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The map label for this gene is folK [H]

Identifier: 108562836

GI number: 108562836

Start: 421895

End: 422386

Strand: Direct

Name: folK [H]

Synonym: HPAG1_0411

Alternate gene names: 108562836

Gene position: 421895-422386 (Clockwise)

Preceding gene: 108562835

Following gene: 108562837

Centisome position: 26.43

GC content: 34.15

Gene sequence:

>492_bases
GTGATGCGAGAGATCCTTACTAACCGCTTTTTCCCCAGCCTTTTTAAAAAAAGGCTTGATTTTTCTAACAGGGTGGTTTT
AGGGTTGGGATCTAATCTTAAAAATCCTTTAAAAATATTAAAAAATTGTTTTTTGTATTTTAAAAATCATAGTAAAATTG
GGAAAATTTTTTCTTCGCCCATTTATATCAATCCTCCTTTTGGTTACACTAATCAACCTAACTTTTATAACGCTACGATT
ATCCTTAAAACATCTTTAAGTTTACGCCATTTTTTTGCTCTGGTTTTTTATATAGAAAGGCGTTTTGGCCGTGCAAGGAA
GCGCGATTTTAAAGACGCTCCAAGAACTTTAGATATTGATATTATCGCTTTCAACCAAGTCATTTTAAGGCAGAACGATT
TGACTTTACCTCACCCTAAATGGAGTGAAAGGGATTCGGTGTTAATGCCGTTGGCTTTGCAACAAATTCTTTTTAAAAAA
GGGGAGTGGTGA

Upstream 100 bases:

>100_bases
GCATGGTGTTTTCTGTAGAGCCTGGGATTTATATCCCTGGATTTTTTGGGGTGCGCATTGAAGATTTAGTGGTGATCAAA
AATTCTAGGGCTGAGCTTTT

Downstream 100 bases:

>100_bases
AATTCTATACCTATAGTGGGGAGACGGCTGCTGAAGCTTTAAAGATCGCTCAAAGCCACCATGGGGTGGATACGCTGGTG
TTTAAAACGCAAGAAATCCG

Product: 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MMREILTNRFFPSLFKKRLDFSNRVVLGLGSNLKNPLKILKNCFLYFKNHSKIGKIFSSPIYINPPFGYTNQPNFYNATI
ILKTSLSLRHFFALVFYIERRFGRARKRDFKDAPRTLDIDIIAFNQVILRQNDLTLPHPKWSERDSVLMPLALQQILFKK
GEW

Sequences:

>Translated_163_residues
MMREILTNRFFPSLFKKRLDFSNRVVLGLGSNLKNPLKILKNCFLYFKNHSKIGKIFSSPIYINPPFGYTNQPNFYNATI
ILKTSLSLRHFFALVFYIERRFGRARKRDFKDAPRTLDIDIIAFNQVILRQNDLTLPHPKWSERDSVLMPLALQQILFKK
GEW
>Mature_163_residues
MMREILTNRFFPSLFKKRLDFSNRVVLGLGSNLKNPLKILKNCFLYFKNHSKIGKIFSSPIYINPPFGYTNQPNFYNATI
ILKTSLSLRHFFALVFYIERRFGRARKRDFKDAPRTLDIDIIAFNQVILRQNDLTLPHPKWSERDSVLMPLALQQILFKK
GEW

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=138, Percent_Identity=31.8840579710145, Blast_Score=74, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19300; Mature: 19300

Theoretical pI: Translated: 11.06; Mature: 11.06

Prosite motif: PS00092 N6_MTASE ; PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMREILTNRFFPSLFKKRLDFSNRVVLGLGSNLKNPLKILKNCFLYFKNHSKIGKIFSSP
CHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHCCC
IYINPPFGYTNQPNFYNATIILKTSLSLRHFFALVFYIERRFGRARKRDFKDAPRTLDID
EEECCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
IIAFNQVILRQNDLTLPHPKWSERDSVLMPLALQQILFKKGEW
EEEHHHEEEECCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMREILTNRFFPSLFKKRLDFSNRVVLGLGSNLKNPLKILKNCFLYFKNHSKIGKIFSSP
CHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHCCC
IYINPPFGYTNQPNFYNATIILKTSLSLRHFFALVFYIERRFGRARKRDFKDAPRTLDID
EEECCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
IIAFNQVILRQNDLTLPHPKWSERDSVLMPLALQQILFKKGEW
EEEHHHEEEECCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]