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The map label for this gene is fabF [H]

Identifier: 103485776

GI number: 103485776

Start: 278556

End: 279815

Strand: Direct

Name: fabF [H]

Synonym: Sala_0281

Alternate gene names: 103485776

Gene position: 278556-279815 (Clockwise)

Preceding gene: 103485775

Following gene: 103485780

Centisome position: 8.33

GC content: 65.16

Gene sequence:

>1260_bases
ATGCGCCGGGTTGTGGTGACGGGTTTGGGTTTGGTGACGCCGCTGGGCGGCGACGTCGAAACCAGCTGGAAAAATCTGAT
CGCGGGCAAATCGGGTGCGGGTCCGATCACGAAATTCGACGCATCGGACCAGAAATGCACCATCGCGTGCGAGGTGAAGC
CCGCCGACCATGAATATGGCTTCGACCCGATGAAGCGCGTCGATCACAAGGTGCAGCGGCAGGTCGATCCCTTCATCATC
TATGGCATCGATGCGGCGGGCCAGGCGCTCGAGGATGCGGGGCTGACCGAGCTGACCGAGGAACAGAAGGTGCGCGCGGG
CTGCTCGATCGGTTCGGGCATCGGCGGGCTGCCGGGCATCGAGAGCGAAAGCCTGCTGCTCGCCGAAAAGGGGCCGGGCC
GCGTCAGTCCACACTTCGTCCACGGTCGCCTGATCAACCTGATTTCGGGCCAGGTCAGCATCAAATATGGGCTCAAGGGC
CCCAACCACGCGGTCGTCACCGCCTGTTCGACCGGCGCGCATTCGATCGGCGACGCGGCGCGGATGATCAAGGACGACGA
TGCCGACATCATGCTCGCGGGCGGCGCCGAGGCGACGATCTGCCCGATCGGCATCGCCGGCTTCGCACAGGCGCGCGCGC
TCAACATGCGCTTCAACGACCGCCCCGAACAGGCGAGCCGCCCCTATGACAGGGACCGCGACGGTTTCGTGATGGGCGAG
GGCGCCGGCGTCGTCGTGCTCGAGGAATATGAACATGCCAAGGCGCGGGGCGCCAAAATCTACGCCGAAGTCGTCGGTTA
CGGCCTGTCGGGCGACGCCTATCACGTCACCGCGCCCGATCCCGAAATGGACGGCGCCTTCCGCTCGATGCAGGCGGCGC
TCAAAAAGGCGGGCATGACCCCCGCCGACATCGACTATATCAACGCGCACGGCACCTCGACGATGGCTGACACGATCGAG
CTTGGCGCGGTGAAGCGGCTGTTCGGCGATGCGATGGCCAATGTGTCGATGAGTTCCACCAAATCGGCGATCGGCCACCT
GCTCGGCGGCGCGGGCGCGGTCGAGACGATCTTCTGCATCCTCGCGATCCGCGACCAGATCGTGCCCCCGACGCTCAACC
TCGACAACCCCGACGAAGGGACCGAGGGTGCCGACCTGGTTCCCAAGGTCGCGAAAAGGCGCAAGGTGCGCGCGGCGCTC
AACAACAGCTTTGGTTTCGGCGGCACCAACGCCAGCCTGATCGTCAAGGCGATCGACTGA

Upstream 100 bases:

>100_bases
ATGGCCCCGCGCCCTGTGACCGGGAAGCCTTTTTCTTGGGCAGGCGATTGATGGATGAATGCGGACACCTGCGGGGGCAG
GGTCGACGAAAGGAAAGATT

Downstream 100 bases:

>100_bases
TCGTCTCCTTCGCGGCGGCCTGCGGTGGGAAGCAGTCGTCGCGAATGCTCCGACGGGTGAAGCGTGACCGGTTTGCCGGC
GGGGCACGCCGCTCCAGGTT

Product: beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MRRVVVTGLGLVTPLGGDVETSWKNLIAGKSGAGPITKFDASDQKCTIACEVKPADHEYGFDPMKRVDHKVQRQVDPFII
YGIDAAGQALEDAGLTELTEEQKVRAGCSIGSGIGGLPGIESESLLLAEKGPGRVSPHFVHGRLINLISGQVSIKYGLKG
PNHAVVTACSTGAHSIGDAARMIKDDDADIMLAGGAEATICPIGIAGFAQARALNMRFNDRPEQASRPYDRDRDGFVMGE
GAGVVVLEEYEHAKARGAKIYAEVVGYGLSGDAYHVTAPDPEMDGAFRSMQAALKKAGMTPADIDYINAHGTSTMADTIE
LGAVKRLFGDAMANVSMSSTKSAIGHLLGGAGAVETIFCILAIRDQIVPPTLNLDNPDEGTEGADLVPKVAKRRKVRAAL
NNSFGFGGTNASLIVKAID

Sequences:

>Translated_419_residues
MRRVVVTGLGLVTPLGGDVETSWKNLIAGKSGAGPITKFDASDQKCTIACEVKPADHEYGFDPMKRVDHKVQRQVDPFII
YGIDAAGQALEDAGLTELTEEQKVRAGCSIGSGIGGLPGIESESLLLAEKGPGRVSPHFVHGRLINLISGQVSIKYGLKG
PNHAVVTACSTGAHSIGDAARMIKDDDADIMLAGGAEATICPIGIAGFAQARALNMRFNDRPEQASRPYDRDRDGFVMGE
GAGVVVLEEYEHAKARGAKIYAEVVGYGLSGDAYHVTAPDPEMDGAFRSMQAALKKAGMTPADIDYINAHGTSTMADTIE
LGAVKRLFGDAMANVSMSSTKSAIGHLLGGAGAVETIFCILAIRDQIVPPTLNLDNPDEGTEGADLVPKVAKRRKVRAAL
NNSFGFGGTNASLIVKAID
>Mature_419_residues
MRRVVVTGLGLVTPLGGDVETSWKNLIAGKSGAGPITKFDASDQKCTIACEVKPADHEYGFDPMKRVDHKVQRQVDPFII
YGIDAAGQALEDAGLTELTEEQKVRAGCSIGSGIGGLPGIESESLLLAEKGPGRVSPHFVHGRLINLISGQVSIKYGLKG
PNHAVVTACSTGAHSIGDAARMIKDDDADIMLAGGAEATICPIGIAGFAQARALNMRFNDRPEQASRPYDRDRDGFVMGE
GAGVVVLEEYEHAKARGAKIYAEVVGYGLSGDAYHVTAPDPEMDGAFRSMQAALKKAGMTPADIDYINAHGTSTMADTIE
LGAVKRLFGDAMANVSMSSTKSAIGHLLGGAGAVETIFCILAIRDQIVPPTLNLDNPDEGTEGADLVPKVAKRRKVRAAL
NNSFGFGGTNASLIVKAID

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=420, Percent_Identity=48.8095238095238, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI223972627, Length=151, Percent_Identity=52.317880794702, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI41872631, Length=447, Percent_Identity=22.5950782997763, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1787337, Length=419, Percent_Identity=53.9379474940334, Blast_Score=396, Evalue=1e-111,
Organism=Escherichia coli, GI1788663, Length=421, Percent_Identity=36.8171021377672, Blast_Score=246, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI71983541, Length=426, Percent_Identity=39.4366197183099, Blast_Score=265, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=46.7924528301887, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI212642053, Length=356, Percent_Identity=26.123595505618, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17550940, Length=422, Percent_Identity=22.5118483412322, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=443, Percent_Identity=40.6320541760722, Blast_Score=289, Evalue=6e-79,
Organism=Drosophila melanogaster, GI24644341, Length=419, Percent_Identity=45.346062052506, Blast_Score=340, Evalue=9e-94,
Organism=Drosophila melanogaster, GI19920632, Length=382, Percent_Identity=25.6544502617801, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI221330659, Length=382, Percent_Identity=25.6544502617801, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24581345, Length=383, Percent_Identity=23.4986945169713, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43974; Mature: 43974

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGLGLVTPLGGDVETSWKNLIAGKSGAGPITKFDASDQKCTIACEVKPADHEYG
CCEEEEECCCEECCCCCCCHHHHHHHHCCCCCCCCCEEECCCCCEEEEEEEEECCCCCCC
FDPMKRVDHKVQRQVDPFIIYGIDAAGQALEDAGLTELTEEQKVRAGCSIGSGIGGLPGI
CCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCC
ESESLLLAEKGPGRVSPHFVHGRLINLISGQVSIKYGLKGPNHAVVTACSTGAHSIGDAA
CCCCEEEEECCCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCEEEEEECCCCCHHHHHH
RMIKDDDADIMLAGGAEATICPIGIAGFAQARALNMRFNDRPEQASRPYDRDRDGFVMGE
HHHCCCCCCEEEECCCCCEEEEECHHHHHHHEEEECCCCCCCHHHCCCCCCCCCCEEEEC
GAGVVVLEEYEHAKARGAKIYAEVVGYGLSGDAYHVTAPDPEMDGAFRSMQAALKKAGMT
CCCEEEEECCCHHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCC
PADIDYINAHGTSTMADTIELGAVKRLFGDAMANVSMSSTKSAIGHLLGGAGAVETIFCI
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHH
LAIRDQIVPPTLNLDNPDEGTEGADLVPKVAKRRKVRAALNNSFGFGGTNASLIVKAID
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEC
>Mature Secondary Structure
MRRVVVTGLGLVTPLGGDVETSWKNLIAGKSGAGPITKFDASDQKCTIACEVKPADHEYG
CCEEEEECCCEECCCCCCCHHHHHHHHCCCCCCCCCEEECCCCCEEEEEEEEECCCCCCC
FDPMKRVDHKVQRQVDPFIIYGIDAAGQALEDAGLTELTEEQKVRAGCSIGSGIGGLPGI
CCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCC
ESESLLLAEKGPGRVSPHFVHGRLINLISGQVSIKYGLKGPNHAVVTACSTGAHSIGDAA
CCCCEEEEECCCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCEEEEEECCCCCHHHHHH
RMIKDDDADIMLAGGAEATICPIGIAGFAQARALNMRFNDRPEQASRPYDRDRDGFVMGE
HHHCCCCCCEEEECCCCCEEEEECHHHHHHHEEEECCCCCCCHHHCCCCCCCCCCEEEEC
GAGVVVLEEYEHAKARGAKIYAEVVGYGLSGDAYHVTAPDPEMDGAFRSMQAALKKAGMT
CCCEEEEECCCHHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCC
PADIDYINAHGTSTMADTIELGAVKRLFGDAMANVSMSSTKSAIGHLLGGAGAVETIFCI
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHH
LAIRDQIVPPTLNLDNPDEGTEGADLVPKVAKRRKVRAALNNSFGFGGTNASLIVKAID
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]