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The map label for this gene is lldD [H]

Identifier: 103487330

GI number: 103487330

Start: 1941166

End: 1942314

Strand: Direct

Name: lldD [H]

Synonym: Sala_1846

Alternate gene names: 103487330

Gene position: 1941166-1942314 (Clockwise)

Preceding gene: 103487329

Following gene: 103487332

Centisome position: 58.03

GC content: 68.93

Gene sequence:

>1149_bases
GTGCGCCTGACCGACTGCCACAACATCGACGATTTCCGCGCGCTCGCTCGGCGGCGCCTGCCCTGGCCGGTGTTCGACTA
TATCGACGGCGCCGCCGACGACGAGGTCACGCGCCGCCGCAACCGCGACGCCTTCGATCAGTGCGACCTTATCCCGCGCG
TGCTCGCGGGCGTCGAAAGCGTCGATATGCGCACGACGCTCTTCGGGCGCGAAATGGCGATGCCGCTGTTCCTGTCGCCC
ACCGCGCTGCAACGCCTGTTCCACTGGCAGGGCGAGCGCGCGGTGCTCCGCGCCGCCGCGAACGCCGGGACGATGGCGGG
TATCTCCAGCCTCGCGACGATCGGCCTCGCCGAAGCGGGCGCGCTGACCGATGGCCCCAAGCTGTTCCAGCTTTATGTCC
ACAAGGACGAGGGGCTCAACCGCGCGATGCTGGACGCCGCGCGCGACGCGAAGTTTGACGCCGTCGCGCTCACGGTCGAT
ACGATCGTGGGCGGCAACCGCGAACGCTGCCTGCGCTCTGGCTTTACCTCGCCGCCGCGCTTCACGCCGGGCAATATGCT
GAGCTACGCCGCGCGACCGGGCTGGGGTCTCGATTATCTGCTACGCGAAAAGTTCAGCCTGCCGAACCTTGCGACGCATG
TGTCCGAAGGGTCGAGCGTCCCCAAATCGGTCGCCGACTATTTCACCTCGATGCTCGACCAGAGCCTCGACTGGAAGCGC
GTCGAGGCGATCCGCCGGCAATGGGACGGCCCCTTCTGCCTCAAGGGCATCGTCGCGGTCGAGGATGCGAAGCGCGCCGC
CGACATCGGCGCCACCGCGATCATGGTGTCGAACCATGGCGGACGCCAGCTCGACGGCAGCATCGCACCCTTCGACGCGC
TCGCGGGAATCGTCGATGCGGTCGGCGACCGGGTCGAGGTGATCTGCGACGGCGGCATCACGCGCGGCACGCATGTGCTG
AAAGCGCTGTCGGCCGGCGCCAAAGCCTGCTCGGGCGGCCGCCTCTATCTCTACGCGCTCGCCGCGGCGGGCGAGGATGG
CGTCGCGCGCGCGATCGCGCTGCTGCGCGCCGAGATCGAGCGTGGCATGAAGCTGATGGGGGCCCGGACCCTCGCCGATC
TCGGCGCCGATAATCTGCGCTGGCGCTGA

Upstream 100 bases:

>100_bases
TTCGTCATCCCGGCGAAGGCCGGGATCTCGCCGGTGCGGTTCCACGAGAGGGTGAGATCCCGGCCTTCGCCGGGATGACG
ATGTAAGGGGACAGACAAGC

Downstream 100 bases:

>100_bases
CCTTCCCCCTTCGTCATCCCCGCGAAAGCGGGGACCCAGTTCCAGCGCCGCATGGACAACCAACTTGGCGGAGGGTTCCC
GCTTTCGCGCGAATGACGAT

Product: (S)-2-hydroxy-acid oxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MRLTDCHNIDDFRALARRRLPWPVFDYIDGAADDEVTRRRNRDAFDQCDLIPRVLAGVESVDMRTTLFGREMAMPLFLSP
TALQRLFHWQGERAVLRAAANAGTMAGISSLATIGLAEAGALTDGPKLFQLYVHKDEGLNRAMLDAARDAKFDAVALTVD
TIVGGNRERCLRSGFTSPPRFTPGNMLSYAARPGWGLDYLLREKFSLPNLATHVSEGSSVPKSVADYFTSMLDQSLDWKR
VEAIRRQWDGPFCLKGIVAVEDAKRAADIGATAIMVSNHGGRQLDGSIAPFDALAGIVDAVGDRVEVICDGGITRGTHVL
KALSAGAKACSGGRLYLYALAAAGEDGVARAIALLRAEIERGMKLMGARTLADLGADNLRWR

Sequences:

>Translated_382_residues
MRLTDCHNIDDFRALARRRLPWPVFDYIDGAADDEVTRRRNRDAFDQCDLIPRVLAGVESVDMRTTLFGREMAMPLFLSP
TALQRLFHWQGERAVLRAAANAGTMAGISSLATIGLAEAGALTDGPKLFQLYVHKDEGLNRAMLDAARDAKFDAVALTVD
TIVGGNRERCLRSGFTSPPRFTPGNMLSYAARPGWGLDYLLREKFSLPNLATHVSEGSSVPKSVADYFTSMLDQSLDWKR
VEAIRRQWDGPFCLKGIVAVEDAKRAADIGATAIMVSNHGGRQLDGSIAPFDALAGIVDAVGDRVEVICDGGITRGTHVL
KALSAGAKACSGGRLYLYALAAAGEDGVARAIALLRAEIERGMKLMGARTLADLGADNLRWR
>Mature_382_residues
MRLTDCHNIDDFRALARRRLPWPVFDYIDGAADDEVTRRRNRDAFDQCDLIPRVLAGVESVDMRTTLFGREMAMPLFLSP
TALQRLFHWQGERAVLRAAANAGTMAGISSLATIGLAEAGALTDGPKLFQLYVHKDEGLNRAMLDAARDAKFDAVALTVD
TIVGGNRERCLRSGFTSPPRFTPGNMLSYAARPGWGLDYLLREKFSLPNLATHVSEGSSVPKSVADYFTSMLDQSLDWKR
VEAIRRQWDGPFCLKGIVAVEDAKRAADIGATAIMVSNHGGRQLDGSIAPFDALAGIVDAVGDRVEVICDGGITRGTHVL
KALSAGAKACSGGRLYLYALAAAGEDGVARAIALLRAEIERGMKLMGARTLADLGADNLRWR

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=364, Percent_Identity=35.1648351648352, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI54234014, Length=375, Percent_Identity=35.2, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI7705393, Length=375, Percent_Identity=35.2, Blast_Score=200, Evalue=2e-51,
Organism=Escherichia coli, GI1790033, Length=372, Percent_Identity=35.752688172043, Blast_Score=214, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI193208036, Length=373, Percent_Identity=31.0991957104558, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI32566217, Length=285, Percent_Identity=30.1754385964912, Blast_Score=134, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6323587, Length=388, Percent_Identity=32.4742268041237, Blast_Score=193, Evalue=5e-50,
Organism=Drosophila melanogaster, GI78707188, Length=367, Percent_Identity=33.2425068119891, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI281363140, Length=367, Percent_Identity=33.2425068119891, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI78707190, Length=367, Percent_Identity=33.2425068119891, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 41438; Mature: 41438

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLTDCHNIDDFRALARRRLPWPVFDYIDGAADDEVTRRRNRDAFDQCDLIPRVLAGVES
CCCCCCCCCHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCHH
VDMRTTLFGREMAMPLFLSPTALQRLFHWQGERAVLRAAANAGTMAGISSLATIGLAEAG
HHHHHHHHHHHHCCCEEECHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCC
ALTDGPKLFQLYVHKDEGLNRAMLDAARDAKFDAVALTVDTIVGGNRERCLRSGFTSPPR
CCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEHHHHCCCHHHHHHCCCCCCCC
FTPGNMLSYAARPGWGLDYLLREKFSLPNLATHVSEGSSVPKSVADYFTSMLDQSLDWKR
CCCCCHHHHCCCCCCCHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHH
VEAIRRQWDGPFCLKGIVAVEDAKRAADIGATAIMVSNHGGRQLDGSIAPFDALAGIVDA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHH
VGDRVEVICDGGITRGTHVLKALSAGAKACSGGRLYLYALAAAGEDGVARAIALLRAEIE
CCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
RGMKLMGARTLADLGADNLRWR
HHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRLTDCHNIDDFRALARRRLPWPVFDYIDGAADDEVTRRRNRDAFDQCDLIPRVLAGVES
CCCCCCCCCHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCHH
VDMRTTLFGREMAMPLFLSPTALQRLFHWQGERAVLRAAANAGTMAGISSLATIGLAEAG
HHHHHHHHHHHHCCCEEECHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCC
ALTDGPKLFQLYVHKDEGLNRAMLDAARDAKFDAVALTVDTIVGGNRERCLRSGFTSPPR
CCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEHHHHCCCHHHHHHCCCCCCCC
FTPGNMLSYAARPGWGLDYLLREKFSLPNLATHVSEGSSVPKSVADYFTSMLDQSLDWKR
CCCCCHHHHCCCCCCCHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHH
VEAIRRQWDGPFCLKGIVAVEDAKRAADIGATAIMVSNHGGRQLDGSIAPFDALAGIVDA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHH
VGDRVEVICDGGITRGTHVLKALSAGAKACSGGRLYLYALAAAGEDGVARAIALLRAEIE
CCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
RGMKLMGARTLADLGADNLRWR
HHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA