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The map label for this gene is murC [H]

Identifier: 103487383

GI number: 103487383

Start: 1998874

End: 2000262

Strand: Direct

Name: murC [H]

Synonym: Sala_1899

Alternate gene names: 103487383

Gene position: 1998874-2000262 (Clockwise)

Preceding gene: 103487378

Following gene: 103487384

Centisome position: 59.75

GC content: 68.25

Gene sequence:

>1389_bases
ATGGCCGAAAACAAATCCTATTTCTTTTGCGGCATCGGCGGGTCGGGCATGTTGCCGCTCGCGATGATCGTGGCGGCACG
CGGCGCAGCGGTCGCGGGCTCGGACCGCAGCCGCGATCAGGGGCGCTCGCCGGACAAGTTCGACTGGATCGAACGCCGCG
GCATCGCCCTTTTCCCGCAGGATGGAAGCGGGGTCGCTGCGGGGCAGACGCTCGTGGCCTCGGCTGCCGTCGAGGACAGC
GTACCCGACGTCGCCGCCGCCAACACGCTCGGCCTGGCGCGGATGTCGCGCGCCGACCTCAACGCCGCGCTGTTCAACGC
CGCGGCGAAGGGGGTCGGCGTCGGCGGGACGAGCGGCAAGTCGACCGTCACGGGGATGATTGGCTGGATCCTTGAGCGCG
CGGGCCAGAAGCCGACCGTGATGAACGGCGCAGTGATGCGCAATTTCGCCTCGCCCGATACGCCCTTCGCCAGCGCGCTC
GTCGGCGGCGACGCCATCTATGTCAGCGAGGTCGACGAAAGCGACGGATCGATCGCACTCTATGCCCCCGATGTCGCGGT
GGTCACCAACATCAGCCTCGACCACAAAAGCCTCGACGAACTGCACCGCCTGTTCGGCGATTTCGCTGCAAAAGCGCGGA
TCGCCGTCATCAACGCCGACGATCCCGAATCGGCGCCGCTGCTCGCGGGCGCGAATGTCCTGCGCTTCGGCTTCGGCGAC
AATGCGGCGATCCGCGGCAGCGATTTCGAGCCGCTGCCCAACGGCTGCCGCTTTGCGGTCCATTTTGCGGCCGACAGCCA
CGACGTCCGGTTGCAGATGCCCGGTCGCCACAATGCAGCCAACGCGCTCGCCGCCATCGCCGCGGCGCGTGCGCTCAACA
TCCCCGTCGCGCAGTCGGTCGCGGCGCTCGCCGATTTCGCCGGGCTGGCACGGCGTTACGAAGTGCTGGGGCAGGCGGGC
GATGTCACGGTGATCGACGATTTCGCCCACAATCCCGACAAGGTCGCCGCAACACTCGCCGCGGTCGCCGAACTGCCCGG
CCGCGCGCTGCTGTTTTTCCAGCCGCACGGCTATGGCCCGCTTCGCCAGATGGGCAAGGAACTGGCGACAAGTTTCGCCG
CCGGTATGCGCGATGGCGACAGGCTCTATGTCTGCGACCCCGTCTATTTCGGCGGCACCGTCGACCGCAGCATCGGCAGC
GAGGCGCTGGTCGCCGACATCGTCGCAGGCGGGGCCGACGCCGTCCACCTGACGACGCGCGCCAACTGCGGCGCCGCGAT
GCTGGACGAAGCACGGCCAGGCGACCGCATCCTGATCCTCGGCGCACGCGACGATACGCTGACCGCGTTCGGACGGGAAC
TGCTGGAAAAGCTCACCCGCCACGCTTGA

Upstream 100 bases:

>100_bases
ACCCAGCTACGACCAGGCGCTTCGCACCAAGTCTGCGCAACCCACTCCCGACGGGAGAGGGAGTGTTGCCATTGCTCCTA
AGACGCCATATCGCGCCGCG

Downstream 100 bases:

>100_bases
TTCTTTCGGGCGAATCTGTATAGGCGCGCTCATTCGGGGCGAGGCTGCGTTGCCATCGCCCCGTTTGCTTTGCACCAATT
CCCGCAAAGCCGGACGACAG

Product: Mur ligase, middle region

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MAENKSYFFCGIGGSGMLPLAMIVAARGAAVAGSDRSRDQGRSPDKFDWIERRGIALFPQDGSGVAAGQTLVASAAVEDS
VPDVAAANTLGLARMSRADLNAALFNAAAKGVGVGGTSGKSTVTGMIGWILERAGQKPTVMNGAVMRNFASPDTPFASAL
VGGDAIYVSEVDESDGSIALYAPDVAVVTNISLDHKSLDELHRLFGDFAAKARIAVINADDPESAPLLAGANVLRFGFGD
NAAIRGSDFEPLPNGCRFAVHFAADSHDVRLQMPGRHNAANALAAIAAARALNIPVAQSVAALADFAGLARRYEVLGQAG
DVTVIDDFAHNPDKVAATLAAVAELPGRALLFFQPHGYGPLRQMGKELATSFAAGMRDGDRLYVCDPVYFGGTVDRSIGS
EALVADIVAGGADAVHLTTRANCGAAMLDEARPGDRILILGARDDTLTAFGRELLEKLTRHA

Sequences:

>Translated_462_residues
MAENKSYFFCGIGGSGMLPLAMIVAARGAAVAGSDRSRDQGRSPDKFDWIERRGIALFPQDGSGVAAGQTLVASAAVEDS
VPDVAAANTLGLARMSRADLNAALFNAAAKGVGVGGTSGKSTVTGMIGWILERAGQKPTVMNGAVMRNFASPDTPFASAL
VGGDAIYVSEVDESDGSIALYAPDVAVVTNISLDHKSLDELHRLFGDFAAKARIAVINADDPESAPLLAGANVLRFGFGD
NAAIRGSDFEPLPNGCRFAVHFAADSHDVRLQMPGRHNAANALAAIAAARALNIPVAQSVAALADFAGLARRYEVLGQAG
DVTVIDDFAHNPDKVAATLAAVAELPGRALLFFQPHGYGPLRQMGKELATSFAAGMRDGDRLYVCDPVYFGGTVDRSIGS
EALVADIVAGGADAVHLTTRANCGAAMLDEARPGDRILILGARDDTLTAFGRELLEKLTRHA
>Mature_461_residues
AENKSYFFCGIGGSGMLPLAMIVAARGAAVAGSDRSRDQGRSPDKFDWIERRGIALFPQDGSGVAAGQTLVASAAVEDSV
PDVAAANTLGLARMSRADLNAALFNAAAKGVGVGGTSGKSTVTGMIGWILERAGQKPTVMNGAVMRNFASPDTPFASALV
GGDAIYVSEVDESDGSIALYAPDVAVVTNISLDHKSLDELHRLFGDFAAKARIAVINADDPESAPLLAGANVLRFGFGDN
AAIRGSDFEPLPNGCRFAVHFAADSHDVRLQMPGRHNAANALAAIAAARALNIPVAQSVAALADFAGLARRYEVLGQAGD
VTVIDDFAHNPDKVAATLAAVAELPGRALLFFQPHGYGPLRQMGKELATSFAAGMRDGDRLYVCDPVYFGGTVDRSIGSE
ALVADIVAGGADAVHLTTRANCGAAMLDEARPGDRILILGARDDTLTAFGRELLEKLTRHA

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=333, Percent_Identity=31.8318318318318, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1790680, Length=458, Percent_Identity=26.8558951965066, Blast_Score=112, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 47933; Mature: 47801

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAENKSYFFCGIGGSGMLPLAMIVAARGAAVAGSDRSRDQGRSPDKFDWIERRGIALFPQ
CCCCCCEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHCCCEEECC
DGSGVAAGQTLVASAAVEDSVPDVAAANTLGLARMSRADLNAALFNAAAKGVGVGGTSGK
CCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
STVTGMIGWILERAGQKPTVMNGAVMRNFASPDTPFASALVGGDAIYVSEVDESDGSIAL
HHHHHHHHHHHHHCCCCCEEECHHHHHCCCCCCCCHHHHHHCCCEEEEEECCCCCCCEEE
YAPDVAVVTNISLDHKSLDELHRLFGDFAAKARIAVINADDPESAPLLAGANVLRFGFGD
EECCEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCEEECCCEEEECCCC
NAAIRGSDFEPLPNGCRFAVHFAADSHDVRLQMPGRHNAANALAAIAAARALNIPVAQSV
CCEECCCCCCCCCCCCEEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHH
AALADFAGLARRYEVLGQAGDVTVIDDFAHNPDKVAATLAAVAELPGRALLFFQPHGYGP
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCH
LRQMGKELATSFAAGMRDGDRLYVCDPVYFGGTVDRSIGSEALVADIVAGGADAVHLTTR
HHHHHHHHHHHHHHCCCCCCEEEEECCEEECCCCCCCCCCHHHHHHHHCCCCCEEEEEEC
ANCGAAMLDEARPGDRILILGARDDTLTAFGRELLEKLTRHA
CCCCHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AENKSYFFCGIGGSGMLPLAMIVAARGAAVAGSDRSRDQGRSPDKFDWIERRGIALFPQ
CCCCCEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHCCCEEECC
DGSGVAAGQTLVASAAVEDSVPDVAAANTLGLARMSRADLNAALFNAAAKGVGVGGTSGK
CCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
STVTGMIGWILERAGQKPTVMNGAVMRNFASPDTPFASALVGGDAIYVSEVDESDGSIAL
HHHHHHHHHHHHHCCCCCEEECHHHHHCCCCCCCCHHHHHHCCCEEEEEECCCCCCCEEE
YAPDVAVVTNISLDHKSLDELHRLFGDFAAKARIAVINADDPESAPLLAGANVLRFGFGD
EECCEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCEEECCCEEEECCCC
NAAIRGSDFEPLPNGCRFAVHFAADSHDVRLQMPGRHNAANALAAIAAARALNIPVAQSV
CCEECCCCCCCCCCCCEEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHH
AALADFAGLARRYEVLGQAGDVTVIDDFAHNPDKVAATLAAVAELPGRALLFFQPHGYGP
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCH
LRQMGKELATSFAAGMRDGDRLYVCDPVYFGGTVDRSIGSEALVADIVAGGADAVHLTTR
HHHHHHHHHHHHHHCCCCCCEEEEECCEEECCCCCCCCCCHHHHHHHHCCCCCEEEEEEC
ANCGAAMLDEARPGDRILILGARDDTLTAFGRELLEKLTRHA
CCCCHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA