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The map label for this gene is merA [H]

Identifier: 103488160

GI number: 103488160

Start: 2827775

End: 2829202

Strand: Reverse

Name: merA [H]

Synonym: Sala_2683

Alternate gene names: 103488160

Gene position: 2829202-2827775 (Counterclockwise)

Preceding gene: 103488161

Following gene: 103488153

Centisome position: 84.58

GC content: 63.66

Gene sequence:

>1428_bases
ATGACGGACTACCATGCGCCCAAAGGAAGAGAGACCGTCTATGACCTTGCCGTCATCGGCGCGGGTTCGGCCGGGTTCTC
CGCTGCGATCACGGCCGCCGATCAGGGCGCCAATGTCGCGCTGATCGGCCACGGGACCATCGGCGGAACCTGCGTCAATG
TCGGCTGCGTCCCGTCGAAGACGATGATCCGCGCCGCCGAGGCGCTGCACGGCGCGCGCGCAGCGGCGCGCTTTCCCGGC
GTTTCCGGCAATGCGCAGGTGGATGACTGGCACAGTCTGATTGCCGCCAAGGACGACCTCGTCTCGGACCTGCGGCAGAG
GAAATATGTCGACCTGCTGCCCGAGTATGACGGCATCACCTATCTGGAGGGCGCTGCACGGCTCGATGGCGCGGGCGTGA
TCGTTGGCGACGAGCCGATTACCGCCGGAAAGATCATCATCGCCACTGGTGGCCGTCCATCCGTACCGCCGATACCGGGC
ATCGAGACAGTGAACTACCTGACGAGCACATCGCTGCTGGACCTACAGGAACTGCCCCGAAGCCTGATCGTCGTCGGCGG
CGGCTATGTCGGCGCGGAACTTGCGCAGATGATGGCGCGTATGGGTGTCGATGTCACTATGGTGTGCCGCTCGCGCCTCC
TGCCTCAGGTGGAGCCGCAGGTGTCGGAAGCTCTGGCCGGGATATTCCGGTCCGAGGGCATGACCCTCTACTGCGGCATC
GCCTATGATGCCTGCCGGGAGGACGAGCGAGGGGTCATGCTCTGCGTCCAGGAAGGCGGCAGGCCGATCGAACTCAAGGC
CGAACGGCTGCTGGTCGCCACGGGGCGCACGCCAAACACCGAGGGGCTGGGGCTCGAGGAAGCGGGCATCGCCCGGGACG
CGCGAGGCGCCATCGTCGTCGATAATCACATGCGCACCTCAAAAGCCGACATCTATGCCGCTGGCGACGTCACCAACCGT
GACCAGTTCGTCTATATGGCGGCCTATGGCGCCAAGCTGGCCGCGCTCAACGCACTGAACGGCGATAGTCTGACCTATGA
TAATGCGACGATGCCGTGGGTCGTGTTCACCGACCCGCAGCTTGCCGGCGTTGGCCTCTCCGAAGCTGCCGCGAAATCAG
CGGGCTTTGAGACAAAAACATCGATTTTGCCGCTCGATCTGGTGCCGCGGGCGCTTGCAGCGCGCGATACGCGCGGGCTT
GTCAAGCTGGTCGCCGATGCCGGGAGCGATCTTCTTCTTGGTGGACAGATCATTGCGCCCGAAGGTGCCGACAGCATCCA
GACATTGGCCCTCGCTCTCAGACACGGCATGACGGTCGCCGAACTTGGTGAAACAATCTTCCCCTATCTAACGACGGTCG
AGGCGCTGAAGCTGGCGGCGCAAGGCTTTGGCAAGGACGTCACAAAGCTATACTGTTGTGCCGGATGA

Upstream 100 bases:

>100_bases
CGCTGCCGCTTCCACAAACGCGGGCTATCCGGCATCGGTCAAGAACAGAAGCCCGTGAGGAGCGCGATGGAGATCCAGAC
GAACGGGAAAAGAAGCTGCC

Downstream 100 bases:

>100_bases
CAAGGCACCACCTGAATTGGTTCTGCAATCCAGCCATGCGCCTTTCCAGCGCCTGCACGCTCACCGCGTCTGCATTGCGC
CTCTTGTCGGAGACGCATCG

Product: mercuric reductase MerA

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MTDYHAPKGRETVYDLAVIGAGSAGFSAAITAADQGANVALIGHGTIGGTCVNVGCVPSKTMIRAAEALHGARAAARFPG
VSGNAQVDDWHSLIAAKDDLVSDLRQRKYVDLLPEYDGITYLEGAARLDGAGVIVGDEPITAGKIIIATGGRPSVPPIPG
IETVNYLTSTSLLDLQELPRSLIVVGGGYVGAELAQMMARMGVDVTMVCRSRLLPQVEPQVSEALAGIFRSEGMTLYCGI
AYDACREDERGVMLCVQEGGRPIELKAERLLVATGRTPNTEGLGLEEAGIARDARGAIVVDNHMRTSKADIYAAGDVTNR
DQFVYMAAYGAKLAALNALNGDSLTYDNATMPWVVFTDPQLAGVGLSEAAAKSAGFETKTSILPLDLVPRALAARDTRGL
VKLVADAGSDLLLGGQIIAPEGADSIQTLALALRHGMTVAELGETIFPYLTTVEALKLAAQGFGKDVTKLYCCAG

Sequences:

>Translated_475_residues
MTDYHAPKGRETVYDLAVIGAGSAGFSAAITAADQGANVALIGHGTIGGTCVNVGCVPSKTMIRAAEALHGARAAARFPG
VSGNAQVDDWHSLIAAKDDLVSDLRQRKYVDLLPEYDGITYLEGAARLDGAGVIVGDEPITAGKIIIATGGRPSVPPIPG
IETVNYLTSTSLLDLQELPRSLIVVGGGYVGAELAQMMARMGVDVTMVCRSRLLPQVEPQVSEALAGIFRSEGMTLYCGI
AYDACREDERGVMLCVQEGGRPIELKAERLLVATGRTPNTEGLGLEEAGIARDARGAIVVDNHMRTSKADIYAAGDVTNR
DQFVYMAAYGAKLAALNALNGDSLTYDNATMPWVVFTDPQLAGVGLSEAAAKSAGFETKTSILPLDLVPRALAARDTRGL
VKLVADAGSDLLLGGQIIAPEGADSIQTLALALRHGMTVAELGETIFPYLTTVEALKLAAQGFGKDVTKLYCCAG
>Mature_474_residues
TDYHAPKGRETVYDLAVIGAGSAGFSAAITAADQGANVALIGHGTIGGTCVNVGCVPSKTMIRAAEALHGARAAARFPGV
SGNAQVDDWHSLIAAKDDLVSDLRQRKYVDLLPEYDGITYLEGAARLDGAGVIVGDEPITAGKIIIATGGRPSVPPIPGI
ETVNYLTSTSLLDLQELPRSLIVVGGGYVGAELAQMMARMGVDVTMVCRSRLLPQVEPQVSEALAGIFRSEGMTLYCGIA
YDACREDERGVMLCVQEGGRPIELKAERLLVATGRTPNTEGLGLEEAGIARDARGAIVVDNHMRTSKADIYAAGDVTNRD
QFVYMAAYGAKLAALNALNGDSLTYDNATMPWVVFTDPQLAGVGLSEAAAKSAGFETKTSILPLDLVPRALAARDTRGLV
KLVADAGSDLLLGGQIIAPEGADSIQTLALALRHGMTVAELGETIFPYLTTVEALKLAAQGFGKDVTKLYCCAG

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=476, Percent_Identity=29.8319327731092, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI50301238, Length=465, Percent_Identity=31.3978494623656, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI22035672, Length=474, Percent_Identity=30.168776371308, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI291045266, Length=455, Percent_Identity=28.1318681318681, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI33519430, Length=419, Percent_Identity=27.4463007159904, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI33519428, Length=419, Percent_Identity=27.4463007159904, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI33519426, Length=419, Percent_Identity=27.4463007159904, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI148277065, Length=419, Percent_Identity=27.4463007159904, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI148277071, Length=419, Percent_Identity=27.4463007159904, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI291045268, Length=450, Percent_Identity=26.8888888888889, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI87081717, Length=456, Percent_Identity=32.4561403508772, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1786307, Length=476, Percent_Identity=30.0420168067227, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1789915, Length=431, Percent_Identity=30.8584686774942, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI87082354, Length=466, Percent_Identity=26.1802575107296, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1789065, Length=188, Percent_Identity=32.4468085106383, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=30.1518438177874, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17557007, Length=488, Percent_Identity=29.7131147540984, Blast_Score=151, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI71983419, Length=434, Percent_Identity=27.8801843317972, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71983429, Length=434, Percent_Identity=27.8801843317972, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71982272, Length=488, Percent_Identity=26.4344262295082, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17559934, Length=187, Percent_Identity=28.8770053475936, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6321091, Length=475, Percent_Identity=32.2105263157895, Blast_Score=199, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6325166, Length=464, Percent_Identity=26.5086206896552, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6325240, Length=481, Percent_Identity=23.7006237006237, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21358499, Length=475, Percent_Identity=31.7894736842105, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24640551, Length=499, Percent_Identity=30.2605210420842, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24640549, Length=493, Percent_Identity=30.2231237322515, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24640553, Length=493, Percent_Identity=30.2231237322515, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI17737741, Length=496, Percent_Identity=30.0403225806452, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 49609; Mature: 49478

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDYHAPKGRETVYDLAVIGAGSAGFSAAITAADQGANVALIGHGTIGGTCVNVGCVPSK
CCCCCCCCCCCEEEEEEEEECCCCCCEEEEEECCCCCCEEEEECCCCCCEEEEECCCCCH
TMIRAAEALHGARAAARFPGVSGNAQVDDWHSLIAAKDDLVSDLRQRKYVDLLPEYDGIT
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
YLEGAARLDGAGVIVGDEPITAGKIIIATGGRPSVPPIPGIETVNYLTSTSLLDLQELPR
EECCCCEECCCEEEECCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHCCHHHHHHCCC
SLIVVGGGYVGAELAQMMARMGVDVTMVCRSRLLPQVEPQVSEALAGIFRSEGMTLYCGI
EEEEEECCHHHHHHHHHHHHHCCCEEEHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEE
AYDACREDERGVMLCVQEGGRPIELKAERLLVATGRTPNTEGLGLEEAGIARDARGAIVV
EHHHCCCCCCCEEEEEECCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEE
DNHMRTSKADIYAAGDVTNRDQFVYMAAYGAKLAALNALNGDSLTYDNATMPWVVFTDPQ
ECCCCCCCCCEEEECCCCCCCCEEEEEECCCEEEEEECCCCCCEEECCCCCCEEEEECCC
LAGVGLSEAAAKSAGFETKTSILPLDLVPRALAARDTRGLVKLVADAGSDLLLGGQIIAP
CCCCCCHHHHHHHCCCCCCCCEEEHHHHHHHHHHCCHHHHHHHHHHCCCCEEECCEEECC
EGADSIQTLALALRHGMTVAELGETIFPYLTTVEALKLAAQGFGKDVTKLYCCAG
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
>Mature Secondary Structure 
TDYHAPKGRETVYDLAVIGAGSAGFSAAITAADQGANVALIGHGTIGGTCVNVGCVPSK
CCCCCCCCCCEEEEEEEEECCCCCCEEEEEECCCCCCEEEEECCCCCCEEEEECCCCCH
TMIRAAEALHGARAAARFPGVSGNAQVDDWHSLIAAKDDLVSDLRQRKYVDLLPEYDGIT
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
YLEGAARLDGAGVIVGDEPITAGKIIIATGGRPSVPPIPGIETVNYLTSTSLLDLQELPR
EECCCCEECCCEEEECCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHCCHHHHHHCCC
SLIVVGGGYVGAELAQMMARMGVDVTMVCRSRLLPQVEPQVSEALAGIFRSEGMTLYCGI
EEEEEECCHHHHHHHHHHHHHCCCEEEHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEE
AYDACREDERGVMLCVQEGGRPIELKAERLLVATGRTPNTEGLGLEEAGIARDARGAIVV
EHHHCCCCCCCEEEEEECCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEE
DNHMRTSKADIYAAGDVTNRDQFVYMAAYGAKLAALNALNGDSLTYDNATMPWVVFTDPQ
ECCCCCCCCCEEEECCCCCCCCEEEEEECCCEEEEEECCCCCCEEECCCCCCEEEEECCC
LAGVGLSEAAAKSAGFETKTSILPLDLVPRALAARDTRGLVKLVADAGSDLLLGGQIIAP
CCCCCCHHHHHHHCCCCCCCCEEEHHHHHHHHHHCCHHHHHHHHHHCCCCEEECCEEECC
EGADSIQTLALALRHGMTVAELGETIFPYLTTVEALKLAAQGFGKDVTKLYCCAG
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]