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The map label for this gene is uvrD [H]

Identifier: 108563318

GI number: 108563318

Start: 928709

End: 930736

Strand: Direct

Name: uvrD [H]

Synonym: HPAG1_0893

Alternate gene names: 108563318

Gene position: 928709-930736 (Clockwise)

Preceding gene: 108563317

Following gene: 108563320

Centisome position: 58.18

GC content: 39.94

Gene sequence:

>2028_bases
TTGTTAGAAACTTTGCAATTAAACCCGGAGCAATTAAAAGCGGCCAAGGCTTTACAAGGGCATAATTTAATCATTGCGAG
TGCTGGCACAGGAAAGACTTCTACGATTGTGGGGCGCATTTTATACTTGCTTGATAACGGCATCAAGCCTGAAGAAATCT
TGCTTTTGACTTTCACCAATAAAGCGAGTAATGAAATGATCGCCAGGGTGGCTAAATATTTTAAATCAAGCTCCAAAATT
GAAGCGGGCACTTTCCATGCGGTAGCGTATCGCTATTTAAAAGAGCATTACCCTAATTTAAGCCTAAAGCAACCCAAAGA
ATTGAGAAAACTTTTAGAAAGCATTGTGGACACTAAAAACGCCATAGATGACGATAAAAAGCCCTACACTTCACAGCATT
TATACGCCCTCTATTCTCTTTATACCAACGCTCTAAAACAAGAAGATTTTAGCGCATGGCTTTCTAATAAAAACCCTGAA
CACGCACCATACGCCGCCCTTTATGAAAACATTTTAGAAGAGTTTGAAAACACTAAAAAAAAGCATAATTATATTGACTA
TAACGACTTACTGCTGCTCTTTAAACAAGCGATGCTAGAAAGACCTAGCCCTTATAAAGAAGTGCTTTGCGATGAATTTC
AAGACACTAACCCCTTACAAGAATCCATTTTAGACGCTATCAACCCTCCCAGTTTGTTTTGCGTGGGCGATTACGATCAG
AGCATTTACGCTTTTAATGGGGCGGATATTTCTATCATTTCTAACTTCACCCAAAAATACAAAAACGCCCAGGTTTTCAC
GCTCACCAAAAACTACCGCTCTTCTAAAGAGATTTTAGATCTCGCTAATCAAGTGATACAGCGCAACGAGCGCATTTACC
CTAAAAATTTGGAAGTGGTGAAATCAGGGAAATTCAATAAGCCTGCGCTTTTAAATTACAACGACAATATCGTGCAATGC
CAAGACATCGCTAAACGCATTGTCATGCGAAAGGATTTTAAAGAAGTGGCAGTGATTTTTAGGAATAACGCGAGCGCGGA
TCAATTAGAAGCCGCTTTAAGATCTTACAATGTGCCAAGCAAAAGGAAAGGGAGCGCGAGCTTTTTTGAATCCAAAGAAG
TGGCGTTAGCGTTAGACATTTGCGCGCTACTCTTTAACCCTAAAGACATTATGGCAGCCATTCATGTTTTAAGCTATATC
AGCGATATTGGCTCTAACACCGCTAAAGACATTCATGAAGCTTTGATGCTTTTAGGCAATGGTGATCTCAAACTAGCCCT
AACCCACCCAAATAAAGAAGCCAAAATTTACACCAAGAAAAAAGAAATCACCTCTATGGGGCTTTTTGAAGAAATTTTTG
CCCTAGAAAATAGCTCAAGGTTTAATAGCGTGATAGATAAAGCGTTCCATTCGCACCCGGTGTTGATGCACCCTAAAATC
TCACTCAATGGGGCTAAAACGCTGAGCGATTTTTTCATTCTCTATACTAAAGCCCCTACCCATTCCCCTAGCGCTTTAAT
CAAACACATTCTAGAAAGCGCGTTTTTTCAAACCTTTAAAACACGCCTTTTAAAAGAGCGATCCAAAAATAAGGACGGCT
CTTATAACGAGTTTAAAAAACTCCAAGCGCAAAAACGCTTCAATGAAAAAATGGATTTGCTAAGCTCTTTGGCGAAAAAT
TACCAAAATTTAGGGCGTTTTTTAAACGGCACTTTAATAGGATCTAGTGAAGCCACGCAAGGCTGTGGCGTGAATTTATT
GAGCGTGCATGCTTCTAAAGGCTTAGAATTTAAAGACGTTTATATTATAGATTTAATGGAGGGCCGTTTCCCTAACCACA
AGCTCATGAATACCGGAGGGGGCATTGAAGAAGAGCGGCGGCTTTTTTATGTCGCTATCACAAGGGCTAAGGAAAATTTA
TGGCTTTCTTATGCGAAAAACGAATTGAGGGAAAACGCCAAACCGAAAGAGCATAAGCCTTCGGTGTTTTTGTATGAAGC
GGGGCTTTTGAAACCCGATTCAAAATAA

Upstream 100 bases:

>100_bases
GCAAGAATTAGGCTTTGTGTGCGATGGGCGTTTTTTGTTTTCGCAACGCTCTTTAGAAAACGCTCTTTTGCCTAAAGACT
TTTTAAATCTAGGATAAAAC

Downstream 100 bases:

>100_bases
AATTGGTTTTTTATTGTTTGTTTAAGCAAAAGATGATATGATTATAGCGATAGTTAAGCCCCTAAGAGCTAGGAACTCTT
AAGAGCTTGTTTTAATAAAG

Product: rep helicase, single-stranded DNA-dependent ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 675; Mature: 675

Protein sequence:

>675_residues
MLETLQLNPEQLKAAKALQGHNLIIASAGTGKTSTIVGRILYLLDNGIKPEEILLLTFTNKASNEMIARVAKYFKSSSKI
EAGTFHAVAYRYLKEHYPNLSLKQPKELRKLLESIVDTKNAIDDDKKPYTSQHLYALYSLYTNALKQEDFSAWLSNKNPE
HAPYAALYENILEEFENTKKKHNYIDYNDLLLLFKQAMLERPSPYKEVLCDEFQDTNPLQESILDAINPPSLFCVGDYDQ
SIYAFNGADISIISNFTQKYKNAQVFTLTKNYRSSKEILDLANQVIQRNERIYPKNLEVVKSGKFNKPALLNYNDNIVQC
QDIAKRIVMRKDFKEVAVIFRNNASADQLEAALRSYNVPSKRKGSASFFESKEVALALDICALLFNPKDIMAAIHVLSYI
SDIGSNTAKDIHEALMLLGNGDLKLALTHPNKEAKIYTKKKEITSMGLFEEIFALENSSRFNSVIDKAFHSHPVLMHPKI
SLNGAKTLSDFFILYTKAPTHSPSALIKHILESAFFQTFKTRLLKERSKNKDGSYNEFKKLQAQKRFNEKMDLLSSLAKN
YQNLGRFLNGTLIGSSEATQGCGVNLLSVHASKGLEFKDVYIIDLMEGRFPNHKLMNTGGGIEEERRLFYVAITRAKENL
WLSYAKNELRENAKPKEHKPSVFLYEAGLLKPDSK

Sequences:

>Translated_675_residues
MLETLQLNPEQLKAAKALQGHNLIIASAGTGKTSTIVGRILYLLDNGIKPEEILLLTFTNKASNEMIARVAKYFKSSSKI
EAGTFHAVAYRYLKEHYPNLSLKQPKELRKLLESIVDTKNAIDDDKKPYTSQHLYALYSLYTNALKQEDFSAWLSNKNPE
HAPYAALYENILEEFENTKKKHNYIDYNDLLLLFKQAMLERPSPYKEVLCDEFQDTNPLQESILDAINPPSLFCVGDYDQ
SIYAFNGADISIISNFTQKYKNAQVFTLTKNYRSSKEILDLANQVIQRNERIYPKNLEVVKSGKFNKPALLNYNDNIVQC
QDIAKRIVMRKDFKEVAVIFRNNASADQLEAALRSYNVPSKRKGSASFFESKEVALALDICALLFNPKDIMAAIHVLSYI
SDIGSNTAKDIHEALMLLGNGDLKLALTHPNKEAKIYTKKKEITSMGLFEEIFALENSSRFNSVIDKAFHSHPVLMHPKI
SLNGAKTLSDFFILYTKAPTHSPSALIKHILESAFFQTFKTRLLKERSKNKDGSYNEFKKLQAQKRFNEKMDLLSSLAKN
YQNLGRFLNGTLIGSSEATQGCGVNLLSVHASKGLEFKDVYIIDLMEGRFPNHKLMNTGGGIEEERRLFYVAITRAKENL
WLSYAKNELRENAKPKEHKPSVFLYEAGLLKPDSK
>Mature_675_residues
MLETLQLNPEQLKAAKALQGHNLIIASAGTGKTSTIVGRILYLLDNGIKPEEILLLTFTNKASNEMIARVAKYFKSSSKI
EAGTFHAVAYRYLKEHYPNLSLKQPKELRKLLESIVDTKNAIDDDKKPYTSQHLYALYSLYTNALKQEDFSAWLSNKNPE
HAPYAALYENILEEFENTKKKHNYIDYNDLLLLFKQAMLERPSPYKEVLCDEFQDTNPLQESILDAINPPSLFCVGDYDQ
SIYAFNGADISIISNFTQKYKNAQVFTLTKNYRSSKEILDLANQVIQRNERIYPKNLEVVKSGKFNKPALLNYNDNIVQC
QDIAKRIVMRKDFKEVAVIFRNNASADQLEAALRSYNVPSKRKGSASFFESKEVALALDICALLFNPKDIMAAIHVLSYI
SDIGSNTAKDIHEALMLLGNGDLKLALTHPNKEAKIYTKKKEITSMGLFEEIFALENSSRFNSVIDKAFHSHPVLMHPKI
SLNGAKTLSDFFILYTKAPTHSPSALIKHILESAFFQTFKTRLLKERSKNKDGSYNEFKKLQAQKRFNEKMDLLSSLAKN
YQNLGRFLNGTLIGSSEATQGCGVNLLSVHASKGLEFKDVYIIDLMEGRFPNHKLMNTGGGIEEERRLFYVAITRAKENL
WLSYAKNELRENAKPKEHKPSVFLYEAGLLKPDSK

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=694, Percent_Identity=27.3775216138329, Blast_Score=216, Evalue=4e-57,
Organism=Escherichia coli, GI48994965, Length=691, Percent_Identity=27.3516642547033, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1787196, Length=361, Percent_Identity=28.5318559556787, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6322369, Length=467, Percent_Identity=26.9807280513919, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6324477, Length=485, Percent_Identity=25.1546391752577, Blast_Score=95, Evalue=3e-20,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 76646; Mature: 76646

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLETLQLNPEQLKAAKALQGHNLIIASAGTGKTSTIVGRILYLLDNGIKPEEILLLTFTN
CCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECC
KASNEMIARVAKYFKSSSKIEAGTFHAVAYRYLKEHYPNLSLKQPKELRKLLESIVDTKN
CCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
AIDDDKKPYTSQHLYALYSLYTNALKQEDFSAWLSNKNPEHAPYAALYENILEEFENTKK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
KHNYIDYNDLLLLFKQAMLERPSPYKEVLCDEFQDTNPLQESILDAINPPSLFCVGDYDQ
HCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEECCCC
SIYAFNGADISIISNFTQKYKNAQVFTLTKNYRSSKEILDLANQVIQRNERIYPKNLEVV
CEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHE
KSGKFNKPALLNYNDNIVQCQDIAKRIVMRKDFKEVAVIFRNNASADQLEAALRSYNVPS
ECCCCCCCEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
KRKGSASFFESKEVALALDICALLFNPKDIMAAIHVLSYISDIGSNTAKDIHEALMLLGN
CCCCCCHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
GDLKLALTHPNKEAKIYTKKKEITSMGLFEEIFALENSSRFNSVIDKAFHSHPVLMHPKI
CCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEECCCC
SLNGAKTLSDFFILYTKAPTHSPSALIKHILESAFFQTFKTRLLKERSKNKDGSYNEFKK
CCCCHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LQAQKRFNEKMDLLSSLAKNYQNLGRFLNGTLIGSSEATQGCGVNLLSVHASKGLEFKDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCEEEEEHHCCCCCCCCE
YIIDLMEGRFPNHKLMNTGGGIEEERRLFYVAITRAKENLWLSYAKNELRENAKPKEHKP
EEEEEECCCCCCCCEECCCCCCCHHCEEEEEEEEECHHHHHHHHHHHHHHHCCCCCCCCC
SVFLYEAGLLKPDSK
CEEEEECCCCCCCCC
>Mature Secondary Structure
MLETLQLNPEQLKAAKALQGHNLIIASAGTGKTSTIVGRILYLLDNGIKPEEILLLTFTN
CCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECC
KASNEMIARVAKYFKSSSKIEAGTFHAVAYRYLKEHYPNLSLKQPKELRKLLESIVDTKN
CCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
AIDDDKKPYTSQHLYALYSLYTNALKQEDFSAWLSNKNPEHAPYAALYENILEEFENTKK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
KHNYIDYNDLLLLFKQAMLERPSPYKEVLCDEFQDTNPLQESILDAINPPSLFCVGDYDQ
HCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEECCCC
SIYAFNGADISIISNFTQKYKNAQVFTLTKNYRSSKEILDLANQVIQRNERIYPKNLEVV
CEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHE
KSGKFNKPALLNYNDNIVQCQDIAKRIVMRKDFKEVAVIFRNNASADQLEAALRSYNVPS
ECCCCCCCEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
KRKGSASFFESKEVALALDICALLFNPKDIMAAIHVLSYISDIGSNTAKDIHEALMLLGN
CCCCCCHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
GDLKLALTHPNKEAKIYTKKKEITSMGLFEEIFALENSSRFNSVIDKAFHSHPVLMHPKI
CCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEECCCC
SLNGAKTLSDFFILYTKAPTHSPSALIKHILESAFFQTFKTRLLKERSKNKDGSYNEFKK
CCCCHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LQAQKRFNEKMDLLSSLAKNYQNLGRFLNGTLIGSSEATQGCGVNLLSVHASKGLEFKDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCEEEEEHHCCCCCCCCE
YIIDLMEGRFPNHKLMNTGGGIEEERRLFYVAITRAKENLWLSYAKNELRENAKPKEHKP
EEEEEECCCCCCCCEECCCCCCCHHCEEEEEEEEECHHHHHHHHHHHHHHHCCCCCCCCC
SVFLYEAGLLKPDSK
CEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]