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The map label for this gene is lpxC

Identifier: 108562820

GI number: 108562820

Start: 404081

End: 404968

Strand: Direct

Name: lpxC

Synonym: HPAG1_0395

Alternate gene names: 108562820

Gene position: 404081-404968 (Clockwise)

Preceding gene: 108562819

Following gene: 108562821

Centisome position: 25.31

GC content: 41.33

Gene sequence:

>888_bases
ATGAAACAAACAACCATTAACCACTCTGTGGAATTAGTAGGGATAGGCTTGCACAAGGGCGTTCCTGTGAAGCTTGTTTT
AGAGCCTTTAGGAGAAAATCAAGGCATTGTTTTTTACCGCTCTGATTTGGGTGTGAAGCTCCCCTTAAAACCTGAAAACA
TCGTGGATACCAAAATGGCAACCGTGTTGGGTAAGGATAACGCTAGAATTTCTACGATTGAGCATTTGCTTTCAGCTGTC
CATGCGTATGGCATTGACAATCTTAAGATCTCTGTGGATAACGAAGAAATCCCTATCATGGATGGGAGTGCTTTGACTTA
TTGCATGCTTTTAGACGAAGCAGGGATTAAAGAATTAGACGCTCCTAAAAAGGTGATGGAAATCAAGCAAGCTATTGAGA
TTAGAGAGGGCGATAAGTTTGTTAAAATTGAGCCAGACAGCCAACTTTCTTTGAATTTCACGATTGATTTTAACCATCCG
GTTATCGCTAAGCAAGCCCATCATTTCGTCTTTAGTAAAACCGCTTACAAAGAGCAAGTCGCTAAAGCTCGCACCTTTGG
GTTTTTGCAAGAAGTGAATTACTTGCGATCCATTGGTTTGGCTAAAGGGGGGAGTTTGAATAATTGCATCGTGCTAGATG
AAAACAGTATCTTGAATAAAGAGGGCTTGAGATGCGAAAAGGAATTCGTGTGCCACAAGATTTTAGACGCTATGGGGGAT
CTAATGGTCTTAGGCATGCCTGTGATGGGCAAATACACTTCTTTTTCAGGGAGTCATAAGCTCAATTCTATGTTGGTTAA
AGCCATTTTAGCGGACGCTAAAAATTACGAAGTTTTAATCGCTACGGATCCGGCTAAAGAGTTTGCGTTGCAAAAGGCTT
TCGCTTAA

Upstream 100 bases:

>100_bases
ATAAAATTTTATCTCTAAAAGAGGTTGAACGGCTTTTGGTAAATAAAAATATTAAAATAATCACTAAAAATGACGATATA
CTAGACATAAAGGAAGTATT

Downstream 100 bases:

>100_bases
TCCTGAATTAGGGTTTATTTTTTGGAATTGGATTTAGTGCTTATCTCTTTAGGCGAGGGGGTTTTGCTTGGGGTGTATCA
AAACAATTTTTTATGCACTT

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MKQTTINHSVELVGIGLHKGVPVKLVLEPLGENQGIVFYRSDLGVKLPLKPENIVDTKMATVLGKDNARISTIEHLLSAV
HAYGIDNLKISVDNEEIPIMDGSALTYCMLLDEAGIKELDAPKKVMEIKQAIEIREGDKFVKIEPDSQLSLNFTIDFNHP
VIAKQAHHFVFSKTAYKEQVAKARTFGFLQEVNYLRSIGLAKGGSLNNCIVLDENSILNKEGLRCEKEFVCHKILDAMGD
LMVLGMPVMGKYTSFSGSHKLNSMLVKAILADAKNYEVLIATDPAKEFALQKAFA

Sequences:

>Translated_295_residues
MKQTTINHSVELVGIGLHKGVPVKLVLEPLGENQGIVFYRSDLGVKLPLKPENIVDTKMATVLGKDNARISTIEHLLSAV
HAYGIDNLKISVDNEEIPIMDGSALTYCMLLDEAGIKELDAPKKVMEIKQAIEIREGDKFVKIEPDSQLSLNFTIDFNHP
VIAKQAHHFVFSKTAYKEQVAKARTFGFLQEVNYLRSIGLAKGGSLNNCIVLDENSILNKEGLRCEKEFVCHKILDAMGD
LMVLGMPVMGKYTSFSGSHKLNSMLVKAILADAKNYEVLIATDPAKEFALQKAFA
>Mature_295_residues
MKQTTINHSVELVGIGLHKGVPVKLVLEPLGENQGIVFYRSDLGVKLPLKPENIVDTKMATVLGKDNARISTIEHLLSAV
HAYGIDNLKISVDNEEIPIMDGSALTYCMLLDEAGIKELDAPKKVMEIKQAIEIREGDKFVKIEPDSQLSLNFTIDFNHP
VIAKQAHHFVFSKTAYKEQVAKARTFGFLQEVNYLRSIGLAKGGSLNNCIVLDENSILNKEGLRCEKEFVCHKILDAMGD
LMVLGMPVMGKYTSFSGSHKLNSMLVKAILADAKNYEVLIATDPAKEFALQKAFA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=291, Percent_Identity=42.9553264604811, Blast_Score=251, Evalue=4e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_HELPH (Q1CUB0)

Other databases:

- EMBL:   CP000241
- RefSeq:   YP_627136.1
- ProteinModelPortal:   Q1CUB0
- SMR:   Q1CUB0
- STRING:   Q1CUB0
- GeneID:   4098772
- GenomeReviews:   CP000241_GR
- KEGG:   hpa:HPAG1_0395
- eggNOG:   COG0774
- HOGENOM:   HBG482342
- OMA:   ATDPAKE
- ProtClustDB:   PRK13186
- BioCyc:   HPYL357544:HPAG1_0395-MONOMER
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 32570; Mature: 32570

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQTTINHSVELVGIGLHKGVPVKLVLEPLGENQGIVFYRSDLGVKLPLKPENIVDTKMA
CCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCEEEEECCCCEECCCCCCCHHHHHHH
TVLGKDNARISTIEHLLSAVHAYGIDNLKISVDNEEIPIMDGSALTYCMLLDEAGIKELD
HHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCCEEEEEEECCCCCCCCC
APKKVMEIKQAIEIREGDKFVKIEPDSQLSLNFTIDFNHPVIAKQAHHFVFSKTAYKEQV
CCHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEEECCCCEEHHHHHHHHHHHHHHHHHH
AKARTFGFLQEVNYLRSIGLAKGGSLNNCIVLDENSILNKEGLRCEKEFVCHKILDAMGD
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCC
LMVLGMPVMGKYTSFSGSHKLNSMLVKAILADAKNYEVLIATDPAKEFALQKAFA
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCC
>Mature Secondary Structure
MKQTTINHSVELVGIGLHKGVPVKLVLEPLGENQGIVFYRSDLGVKLPLKPENIVDTKMA
CCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCEEEEECCCCEECCCCCCCHHHHHHH
TVLGKDNARISTIEHLLSAVHAYGIDNLKISVDNEEIPIMDGSALTYCMLLDEAGIKELD
HHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCCEEEEEEECCCCCCCCC
APKKVMEIKQAIEIREGDKFVKIEPDSQLSLNFTIDFNHPVIAKQAHHFVFSKTAYKEQV
CCHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEEECCCCEEHHHHHHHHHHHHHHHHHH
AKARTFGFLQEVNYLRSIGLAKGGSLNNCIVLDENSILNKEGLRCEKEFVCHKILDAMGD
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCC
LMVLGMPVMGKYTSFSGSHKLNSMLVKAILADAKNYEVLIATDPAKEFALQKAFA
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA