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The map label for this gene is lig [H]

Identifier: 103485785

GI number: 103485785

Start: 287765

End: 289417

Strand: Direct

Name: lig [H]

Synonym: Sala_0290

Alternate gene names: 103485785

Gene position: 287765-289417 (Clockwise)

Preceding gene: 103485784

Following gene: 103485786

Centisome position: 8.6

GC content: 66.24

Gene sequence:

>1653_bases
GTGAAGGCGCTTGCCGCCCTGATCGACCGGCTGATCTACACGCGCTCGCGCAACAGCAAGCTGGCGCTGATTGCCGATTA
TCTGAGGTGCACGCCCGACCCCGATCGTGGCTGGGCGATCGCGGCGCTGACCGAGAGCCTCGACTTTCCGGCGGTGAAGG
CGGGGATGGTGCGTGCATTGCTGGCGACGCGGGTCGATGAGCAATTGTTCCGGCTGTCGCGCCATTTTGTGGGCGACACG
GCCGAGACGGCAGCGCTGCTGTGGCCTGAACCTTTTCAGCCCTCCCCTTCAGGGGAGGGGCTGGGGGTGGGGGCCATCGG
CCTTGCACAAGGTGTCGAGCCCCCACCCCAAACCCCTCCCCTGAAGGGGAGGGGCTTAACTGTCACCCAAGCCGTCGACG
CGCTGGCGGCGGCAAGCCGCAGCGATGCGCCCGCTATCCTCGCCGATCTGCTCGACCGGCTCGACGCCGATGGGCGTTAT
GCGCTGCTCAAGCTCGCGCTCGGCGGGATGCGCGTCGGCGTGTCGGCGCGGCTCGCCAAACAGGCGTTTGCGCAGGCCTT
CGACGTGCCTGTCGACGATGTCGAGGAGCTGTGGCACGCGATCCCGCCGCCCTATGCGCCACTCTTTGCATGGGGCGAGG
GGCGCGCTGAGCGCCCCGACCTTGCCGATGTCGCCTTTTTCCGCCCCTTCATGCTCGCGCATCCGCTGGAGGAGGAAAGC
GTCGATCTTGCCGACTATGCCGCCGAATGGAAATGGGACGGCATCCGCGTCCAGATCGTGCGCGGCGGCGGCGAAACGCG
CATCTACAGCCGCGGCGGTGAGGAAATCGGCGCCGCTTTCCCCGAACTGATCGCGGCGTTCGATCAGGATGCGGTGATCG
ATGGCGAATTGCTCGTGCGTGGCGAGGTGCAGGGCGGGGAAGCGGCAAGCTTCAACGCGTTGCAACAACGCCTCGGCCGC
AAGACCGTTTCGAAGAAGATGCTCGCCGACTATCCGGCCTTCGTGCGCGTCTATGACCTGTTGGCGGTTGATGGCGACGA
CCTGCGCCCTCTGCCATGGACCGAACGACGGCGGCGGCTGGAGGCGTTCGTGCCGCGCCTCGCCAGCAGCCATTTCGACC
TGTCGCAACTGATCGAGGCGGCCGATTTCGACGACCTCGCCGAACGCCGCGCGGGCGCGCGCGATGCCGCGATCGAGGGG
GTGATGCTCAAGCGCCGCGACGCACCCTATGTCGCGGGCCGCCGCGCGGGACTCTGGTATAAATGGAAACGCGACCCGCT
CACCGCCGATTGCGTGATGATGTATGCGCAGCGCGGTAACGGGCGGCGCGCGAGCTTCTATTCGGACTATACCTTCGGCT
GCTGGTCCGACGCGGGCGAATTGCTGCCGGTGGGCAAGGCCTATTCGGGCTTTACCGACGAAGAGCTGAAATGGCTCGAC
AAGTTCGTGCGCGAACACACGCTGAACCGTTTCGGGCCGGTGCGCGAAGTCGAAAAGTCGCTCGTGCTCGAAGTCGCCTT
CGATTCGATCCACAGCAGCAAGCGCCACAAATCAGGGCTCGCCATGCGTTTCCCGCGCATTTCGCGCATCCGCCGCGACA
AGCCCGCGGAAGAGGCCGACCGGATCGCGACCTTGCGGGCGATGGTGACCTGA

Upstream 100 bases:

>100_bases
TCACCCACGGCAGCGAGGACGGTTTGCTGCGCTGGTGCGAATTGCATCAGCGTCAGGCGCGCGCGCTGCACCTCGTCGGT
CGCGATCTGGAGGAAGAGGC

Downstream 100 bases:

>100_bases
TTGCCCTTCGTCATTGCGAGCGGAGCGAAGCAATCCCCAGCCACCGTTGTGGCGCGGCGTCGATGGCTGGAGATTGCTTC
GTCGCTTTGCTCCTCGCAAT

Product: ATP-dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MKALAALIDRLIYTRSRNSKLALIADYLRCTPDPDRGWAIAALTESLDFPAVKAGMVRALLATRVDEQLFRLSRHFVGDT
AETAALLWPEPFQPSPSGEGLGVGAIGLAQGVEPPPQTPPLKGRGLTVTQAVDALAAASRSDAPAILADLLDRLDADGRY
ALLKLALGGMRVGVSARLAKQAFAQAFDVPVDDVEELWHAIPPPYAPLFAWGEGRAERPDLADVAFFRPFMLAHPLEEES
VDLADYAAEWKWDGIRVQIVRGGGETRIYSRGGEEIGAAFPELIAAFDQDAVIDGELLVRGEVQGGEAASFNALQQRLGR
KTVSKKMLADYPAFVRVYDLLAVDGDDLRPLPWTERRRRLEAFVPRLASSHFDLSQLIEAADFDDLAERRAGARDAAIEG
VMLKRRDAPYVAGRRAGLWYKWKRDPLTADCVMMYAQRGNGRRASFYSDYTFGCWSDAGELLPVGKAYSGFTDEELKWLD
KFVREHTLNRFGPVREVEKSLVLEVAFDSIHSSKRHKSGLAMRFPRISRIRRDKPAEEADRIATLRAMVT

Sequences:

>Translated_550_residues
MKALAALIDRLIYTRSRNSKLALIADYLRCTPDPDRGWAIAALTESLDFPAVKAGMVRALLATRVDEQLFRLSRHFVGDT
AETAALLWPEPFQPSPSGEGLGVGAIGLAQGVEPPPQTPPLKGRGLTVTQAVDALAAASRSDAPAILADLLDRLDADGRY
ALLKLALGGMRVGVSARLAKQAFAQAFDVPVDDVEELWHAIPPPYAPLFAWGEGRAERPDLADVAFFRPFMLAHPLEEES
VDLADYAAEWKWDGIRVQIVRGGGETRIYSRGGEEIGAAFPELIAAFDQDAVIDGELLVRGEVQGGEAASFNALQQRLGR
KTVSKKMLADYPAFVRVYDLLAVDGDDLRPLPWTERRRRLEAFVPRLASSHFDLSQLIEAADFDDLAERRAGARDAAIEG
VMLKRRDAPYVAGRRAGLWYKWKRDPLTADCVMMYAQRGNGRRASFYSDYTFGCWSDAGELLPVGKAYSGFTDEELKWLD
KFVREHTLNRFGPVREVEKSLVLEVAFDSIHSSKRHKSGLAMRFPRISRIRRDKPAEEADRIATLRAMVT
>Mature_550_residues
MKALAALIDRLIYTRSRNSKLALIADYLRCTPDPDRGWAIAALTESLDFPAVKAGMVRALLATRVDEQLFRLSRHFVGDT
AETAALLWPEPFQPSPSGEGLGVGAIGLAQGVEPPPQTPPLKGRGLTVTQAVDALAAASRSDAPAILADLLDRLDADGRY
ALLKLALGGMRVGVSARLAKQAFAQAFDVPVDDVEELWHAIPPPYAPLFAWGEGRAERPDLADVAFFRPFMLAHPLEEES
VDLADYAAEWKWDGIRVQIVRGGGETRIYSRGGEEIGAAFPELIAAFDQDAVIDGELLVRGEVQGGEAASFNALQQRLGR
KTVSKKMLADYPAFVRVYDLLAVDGDDLRPLPWTERRRRLEAFVPRLASSHFDLSQLIEAADFDDLAERRAGARDAAIEG
VMLKRRDAPYVAGRRAGLWYKWKRDPLTADCVMMYAQRGNGRRASFYSDYTFGCWSDAGELLPVGKAYSGFTDEELKWLD
KFVREHTLNRFGPVREVEKSLVLEVAFDSIHSSKRHKSGLAMRFPRISRIRRDKPAEEADRIATLRAMVT

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=359, Percent_Identity=26.7409470752089, Blast_Score=98, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71985269, Length=495, Percent_Identity=27.8787878787879, Blast_Score=115, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6320038, Length=339, Percent_Identity=28.6135693215339, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24762424, Length=329, Percent_Identity=29.483282674772, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI85815841, Length=331, Percent_Identity=29.9093655589124, Blast_Score=99, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 60879; Mature: 60879

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00697 DNA_LIGASE_A1 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALAALIDRLIYTRSRNSKLALIADYLRCTPDPDRGWAIAALTESLDFPAVKAGMVRAL
CCHHHHHHHHHHHHCCCCCCEEHEEHHHHCCCCCCCCEEEEEHHHCCCCCHHHHHHHHHH
LATRVDEQLFRLSRHFVGDTAETAALLWPEPFQPSPSGEGLGVGAIGLAQGVEPPPQTPP
HHHHHHHHHHHHHHHHCCCCHHCEEEECCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCC
LKGRGLTVTQAVDALAAASRSDAPAILADLLDRLDADGRYALLKLALGGMRVGVSARLAK
CCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCHHCCHHHHHHH
QAFAQAFDVPVDDVEELWHAIPPPYAPLFAWGEGRAERPDLADVAFFRPFMLAHPLEEES
HHHHHHHCCCHHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
VDLADYAAEWKWDGIRVQIVRGGGETRIYSRGGEEIGAAFPELIAAFDQDAVIDGELLVR
CCHHHHHHHCEECCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHCCCCCEECCCEEEE
GEVQGGEAASFNALQQRLGRKTVSKKMLADYPAFVRVYDLLAVDGDDLRPLPWTERRRRL
EECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
EAFVPRLASSHFDLSQLIEAADFDDLAERRAGARDAAIEGVMLKRRDAPYVAGRRAGLWY
HHHHHHHHCCCCCHHHHHHHCCHHHHHHHHCCCHHHHHHHHHEECCCCCCCCCCCCCCEE
KWKRDPLTADCVMMYAQRGNGRRASFYSDYTFGCWSDAGELLPVGKAYSGFTDEELKWLD
EECCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHH
KFVREHTLNRFGPVREVEKSLVLEVAFDSIHSSKRHKSGLAMRFPRISRIRRDKPAEEAD
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHCCCCHHHHH
RIATLRAMVT
HHHHHHHHCC
>Mature Secondary Structure
MKALAALIDRLIYTRSRNSKLALIADYLRCTPDPDRGWAIAALTESLDFPAVKAGMVRAL
CCHHHHHHHHHHHHCCCCCCEEHEEHHHHCCCCCCCCEEEEEHHHCCCCCHHHHHHHHHH
LATRVDEQLFRLSRHFVGDTAETAALLWPEPFQPSPSGEGLGVGAIGLAQGVEPPPQTPP
HHHHHHHHHHHHHHHHCCCCHHCEEEECCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCC
LKGRGLTVTQAVDALAAASRSDAPAILADLLDRLDADGRYALLKLALGGMRVGVSARLAK
CCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCHHCCHHHHHHH
QAFAQAFDVPVDDVEELWHAIPPPYAPLFAWGEGRAERPDLADVAFFRPFMLAHPLEEES
HHHHHHHCCCHHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
VDLADYAAEWKWDGIRVQIVRGGGETRIYSRGGEEIGAAFPELIAAFDQDAVIDGELLVR
CCHHHHHHHCEECCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHCCCCCEECCCEEEE
GEVQGGEAASFNALQQRLGRKTVSKKMLADYPAFVRVYDLLAVDGDDLRPLPWTERRRRL
EECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
EAFVPRLASSHFDLSQLIEAADFDDLAERRAGARDAAIEGVMLKRRDAPYVAGRRAGLWY
HHHHHHHHCCCCCHHHHHHHCCHHHHHHHHCCCHHHHHHHHHEECCCCCCCCCCCCCCEE
KWKRDPLTADCVMMYAQRGNGRRASFYSDYTFGCWSDAGELLPVGKAYSGFTDEELKWLD
EECCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHH
KFVREHTLNRFGPVREVEKSLVLEVAFDSIHSSKRHKSGLAMRFPRISRIRRDKPAEEAD
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHCCCCHHHHH
RIATLRAMVT
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA