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The map label for this gene is parC [H]

Identifier: 103487589

GI number: 103487589

Start: 2214367

End: 2216700

Strand: Direct

Name: parC [H]

Synonym: Sala_2108

Alternate gene names: 103487589

Gene position: 2214367-2216700 (Clockwise)

Preceding gene: 103487588

Following gene: 103487590

Centisome position: 66.2

GC content: 65.9

Gene sequence:

>2334_bases
ATGGCGCGTCAGCCTTGCTATCGGCGGCCGATAATGGCCAGCACAACCGACGACCTTCCCCCTTCCGAGTCCGGCACCAG
CATCGATACCCCGTTCGACAGCGCGCTGTCGCAGCGCTATCTCGTCTATGCGCTGTCGACGATCACCGCGCGCTCGCTCC
CCGACCTTCGCGACGGGCTGAAGCCCGTCCACCGCCGCCTTTTGTGGGCGATGCGCGCGATGCGGCTCGACCCGAGCCAG
GGCTACAAGAAATCGGCGCGCGTCGTCGGCGACGTCATCGGCAAGTTCCACCCGCACGGCGACACCGCGGTTTACGACGC
GATGGTCCGCCTCGCGCAGGATTTTTCGCTCCGCTATCCGCTCGTCGACGGCCAGGGCAATTTCGGCAATATCGATGGCG
ATAACGCCGCCGCCTATCGCTATACCGAAGCGCGCCTGACGCGCGTTGCGGTCGACCTGATGCAGGGGCTCGACGAAGGC
ACGGTCGATTTCCGCCCGACCTATAATGGCGAAGACGAAGAGCCCGAGATCATGCCGGGGCTTTTCCCGAACCTGCTCGC
CAATGGGGCGAGCGGGATCGCGGTCGGGATGGCGACGAACATCCCGCCGCACAATGCCGCCGAGGTGATCGACGCCGCGC
TGCTGCTGATCGACAATCCAAAAGCCGGGCTGTCCGATCTGCTCGACCATGTGAAGGGCCCCGATTTCCCCACCGGCGGC
ATCGTCGCCGAGAATGCGGAGACGATCGCGCAGGCCTATGAAAGCGGGCGCGGCAGCTTTCGCGTCCGCGCGCGCTTTTC
GATCGGCAAGGATGCTGACGGCAAGTGGGAAGCCGACGGGATCGAGAAGCTGTCCGGCGGCACCTGGCAGCTCGTCATCA
GCGAGATTCCCTATGGCGTTGCCAAGGGAAAGCTGATCGAACAGGTGGCGCAGCTGATCGCCGACAGGAAACTGCCAATT
CTGGAAGATGTCCGCGACGAAAGCGCGGAGGATCTGCGCATCGTGCTGGTGCCCAAGAGCCGCAACGTCGACGCCGAGGT
GCTGAAGGACAGCCTCTATCGCCTGACCGACCTTGAAAGCCGTTTCGCGCTCAATCTGAACGTGCTCGACGCGACGCGCA
CGCCCAAGGTCATGGGGCTGAAACAACTGCTCACCGAATGGCTCCAGCACCAGATCATCGTGCTCGTCCGCCGCGCCGAG
CACCGGATCGCGAAGATCGACGACCGGCTGGAGCTGGTCGCCGGTTACATCATCGCCTTTTTGAACCTTGACCGGATCAT
CGAGATCATCCGTACCGAGGACGAACCCAAGCCGGTGATGATCGCCGAGTTCGAGCTGACCGACCGGCAGGCCGAGGCGA
TATTGAACATGCGGCTGCGGTCCTTGCGCAAGCTCGAGGAAATGGAGCTGAAGCGCGAGCAGACCGATTTGACCGCCGAG
CGCGAGGAACTGGCAAAGCTGGTCGAGAGCCCCGCGCGCCAGCGCACCCGGCTGCGCAAGGACCTCGAAAGGCTGCGCGG
CGTCTATGGCCTCGACACGTCGCTTGGCGCGCGCCGCACGACGATCGCCGAAGCCGCGCCGACGCGGGAGATTCCGCTCG
ACGCGATGATCGAAAAGGAGCCGGTGACGGTGATCCTGTCGAAGCGCGGCTGGATTCGCGCGCAGCGCGGCCATGTCGCG
CCCGACCAGTGGGGCGAGTTCAAGTTCAAGGAAGGCGACGAATTGTTGTTCGCCGCGCATGCGCAGACGACCGACAAGCT
GTTGATCGCCGCGAGCGACGGGCGCTTTTTCACCGTCGGGGCGGACAAATTGCCCGGCGGGCGCGGGTTCGGCGAGCCGC
TGCGGCTGATGGTCGACATCGACCCCGACGCGCGGATCGTCGCGATGGTCCCCGCGAGCGCCGGGGGCCGCCTGCTGCTC
GCCTCGACGAGCGGGCACGGTTTCATCGTCAACACCGACGATGTCACCGCCGAAACGCGCAAGGGCCGCAATGTCGTCAA
TCTGAAACCCAGGGCGGCGCTTGTCGTCGCCCGCCCGATCGCGCCGGGCGACGACAGCGTCGCGGTGGTCGGCGACAATC
GCAAGCTGGTTGTATTCCCGCTCGCCGAAGTGCCGGTGATGGGGCGCGGCCAGGGCGTGATGCTGCAACGTTATCGCGAC
GGCGGCCTGTCCGACGCAGTGAGCTTTGTCCTTGCCGAGGGACTGAGCTGGGCGATGGGCGGCGACAGCGGCCGCACGCG
CACCGAAACCGACCTGGCACCCTGGCGCGTCGCGCGCGGCGCGGCGGGACGGATGCCGCCAACCGGTTTTCCGCGCAACA
ACCGCTTCGCCTGA

Upstream 100 bases:

>100_bases
CTCGTCGGGCACGGTGCGCTGGGTGCGCGGCGAGCATCGCGCCGGCTGATCGGGCGCTTCACGAAGGAGAGGACACCGTG
CGCCGACGCAAGGCTTTGCC

Downstream 100 bases:

>100_bases
CCGCAAAAGCGCGTCGCCGTAAATCCCTTCTTTACTCCCCGCACCCTAGTCATGGGGAAATGGGGAAAGGTCGCACAAAA
CCCGCTGTTATGCCTATTGA

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 777; Mature: 776

Protein sequence:

>777_residues
MARQPCYRRPIMASTTDDLPPSESGTSIDTPFDSALSQRYLVYALSTITARSLPDLRDGLKPVHRRLLWAMRAMRLDPSQ
GYKKSARVVGDVIGKFHPHGDTAVYDAMVRLAQDFSLRYPLVDGQGNFGNIDGDNAAAYRYTEARLTRVAVDLMQGLDEG
TVDFRPTYNGEDEEPEIMPGLFPNLLANGASGIAVGMATNIPPHNAAEVIDAALLLIDNPKAGLSDLLDHVKGPDFPTGG
IVAENAETIAQAYESGRGSFRVRARFSIGKDADGKWEADGIEKLSGGTWQLVISEIPYGVAKGKLIEQVAQLIADRKLPI
LEDVRDESAEDLRIVLVPKSRNVDAEVLKDSLYRLTDLESRFALNLNVLDATRTPKVMGLKQLLTEWLQHQIIVLVRRAE
HRIAKIDDRLELVAGYIIAFLNLDRIIEIIRTEDEPKPVMIAEFELTDRQAEAILNMRLRSLRKLEEMELKREQTDLTAE
REELAKLVESPARQRTRLRKDLERLRGVYGLDTSLGARRTTIAEAAPTREIPLDAMIEKEPVTVILSKRGWIRAQRGHVA
PDQWGEFKFKEGDELLFAAHAQTTDKLLIAASDGRFFTVGADKLPGGRGFGEPLRLMVDIDPDARIVAMVPASAGGRLLL
ASTSGHGFIVNTDDVTAETRKGRNVVNLKPRAALVVARPIAPGDDSVAVVGDNRKLVVFPLAEVPVMGRGQGVMLQRYRD
GGLSDAVSFVLAEGLSWAMGGDSGRTRTETDLAPWRVARGAAGRMPPTGFPRNNRFA

Sequences:

>Translated_777_residues
MARQPCYRRPIMASTTDDLPPSESGTSIDTPFDSALSQRYLVYALSTITARSLPDLRDGLKPVHRRLLWAMRAMRLDPSQ
GYKKSARVVGDVIGKFHPHGDTAVYDAMVRLAQDFSLRYPLVDGQGNFGNIDGDNAAAYRYTEARLTRVAVDLMQGLDEG
TVDFRPTYNGEDEEPEIMPGLFPNLLANGASGIAVGMATNIPPHNAAEVIDAALLLIDNPKAGLSDLLDHVKGPDFPTGG
IVAENAETIAQAYESGRGSFRVRARFSIGKDADGKWEADGIEKLSGGTWQLVISEIPYGVAKGKLIEQVAQLIADRKLPI
LEDVRDESAEDLRIVLVPKSRNVDAEVLKDSLYRLTDLESRFALNLNVLDATRTPKVMGLKQLLTEWLQHQIIVLVRRAE
HRIAKIDDRLELVAGYIIAFLNLDRIIEIIRTEDEPKPVMIAEFELTDRQAEAILNMRLRSLRKLEEMELKREQTDLTAE
REELAKLVESPARQRTRLRKDLERLRGVYGLDTSLGARRTTIAEAAPTREIPLDAMIEKEPVTVILSKRGWIRAQRGHVA
PDQWGEFKFKEGDELLFAAHAQTTDKLLIAASDGRFFTVGADKLPGGRGFGEPLRLMVDIDPDARIVAMVPASAGGRLLL
ASTSGHGFIVNTDDVTAETRKGRNVVNLKPRAALVVARPIAPGDDSVAVVGDNRKLVVFPLAEVPVMGRGQGVMLQRYRD
GGLSDAVSFVLAEGLSWAMGGDSGRTRTETDLAPWRVARGAAGRMPPTGFPRNNRFA
>Mature_776_residues
ARQPCYRRPIMASTTDDLPPSESGTSIDTPFDSALSQRYLVYALSTITARSLPDLRDGLKPVHRRLLWAMRAMRLDPSQG
YKKSARVVGDVIGKFHPHGDTAVYDAMVRLAQDFSLRYPLVDGQGNFGNIDGDNAAAYRYTEARLTRVAVDLMQGLDEGT
VDFRPTYNGEDEEPEIMPGLFPNLLANGASGIAVGMATNIPPHNAAEVIDAALLLIDNPKAGLSDLLDHVKGPDFPTGGI
VAENAETIAQAYESGRGSFRVRARFSIGKDADGKWEADGIEKLSGGTWQLVISEIPYGVAKGKLIEQVAQLIADRKLPIL
EDVRDESAEDLRIVLVPKSRNVDAEVLKDSLYRLTDLESRFALNLNVLDATRTPKVMGLKQLLTEWLQHQIIVLVRRAEH
RIAKIDDRLELVAGYIIAFLNLDRIIEIIRTEDEPKPVMIAEFELTDRQAEAILNMRLRSLRKLEEMELKREQTDLTAER
EELAKLVESPARQRTRLRKDLERLRGVYGLDTSLGARRTTIAEAAPTREIPLDAMIEKEPVTVILSKRGWIRAQRGHVAP
DQWGEFKFKEGDELLFAAHAQTTDKLLIAASDGRFFTVGADKLPGGRGFGEPLRLMVDIDPDARIVAMVPASAGGRLLLA
STSGHGFIVNTDDVTAETRKGRNVVNLKPRAALVVARPIAPGDDSVAVVGDNRKLVVFPLAEVPVMGRGQGVMLQRYRDG
GLSDAVSFVLAEGLSWAMGGDSGRTRTETDLAPWRVARGAAGRMPPTGFPRNNRFA

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=187, Percent_Identity=31.0160427807487, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1789396, Length=676, Percent_Identity=40.0887573964497, Blast_Score=507, Evalue=1e-144,
Organism=Escherichia coli, GI1788562, Length=725, Percent_Identity=36.9655172413793, Blast_Score=426, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI212645845, Length=287, Percent_Identity=27.5261324041812, Blast_Score=76, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17535065, Length=202, Percent_Identity=32.1782178217822, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI212645657, Length=192, Percent_Identity=31.7708333333333, Blast_Score=73, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=200, Percent_Identity=30, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.3

Molecular weight: Translated: 85533; Mature: 85402

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARQPCYRRPIMASTTDDLPPSESGTSIDTPFDSALSQRYLVYALSTITARSLPDLRDGL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
KPVHRRLLWAMRAMRLDPSQGYKKSARVVGDVIGKFHPHGDTAVYDAMVRLAQDFSLRYP
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEECC
LVDGQGNFGNIDGDNAAAYRYTEARLTRVAVDLMQGLDEGTVDFRPTYNGEDEEPEIMPG
EECCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCC
LFPNLLANGASGIAVGMATNIPPHNAAEVIDAALLLIDNPKAGLSDLLDHVKGPDFPTGG
CCHHHHHCCCCCEEEEEECCCCCCCHHHHHHEEEEEEECCCCCHHHHHHHHCCCCCCCCC
IVAENAETIAQAYESGRGSFRVRARFSIGKDADGKWEADGIEKLSGGTWQLVISEIPYGV
EEECCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCHHHHCCCEEEEEEECCCCCH
AKGKLIEQVAQLIADRKLPILEDVRDESAEDLRIVLVPKSRNVDAEVLKDSLYRLTDLES
HCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCC
RFALNLNVLDATRTPKVMGLKQLLTEWLQHQIIVLVRRAEHRIAKIDDRLELVAGYIIAF
EEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNLDRIIEIIRTEDEPKPVMIAEFELTDRQAEAILNMRLRSLRKLEEMELKREQTDLTAE
HHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
REELAKLVESPARQRTRLRKDLERLRGVYGLDTSLGARRTTIAEAAPTREIPLDAMIEKE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHCCCC
PVTVILSKRGWIRAQRGHVAPDQWGEFKFKEGDELLFAAHAQTTDKLLIAASDGRFFTVG
CEEEEEECCCCEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEC
ADKLPGGRGFGEPLRLMVDIDPDARIVAMVPASAGGRLLLASTSGHGFIVNTDDVTAETR
CCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCEEEEEECCCCEEEEECCCCCHHHH
KGRNVVNLKPRAALVVARPIAPGDDSVAVVGDNRKLVVFPLAEVPVMGRGQGVMLQRYRD
CCCCEEEECCCEEEEEEECCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCCEEEEEECC
GGLSDAVSFVLAEGLSWAMGGDSGRTRTETDLAPWRVARGAAGRMPPTGFPRNNRFA
CCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ARQPCYRRPIMASTTDDLPPSESGTSIDTPFDSALSQRYLVYALSTITARSLPDLRDGL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
KPVHRRLLWAMRAMRLDPSQGYKKSARVVGDVIGKFHPHGDTAVYDAMVRLAQDFSLRYP
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEECC
LVDGQGNFGNIDGDNAAAYRYTEARLTRVAVDLMQGLDEGTVDFRPTYNGEDEEPEIMPG
EECCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCC
LFPNLLANGASGIAVGMATNIPPHNAAEVIDAALLLIDNPKAGLSDLLDHVKGPDFPTGG
CCHHHHHCCCCCEEEEEECCCCCCCHHHHHHEEEEEEECCCCCHHHHHHHHCCCCCCCCC
IVAENAETIAQAYESGRGSFRVRARFSIGKDADGKWEADGIEKLSGGTWQLVISEIPYGV
EEECCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCHHHHCCCEEEEEEECCCCCH
AKGKLIEQVAQLIADRKLPILEDVRDESAEDLRIVLVPKSRNVDAEVLKDSLYRLTDLES
HCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCC
RFALNLNVLDATRTPKVMGLKQLLTEWLQHQIIVLVRRAEHRIAKIDDRLELVAGYIIAF
EEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNLDRIIEIIRTEDEPKPVMIAEFELTDRQAEAILNMRLRSLRKLEEMELKREQTDLTAE
HHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
REELAKLVESPARQRTRLRKDLERLRGVYGLDTSLGARRTTIAEAAPTREIPLDAMIEKE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHCCCC
PVTVILSKRGWIRAQRGHVAPDQWGEFKFKEGDELLFAAHAQTTDKLLIAASDGRFFTVG
CEEEEEECCCCEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEC
ADKLPGGRGFGEPLRLMVDIDPDARIVAMVPASAGGRLLLASTSGHGFIVNTDDVTAETR
CCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCEEEEEECCCCEEEEECCCCCHHHH
KGRNVVNLKPRAALVVARPIAPGDDSVAVVGDNRKLVVFPLAEVPVMGRGQGVMLQRYRD
CCCCEEEECCCEEEEEEECCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCCEEEEEECC
GGLSDAVSFVLAEGLSWAMGGDSGRTRTETDLAPWRVARGAAGRMPPTGFPRNNRFA
CCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]