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The map label for this gene is ywrD [H]

Identifier: 103487465

GI number: 103487465

Start: 2089932

End: 2091629

Strand: Direct

Name: ywrD [H]

Synonym: Sala_1982

Alternate gene names: 103487465

Gene position: 2089932-2091629 (Clockwise)

Preceding gene: 103487464

Following gene: 103487466

Centisome position: 62.48

GC content: 66.55

Gene sequence:

>1698_bases
GTGCGCCCCGACGTCCATGCCGGCGACCGCCCGGTCGGTGCGAGCTTTGCGTCGCGCACCGCCGTTTATGGCCTCAGCGG
CGCGGTGGGCACCGCGCACCCGCTCGCGACGCAGGCGGGGATCGACATGCTGAGGCGCGGCGGGTCGGCGGTCGACGCCG
CGATCGCAATCAATGCGTGCCTCGGCCTGCTCGAACCCACCGCGAACGGCATCGGCGGCGACGTCTATGCGATGATATGG
GATCCCAGGACAAAGAAGCTGGCGGGGCTGGCCGGGTCGGGGAAAAGCCCGCGCGGGCTGGATCTCGCGACGGTTCGGTC
GCGCGCGCGCGGCGGCACCCTGCCCGCCTATGGCGCGATTACCGTGTCGGTTCCCGGCACGGTCGACGGCTGGTGGACGA
TGCACCAGCGCTACGGCAAGCTGCCGTGGAAGGAACTGTTCGAGCCCGTCATCGCGCACGCCGAGGTGGGCGCGCCCGTG
CCCGACATGATCGCCTATTATATGCGGCGCAGCCTTGCCGGATTCCGCCAGCCGGGCCGCGGGATCGAAGAGATCGACAA
TGCGCTGCGCACCTGGGGCCTGAACGACGGCAAGGGACCGATGGCGGGGCAGGTGTTCCGTAACCCCGACCTTGCGCGCA
CCTTCCGCCTGATTGCCGAAGGCGGGCGCGACGCCTTTTACGAGGGTGAAATCGCGCGGACGATCGATGCCTATTTCAAA
CGGATCGGCGGCTGGCTGCGCTACGAGGATCTGGCCGCGCATCGATCCGAATGGATCGAGCCGCACAAGACCGCCTATCG
CGGCACCGACGTTTATGCGCTGGGCGCCAACACCCAGGGCATCGCGACCTTGCAGATGCTCAATATCCTCGAACATTTCG
ACCTGAAGGGCGCGGGATTCCAGTCGGCGCTGTCGATTCACCTGCAGGCGGAGGCGAAGCGCCTCGCCTATGAAGACCGC
GCGCGCTATTATGCCGATCCGCACTTTGCCAGGGTGCCGGTCGAATGGCTGATTTCAAAGGACTATGCCGCCGAACGCGC
AAAGCTGATCCGCCCCGACCGCCTGCTCACCCCCGTCCATCCGGGGCAAGCGCCGAGCCATGGCGACACGACCTATTTCA
GCTGCGCCGACAAGGACGGGATGATGGTGTCGATGATCCAGTCGAACTTCCGCGGCATGGGGTCGGGGCTGGTTGCCGAC
GGCCTCGGCTTCATGTTCCAGGACCGTGGGCAATTGTTCAGCCTTCAGGATGGGCATCCGAACATCTACGCGCCCGGAAA
GCGGCCGTTCCAGACGATCATCCCCGGCTTTGCAGCGCGCGGCGACGTGCCGTGGATGAGTTTCGGCGTGATGGGCGGCG
ACATGCAGCCACAAGGACAGACGCAGATCATCGTGGGCCGCGTCGATTACGGGCTCGAAATCCAGTCGGCGGGCGACTCG
CCGCGCTGGCATCACGAGGGATCGTCCGAAACGATGGGCGAGGATGCGGCGGGCCTTGGCCCGAACGGCCTCTTGCGGCT
CGAAAGCGGCGTGCCCGATGCAAGTCGGCGACGGCTGGCCGAGATCGGCTGGACGCTGGGCGAATCCGATGGCGGGTTCG
GACGCTATCAATGCGTCGAACATCGGATGGACGGCGATACGCGCGTTTACGCCGCGGCGAGCGAAATGCGCGCCGACGGA
TGTGCGCTCGCCTATTGA

Upstream 100 bases:

>100_bases
AGCTGGCTTCGCGGAGGGCAGAAAGCCCAAGGCCGCGCCCGCGGCCGCCAGGCCGGACAAGACCACTCCGCCGGTGTGGG
AATCGGGTGCCGACCGGTTC

Downstream 100 bases:

>100_bases
AACTGGCGGGCGGAAACCCGCTCGTTTCGGCGCGGCCTCACCTCCCCCCTCCGCCAAAATTATCGAACACGATATACGAA
TATTTACCTTCTTCCTTTAG

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MRPDVHAGDRPVGASFASRTAVYGLSGAVGTAHPLATQAGIDMLRRGGSAVDAAIAINACLGLLEPTANGIGGDVYAMIW
DPRTKKLAGLAGSGKSPRGLDLATVRSRARGGTLPAYGAITVSVPGTVDGWWTMHQRYGKLPWKELFEPVIAHAEVGAPV
PDMIAYYMRRSLAGFRQPGRGIEEIDNALRTWGLNDGKGPMAGQVFRNPDLARTFRLIAEGGRDAFYEGEIARTIDAYFK
RIGGWLRYEDLAAHRSEWIEPHKTAYRGTDVYALGANTQGIATLQMLNILEHFDLKGAGFQSALSIHLQAEAKRLAYEDR
ARYYADPHFARVPVEWLISKDYAAERAKLIRPDRLLTPVHPGQAPSHGDTTYFSCADKDGMMVSMIQSNFRGMGSGLVAD
GLGFMFQDRGQLFSLQDGHPNIYAPGKRPFQTIIPGFAARGDVPWMSFGVMGGDMQPQGQTQIIVGRVDYGLEIQSAGDS
PRWHHEGSSETMGEDAAGLGPNGLLRLESGVPDASRRRLAEIGWTLGESDGGFGRYQCVEHRMDGDTRVYAAASEMRADG
CALAY

Sequences:

>Translated_565_residues
MRPDVHAGDRPVGASFASRTAVYGLSGAVGTAHPLATQAGIDMLRRGGSAVDAAIAINACLGLLEPTANGIGGDVYAMIW
DPRTKKLAGLAGSGKSPRGLDLATVRSRARGGTLPAYGAITVSVPGTVDGWWTMHQRYGKLPWKELFEPVIAHAEVGAPV
PDMIAYYMRRSLAGFRQPGRGIEEIDNALRTWGLNDGKGPMAGQVFRNPDLARTFRLIAEGGRDAFYEGEIARTIDAYFK
RIGGWLRYEDLAAHRSEWIEPHKTAYRGTDVYALGANTQGIATLQMLNILEHFDLKGAGFQSALSIHLQAEAKRLAYEDR
ARYYADPHFARVPVEWLISKDYAAERAKLIRPDRLLTPVHPGQAPSHGDTTYFSCADKDGMMVSMIQSNFRGMGSGLVAD
GLGFMFQDRGQLFSLQDGHPNIYAPGKRPFQTIIPGFAARGDVPWMSFGVMGGDMQPQGQTQIIVGRVDYGLEIQSAGDS
PRWHHEGSSETMGEDAAGLGPNGLLRLESGVPDASRRRLAEIGWTLGESDGGFGRYQCVEHRMDGDTRVYAAASEMRADG
CALAY
>Mature_565_residues
MRPDVHAGDRPVGASFASRTAVYGLSGAVGTAHPLATQAGIDMLRRGGSAVDAAIAINACLGLLEPTANGIGGDVYAMIW
DPRTKKLAGLAGSGKSPRGLDLATVRSRARGGTLPAYGAITVSVPGTVDGWWTMHQRYGKLPWKELFEPVIAHAEVGAPV
PDMIAYYMRRSLAGFRQPGRGIEEIDNALRTWGLNDGKGPMAGQVFRNPDLARTFRLIAEGGRDAFYEGEIARTIDAYFK
RIGGWLRYEDLAAHRSEWIEPHKTAYRGTDVYALGANTQGIATLQMLNILEHFDLKGAGFQSALSIHLQAEAKRLAYEDR
ARYYADPHFARVPVEWLISKDYAAERAKLIRPDRLLTPVHPGQAPSHGDTTYFSCADKDGMMVSMIQSNFRGMGSGLVAD
GLGFMFQDRGQLFSLQDGHPNIYAPGKRPFQTIIPGFAARGDVPWMSFGVMGGDMQPQGQTQIIVGRVDYGLEIQSAGDS
PRWHHEGSSETMGEDAAGLGPNGLLRLESGVPDASRRRLAEIGWTLGESDGGFGRYQCVEHRMDGDTRVYAAASEMRADG
CALAY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=484, Percent_Identity=29.3388429752066, Blast_Score=158, Evalue=2e-38,
Organism=Homo sapiens, GI73915090, Length=484, Percent_Identity=29.3388429752066, Blast_Score=158, Evalue=2e-38,
Organism=Homo sapiens, GI73915096, Length=484, Percent_Identity=29.3388429752066, Blast_Score=158, Evalue=2e-38,
Organism=Homo sapiens, GI73915094, Length=484, Percent_Identity=29.3388429752066, Blast_Score=158, Evalue=2e-38,
Organism=Homo sapiens, GI113429324, Length=470, Percent_Identity=28.7234042553192, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI113429326, Length=475, Percent_Identity=28.2105263157895, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI109148539, Length=492, Percent_Identity=26.6260162601626, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI153266901, Length=485, Percent_Identity=23.7113402061856, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI153266885, Length=486, Percent_Identity=23.0452674897119, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1789856, Length=506, Percent_Identity=30.8300395256917, Blast_Score=224, Evalue=9e-60,
Organism=Caenorhabditis elegans, GI193208245, Length=524, Percent_Identity=24.618320610687, Blast_Score=125, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI193208247, Length=508, Percent_Identity=24.6062992125984, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI72000294, Length=553, Percent_Identity=23.6889692585895, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI212646519, Length=553, Percent_Identity=23.869801084991, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17506189, Length=492, Percent_Identity=24.390243902439, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17542894, Length=501, Percent_Identity=26.5469061876248, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI161077880, Length=480, Percent_Identity=26.0416666666667, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI161077878, Length=480, Percent_Identity=26.0416666666667, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI18859893, Length=500, Percent_Identity=28.2, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45551474, Length=480, Percent_Identity=26.0416666666667, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24642670, Length=480, Percent_Identity=26.0416666666667, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24642666, Length=480, Percent_Identity=26.0416666666667, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI161077496, Length=489, Percent_Identity=27.19836400818, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI18859741, Length=485, Percent_Identity=23.2989690721649, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61278; Mature: 61278

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPDVHAGDRPVGASFASRTAVYGLSGAVGTAHPLATQAGIDMLRRGGSAVDAAIAINAC
CCCCCCCCCCCCCCHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
LGLLEPTANGIGGDVYAMIWDPRTKKLAGLAGSGKSPRGLDLATVRSRARGGTLPAYGAI
HHHHCCCCCCCCCCEEEEEECCCCHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEE
TVSVPGTVDGWWTMHQRYGKLPWKELFEPVIAHAEVGAPVPDMIAYYMRRSLAGFRQPGR
EEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
GIEEIDNALRTWGLNDGKGPMAGQVFRNPDLARTFRLIAEGGRDAFYEGEIARTIDAYFK
CHHHHHHHHHHCCCCCCCCCCCCHHHCCCCHHHHHHHHHCCCCCCEECCHHHHHHHHHHH
RIGGWLRYEDLAAHRSEWIEPHKTAYRGTDVYALGANTQGIATLQMLNILEHFDLKGAGF
HHCCHHHHHHHHHHHHHCCCHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCC
QSALSIHLQAEAKRLAYEDRARYYADPHFARVPVEWLISKDYAAERAKLIRPDRLLTPVH
CCEEEEEEEHHHHHHHHHHHHHHCCCCCCEECCHHHHHCCHHHHHHHHHCCCCCCCCCCC
PGQAPSHGDTTYFSCADKDGMMVSMIQSNFRGMGSGLVADGLGFMFQDRGQLFSLQDGHP
CCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCHHHHCCCHHEECCCCEEEEECCCC
NIYAPGKRPFQTIIPGFAARGDVPWMSFGVMGGDMQPQGQTQIIVGRVDYGLEIQSAGDS
CEECCCCCCHHHHCCCHHCCCCCCEEEEECCCCCCCCCCCEEEEEEEECCCEEEECCCCC
PRWHHEGSSETMGEDAAGLGPNGLLRLESGVPDASRRRLAEIGWTLGESDGGFGRYQCVE
CCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCEECCCCCCCCHHHHHH
HRMDGDTRVYAAASEMRADGCALAY
HHCCCCCEEEEEHHHHCCCCCCCCC
>Mature Secondary Structure
MRPDVHAGDRPVGASFASRTAVYGLSGAVGTAHPLATQAGIDMLRRGGSAVDAAIAINAC
CCCCCCCCCCCCCCHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
LGLLEPTANGIGGDVYAMIWDPRTKKLAGLAGSGKSPRGLDLATVRSRARGGTLPAYGAI
HHHHCCCCCCCCCCEEEEEECCCCHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEE
TVSVPGTVDGWWTMHQRYGKLPWKELFEPVIAHAEVGAPVPDMIAYYMRRSLAGFRQPGR
EEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
GIEEIDNALRTWGLNDGKGPMAGQVFRNPDLARTFRLIAEGGRDAFYEGEIARTIDAYFK
CHHHHHHHHHHCCCCCCCCCCCCHHHCCCCHHHHHHHHHCCCCCCEECCHHHHHHHHHHH
RIGGWLRYEDLAAHRSEWIEPHKTAYRGTDVYALGANTQGIATLQMLNILEHFDLKGAGF
HHCCHHHHHHHHHHHHHCCCHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCC
QSALSIHLQAEAKRLAYEDRARYYADPHFARVPVEWLISKDYAAERAKLIRPDRLLTPVH
CCEEEEEEEHHHHHHHHHHHHHHCCCCCCEECCHHHHHCCHHHHHHHHHCCCCCCCCCCC
PGQAPSHGDTTYFSCADKDGMMVSMIQSNFRGMGSGLVADGLGFMFQDRGQLFSLQDGHP
CCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCHHHHCCCHHEECCCCEEEEECCCC
NIYAPGKRPFQTIIPGFAARGDVPWMSFGVMGGDMQPQGQTQIIVGRVDYGLEIQSAGDS
CEECCCCCCHHHHCCCHHCCCCCCEEEEECCCCCCCCCCCEEEEEEEECCCEEEECCCCC
PRWHHEGSSETMGEDAAGLGPNGLLRLESGVPDASRRRLAEIGWTLGESDGGFGRYQCVE
CCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCEECCCCCCCCHHHHHH
HRMDGDTRVYAAASEMRADGCALAY
HHCCCCCEEEEEHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]