTTTCTA
AGGTGAGCTTGTCGTTGTTTTTTAAGGATTTTTTCAAGGGGTTATCGCTCACTTTAAGCGTGGGATTGTTGTTGATTTAC
ACCCTCATTATGATCATTGAACATGTGGAGCATTGGGAGATTAGCTCGTTTTTTGTCGTGTTTGTTTTTATGATATTAGC
TAATCTTTTTTACCCTAAAATCGCCCAGCTTTTCAACCAATTCACCCCCTTGAATAACCGGGATTTGGAGAGTCAAATTG
AGGGCATGATGGATAAGGTGGGTTTTAAATCTGAAGGTATCTTTGTGATGGACGCTAGCAAGAGGGATGGGCGTTTGAAC
GCGTATTTTGGGGGCTTGGGCAAAAACAAGCGGGTGGTGTTGTTTGACACTCTGATCTCTAAAGTTGGGACAGAAGGGCT
TTTAGCCATTTTAGGGCATGAATTAGGGCATTTTAAAAATAAGGATTTGTTGAAAAGTTTAGGGATTATGGGAGGCTTGC
TCGCTCTTGTTTTTGCTTTAATCGCTCATTTGCCACCGATCGTTTTTGAAGGCTTTAATGTCTCGCAAACGCCAGCGAGT
TTGATTGCGATTTTGCTCTTGTTTTTGCCGGTGTTTTCTTTTTACGCCATGCCTTTGATCGGGTTTTTTAGCCGAAAGAA
CGAATACAATGCGGACAAATTTGGGGCGAGTTTAAGTTCTAAAGAGACTTTAGCCAAAGCGTTAGTGTCTATTGTAAGCG
AGAATAAAGCGTTCCCCTATTCGCACCCTTTTTATGTTTTCTTGCATTTCACCCACCCGCCCCTATTAGAGCGCTTGAAA
GCTTTGGATTATGAAATTGAATGA

Upstream 100 bases:

>100_bases
TTTTTCTACCATATTTATTTAATTTTATGGTAAATTTTTGAAAAATTGTTATAATTCCTACACTTTTATTGGCAAATTGA
TTAAGAAAGGAGTTTAGAAC

Downstream 100 bases:

>100_bases
CCCTTTCACAAGCCCTAAACAAAGCCAAAAAAGGATTATCGCAAAAAGGCTTTAGGGGGGGGTTAGAGTCTGAAATTTTA
TTAGGCTTTGTCTTGCAAAA

Product: zinc-metalloprotease

Products: NA

Alternate protein names: PSP23 [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MLDIWIDMIICIFYLLFFTTPYIVGDILQLNFIRQKLCEKPVLLPQKDYEEAGNYAIRKMQLSIISQILDGIIFAGWVFF
GLTHLEDLTHYLNLSETLGDLVFALLFLAIQSVLSLPISYYTTMHLDKEFGFSKVSLSLFFKDFFKGLSLTLSVGLLLIY
TLIMIIEHVEHWEISSFFVVFVFMILANLFYPKIAQLFNQFTPLNNRDLESQIEGMMDKVGFKSEGIFVMDASKRDGRLN
AYFGGLGKNKRVVLFDTLISKVGTEGLLAILGHELGHFKNKDLLKSLGIMGGLLALVFALIAHLPPIVFEGFNVSQTPAS
LIAILLLFLPVFSFYAMPLIGFFSRKNEYNADKFGASLSSKETLAKALVSIVSENKAFPYSHPFYVFLHFTHPPLLERLK
ALDYEIE

Sequences:

>Translated_407_residues
MLDIWIDMIICIFYLLFFTTPYIVGDILQLNFIRQKLCEKPVLLPQKDYEEAGNYAIRKMQLSIISQILDGIIFAGWVFF
GLTHLEDLTHYLNLSETLGDLVFALLFLAIQSVLSLPISYYTTMHLDKEFGFSKVSLSLFFKDFFKGLSLTLSVGLLLIY
TLIMIIEHVEHWEISSFFVVFVFMILANLFYPKIAQLFNQFTPLNNRDLESQIEGMMDKVGFKSEGIFVMDASKRDGRLN
AYFGGLGKNKRVVLFDTLISKVGTEGLLAILGHELGHFKNKDLLKSLGIMGGLLALVFALIAHLPPIVFEGFNVSQTPAS
LIAILLLFLPVFSFYAMPLIGFFSRKNEYNADKFGASLSSKETLAKALVSIVSENKAFPYSHPFYVFLHFTHPPLLERLK
ALDYEIE
>Mature_407_residues
MLDIWIDMIICIFYLLFFTTPYIVGDILQLNFIRQKLCEKPVLLPQKDYEEAGNYAIRKMQLSIISQILDGIIFAGWVFF
GLTHLEDLTHYLNLSETLGDLVFALLFLAIQSVLSLPISYYTTMHLDKEFGFSKVSLSLFFKDFFKGLSLTLSVGLLLIY
TLIMIIEHVEHWEISSFFVVFVFMILANLFYPKIAQLFNQFTPLNNRDLESQIEGMMDKVGFKSEGIFVMDASKRDGRLN
AYFGGLGKNKRVVLFDTLISKVGTEGLLAILGHELGHFKNKDLLKSLGIMGGLLALVFALIAHLPPIVFEGFNVSQTPAS
LIAILLLFLPVFSFYAMPLIGFFSRKNEYNADKFGASLSSKETLAKALVSIVSENKAFPYSHPFYVFLHFTHPPLLERLK
ALDYEIE

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Homo sapiens, GI18379366, Length=352, Percent_Identity=31.8181818181818, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17505484, Length=417, Percent_Identity=26.6187050359712, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6322577, Length=316, Percent_Identity=34.4936708860759, Blast_Score=154, Evalue=2e-38,
Organism=Drosophila melanogaster, GI19922414, Length=339, Percent_Identity=30.9734513274336, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24654305, Length=401, Percent_Identity=26.6832917705736, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI78707252, Length=399, Percent_Identity=25.062656641604, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI78707254, Length=399, Percent_Identity=25.062656641604, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 46223; Mature: 46223

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 3145906 [H]