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The map label for this gene is caiD [H]

Identifier: 103487292

GI number: 103487292

Start: 1903762

End: 1904556

Strand: Direct

Name: caiD [H]

Synonym: Sala_1808

Alternate gene names: 103487292

Gene position: 1903762-1904556 (Clockwise)

Preceding gene: 103487291

Following gene: 103487293

Centisome position: 56.91

GC content: 68.43

Gene sequence:

>795_bases
ATGACCGACACCACCATCCTCACCGAACGCCGTGGCCACATCCTGACCGTCACGATCAACCGGCCCGAAGCGCGCAACGC
GGTCAACGCCGCGGTCCACGTCGGCATTGGCACCGCGCTCGAAACTGCGGAAAACGATCCCGAAATCCGCACGGTCATCA
TCACCGGCGCGGGCGACAAAAGCTTTTGCGCGGGCGCCGACCTGGTCGCCCTGTCGCGCGGTGAAAGCCTTTATCCCGAC
GATCCGGCGCAGCAGGCGTGGGGGTTTGCCGGCATGGTCGCGCACCCGATCTCGAAACCGATCATCGCCGCGGTCAACGG
CTTCGCCTTCGGCGGCGGCTGCGAGATCGCGCTGATGAGCGACATCATTATCGCCGCCGACCATGCGCAGTTCGGGCTTC
CCGAGGTCAAGGTCGGGCTGTTCGCCGCGGCGGGCGGCGCCTTCCGCCTCGCGCAGCAAATCCCGCGCAAGCTGGCGATG
GAATATCTGCTGACCGGCGACCCGATCCCCGCCGCGCGCGCCGCCGAGTTCGGCCTCGTCAACCATGTCGTCCCGCTCGC
CGAGCTGATGCCCACCGCGATCGCGCTCGCCGACAAGATCGCCGCCAACGCGCCACTCTCGGTGCAGGCGTCGAAGCGCG
TCGCGCTGGGCATCCAGGACGGCCGCATCGCCGCCGACGCGCCCTATTGGGAGCATAACACCCTCGAGCGCAGCGCGCTG
ATGCGCAGCGAGGACGCGCGCGAAGGCCCGCGCGCCTTTGCGGAAAAGCGCAAGCCCGAATGGAAAGCGCGCTAG

Upstream 100 bases:

>100_bases
CTTCGCTGCGCTCGCAATGACGGCGAGAGCCGCTGCATCCTTTCCAGTTGACGTAAACGTCAACCAACCGCGATACTCGC
CCGAAAGGGAGAGATTCGCG

Downstream 100 bases:

>100_bases
GATGACGATAACACTCGGCTCCCAATTTCCGTTCGCATCGAGCGAAGTCGAGATGCCCATCGGCGCGGCGCCTGCCTGCG
GTGTGTCTCGACTTCGCTCG

Product: enoyl-CoA hydratase/isomerase

Products: L-Carnitine.; L-carnitinyl-CoA [C]

Alternate protein names: Crotonobetainyl-CoA hydratase [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MTDTTILTERRGHILTVTINRPEARNAVNAAVHVGIGTALETAENDPEIRTVIITGAGDKSFCAGADLVALSRGESLYPD
DPAQQAWGFAGMVAHPISKPIIAAVNGFAFGGGCEIALMSDIIIAADHAQFGLPEVKVGLFAAAGGAFRLAQQIPRKLAM
EYLLTGDPIPAARAAEFGLVNHVVPLAELMPTAIALADKIAANAPLSVQASKRVALGIQDGRIAADAPYWEHNTLERSAL
MRSEDAREGPRAFAEKRKPEWKAR

Sequences:

>Translated_264_residues
MTDTTILTERRGHILTVTINRPEARNAVNAAVHVGIGTALETAENDPEIRTVIITGAGDKSFCAGADLVALSRGESLYPD
DPAQQAWGFAGMVAHPISKPIIAAVNGFAFGGGCEIALMSDIIIAADHAQFGLPEVKVGLFAAAGGAFRLAQQIPRKLAM
EYLLTGDPIPAARAAEFGLVNHVVPLAELMPTAIALADKIAANAPLSVQASKRVALGIQDGRIAADAPYWEHNTLERSAL
MRSEDAREGPRAFAEKRKPEWKAR
>Mature_263_residues
TDTTILTERRGHILTVTINRPEARNAVNAAVHVGIGTALETAENDPEIRTVIITGAGDKSFCAGADLVALSRGESLYPDD
PAQQAWGFAGMVAHPISKPIIAAVNGFAFGGGCEIALMSDIIIAADHAQFGLPEVKVGLFAAAGGAFRLAQQIPRKLAME
YLLTGDPIPAARAAEFGLVNHVVPLAELMPTAIALADKIAANAPLSVQASKRVALGIQDGRIAADAPYWEHNTLERSALM
RSEDAREGPRAFAEKRKPEWKAR

Specific function: Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=263, Percent_Identity=38.4030418250951, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI31542718, Length=250, Percent_Identity=31.6, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI70995211, Length=256, Percent_Identity=33.59375, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI37594471, Length=203, Percent_Identity=29.064039408867, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI37594469, Length=203, Percent_Identity=29.5566502463054, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI20127408, Length=187, Percent_Identity=29.9465240641711, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI68989263, Length=181, Percent_Identity=33.7016574585635, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4502327, Length=258, Percent_Identity=29.0697674418605, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI45643119, Length=218, Percent_Identity=27.5229357798165, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI260275230, Length=218, Percent_Identity=27.5229357798165, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI260274832, Length=218, Percent_Identity=27.5229357798165, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI221142681, Length=272, Percent_Identity=42.2794117647059, Blast_Score=185, Evalue=3e-48,
Organism=Escherichia coli, GI1787659, Length=262, Percent_Identity=36.6412213740458, Blast_Score=164, Evalue=4e-42,
Organism=Escherichia coli, GI1788597, Length=251, Percent_Identity=33.0677290836653, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI87082183, Length=225, Percent_Identity=34.2222222222222, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1787660, Length=270, Percent_Identity=32.962962962963, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788682, Length=203, Percent_Identity=31.5270935960591, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1790281, Length=217, Percent_Identity=29.0322580645161, Blast_Score=85, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17554946, Length=265, Percent_Identity=35.0943396226415, Blast_Score=155, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI25145438, Length=251, Percent_Identity=36.2549800796813, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17560910, Length=260, Percent_Identity=28.8461538461538, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17540714, Length=238, Percent_Identity=31.0924369747899, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI25144160, Length=194, Percent_Identity=28.8659793814433, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25144157, Length=194, Percent_Identity=28.8659793814433, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17534483, Length=246, Percent_Identity=27.6422764227642, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17549921, Length=219, Percent_Identity=28.7671232876712, Blast_Score=90, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17535521, Length=251, Percent_Identity=26.2948207171315, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17536985, Length=221, Percent_Identity=28.0542986425339, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17558304, Length=219, Percent_Identity=27.8538812785388, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17540306, Length=226, Percent_Identity=30.0884955752212, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25144276, Length=189, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508951, Length=189, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17508953, Length=189, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320241, Length=183, Percent_Identity=25.1366120218579, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI20129971, Length=254, Percent_Identity=36.6141732283465, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24653477, Length=254, Percent_Identity=36.6141732283465, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24653139, Length=269, Percent_Identity=33.0855018587361, Blast_Score=120, Evalue=9e-28,
Organism=Drosophila melanogaster, GI21357171, Length=198, Percent_Identity=30.3030303030303, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24650670, Length=197, Percent_Identity=31.4720812182741, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19922422, Length=271, Percent_Identity=25.830258302583, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24654903, Length=187, Percent_Identity=28.8770053475936, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28571729, Length=185, Percent_Identity=28.6486486486486, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571730, Length=185, Percent_Identity=28.6486486486486, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19920382, Length=212, Percent_Identity=29.2452830188679, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022852
- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: 4.2.1.- [C]

Molecular weight: Translated: 27962; Mature: 27831

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTTILTERRGHILTVTINRPEARNAVNAAVHVGIGTALETAENDPEIRTVIITGAGDK
CCCCEEEEECCCEEEEEEECCCCCCCHHHEEEEEECCHHHHCCCCCCCEEEEEEECCCCC
SFCAGADLVALSRGESLYPDDPAQQAWGFAGMVAHPISKPIIAAVNGFAFGGGCEIALMS
CCCCCCCEEEECCCCCCCCCCHHHHHCCHHHHHHHHCCCCHHHHHCCEEECCCCEEEEEC
DIIIAADHAQFGLPEVKVGLFAAAGGAFRLAQQIPRKLAMEYLLTGDPIPAARAAEFGLV
CEEEEECCCCCCCCHHEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
NHVVPLAELMPTAIALADKIAANAPLSVQASKRVALGIQDGRIAADAPYWEHNTLERSAL
HHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEECCCEEEECCCCCCCCHHHHHHH
MRSEDAREGPRAFAEKRKPEWKAR
HHCCCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TDTTILTERRGHILTVTINRPEARNAVNAAVHVGIGTALETAENDPEIRTVIITGAGDK
CCCEEEEECCCEEEEEEECCCCCCCHHHEEEEEECCHHHHCCCCCCCEEEEEEECCCCC
SFCAGADLVALSRGESLYPDDPAQQAWGFAGMVAHPISKPIIAAVNGFAFGGGCEIALMS
CCCCCCCEEEECCCCCCCCCCHHHHHCCHHHHHHHHCCCCHHHHHCCEEECCCCEEEEEC
DIIIAADHAQFGLPEVKVGLFAAAGGAFRLAQQIPRKLAMEYLLTGDPIPAARAAEFGLV
CEEEEECCCCCCCCHHEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
NHVVPLAELMPTAIALADKIAANAPLSVQASKRVALGIQDGRIAADAPYWEHNTLERSAL
HHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEECCCEEEECCCCCCCCHHHHHHH
MRSEDAREGPRAFAEKRKPEWKAR
HHCCCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-Carnitine; D-carnitinyl-CoA [C]

Specific reaction: D-Carnitine = L-Carnitine. D-carnitinyl-CoA = L-carnitinyl-CoA [C]

General reaction: Isomerases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA