Click here to switch to the map view.

The map label for this gene is ppiD [H]

Identifier: 108563383

GI number: 108563383

Start: 1005016

End: 1006479

Strand: Direct

Name: ppiD [H]

Synonym: HPAG1_0958

Alternate gene names: 108563383

Gene position: 1005016-1006479 (Clockwise)

Preceding gene: 108563381

Following gene: 108563384

Centisome position: 62.96

GC content: 36.95

Gene sequence:

>1464_bases
ATGATTGAATGGATGCAAAATCATAGAAAGTATTTAGTGGTTACAATATGGATAAGCACGATCGCTTTTATTGCTGCCGG
AATGATAGGCTGGGGGCAATACAACTTTTCTTTAGATAGCGATAGCGCTGCCAAAGTGGGACAGATTAAGATTTCTCAAG
AAGAATTAGCCCAAGAATACCGCCGCCTTAAAGACGCATATGCTGAGTCTATCCCTGATTTTAAAGAACTCACCAAAGAT
CAAATCAAAGCCATGCATTTGGAAAAAAGCGCTCTAGATTCGCTCATCAATCAAGCTTTATTGAGGAATCTCGCTTTAGA
TTTAGGGCTTGGCGCTACAAAGCAAGAAGTGGCGAAAGAAATCAGAAAAACGAGCGTTTTTCAAAAAGATGGTGTTTTTG
ATGAAGAATTGTATAAAAATATCTTAAAACAAAGCCATTACCGCCCCAAGCATTTTGAAGAAAGCGTTGAAAGGCTTTTA
ATCCTTCAAAAAATCAGCGCTCTATTCCCCAAAACCACTACCCCTTTAGAGCAATCTAGCCTATCGCTTTGGGCAAAATT
GCAAGACAAATTAGACATTCTTATCCTAAACCCTAGTGATGTTAAAATCTCTCTTAATGAAGAAGAGATGAAAAAATATT
ACGAGTCCCATAAAAAGGATTTTAAAAAGCCCACAAGCTTTAAAACACGCTCTTTATATTTTGACGCTAGTTTAGAAAAA
CCTGATTTGAAAGAGTTGGAGGAATACTACCATAAAAACAAGGTGTCTTATTTGGACAAAGAGGGGAAATTGCAGGATTT
TAAAAGCGTTCAAGAGCAAGTCAAACATGATTTAAGCATGCAAAAAGCGAATGAAAAAGCCTTAAGGAGTTATATCGCTC
TAAAAAAGGGGAATGTGCAAAACTACACCACGCAAGATTTTGAAGAAAACAACTCCCCCTATACTGCTGAAATCACGCAA
AAACTCGCCGCTCTCAAGCCCCTTGAAATCCTAAAACCAGAGCCTTTTAAAGATGGTTTTATTGTGGTGCAGCTCATCTC
TCAAACCAAAGACGAATTGCAAAATTTTAATGAAGCTAAAAGCGCTCTTAAAACCCGCCTAACTCAAGAAAAAACCCTTA
TGGCGTTGCAAACTTTAGCTAAAGAAAAGCTTAAGGATTTTAAAGGCAAAAGCGTGGGCTATGTAAGCCCTAATTTTGGA
GGCACTATTAGCGAACTTAACCAAGAAGAAAGCGCTAAGTTTATCAACACCCTTTTTAACCGCCAAGAAAAAAAGGGGTT
TATTACTATTGGTAATAAAGTGGTGCTTTATCAAATCACAGAACAAAATTTCAACCACTCATTTAGCACAGAAGAAAGCC
AGTATATGCAGCGTTTAGTCAATAACACTAAAACGGATTTTTTTGATAAAGCGTTGATAGAAGAATTGAAAAAACGCTAT
AAGATAGTCAAATACATTCAATAA

Upstream 100 bases:

>100_bases
TTAATAACCTTTGGTTAAAATAGGGTTATTTGATTTTACTATAAGGTTGTTTAAACCTGAATTTCACATTTTTGATTTTT
TAAAAGGGATTAGAGTTCTT

Downstream 100 bases:

>100_bases
ATGCAAGGGGAAATCATGGAACATAAAGAAATCGTTATAGGGGTTGATATAGGCTCTAGAAAGATTTGTGCGATAGTGGC
TGAATTTAAAGAAGGGATTT

Product: peptidyl-prolyl cis-trans isomerase D

Products: NA

Alternate protein names: PPIase D; Rotamase D [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MIEWMQNHRKYLVVTIWISTIAFIAAGMIGWGQYNFSLDSDSAAKVGQIKISQEELAQEYRRLKDAYAESIPDFKELTKD
QIKAMHLEKSALDSLINQALLRNLALDLGLGATKQEVAKEIRKTSVFQKDGVFDEELYKNILKQSHYRPKHFEESVERLL
ILQKISALFPKTTTPLEQSSLSLWAKLQDKLDILILNPSDVKISLNEEEMKKYYESHKKDFKKPTSFKTRSLYFDASLEK
PDLKELEEYYHKNKVSYLDKEGKLQDFKSVQEQVKHDLSMQKANEKALRSYIALKKGNVQNYTTQDFEENNSPYTAEITQ
KLAALKPLEILKPEPFKDGFIVVQLISQTKDELQNFNEAKSALKTRLTQEKTLMALQTLAKEKLKDFKGKSVGYVSPNFG
GTISELNQEESAKFINTLFNRQEKKGFITIGNKVVLYQITEQNFNHSFSTEESQYMQRLVNNTKTDFFDKALIEELKKRY
KIVKYIQ

Sequences:

>Translated_487_residues
MIEWMQNHRKYLVVTIWISTIAFIAAGMIGWGQYNFSLDSDSAAKVGQIKISQEELAQEYRRLKDAYAESIPDFKELTKD
QIKAMHLEKSALDSLINQALLRNLALDLGLGATKQEVAKEIRKTSVFQKDGVFDEELYKNILKQSHYRPKHFEESVERLL
ILQKISALFPKTTTPLEQSSLSLWAKLQDKLDILILNPSDVKISLNEEEMKKYYESHKKDFKKPTSFKTRSLYFDASLEK
PDLKELEEYYHKNKVSYLDKEGKLQDFKSVQEQVKHDLSMQKANEKALRSYIALKKGNVQNYTTQDFEENNSPYTAEITQ
KLAALKPLEILKPEPFKDGFIVVQLISQTKDELQNFNEAKSALKTRLTQEKTLMALQTLAKEKLKDFKGKSVGYVSPNFG
GTISELNQEESAKFINTLFNRQEKKGFITIGNKVVLYQITEQNFNHSFSTEESQYMQRLVNNTKTDFFDKALIEELKKRY
KIVKYIQ
>Mature_487_residues
MIEWMQNHRKYLVVTIWISTIAFIAAGMIGWGQYNFSLDSDSAAKVGQIKISQEELAQEYRRLKDAYAESIPDFKELTKD
QIKAMHLEKSALDSLINQALLRNLALDLGLGATKQEVAKEIRKTSVFQKDGVFDEELYKNILKQSHYRPKHFEESVERLL
ILQKISALFPKTTTPLEQSSLSLWAKLQDKLDILILNPSDVKISLNEEEMKKYYESHKKDFKKPTSFKTRSLYFDASLEK
PDLKELEEYYHKNKVSYLDKEGKLQDFKSVQEQVKHDLSMQKANEKALRSYIALKKGNVQNYTTQDFEENNSPYTAEITQ
KLAALKPLEILKPEPFKDGFIVVQLISQTKDELQNFNEAKSALKTRLTQEKTLMALQTLAKEKLKDFKGKSVGYVSPNFG
GTISELNQEESAKFINTLFNRQEKKGFITIGNKVVLYQITEQNFNHSFSTEESQYMQRLVNNTKTDFFDKALIEELKKRY
KIVKYIQ

Specific function: PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=266, Percent_Identity=24.812030075188, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 56495; Mature: 56495

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEWMQNHRKYLVVTIWISTIAFIAAGMIGWGQYNFSLDSDSAAKVGQIKISQEELAQEY
CCCCHHCCCCEEEEHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHCEEEECHHHHHHHH
RRLKDAYAESIPDFKELTKDQIKAMHLEKSALDSLINQALLRNLALDLGLGATKQEVAKE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
IRKTSVFQKDGVFDEELYKNILKQSHYRPKHFEESVERLLILQKISALFPKTTTPLEQSS
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
LSLWAKLQDKLDILILNPSDVKISLNEEEMKKYYESHKKDFKKPTSFKTRSLYFDASLEK
HHHHHHHHCCCEEEEECCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
PDLKELEEYYHKNKVSYLDKEGKLQDFKSVQEQVKHDLSMQKANEKALRSYIALKKGNVQ
CCHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NYTTQDFEENNSPYTAEITQKLAALKPLEILKPEPFKDGFIVVQLISQTKDELQNFNEAK
CCCCCCHHCCCCCCHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SALKTRLTQEKTLMALQTLAKEKLKDFKGKSVGYVSPNFGGTISELNQEESAKFINTLFN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCHHHHCHHHHHHHHHHHHH
RQEKKGFITIGNKVVLYQITEQNFNHSFSTEESQYMQRLVNNTKTDFFDKALIEELKKRY
HHHCCCEEEECCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
KIVKYIQ
HHHHHCC
>Mature Secondary Structure
MIEWMQNHRKYLVVTIWISTIAFIAAGMIGWGQYNFSLDSDSAAKVGQIKISQEELAQEY
CCCCHHCCCCEEEEHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHCEEEECHHHHHHHH
RRLKDAYAESIPDFKELTKDQIKAMHLEKSALDSLINQALLRNLALDLGLGATKQEVAKE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
IRKTSVFQKDGVFDEELYKNILKQSHYRPKHFEESVERLLILQKISALFPKTTTPLEQSS
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
LSLWAKLQDKLDILILNPSDVKISLNEEEMKKYYESHKKDFKKPTSFKTRSLYFDASLEK
HHHHHHHHCCCEEEEECCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
PDLKELEEYYHKNKVSYLDKEGKLQDFKSVQEQVKHDLSMQKANEKALRSYIALKKGNVQ
CCHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NYTTQDFEENNSPYTAEITQKLAALKPLEILKPEPFKDGFIVVQLISQTKDELQNFNEAK
CCCCCCHHCCCCCCHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SALKTRLTQEKTLMALQTLAKEKLKDFKGKSVGYVSPNFGGTISELNQEESAKFINTLFN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCHHHHCHHHHHHHHHHHHH
RQEKKGFITIGNKVVLYQITEQNFNHSFSTEESQYMQRLVNNTKTDFFDKALIEELKKRY
HHHCCCEEEECCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
KIVKYIQ
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]