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The map label for this gene is groEL [H]

Identifier: 103487560

GI number: 103487560

Start: 2183461

End: 2185080

Strand: Direct

Name: groEL [H]

Synonym: Sala_2079

Alternate gene names: 103487560

Gene position: 2183461-2185080 (Clockwise)

Preceding gene: 103487559

Following gene: 103487563

Centisome position: 65.27

GC content: 63.77

Gene sequence:

>1620_bases
ATGGCTGCCAAGGAAGTGAAATTTGCGTCGGACGCGCGTGATCGCATGCTGCGCGGCGTGGATACGCTTGCGAATGCAGT
GAAGGTCACGCTCGGCCCCAAGGGTCGCAACGTGGTTATCGAAAAGAGTTTCGGCGCGCCGCGCATCACCAAGGACGGCG
TCACTGTCGCCAAGGAGATCGAACTCGCCGACAAGTTCGAGAACATGGGTGCGCAGATGCTGCGCGAGGTCGCCTCGAAA
CAGAATGACAAGGCCGGCGACGGCACCACCACCGCAACCGTGCTTGCGCAGGCGATCGTCCGCGAGGGATCGAAAGCGGT
GGCCGCGGGCATGAACCCGATGGACGTGAAGCGCGGCATCGACCTCGCCGTGAAGGCCGTGGTGAAGGATCTCGAAACCC
ATGCCAAGAAGGTCAGCGCCAACAGCGAAATCGCCCAGGTCGCAACCATCTCGGCGAACGGCGACGAGGAGGTGGGCCGC
ATCCTCGCCGAAGCGATGGACAAGGTCGGCAACGAAGGCGTCATCACCGTCGAGGAGGCGAAGAGCCTGGCGACCGAACT
CGAAACGGTCGAAGGCATGCAGTTCGACCGCGGCTATCTGTCGCCCTATTTCATCACCAATGCCGAAAAGCTGAAGGTCG
AACTCGACGACCCCTATATCCTGATCCACGAAAAGAAGCTTTCGAACCTGCAGGCGATGCTGCCGCTGCTGGAAGCGGTC
GTGCAGTCGGGCAAGCCGCTGCTCATCATCGCCGAAGATGTCGAGGGCGAGGCATTGGCAACGCTGGTCGTCAACCGCCT
GCGCGGCGGGCTCAAGGTCGCCGCGGTCAAGGCGCCGGGCTTTGGCGACCGTCGCAAGGCGATGCTGGAAGATATCGCGA
TCCTCACCGGCGGCAATGTCGTGAGCGAAGACCTGGGCATCAAGCTGGAGAATGTCACGGTCAACATGCTCGGGCGCGCC
AAGAAGGTCGTGATCGACAAGGATAATACGACGATCGTCGACGGCGTCGGCGCCAGGACCGACATCGACGCACGCATCGC
CCAGATTCGCCAGCAGATCGACACGACGACCAGCGACTATGACCGCGAGAAGCTGCAGGAACGCCTCGCCAAGCTCGCGG
GTGGCGTTGCGGTGATCCGCGTCGGCGGCGCAACCGAGGTCGAAGTCAAGGAGCGCAAGGATCGCGTCGACGACGCGCTT
CACGCGACGCGTGCTGCGGTGGAAGAAGGCATTCTTCCCGGCGGCGGCATTGCACTGCTCCGCGCGCTCAAGGCGCTCGA
CGGCCTCAAGGCGGCGAACGACGATCAGCAGTCCGGCATCGACATCGTCCGCCGCGCGCTCCGCGCTCCGGCGCGCCAGA
TCGCCGACAACGCGGGCGAGGATGGTGCGTGGATCGTCGGCAAACTGCTCGAAAGCAGCGACTATAACTGGGGCTTCAAT
GCTGCCACCGGCGAATATGAAGACCTCGTCAAAGCGGGTGTGATCGACCCGGCGAAGGTCGTCCGCACGGCGCTGCAGGA
CGCGGCCTCAGTCGCCGCGCTGCTGATCACGACCGAGGCACTCGTCGCCGAGCTGCCGAAGGAAGAGAAAGCCGCGCCGA
TGCCGGCGATGGACTTCTGA

Upstream 100 bases:

>100_bases
ATCCTGGGCGTTATCGAGCAGGCCGAAGCGCTCAAGAAGGCGGCGTGACGGCCTTCGTTCCGCGAATATCGTGAAAGGAA
TCTGACAAGGAGGTATCCCA

Downstream 100 bases:

>100_bases
ACCACCTCGGGGGTGGCGGGATTCCGCCGCCCCCCATTGCAGCGGCGCGCTGAAAGAAAATTGCGTGGGATTTACCCGTC
AAAATCCCCCCCCCCGACCC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1 [H]

Number of amino acids: Translated: 539; Mature: 538

Protein sequence:

>539_residues
MAAKEVKFASDARDRMLRGVDTLANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEIELADKFENMGAQMLREVASK
QNDKAGDGTTTATVLAQAIVREGSKAVAAGMNPMDVKRGIDLAVKAVVKDLETHAKKVSANSEIAQVATISANGDEEVGR
ILAEAMDKVGNEGVITVEEAKSLATELETVEGMQFDRGYLSPYFITNAEKLKVELDDPYILIHEKKLSNLQAMLPLLEAV
VQSGKPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGNVVSEDLGIKLENVTVNMLGRA
KKVVIDKDNTTIVDGVGARTDIDARIAQIRQQIDTTTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKERKDRVDDAL
HATRAAVEEGILPGGGIALLRALKALDGLKAANDDQQSGIDIVRRALRAPARQIADNAGEDGAWIVGKLLESSDYNWGFN
AATGEYEDLVKAGVIDPAKVVRTALQDAASVAALLITTEALVAELPKEEKAAPMPAMDF

Sequences:

>Translated_539_residues
MAAKEVKFASDARDRMLRGVDTLANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEIELADKFENMGAQMLREVASK
QNDKAGDGTTTATVLAQAIVREGSKAVAAGMNPMDVKRGIDLAVKAVVKDLETHAKKVSANSEIAQVATISANGDEEVGR
ILAEAMDKVGNEGVITVEEAKSLATELETVEGMQFDRGYLSPYFITNAEKLKVELDDPYILIHEKKLSNLQAMLPLLEAV
VQSGKPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGNVVSEDLGIKLENVTVNMLGRA
KKVVIDKDNTTIVDGVGARTDIDARIAQIRQQIDTTTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKERKDRVDDAL
HATRAAVEEGILPGGGIALLRALKALDGLKAANDDQQSGIDIVRRALRAPARQIADNAGEDGAWIVGKLLESSDYNWGFN
AATGEYEDLVKAGVIDPAKVVRTALQDAASVAALLITTEALVAELPKEEKAAPMPAMDF
>Mature_538_residues
AAKEVKFASDARDRMLRGVDTLANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEIELADKFENMGAQMLREVASKQ
NDKAGDGTTTATVLAQAIVREGSKAVAAGMNPMDVKRGIDLAVKAVVKDLETHAKKVSANSEIAQVATISANGDEEVGRI
LAEAMDKVGNEGVITVEEAKSLATELETVEGMQFDRGYLSPYFITNAEKLKVELDDPYILIHEKKLSNLQAMLPLLEAVV
QSGKPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGNVVSEDLGIKLENVTVNMLGRAK
KVVIDKDNTTIVDGVGARTDIDARIAQIRQQIDTTTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKERKDRVDDALH
ATRAAVEEGILPGGGIALLRALKALDGLKAANDDQQSGIDIVRRALRAPARQIADNAGEDGAWIVGKLLESSDYNWGFNA
ATGEYEDLVKAGVIDPAKVVRTALQDAASVAALLITTEALVAELPKEEKAAPMPAMDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=529, Percent_Identity=56.3327032136106, Blast_Score=594, Evalue=1e-170,
Organism=Homo sapiens, GI31542947, Length=529, Percent_Identity=56.3327032136106, Blast_Score=594, Evalue=1e-170,
Organism=Escherichia coli, GI1790586, Length=531, Percent_Identity=66.8549905838041, Blast_Score=701, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=55.4924242424242, Blast_Score=583, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI193210679, Length=239, Percent_Identity=52.7196652719665, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI25144674, Length=173, Percent_Identity=27.7456647398844, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=57.7946768060836, Blast_Score=606, Evalue=1e-174,
Organism=Saccharomyces cerevisiae, GI6322524, Length=122, Percent_Identity=31.1475409836066, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=57.5757575757576, Blast_Score=608, Evalue=1e-174,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=57.5757575757576, Blast_Score=608, Evalue=1e-174,
Organism=Drosophila melanogaster, GI45550936, Length=528, Percent_Identity=54.3560606060606, Blast_Score=576, Evalue=1e-164,
Organism=Drosophila melanogaster, GI45550132, Length=528, Percent_Identity=54.3560606060606, Blast_Score=576, Evalue=1e-164,
Organism=Drosophila melanogaster, GI45550935, Length=528, Percent_Identity=54.3560606060606, Blast_Score=576, Evalue=1e-164,
Organism=Drosophila melanogaster, GI17864606, Length=526, Percent_Identity=47.148288973384, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24584129, Length=531, Percent_Identity=38.7947269303202, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI19921262, Length=531, Percent_Identity=38.7947269303202, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI18858175, Length=556, Percent_Identity=24.1007194244604, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571140, Length=556, Percent_Identity=24.1007194244604, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57410; Mature: 57279

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKEVKFASDARDRMLRGVDTLANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEI
CCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHH
ELADKFENMGAQMLREVASKQNDKAGDGTTTATVLAQAIVREGSKAVAAGMNPMDVKRGI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHH
DLAVKAVVKDLETHAKKVSANSEIAQVATISANGDEEVGRILAEAMDKVGNEGVITVEEA
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEHHHH
KSLATELETVEGMQFDRGYLSPYFITNAEKLKVELDDPYILIHEKKLSNLQAMLPLLEAV
HHHHHHHHHHCCCCCCCCCCCCEEEECCEEEEEEECCCEEEEECHHHHHHHHHHHHHHHH
VQSGKPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGNV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHEECCCE
VSEDLGIKLENVTVNMLGRAKKVVIDKDNTTIVDGVGARTDIDARIAQIRQQIDTTTSDY
EHHHHCEEEEEEEEEECCCCEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCHH
DREKLQERLAKLAGGVAVIRVGGATEVEVKERKDRVDDALHATRAAVEEGILPGGGIALL
HHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RALKALDGLKAANDDQQSGIDIVRRALRAPARQIADNAGEDGAWIVGKLLESSDYNWGFN
HHHHHHHCCCCCCCCHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCC
AATGEYEDLVKAGVIDPAKVVRTALQDAASVAALLITTEALVAELPKEEKAAPMPAMDF
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCC
>Mature Secondary Structure 
AAKEVKFASDARDRMLRGVDTLANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEI
CCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHH
ELADKFENMGAQMLREVASKQNDKAGDGTTTATVLAQAIVREGSKAVAAGMNPMDVKRGI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHH
DLAVKAVVKDLETHAKKVSANSEIAQVATISANGDEEVGRILAEAMDKVGNEGVITVEEA
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEHHHH
KSLATELETVEGMQFDRGYLSPYFITNAEKLKVELDDPYILIHEKKLSNLQAMLPLLEAV
HHHHHHHHHHCCCCCCCCCCCCEEEECCEEEEEEECCCEEEEECHHHHHHHHHHHHHHHH
VQSGKPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGNV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHEECCCE
VSEDLGIKLENVTVNMLGRAKKVVIDKDNTTIVDGVGARTDIDARIAQIRQQIDTTTSDY
EHHHHCEEEEEEEEEECCCCEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCHH
DREKLQERLAKLAGGVAVIRVGGATEVEVKERKDRVDDALHATRAAVEEGILPGGGIALL
HHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RALKALDGLKAANDDQQSGIDIVRRALRAPARQIADNAGEDGAWIVGKLLESSDYNWGFN
HHHHHHHCCCCCCCCHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCC
AATGEYEDLVKAGVIDPAKVVRTALQDAASVAALLITTEALVAELPKEEKAAPMPAMDF
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA