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The map label for this gene is purQ

Identifier: 103486084

GI number: 103486084

Start: 600414

End: 601079

Strand: Direct

Name: purQ

Synonym: Sala_0591

Alternate gene names: 103486084

Gene position: 600414-601079 (Clockwise)

Preceding gene: 103486083

Following gene: 103486088

Centisome position: 17.95

GC content: 68.32

Gene sequence:

>666_bases
ATGAAGACCGCCGTCATCGTCTTTCCCGGCTCCAACTGCGACCGCGACATGGCCGTCGCGCTCGAGACCGTCACGGGCAA
GGCGCCCGCGATGGTATGGCACCGCGAGACCGGGCTGCCTGAGGGCACCGATTTCATCGCGCTGCCGGGGGGCTTTTCCT
ATGGTGATTATCTCCGCTCGGGGGCGATGGCGGCGCGTTCGCCGATCCTGCGCGCAGTCGCCGAGGCCGCGGGTCGCGGC
GTTCCGGTGCTTGGCGTCTGCAACGGTTTTCAGGTGCTGACCGAGGCGGGGCTGCTTCCCGGCGCGCTGATGCGCAACGC
GGGGCTCAACTTCGTCTGCCGCACCGTGCCGCTCAAGGTCGAGAACAGCCAGTCGCTGTTCACCGCAGCCTATGGCGCGG
GCGAGGAAATCGCGATTCCGGTGGCGCATCACGACGGCAATTATTTCGCCGACGCCGATACGCTCGACCGGATCGAGGGT
GAGGGGCGCGTCGCCTTTCGCTATCTGGACGGCGTCAACGGTTCGGCGCGTGACATTGCGGGCGTCCTCAACGATGCGGG
CAATGTGCTCGGCATGATGCCGCACCCCGAGCGCGCGATCGACCGCGCGCACGGCGGCACCGACGGGCTACGCCTGTTCG
AGGCGGCGCTCGGCGTCCTCGCCTGA

Upstream 100 bases:

>100_bases
GCCATGTGCGCCAGGTTGCTCGCCAACACGGTGATCGAAAACTACCGCATCGAACGCGCCTGAGCCGAGCCAAGCTGATC
CAAGCCAAGGAGCCTGCCCC

Downstream 100 bases:

>100_bases
CGCCGCATCGGTCCCTGGCAGCCAGCGTCCGACGAGTGCCAGCACCGTTGGCCAGAACATCGTATTCCAGATGTCATGCC
AGTGCGCGGTGTCGGGCTGA

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MKTAVIVFPGSNCDRDMAVALETVTGKAPAMVWHRETGLPEGTDFIALPGGFSYGDYLRSGAMAARSPILRAVAEAAGRG
VPVLGVCNGFQVLTEAGLLPGALMRNAGLNFVCRTVPLKVENSQSLFTAAYGAGEEIAIPVAHHDGNYFADADTLDRIEG
EGRVAFRYLDGVNGSARDIAGVLNDAGNVLGMMPHPERAIDRAHGGTDGLRLFEAALGVLA

Sequences:

>Translated_221_residues
MKTAVIVFPGSNCDRDMAVALETVTGKAPAMVWHRETGLPEGTDFIALPGGFSYGDYLRSGAMAARSPILRAVAEAAGRG
VPVLGVCNGFQVLTEAGLLPGALMRNAGLNFVCRTVPLKVENSQSLFTAAYGAGEEIAIPVAHHDGNYFADADTLDRIEG
EGRVAFRYLDGVNGSARDIAGVLNDAGNVLGMMPHPERAIDRAHGGTDGLRLFEAALGVLA
>Mature_221_residues
MKTAVIVFPGSNCDRDMAVALETVTGKAPAMVWHRETGLPEGTDFIALPGGFSYGDYLRSGAMAARSPILRAVAEAAGRG
VPVLGVCNGFQVLTEAGLLPGALMRNAGLNFVCRTVPLKVENSQSLFTAAYGAGEEIAIPVAHHDGNYFADADTLDRIEG
EGRVAFRYLDGVNGSARDIAGVLNDAGNVLGMMPHPERAIDRAHGGTDGLRLFEAALGVLA

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Escherichia coli, GI48994899, Length=181, Percent_Identity=35.9116022099448, Blast_Score=71, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6321498, Length=189, Percent_Identity=32.2751322751323, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24582111, Length=236, Percent_Identity=29.6610169491525, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24582109, Length=236, Percent_Identity=29.6610169491525, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17137292, Length=236, Percent_Identity=29.6610169491525, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_SPHAL (Q1GVL0)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_615645.1
- ProteinModelPortal:   Q1GVL0
- SMR:   Q1GVL0
- GeneID:   4080618
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_0591
- NMPDR:   fig|317655.9.peg.547
- HOGENOM:   HBG302712
- OMA:   HPENHVE
- ProtClustDB:   PRK03619
- BioCyc:   SALA317655:SALA_0591-MONOMER
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR011698
- InterPro:   IPR010075
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF07685 GATase_3

EC number: =6.3.5.3

Molecular weight: Translated: 23098; Mature: 23098

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 87-87 ACT_SITE 195-195 ACT_SITE 197-197

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTAVIVFPGSNCDRDMAVALETVTGKAPAMVWHRETGLPEGTDFIALPGGFSYGDYLRS
CCEEEEEECCCCCCCCCEEEEEHHCCCCCEEEEECCCCCCCCCCEEEECCCCCHHHHHHH
GAMAARSPILRAVAEAAGRGVPVLGVCNGFQVLTEAGLLPGALMRNAGLNFVCRTVPLKV
CCHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHCCCCCHHHHHCCCCCEEEEEEEEEE
ENSQSLFTAAYGAGEEIAIPVAHHDGNYFADADTLDRIEGEGRVAFRYLDGVNGSARDIA
CCCCCEEEEECCCCCEEEEEEEECCCCEEECCCHHHHHCCCCEEEEEEECCCCCCHHHHH
GVLNDAGNVLGMMPHPERAIDRAHGGTDGLRLFEAALGVLA
HHHHCCCCEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTAVIVFPGSNCDRDMAVALETVTGKAPAMVWHRETGLPEGTDFIALPGGFSYGDYLRS
CCEEEEEECCCCCCCCCEEEEEHHCCCCCEEEEECCCCCCCCCCEEEECCCCCHHHHHHH
GAMAARSPILRAVAEAAGRGVPVLGVCNGFQVLTEAGLLPGALMRNAGLNFVCRTVPLKV
CCHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHCCCCCHHHHHCCCCCEEEEEEEEEE
ENSQSLFTAAYGAGEEIAIPVAHHDGNYFADADTLDRIEGEGRVAFRYLDGVNGSARDIA
CCCCCEEEEECCCCCEEEEEEEECCCCEEECCCHHHHHCCCCEEEEEEECCCCCCHHHHH
GVLNDAGNVLGMMPHPERAIDRAHGGTDGLRLFEAALGVLA
HHHHCCCCEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA