Click here to switch to the map view.

The map label for this gene is emrA [H]

Identifier: 103487563

GI number: 103487563

Start: 2187476

End: 2188591

Strand: Direct

Name: emrA [H]

Synonym: Sala_2082

Alternate gene names: 103487563

Gene position: 2187476-2188591 (Clockwise)

Preceding gene: 103487560

Following gene: 103487564

Centisome position: 65.39

GC content: 72.31

Gene sequence:

>1116_bases
ATGGACCAGCTCGCCCCCAGCCGTCCCGAGGCCGAAGCTGCGGCGCCGCCGCCCGCCGCGCCCAGGGCCGACCCCTTGCC
GTCCCCCGCCGCCGATACTGCGGCGCGCCCCGGCTGGCGGACGCGCCTGATCATGTTCGGCCTGCCGCTGGCGCTCGTCG
CGGGCGGCGCCGGCTGGTGGCTGCTGAGCGGCGGGTCGGTGTCGACCGACAATGCCTATGTCCAGATGGACAAGGTCTCG
GTCGCCGCCGAGGTCGGCGGGCGCATCACCGAAGTAGCCGTCCGCGACGGCGAGCAGGTCGCCAAGGGGCAACTCCTTTT
CCGCATCGACAGCGAACCCTATGCGCTGAACGTCGCTCAAGCCACCGCCGCCATCGACGCGGCGCGGGTCGAGGTCGGCA
ATCTCGCCGCGGGCGCGAACACATCCGCCGTCGAAATCGCCGCGGCGCGCGAGGAGGTGAGATTCGCCCAGGTCAATTTC
GAGCGGCAGGCGGCGCTGATGGAAAAGGGCTTCACGACGCGCGCCGCCTATGATGCGTCGCGCCACGCGCTCGCCCAGGC
ACGCGAGCGCGTGCGGCAGGCCGAGGCCGCCGCGGTGGAAGCGCGCACCAGGCTCGCCGCCGGTCCCGCAAGCGGCATCA
ATCCGCAGGTCGAGGCCGCGCGCGTCCAGCGCGCGCAGGCCGAGGTCAACCTCGCGCGCACCAGCGTCCGCGCGCCCAGC
GCGGGCCGTGTCGCGCAGGCCGACCGGCTGCAGGTCGGACAGGCGATGGTCGCCGGGCTGCCCGCGCTCACCCTCGTCGA
CACCGCGCACCCGTGGGTCGAAGCCAATTTCAAGGAAACCGACCTCGCCGACATGCGGGTCGGCCAGCGCGCCGAAATCC
GCTTCGACGCCTATCCGGGACTCAAAGTCCGCGGCCATGTGCTGATGATCGGCGCGGGTACGGGGAGCGAGTTCTCGGTG
CTTCCGGCGCAGAACGCCACCGGCAACTGGGTCAAGGTGACGCAGCGCGTCCCCGTGCGCATCGCCTTCGACGAAAAGCC
CGCGCGCGACATGATCGCCGGGCTGTCGGCCGAGGTGACGGTGTTTACCGGCGGCGGGACGGTGGCGGGGAAGTAG

Upstream 100 bases:

>100_bases
GACTGAGCGCCGCCGAACGCGACCAGCTCGTCGATCTGGTCGAGCGGGTGCGCGCCAACCTGTCGCGCCGCGTCTGCCCG
AAAGAAGCGGAGCCCGCCTG

Downstream 100 bases:

>100_bases
GGGTGCGCACCATGTCAAGCCATTGCCACCTCGACAATCCTCCCCATCGACTTGCGATGGGGAGGTGGCAGCCCGCAGGG
CTGACGGAGGGGCGATGACA

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MDQLAPSRPEAEAAAPPPAAPRADPLPSPAADTAARPGWRTRLIMFGLPLALVAGGAGWWLLSGGSVSTDNAYVQMDKVS
VAAEVGGRITEVAVRDGEQVAKGQLLFRIDSEPYALNVAQATAAIDAARVEVGNLAAGANTSAVEIAAAREEVRFAQVNF
ERQAALMEKGFTTRAAYDASRHALAQARERVRQAEAAAVEARTRLAAGPASGINPQVEAARVQRAQAEVNLARTSVRAPS
AGRVAQADRLQVGQAMVAGLPALTLVDTAHPWVEANFKETDLADMRVGQRAEIRFDAYPGLKVRGHVLMIGAGTGSEFSV
LPAQNATGNWVKVTQRVPVRIAFDEKPARDMIAGLSAEVTVFTGGGTVAGK

Sequences:

>Translated_371_residues
MDQLAPSRPEAEAAAPPPAAPRADPLPSPAADTAARPGWRTRLIMFGLPLALVAGGAGWWLLSGGSVSTDNAYVQMDKVS
VAAEVGGRITEVAVRDGEQVAKGQLLFRIDSEPYALNVAQATAAIDAARVEVGNLAAGANTSAVEIAAAREEVRFAQVNF
ERQAALMEKGFTTRAAYDASRHALAQARERVRQAEAAAVEARTRLAAGPASGINPQVEAARVQRAQAEVNLARTSVRAPS
AGRVAQADRLQVGQAMVAGLPALTLVDTAHPWVEANFKETDLADMRVGQRAEIRFDAYPGLKVRGHVLMIGAGTGSEFSV
LPAQNATGNWVKVTQRVPVRIAFDEKPARDMIAGLSAEVTVFTGGGTVAGK
>Mature_371_residues
MDQLAPSRPEAEAAAPPPAAPRADPLPSPAADTAARPGWRTRLIMFGLPLALVAGGAGWWLLSGGSVSTDNAYVQMDKVS
VAAEVGGRITEVAVRDGEQVAKGQLLFRIDSEPYALNVAQATAAIDAARVEVGNLAAGANTSAVEIAAAREEVRFAQVNF
ERQAALMEKGFTTRAAYDASRHALAQARERVRQAEAAAVEARTRLAAGPASGINPQVEAARVQRAQAEVNLARTSVRAPS
AGRVAQADRLQVGQAMVAGLPALTLVDTAHPWVEANFKETDLADMRVGQRAEIRFDAYPGLKVRGHVLMIGAGTGSEFSV
LPAQNATGNWVKVTQRVPVRIAFDEKPARDMIAGLSAEVTVFTGGGTVAGK

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788711, Length=340, Percent_Identity=31.1764705882353, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1790519, Length=304, Percent_Identity=36.1842105263158, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1789041, Length=314, Percent_Identity=31.2101910828025, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI87081951, Length=321, Percent_Identity=28.3489096573209, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1789637, Length=337, Percent_Identity=29.080118694362, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790024, Length=244, Percent_Identity=27.8688524590164, Blast_Score=68, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 38882; Mature: 38882

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQLAPSRPEAEAAAPPPAAPRADPLPSPAADTAARPGWRTRLIMFGLPLALVAGGAGWW
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHEEEEECCCCHHHHCCCCCEE
LLSGGSVSTDNAYVQMDKVSVAAEVGGRITEVAVRDGEQVAKGQLLFRIDSEPYALNVAQ
EEECCCCCCCCEEEEEEEEEEHHHHCCEEEEEEECCCCHHCCCEEEEEECCCCEEEEHHH
ATAAIDAARVEVGNLAAGANTSAVEIAAAREEVRFAQVNFERQAALMEKGFTTRAAYDAS
HHHHHHHHHEEECCEECCCCCCEEEEEEHHHHHEEEEECHHHHHHHHHCCCCCHHHHHHH
RHALAQARERVRQAEAAAVEARTRLAAGPASGINPQVEAARVQRAQAEVNLARTSVRAPS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
AGRVAQADRLQVGQAMVAGLPALTLVDTAHPWVEANFKETDLADMRVGQRAEIRFDAYPG
CCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCEECCCCCCCHHHHCCCCCEEEEEECCCC
LKVRGHVLMIGAGTGSEFSVLPAQNATGNWVKVTQRVPVRIAFDEKPARDMIAGLSAEVT
CEEECEEEEEECCCCCCEEEEECCCCCCCEEEEEECCCEEEEECCCCHHHHHHCCCCEEE
VFTGGGTVAGK
EEECCCCCCCC
>Mature Secondary Structure
MDQLAPSRPEAEAAAPPPAAPRADPLPSPAADTAARPGWRTRLIMFGLPLALVAGGAGWW
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHEEEEECCCCHHHHCCCCCEE
LLSGGSVSTDNAYVQMDKVSVAAEVGGRITEVAVRDGEQVAKGQLLFRIDSEPYALNVAQ
EEECCCCCCCCEEEEEEEEEEHHHHCCEEEEEEECCCCHHCCCEEEEEECCCCEEEEHHH
ATAAIDAARVEVGNLAAGANTSAVEIAAAREEVRFAQVNFERQAALMEKGFTTRAAYDAS
HHHHHHHHHEEECCEECCCCCCEEEEEEHHHHHEEEEECHHHHHHHHHCCCCCHHHHHHH
RHALAQARERVRQAEAAAVEARTRLAAGPASGINPQVEAARVQRAQAEVNLARTSVRAPS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
AGRVAQADRLQVGQAMVAGLPALTLVDTAHPWVEANFKETDLADMRVGQRAEIRFDAYPG
CCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCEECCCCCCCHHHHCCCCCEEEEEECCCC
LKVRGHVLMIGAGTGSEFSVLPAQNATGNWVKVTQRVPVRIAFDEKPARDMIAGLSAEVT
CEEECEEEEEECCCCCCEEEEECCCCCCCEEEEEECCCEEEEECCCCHHHHHHCCCCEEE
VFTGGGTVAGK
EEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]