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The map label for this gene is trxA

Identifier: 108563235

GI number: 108563235

Start: 844937

End: 845257

Strand: Direct

Name: trxA

Synonym: HPAG1_0810

Alternate gene names: 108563235

Gene position: 844937-845257 (Clockwise)

Preceding gene: 108563234

Following gene: 108563236

Centisome position: 52.93

GC content: 38.63

Gene sequence:

>321_bases
ATGAGTCACTATATTGAATTAACTGAAGAAAATTTTGAAAGCACCATTAAAAAAGGGGTTGCGTTAGTGGATTTTTGGGC
GCCATGGTGTGGTCCTTGTAAAATGCTATCCCCTGTGATTGATGAATTAGCTAGCGAATATGAAGGTAAGGCTAAGATTT
GTAAAGTCAATACCGATGAGCAAGAAGAATTGAGCGCGAAATTTGGGATTAGAAGCATTCCTACGCTTTTATTCACAAAA
GATGGCGAAGTCGTCCATCAGTTGGTGGGCGTGCAAACTAAAGTTGCTTTAAAAGAGCAATTGAACAAACTTTTAGGCTA
A

Upstream 100 bases:

>100_bases
ATCACTTTTTAGATTTTTATCCAAAACCCATGCGTTTTCATTAACATTCTTAAGCTAATATAATTCTCGTTAATCAAAAT
CATATATTTAGGAGTAACTA

Downstream 100 bases:

>100_bases
TAGCATGATAGATTGTGCGATTATTGGAGGTGGTCCTGCAGGTTTGAGTGCGGGGCTTTATGCCACTAGAGGCGGTGTTA
AAAACGCCGTTTTGTTTGAA

Product: thioredoxin

Products: NA

Alternate protein names: Trx

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MSHYIELTEENFESTIKKGVALVDFWAPWCGPCKMLSPVIDELASEYEGKAKICKVNTDEQEELSAKFGIRSIPTLLFTK
DGEVVHQLVGVQTKVALKEQLNKLLG

Sequences:

>Translated_106_residues
MSHYIELTEENFESTIKKGVALVDFWAPWCGPCKMLSPVIDELASEYEGKAKICKVNTDEQEELSAKFGIRSIPTLLFTK
DGEVVHQLVGVQTKVALKEQLNKLLG
>Mature_105_residues
SHYIELTEENFESTIKKGVALVDFWAPWCGPCKMLSPVIDELASEYEGKAKICKVNTDEQEELSAKFGIRSIPTLLFTKD
GEVVHQLVGVQTKVALKEQLNKLLG

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI21361403, Length=85, Percent_Identity=37.6470588235294, Blast_Score=76, Evalue=5e-15,
Organism=Homo sapiens, GI42794771, Length=89, Percent_Identity=39.3258426966292, Blast_Score=73, Evalue=5e-14,
Organism=Homo sapiens, GI224493972, Length=89, Percent_Identity=39.3258426966292, Blast_Score=73, Evalue=6e-14,
Organism=Homo sapiens, GI21361657, Length=109, Percent_Identity=35.7798165137615, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI38505222, Length=106, Percent_Identity=30.188679245283, Blast_Score=64, Evalue=2e-11,
Organism=Homo sapiens, GI5031973, Length=96, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=8e-11,
Organism=Escherichia coli, GI87082331, Length=100, Percent_Identity=50, Blast_Score=109, Evalue=5e-26,
Organism=Escherichia coli, GI1788936, Length=102, Percent_Identity=44.1176470588235, Blast_Score=99, Evalue=7e-23,
Organism=Escherichia coli, GI87081747, Length=104, Percent_Identity=27.8846153846154, Blast_Score=65, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=89, Percent_Identity=37.0786516853933, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71980565, Length=83, Percent_Identity=39.7590361445783, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI212646193, Length=103, Percent_Identity=33.0097087378641, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=82, Percent_Identity=34.1463414634146, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=81, Percent_Identity=44.4444444444444, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=83, Percent_Identity=38.5542168674699, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=73, Percent_Identity=39.7260273972603, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI25144092, Length=94, Percent_Identity=36.1702127659575, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=96, Percent_Identity=35.4166666666667, Blast_Score=71, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=84, Percent_Identity=38.0952380952381, Blast_Score=69, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319925, Length=94, Percent_Identity=31.9148936170213, Blast_Score=62, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639826, Length=74, Percent_Identity=40.5405405405405, Blast_Score=82, Evalue=5e-17,
Organism=Drosophila melanogaster, GI28573567, Length=98, Percent_Identity=36.734693877551, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24664269, Length=69, Percent_Identity=42.0289855072464, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17648013, Length=75, Percent_Identity=38.6666666666667, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24583090, Length=75, Percent_Identity=38.6666666666667, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17530795, Length=69, Percent_Identity=36.231884057971, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19921434, Length=74, Percent_Identity=41.8918918918919, Blast_Score=65, Evalue=6e-12,
Organism=Drosophila melanogaster, GI18859803, Length=104, Percent_Identity=30.7692307692308, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI21358065, Length=87, Percent_Identity=35.632183908046, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): THIO_HELPJ (P66929)

Other databases:

- EMBL:   AE001439
- RefSeq:   NP_223481.1
- ProteinModelPortal:   P66929
- SMR:   P66929
- STRING:   P66929
- GeneID:   890132
- GenomeReviews:   AE001439_GR
- KEGG:   hpj:jhp0763
- eggNOG:   COG0526
- HOGENOM:   HBG493509
- OMA:   SELKICK
- ProtClustDB:   CLSK2459851
- BioCyc:   HPYL85963:JHP0763-MONOMER
- GO:   GO:0006810
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10438
- PIRSF:   PIRSF000077
- PRINTS:   PR00421
- TIGRFAMs:   TIGR01068

Pfam domain/function: PF00085 Thioredoxin; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 11855; Mature: 11724

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00194 THIOREDOXIN_1; PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHYIELTEENFESTIKKGVALVDFWAPWCGPCKMLSPVIDELASEYEGKAKICKVNTDE
CCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCC
QEELSAKFGIRSIPTLLFTKDGEVVHQLVGVQTKVALKEQLNKLLG
HHHHHHHCCHHHCCHHEEECCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SHYIELTEENFESTIKKGVALVDFWAPWCGPCKMLSPVIDELASEYEGKAKICKVNTDE
CCCHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCC
QEELSAKFGIRSIPTLLFTKDGEVVHQLVGVQTKVALKEQLNKLLG
HHHHHHHCCHHHCCHHEEECCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682