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The map label for this gene is degP [H]

Identifier: 103485877

GI number: 103485877

Start: 394545

End: 395678

Strand: Direct

Name: degP [H]

Synonym: Sala_0382

Alternate gene names: 103485877

Gene position: 394545-395678 (Clockwise)

Preceding gene: 103485876

Following gene: 103485880

Centisome position: 11.79

GC content: 59.44

Gene sequence:

>1134_bases
ATGGATAGATCCCCTAACCTCAAGGTATCGAAGTCAAAAACCTACTTCGAACTCCTTATCATCATGAACGTCCTTCTTCT
TGCCGCTTCAGCAGCCCTCTTGATCAACCAGTCCGCTCCGGTCGCCGAACCACGCGTCGTCACTGCGCGAGGCGATCTTG
GCGCAGATGAACGTGCGACAATCGACCTGTTCCGGAACGCACGCGAGTCCGTCGTCTTCATATCGACACGGCAGCGGGTG
GCCGATTTCTGGACACGCAATGTCTATAGCGTGCCGCGCGGTTCCGGCTCGGGTCTCGTATGGGACGAGGCCGGCCATAT
TGTCACAAATTTCCATGTCATCGAGGGCGCCTCCGAAGCGCAAATCCAGCTTGCTGACGGTCGCCAGTTTTCCGCCACGC
TGGTCGGTGTTAGCCCACAACACGATCTTGCTGTCCTGAAAATAGGCGGTGCGGGCTTCACTGCGCCCGCGCGGGTGCCA
ATCGGCACGAGCATCGATCTGCAGGTGGGGCAGAATGTCTTCGCAATTGGAAACCCGTTCGGCCTAGACTGGACCCTGAC
CAAGGGGATTGTTTCGGCGCTGGATCGTTCGCTGCCGAATGAAAATGGCCCCGACATTCGGCACCTCATCCAGACCGATG
CCGCCATCAATCCAGGCAATTCGGGTGGTCCGCTGCTCGATTCCGCAGGCAGACTGATCGGGATCAATACCGCAATCTAT
AGTCCCTCCGGGGCATCGGCAGGAATCGGCTTTGCCGTGCCGGTTGATACGGTCATGCGGGTCGTGCCGCAGCTCATTTC
GGAAGGGCGCTATACGCGGCCCAGCCTTGGCTTTGAAAGCGATGACGATATAAACGATCGGCTCAAACGCGCTTCGGGGA
TCGAAGGGGTTTTCGTCCTGCGGGTGGATCCCGGGTCCTCGGCGGATCGCGCCGGTCTGGTTGCTGCGCAGCGTACGAGG
CGCGGTGTCGCTCCTGGAGACATCGTTACCGCTCTGAACGGCAAACCCGTTTCCAGAGTCGGCGATCTGCTCGCCCGACT
AGACGATTTTCGGGTCGGACAAAGCGTCGAACTTACGCTGATGCGCGGCGGCGAAGAGCGAATGGTCAGGCTCGAACTCG
AACCGGGAAGCTGA

Upstream 100 bases:

>100_bases
AGCGCTGTATAAGAAGGGTTTGGCAAAAAATACATCATCACGAGCGACCCTGGCCTCACTCGACGGTTGATTTGGGCTGC
CGCGCCCGTAAGTTTCCTCC

Downstream 100 bases:

>100_bases
TGCACGAAGAAGGGCCGGTCCCATCGGTGAGACCAGCCCTCCTGTCTGCCATTAACCGGCGTTGATCGGGATCGTCTTGC
GTCCATGTGCCGCTTCTGCG

Product: peptidase S1 and S6, chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MDRSPNLKVSKSKTYFELLIIMNVLLLAASAALLINQSAPVAEPRVVTARGDLGADERATIDLFRNARESVVFISTRQRV
ADFWTRNVYSVPRGSGSGLVWDEAGHIVTNFHVIEGASEAQIQLADGRQFSATLVGVSPQHDLAVLKIGGAGFTAPARVP
IGTSIDLQVGQNVFAIGNPFGLDWTLTKGIVSALDRSLPNENGPDIRHLIQTDAAINPGNSGGPLLDSAGRLIGINTAIY
SPSGASAGIGFAVPVDTVMRVVPQLISEGRYTRPSLGFESDDDINDRLKRASGIEGVFVLRVDPGSSADRAGLVAAQRTR
RGVAPGDIVTALNGKPVSRVGDLLARLDDFRVGQSVELTLMRGGEERMVRLELEPGS

Sequences:

>Translated_377_residues
MDRSPNLKVSKSKTYFELLIIMNVLLLAASAALLINQSAPVAEPRVVTARGDLGADERATIDLFRNARESVVFISTRQRV
ADFWTRNVYSVPRGSGSGLVWDEAGHIVTNFHVIEGASEAQIQLADGRQFSATLVGVSPQHDLAVLKIGGAGFTAPARVP
IGTSIDLQVGQNVFAIGNPFGLDWTLTKGIVSALDRSLPNENGPDIRHLIQTDAAINPGNSGGPLLDSAGRLIGINTAIY
SPSGASAGIGFAVPVDTVMRVVPQLISEGRYTRPSLGFESDDDINDRLKRASGIEGVFVLRVDPGSSADRAGLVAAQRTR
RGVAPGDIVTALNGKPVSRVGDLLARLDDFRVGQSVELTLMRGGEERMVRLELEPGS
>Mature_377_residues
MDRSPNLKVSKSKTYFELLIIMNVLLLAASAALLINQSAPVAEPRVVTARGDLGADERATIDLFRNARESVVFISTRQRV
ADFWTRNVYSVPRGSGSGLVWDEAGHIVTNFHVIEGASEAQIQLADGRQFSATLVGVSPQHDLAVLKIGGAGFTAPARVP
IGTSIDLQVGQNVFAIGNPFGLDWTLTKGIVSALDRSLPNENGPDIRHLIQTDAAINPGNSGGPLLDSAGRLIGINTAIY
SPSGASAGIGFAVPVDTVMRVVPQLISEGRYTRPSLGFESDDDINDRLKRASGIEGVFVLRVDPGSSADRAGLVAAQRTR
RGVAPGDIVTALNGKPVSRVGDLLARLDDFRVGQSVELTLMRGGEERMVRLELEPGS

Specific function: Serine protease that is required at high temperature. Involved in the degradation of damaged proteins. Shared specificity with hhoA/degQ [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=309, Percent_Identity=31.0679611650485, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI22129776, Length=273, Percent_Identity=35.5311355311355, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI24308541, Length=307, Percent_Identity=29.9674267100977, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI7019477, Length=337, Percent_Identity=30.2670623145401, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1786356, Length=287, Percent_Identity=42.5087108013937, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1789629, Length=286, Percent_Identity=41.958041958042, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1789630, Length=288, Percent_Identity=34.0277777777778, Blast_Score=141, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24646839, Length=338, Percent_Identity=30.7692307692308, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 40037; Mature: 40037

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRSPNLKVSKSKTYFELLIIMNVLLLAASAALLINQSAPVAEPRVVTARGDLGADERAT
CCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCEEEEECCCCCCCCHHH
IDLFRNARESVVFISTRQRVADFWTRNVYSVPRGSGSGLVWDEAGHIVTNFHVIEGASEA
HHHHHCCCCCEEEEECHHHHHHHHHCCEEECCCCCCCEEEEECCCCEEEEEEEEECCCCC
QIQLADGRQFSATLVGVSPQHDLAVLKIGGAGFTAPARVPIGTSIDLQVGQNVFAIGNPF
EEEEECCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCEEEHEECCEEEEECCCC
GLDWTLTKGIVSALDRSLPNENGPDIRHLIQTDAAINPGNSGGPLLDSAGRLIGINTAIY
CCCEEHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHCCCCEEEEEEEEE
SPSGASAGIGFAVPVDTVMRVVPQLISEGRYTRPSLGFESDDDINDRLKRASGIEGVFVL
CCCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEE
RVDPGSSADRAGLVAAQRTRRGVAPGDIVTALNGKPVSRVGDLLARLDDFRVGQSVELTL
EECCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEE
MRGGEERMVRLELEPGS
EECCCCEEEEEEECCCC
>Mature Secondary Structure
MDRSPNLKVSKSKTYFELLIIMNVLLLAASAALLINQSAPVAEPRVVTARGDLGADERAT
CCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCEEEEECCCCCCCCHHH
IDLFRNARESVVFISTRQRVADFWTRNVYSVPRGSGSGLVWDEAGHIVTNFHVIEGASEA
HHHHHCCCCCEEEEECHHHHHHHHHCCEEECCCCCCCEEEEECCCCEEEEEEEEECCCCC
QIQLADGRQFSATLVGVSPQHDLAVLKIGGAGFTAPARVPIGTSIDLQVGQNVFAIGNPF
EEEEECCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCEEEHEECCEEEEECCCC
GLDWTLTKGIVSALDRSLPNENGPDIRHLIQTDAAINPGNSGGPLLDSAGRLIGINTAIY
CCCEEHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHCCCCEEEEEEEEE
SPSGASAGIGFAVPVDTVMRVVPQLISEGRYTRPSLGFESDDDINDRLKRASGIEGVFVL
CCCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEE
RVDPGSSADRAGLVAAQRTRRGVAPGDIVTALNGKPVSRVGDLLARLDDFRVGQSVELTL
EECCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEE
MRGGEERMVRLELEPGS
EECCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1645840; 11677609 [H]