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The map label for this gene is echA12 [H]

Identifier: 103485793

GI number: 103485793

Start: 296539

End: 297327

Strand: Direct

Name: echA12 [H]

Synonym: Sala_0298

Alternate gene names: 103485793

Gene position: 296539-297327 (Clockwise)

Preceding gene: 103485792

Following gene: 103485794

Centisome position: 8.86

GC content: 69.84

Gene sequence:

>789_bases
GTGAGCGCGCTGCTGATCGAGGCGCGCGGTGCGGTCGAGATCGCGACGCTGAACCGGCCCGAACGGCTGAATGCGCTGAA
CGAGGAGCTGGTCGACGAACTCAACGCCTATTTCGGCGGGCTCGTGGAGCGGCCCGACGTGCGCGTCGTGATCCTGCGCG
GCGCGGGGCGCGGTTTCTGCGCGGGACTCGATATTCAGGAGGACCGGGCGGGCGACGAGACGCCGGTGCTTCGCACGCTG
CGCACGCAGACGCGCATCGGCAACATCTATCGCAAGATGCGCGCCTGTCCGCAGCCGGTCATCGCGCTGGGCCATGGCGC
CGCGTGCGGGGGCGGCCTGTCGCTGCTGCTCGCGTCGGACGTGCGCTATGCCACGCCGTCGCTGCGCTGCAATGCCGCCT
ATATCCGCATCGGGCTGGGCGGGTGCGACATGGCGTCGAGCTATTTCCTGCCGCGGCTGGTCGGCGCGAGCCTCGCCGCC
GAGATGATCCTGACCGGGCGCTTTATCGACGCCGAGCGCGCGCTGCGCGCCGGGCTGGTGAGCGAGATCGTCGGGGAGGA
GGCGTTGCTCGACCGCGGACTGGCGCTCGCCGACGAGATGCTGGCGACGAGTCCGCACGGGCTGCGCCTGTCGAAGCAGG
CGCTGAACCTCAACCTCGACGCGCCGAGTCTGGACGCCGCGATGGCGATCGAGGACCGGCAGCAGGTGATTCTGTCGGCG
ACCGAGGATCACAAGGAGGCGCTGGCCGCTTTTCTGGAGAAGCGCGCGCCCGAATATCGCGAGCGATAG

Upstream 100 bases:

>100_bases
GCCCCGCGACCGACCTGCACGCGCCGCTGCTGTTGCTTTGCTCCGACGCCGCGGCGGGCGTCACGGGAAGCGTGTTCACG
ATCGACGACGGGCAGACTTT

Downstream 100 bases:

>100_bases
GATCGCCGCGCACGCCCCATTGACTTGCCATTATATTGGCATAGTAAATGCCATATCCCTTGGGGGTGGGAGTGATGGCA
GCAGGCTGGAGGACCACCAG

Product: enoyl-CoA hydratase/isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MSALLIEARGAVEIATLNRPERLNALNEELVDELNAYFGGLVERPDVRVVILRGAGRGFCAGLDIQEDRAGDETPVLRTL
RTQTRIGNIYRKMRACPQPVIALGHGAACGGGLSLLLASDVRYATPSLRCNAAYIRIGLGGCDMASSYFLPRLVGASLAA
EMILTGRFIDAERALRAGLVSEIVGEEALLDRGLALADEMLATSPHGLRLSKQALNLNLDAPSLDAAMAIEDRQQVILSA
TEDHKEALAAFLEKRAPEYRER

Sequences:

>Translated_262_residues
MSALLIEARGAVEIATLNRPERLNALNEELVDELNAYFGGLVERPDVRVVILRGAGRGFCAGLDIQEDRAGDETPVLRTL
RTQTRIGNIYRKMRACPQPVIALGHGAACGGGLSLLLASDVRYATPSLRCNAAYIRIGLGGCDMASSYFLPRLVGASLAA
EMILTGRFIDAERALRAGLVSEIVGEEALLDRGLALADEMLATSPHGLRLSKQALNLNLDAPSLDAAMAIEDRQQVILSA
TEDHKEALAAFLEKRAPEYRER
>Mature_261_residues
SALLIEARGAVEIATLNRPERLNALNEELVDELNAYFGGLVERPDVRVVILRGAGRGFCAGLDIQEDRAGDETPVLRTLR
TQTRIGNIYRKMRACPQPVIALGHGAACGGGLSLLLASDVRYATPSLRCNAAYIRIGLGGCDMASSYFLPRLVGASLAAE
MILTGRFIDAERALRAGLVSEIVGEEALLDRGLALADEMLATSPHGLRLSKQALNLNLDAPSLDAAMAIEDRQQVILSAT
EDHKEALAAFLEKRAPEYRER

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=270, Percent_Identity=32.2222222222222, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI70995211, Length=249, Percent_Identity=32.9317269076305, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI4502327, Length=268, Percent_Identity=32.4626865671642, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI37594471, Length=193, Percent_Identity=32.1243523316062, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI37594469, Length=193, Percent_Identity=32.1243523316062, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI221136756, Length=203, Percent_Identity=26.6009852216749, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI221136753, Length=203, Percent_Identity=26.6009852216749, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI221307494, Length=205, Percent_Identity=26.8292682926829, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI31542718, Length=248, Percent_Identity=26.6129032258064, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4757966, Length=181, Percent_Identity=29.2817679558011, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI51538581, Length=181, Percent_Identity=29.2817679558011, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI25453481, Length=181, Percent_Identity=29.2817679558011, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI51538573, Length=181, Percent_Identity=29.2817679558011, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4757968, Length=181, Percent_Identity=29.2817679558011, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI49355787, Length=181, Percent_Identity=29.2817679558011, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI20127408, Length=183, Percent_Identity=29.5081967213115, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI116235487, Length=198, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787659, Length=266, Percent_Identity=34.5864661654135, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1787660, Length=261, Percent_Identity=33.7164750957854, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI87082183, Length=252, Percent_Identity=27.7777777777778, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788597, Length=251, Percent_Identity=29.4820717131474, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI221142681, Length=267, Percent_Identity=28.4644194756554, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790281, Length=176, Percent_Identity=30.1136363636364, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788682, Length=196, Percent_Identity=33.1632653061224, Blast_Score=74, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI25145438, Length=252, Percent_Identity=32.1428571428571, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17534483, Length=258, Percent_Identity=29.0697674418605, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17536985, Length=267, Percent_Identity=27.3408239700375, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17554946, Length=255, Percent_Identity=30.1960784313725, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17540714, Length=227, Percent_Identity=28.6343612334802, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17560910, Length=197, Percent_Identity=30.4568527918782, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17549921, Length=253, Percent_Identity=26.8774703557312, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI25144160, Length=191, Percent_Identity=31.413612565445, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25144157, Length=191, Percent_Identity=31.413612565445, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17540306, Length=242, Percent_Identity=28.099173553719, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17535521, Length=257, Percent_Identity=25.6809338521401, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320241, Length=194, Percent_Identity=25.7731958762887, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24653139, Length=267, Percent_Identity=32.9588014981273, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI19920382, Length=249, Percent_Identity=29.718875502008, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI20129971, Length=252, Percent_Identity=30.5555555555556, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24653477, Length=252, Percent_Identity=30.5555555555556, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21357171, Length=196, Percent_Identity=29.5918367346939, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24654903, Length=183, Percent_Identity=25.6830601092896, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19922422, Length=263, Percent_Identity=24.7148288973384, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 28251; Mature: 28120

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALLIEARGAVEIATLNRPERLNALNEELVDELNAYFGGLVERPDVRVVILRGAGRGFC
CCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEE
AGLDIQEDRAGDETPVLRTLRTQTRIGNIYRKMRACPQPVIALGHGAACGGGLSLLLASD
ECCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHCC
VRYATPSLRCNAAYIRIGLGGCDMASSYFLPRLVGASLAAEMILTGRFIDAERALRAGLV
CHHCCCCCEECEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCEECHHHHHHHHHH
SEIVGEEALLDRGLALADEMLATSPHGLRLSKQALNLNLDAPSLDAAMAIEDRQQVILSA
HHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEHHHHEECCCCCCCCHHHHHHHHHHHEEEC
TEDHKEALAAFLEKRAPEYRER
CHHHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure 
SALLIEARGAVEIATLNRPERLNALNEELVDELNAYFGGLVERPDVRVVILRGAGRGFC
CEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEE
AGLDIQEDRAGDETPVLRTLRTQTRIGNIYRKMRACPQPVIALGHGAACGGGLSLLLASD
ECCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHCC
VRYATPSLRCNAAYIRIGLGGCDMASSYFLPRLVGASLAAEMILTGRFIDAERALRAGLV
CHHCCCCCEECEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCEECHHHHHHHHHH
SEIVGEEALLDRGLALADEMLATSPHGLRLSKQALNLNLDAPSLDAAMAIEDRQQVILSA
HHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEHHHHEECCCCCCCCHHHHHHHHHHHEEEC
TEDHKEALAAFLEKRAPEYRER
CHHHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]