Click here to switch to the map view.

The map label for this gene is carI [H]

Identifier: 222109224

GI number: 222109224

Start: 129203

End: 129871

Strand: Direct

Name: carI [H]

Synonym: Avi_9666

Alternate gene names: 222109224

Gene position: 129203-129871 (Clockwise)

Preceding gene: 222109223

Following gene: NA

Centisome position: 99.06

GC content: 54.41

Gene sequence:

>669_bases
ATGTTGGTTCATGTCATTACTTCTTCGAATAGCGCATTATATCCAACTGAACTGGATGAACTTTTCCGAATTCGCCACAA
GATCTACGTGGAAGAAAAGGGGTGGCGTGAAACATCGCCTGATGGAATGGAACGCGACCAGTTCGATACCGAGCATGCCG
TTCATCTCGTAGGAATCGAGGATGGGCGAATTATTGCAGGGTCAAGGTTTGTTCCAACCACGCAACCGCACCTGCTCAGC
GAGGTGTTCCCGCATCTTTGCACCCGGCCAGGCGTTCTTCGCCATGAACGCGTCGCTGAGTGGACCCGTGGGTTCATCAT
CCCGGAGTTCCGCGAGAAGGCCGGTCTTTTGATCAAGGCGCAATTCTGCACCGCCGTCATGGAATATTGCTTGAACCAGG
GCATCGAGCAGATAGGCGGAATCCAGGAGATCTACTGGTTGCCATTGTGGAAGCGTTTCGGTTGGCGGGTCAAAGTGATC
GGGGATGCGGCCGAAATTGATAGTGTCCTGTGTGTCCCGGCATATTTCGAGGTCTCCGTTGAGGCCTTGGAAGGCGTGCG
CAGACGGGCCAATCTTTCCAGCAGCAACCTGATCGAACAGGGAAGGCTCGAACCGTTCGTTCCGGCACAGGCTCCCGCTT
TCGATGTCTCGGTATTCTCGGCGGTATAG

Upstream 100 bases:

>100_bases
GGCCTGATCAATTCGGTCTAGCTTGTCAAGATAAGGAACCTGAACTTTCGCGAATCGTGGAGGCATCTAAAGTTGCGTCA
TCTTTCAAGAGGACGCGCAG

Downstream 100 bases:

>100_bases
CTCCGACCCTTTGAAACTTCCCCTCTCCTCTCGTGGGAGGGGCAGGTCCTGTAGAGATGATGGAGCCACGCGATTAATGG
ATACAGCTGTTAAAAGAACA

Product: autoinducer (acylhomoserine lactone) synthase

Products: NA

Alternate protein names: Autoinducer synthesis protein CarI [H]

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MLVHVITSSNSALYPTELDELFRIRHKIYVEEKGWRETSPDGMERDQFDTEHAVHLVGIEDGRIIAGSRFVPTTQPHLLS
EVFPHLCTRPGVLRHERVAEWTRGFIIPEFREKAGLLIKAQFCTAVMEYCLNQGIEQIGGIQEIYWLPLWKRFGWRVKVI
GDAAEIDSVLCVPAYFEVSVEALEGVRRRANLSSSNLIEQGRLEPFVPAQAPAFDVSVFSAV

Sequences:

>Translated_222_residues
MLVHVITSSNSALYPTELDELFRIRHKIYVEEKGWRETSPDGMERDQFDTEHAVHLVGIEDGRIIAGSRFVPTTQPHLLS
EVFPHLCTRPGVLRHERVAEWTRGFIIPEFREKAGLLIKAQFCTAVMEYCLNQGIEQIGGIQEIYWLPLWKRFGWRVKVI
GDAAEIDSVLCVPAYFEVSVEALEGVRRRANLSSSNLIEQGRLEPFVPAQAPAFDVSVFSAV
>Mature_222_residues
MLVHVITSSNSALYPTELDELFRIRHKIYVEEKGWRETSPDGMERDQFDTEHAVHLVGIEDGRIIAGSRFVPTTQPHLLS
EVFPHLCTRPGVLRHERVAEWTRGFIIPEFREKAGLLIKAQFCTAVMEYCLNQGIEQIGGIQEIYWLPLWKRFGWRVKVI
GDAAEIDSVLCVPAYFEVSVEALEGVRRRANLSSSNLIEQGRLEPFVPAQAPAFDVSVFSAV

Specific function: Required for the synthesis of OHHL (N-(3-oxohexanoyl)-L- homoserine lactone), an autoinducer molecule which binds to CarR and thus acts in the control of the biosynthesis of carbapenem antibiotics [H]

COG id: COG3916

COG function: function code TQ; N-acyl-L-homoserine lactone synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the autoinducer synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016181
- InterPro:   IPR001690
- InterPro:   IPR018311 [H]

Pfam domain/function: PF00765 Autoind_synth [H]

EC number: =2.3.1.184 [H]

Molecular weight: Translated: 25207; Mature: 25207

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVHVITSSNSALYPTELDELFRIRHKIYVEEKGWRETSPDGMERDQFDTEHAVHLVGIE
CEEEEEECCCCEECCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEC
DGRIIAGSRFVPTTQPHLLSEVFPHLCTRPGVLRHERVAEWTRGFIIPEFREKAGLLIKA
CCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHCCCEEEH
QFCTAVMEYCLNQGIEQIGGIQEIYWLPLWKRFGWRVKVIGDAAEIDSVLCVPAYFEVSV
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEECCHHHHCCEEEECHHHHHHH
EALEGVRRRANLSSSNLIEQGRLEPFVPAQAPAFDVSVFSAV
HHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHCC
>Mature Secondary Structure
MLVHVITSSNSALYPTELDELFRIRHKIYVEEKGWRETSPDGMERDQFDTEHAVHLVGIE
CEEEEEECCCCEECCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEC
DGRIIAGSRFVPTTQPHLLSEVFPHLCTRPGVLRHERVAEWTRGFIIPEFREKAGLLIKA
CCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHCCCEEEH
QFCTAVMEYCLNQGIEQIGGIQEIYWLPLWKRFGWRVKVIGDAAEIDSVLCVPAYFEVSV
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEECCHHHHCCEEEECHHHHHHH
EALEGVRRRANLSSSNLIEQGRLEPFVPAQAPAFDVSVFSAV
HHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7968529 [H]