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The map label for this gene is kefBC [H]

Identifier: 103485882

GI number: 103485882

Start: 399785

End: 401482

Strand: Direct

Name: kefBC [H]

Synonym: Sala_0387

Alternate gene names: 103485882

Gene position: 399785-401482 (Clockwise)

Preceding gene: 103485881

Following gene: 103485887

Centisome position: 11.95

GC content: 56.54

Gene sequence:

>1698_bases
ATGGAAGAACTCTTTTTCTCTGTGTTCATTCTCTTTGCTTCCATCCTGGTGGCCGGCTTGCTGTTTCATCTCATGAAGGC
TCCAACGATCCTGGGCTATATTGCTGTCGGTATTCTTCTGGGGTCCTCAGTCACCGGATTGTTTCCCGATGGTCCGGCGC
TGGACTTCATGGCCGAGGCAGGCATTATCCTCCTGCTGTTCATGGTAGGCTTGGAATTTTCGCTTACCGAATTCTGGAGC
GACAAGGGCAAAATACTGAAGGCTGGCGCGCTGCAGGGGTTTCTTGTCGGGCTGCCCGTGGGAAGCCTCGTTTGGTGCCT
GGGGTGGGGAATCGCGCCCGCGATCTTGCTGGGCGCATCGGTCGCAATGTCCTCGACCGCATTGTCGGCAAAGCAGTTGG
CAGACCACGGGGAATTGACCACCCGGCACGGGCGTGTGGCCATTTCGGTGCTGGTCTTTCAAGACTTGGCGGCCATTCCA
CTACTTGCCATGCTCGCGATCTGGCAATCTGGCGGACAGCCCGGTCCGGTCGAGATATCGCTCGAAATCCTCAAGGTCCT
GGCAATCTTCGCAGTCGCGCTGGTTTTGGCGAGGCCTGTACTCCGCAGCCTGCTGATGGCAATCTATCGGCGCGGCAATT
CCGAGCTGCTGGTCCTTGCCGCTCTCGCGATTATTGCCATGGCAGCGCAATCCGCCCATCTCGCCGGAGCTTCCGCTGCT
CTGGGTGCATTTCTGGCGGGACTTATTTTGGGTGAAAGCGATGTCCGGCACCGGATCGAGGAAGACTTGCGGCCTTTTCG
GGACGTTTTCGCCAGTATTTTCTTCGTCTCGATCGGCTTGCAGCTGGACCTGAGCCAGCTTGGGAGCAGTCCGCTTGCGG
TCCTTGCCTGGCTATTGGTTCTCCTTCCTGCAAAAGCATTGCTGAATTTTATCGCACTGAAGATATCCGGATCCTCTGCG
CGTGATGCGCTGCAGACGGCTGTAATTCTGGCTCATGGTGGGGAATTCGGACTTTTGCTCCTTTCCGGAGCTCTTACCGC
TTCGCTGATATCGACCGAAATGGGCCAGCCACTGCTGCTGGCGCTTGTCGTTTCGATGGGTCTTGGGCCAATTCTTTTCC
GATCTTCGGAAACCATCGCGCGGAACCTCTGCGGCGGGAAATCCGGAATGACCAATCTACCGCAAAGGGAGGAGGTGGAA
GTCGCTCGCGAAGTCAGGGCTTGCATCAATCACATCGTTTTCTGCGGCGCGGACAACCTTGCGCGATCAGCGGCGAGAGC
GGTGAGACTGGCAGAACTCGACTTTGTGATGATCGAACCAGATTTGAGACTTTATTTGACCGCGCGCGAAGAAGGGCTGC
CAGTCATTCTCGGCGACCCGGGTCGCACCGCTACGCTCGAGGCGGCGCGCGCAAACGTCGCGGCGGCAATCGTGATAACG
AAACCGTTTTCGCAAAGGCAAAACCGGATTGTGGACTGGTTTCTCGAAGGCAACGCTCACGGGAAAATCGTCTTGCTCGG
CACATCTCAGGATAGGGATGAGACGATGCACACCGACCAACGGATCCTGCAGTTAGACCCGGAGCTATATCTGGGAATGG
ATTTGGCACGTCTGGTACTGTCGGCTGTCGATCTTCCTAAAAATGAGATCGAGAAAATTTCCTGCACCTTGACTTCCGAT
GCTGCAGACCATGCTTGA

Upstream 100 bases:

>100_bases
GAGGCCGACCGACCTGTCTGACATGCCGTATTTCGTGAAACTGCGAAATGGCTTTGCGCGGCTGTTTTCGCCGATCCTTT
GAAACTGGCGGAAAGCGATA

Downstream 100 bases:

>100_bases
TGTCTGCCCTGCGCACGAATTTACAATGAGCGGCAAGGCCTTATCTGTCGTGTCAGTCGTCGGCTAGCCATGGATCGGGC
TGTACGTTTGCAAGCGGGAG

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MEELFFSVFILFASILVAGLLFHLMKAPTILGYIAVGILLGSSVTGLFPDGPALDFMAEAGIILLLFMVGLEFSLTEFWS
DKGKILKAGALQGFLVGLPVGSLVWCLGWGIAPAILLGASVAMSSTALSAKQLADHGELTTRHGRVAISVLVFQDLAAIP
LLAMLAIWQSGGQPGPVEISLEILKVLAIFAVALVLARPVLRSLLMAIYRRGNSELLVLAALAIIAMAAQSAHLAGASAA
LGAFLAGLILGESDVRHRIEEDLRPFRDVFASIFFVSIGLQLDLSQLGSSPLAVLAWLLVLLPAKALLNFIALKISGSSA
RDALQTAVILAHGGEFGLLLLSGALTASLISTEMGQPLLLALVVSMGLGPILFRSSETIARNLCGGKSGMTNLPQREEVE
VAREVRACINHIVFCGADNLARSAARAVRLAELDFVMIEPDLRLYLTAREEGLPVILGDPGRTATLEAARANVAAAIVIT
KPFSQRQNRIVDWFLEGNAHGKIVLLGTSQDRDETMHTDQRILQLDPELYLGMDLARLVLSAVDLPKNEIEKISCTLTSD
AADHA

Sequences:

>Translated_565_residues
MEELFFSVFILFASILVAGLLFHLMKAPTILGYIAVGILLGSSVTGLFPDGPALDFMAEAGIILLLFMVGLEFSLTEFWS
DKGKILKAGALQGFLVGLPVGSLVWCLGWGIAPAILLGASVAMSSTALSAKQLADHGELTTRHGRVAISVLVFQDLAAIP
LLAMLAIWQSGGQPGPVEISLEILKVLAIFAVALVLARPVLRSLLMAIYRRGNSELLVLAALAIIAMAAQSAHLAGASAA
LGAFLAGLILGESDVRHRIEEDLRPFRDVFASIFFVSIGLQLDLSQLGSSPLAVLAWLLVLLPAKALLNFIALKISGSSA
RDALQTAVILAHGGEFGLLLLSGALTASLISTEMGQPLLLALVVSMGLGPILFRSSETIARNLCGGKSGMTNLPQREEVE
VAREVRACINHIVFCGADNLARSAARAVRLAELDFVMIEPDLRLYLTAREEGLPVILGDPGRTATLEAARANVAAAIVIT
KPFSQRQNRIVDWFLEGNAHGKIVLLGTSQDRDETMHTDQRILQLDPELYLGMDLARLVLSAVDLPKNEIEKISCTLTSD
AADHA
>Mature_565_residues
MEELFFSVFILFASILVAGLLFHLMKAPTILGYIAVGILLGSSVTGLFPDGPALDFMAEAGIILLLFMVGLEFSLTEFWS
DKGKILKAGALQGFLVGLPVGSLVWCLGWGIAPAILLGASVAMSSTALSAKQLADHGELTTRHGRVAISVLVFQDLAAIP
LLAMLAIWQSGGQPGPVEISLEILKVLAIFAVALVLARPVLRSLLMAIYRRGNSELLVLAALAIIAMAAQSAHLAGASAA
LGAFLAGLILGESDVRHRIEEDLRPFRDVFASIFFVSIGLQLDLSQLGSSPLAVLAWLLVLLPAKALLNFIALKISGSSA
RDALQTAVILAHGGEFGLLLLSGALTASLISTEMGQPLLLALVVSMGLGPILFRSSETIARNLCGGKSGMTNLPQREEVE
VAREVRACINHIVFCGADNLARSAARAVRLAELDFVMIEPDLRLYLTAREEGLPVILGDPGRTATLEAARANVAAAIVIT
KPFSQRQNRIVDWFLEGNAHGKIVLLGTSQDRDETMHTDQRILQLDPELYLGMDLARLVLSAVDLPKNEIEKISCTLTSD
AADHA

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=380, Percent_Identity=29.4736842105263, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1786232, Length=496, Percent_Identity=28.4274193548387, Blast_Score=175, Evalue=7e-45,
Organism=Escherichia coli, GI1786685, Length=516, Percent_Identity=28.6821705426357, Blast_Score=164, Evalue=2e-41,
Organism=Escherichia coli, GI1789749, Length=452, Percent_Identity=28.5398230088496, Blast_Score=149, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6322367, Length=393, Percent_Identity=24.1730279898219, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 60080; Mature: 60080

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEELFFSVFILFASILVAGLLFHLMKAPTILGYIAVGILLGSSVTGLFPDGPALDFMAEA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
GIILLLFMVGLEFSLTEFWSDKGKILKAGALQGFLVGLPVGSLVWCLGWGIAPAILLGAS
HHHHHHHHHCCCHHHHHHHCCCCCEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VAMSSTALSAKQLADHGELTTRHGRVAISVLVFQDLAAIPLLAMLAIWQSGGQPGPVEIS
HHHHHHHHHHHHHHCCCCCEECCCHHEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEH
LEILKVLAIFAVALVLARPVLRSLLMAIYRRGNSELLVLAALAIIAMAAQSAHLAGASAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHH
LGAFLAGLILGESDVRHRIEEDLRPFRDVFASIFFVSIGLQLDLSQLGSSPLAVLAWLLV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHCCCCHHHHHHHHHH
LLPAKALLNFIALKISGSSARDALQTAVILAHGGEFGLLLLSGALTASLISTEMGQPLLL
HHHHHHHHHHHEEEECCCCHHHHHHHHEEEEECCCEEHHHHHHHHHHHHHHHHCCCHHHH
ALVVSMGLGPILFRSSETIARNLCGGKSGMTNLPQREEVEVAREVRACINHIVFCGADNL
HHHHHHCCCCEEECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCHH
ARSAARAVRLAELDFVMIEPDLRLYLTAREEGLPVILGDPGRTATLEAARANVAAAIVIT
HHHHHHHHHHEECCEEEECCCEEEEEEECCCCCEEEECCCCCCEEHHHHHCCEEEEEEEE
KPFSQRQNRIVDWFLEGNAHGKIVLLGTSQDRDETMHTDQRILQLDPELYLGMDLARLVL
CCHHHHCCCEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
SAVDLPKNEIEKISCTLTSDAADHA
HHHCCCHHHHHEEEEEEECCCCCCC
>Mature Secondary Structure
MEELFFSVFILFASILVAGLLFHLMKAPTILGYIAVGILLGSSVTGLFPDGPALDFMAEA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
GIILLLFMVGLEFSLTEFWSDKGKILKAGALQGFLVGLPVGSLVWCLGWGIAPAILLGAS
HHHHHHHHHCCCHHHHHHHCCCCCEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VAMSSTALSAKQLADHGELTTRHGRVAISVLVFQDLAAIPLLAMLAIWQSGGQPGPVEIS
HHHHHHHHHHHHHHCCCCCEECCCHHEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEH
LEILKVLAIFAVALVLARPVLRSLLMAIYRRGNSELLVLAALAIIAMAAQSAHLAGASAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHH
LGAFLAGLILGESDVRHRIEEDLRPFRDVFASIFFVSIGLQLDLSQLGSSPLAVLAWLLV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHCCCCHHHHHHHHHH
LLPAKALLNFIALKISGSSARDALQTAVILAHGGEFGLLLLSGALTASLISTEMGQPLLL
HHHHHHHHHHHEEEECCCCHHHHHHHHEEEEECCCEEHHHHHHHHHHHHHHHHCCCHHHH
ALVVSMGLGPILFRSSETIARNLCGGKSGMTNLPQREEVEVAREVRACINHIVFCGADNL
HHHHHHCCCCEEECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCHH
ARSAARAVRLAELDFVMIEPDLRLYLTAREEGLPVILGDPGRTATLEAARANVAAAIVIT
HHHHHHHHHHEECCEEEECCCEEEEEEECCCCCEEEECCCCCCEEHHHHHCCEEEEEEEE
KPFSQRQNRIVDWFLEGNAHGKIVLLGTSQDRDETMHTDQRILQLDPELYLGMDLARLVL
CCHHHHCCCEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
SAVDLPKNEIEKISCTLTSDAADHA
HHHCCCHHHHHEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]