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The map label for this gene is gcvT [H]

Identifier: 229007177

GI number: 229007177

Start: 1461090

End: 1462229

Strand: Reverse

Name: gcvT [H]

Synonym: Atu1464

Alternate gene names: 229007177

Gene position: 1462229-1461090 (Counterclockwise)

Preceding gene: 15888793

Following gene: 15888789

Centisome position: 51.46

GC content: 60.96

Gene sequence:

>1140_bases
TTGGACGATACCGCCGCGCTGAAAACCACGCCGCTGCATTCCCTGCACACATCGCTTGGCGCCCGTATGGTGCCTTTCGC
CGGTTACGACATGCCTGTGCAATATCCGGCCGGCGTGCTGAAGGAACATCTTCAGACCCGCACCTCCGCCGGTCTGTTTG
ACGTGTCCCACATGGGCCAGGTGATCCTGAAGGCGAGGTCCGGCAACAATGAAGATGCCGCACGCGCGCTCGAAAAGCTG
GTGCCGGTCGATATTTTCGGTCTCAAGGAAGGCCGCCAGCGCTACGGTTTCTTCACAGACGACAACGGCAACATTCTCGA
CGATCTGATGATCACCAATCGTGGCGATCATCTTTTCGTCGTCGTCAATGCTTCCTGCAAGGATGCCGATGTCGCCCATA
TGAAGGCGCATCTTTCCGATACCTGCGAGATCACTCTTCTCGTTGACCGCGCCCTGATCGCGCTGCAGGGACCGCGCGCC
GAAGCGGTGCTTGCAGAACTGTGGGCTGGCGTTTCCGAGATGAAGTTCATGGACGTGCAGGGAGTACCGCTGCATGATGT
GCCCTGCATCGTTTCCCGTTCCGGCTACTCCGGAGAAGACGGCTTTGAAATTTCGGTGCCCGCGGACAAGGCTGAGGAAA
TCGCCAAAGCCCTGCTCGAACATCCTGATTGCGAGCCGATCGGGCTTGGCGCGCGTGACAGCCTGCGCCTGGAAGCGGGC
CTTTGTCTTTATGGTAACGATATCGACACCACGACCTCCCCCATCGAAGCCTCGCTCGAATGGGCGATCCAGAAGGCGCG
CCGCGCCGGCGGTGAACGCGAAGGCGGTTTTCCGGGTGCAGAACGCATTCTCCGCGAGCTCAAGGACGGCACATCGCGCC
GCCGTGTCGGTCTGAAGCCGGAAGGCAAGGCCCCGGTGCGCGGCCATTCGAAGCTTTTTGCGGATGCCGAAGGCGTGACG
GAAATCGGCGAAGTGACGTCCGGCGGTTTCGGCCCCTCGGTCGAAGGCCCTGTCGCCATGGGATACGTGCCTGTTTCCTA
CGCGGCTCCCGGTACGGCGATCTTTGCGGAAGTGCGCGGCAAATATCTGCCCGTCACCGTCGCCGCCCTGCCCTTCATCA
AGCCCACCTACAAACGCTAA

Upstream 100 bases:

>100_bases
TAACAATCTCAGGCGACAAGGACAGAGGGGGCTCTTGAACCGGCGCTTTCGCGCCATGACCTGAGCCCGCGCGATTGTTC
GCGTAACCCTGGAGGCGTCC

Downstream 100 bases:

>100_bases
TCCTCATTCCATCTCCGGAGAGAACACGATGCTGAAATTTACCGCAGAACACGAATGGCTGAAGTTCGAAGGCGATATCG
CCACCGTCGGCATCACCAGC

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MDDTAALKTTPLHSLHTSLGARMVPFAGYDMPVQYPAGVLKEHLQTRTSAGLFDVSHMGQVILKARSGNNEDAARALEKL
VPVDIFGLKEGRQRYGFFTDDNGNILDDLMITNRGDHLFVVVNASCKDADVAHMKAHLSDTCEITLLVDRALIALQGPRA
EAVLAELWAGVSEMKFMDVQGVPLHDVPCIVSRSGYSGEDGFEISVPADKAEEIAKALLEHPDCEPIGLGARDSLRLEAG
LCLYGNDIDTTTSPIEASLEWAIQKARRAGGEREGGFPGAERILRELKDGTSRRRVGLKPEGKAPVRGHSKLFADAEGVT
EIGEVTSGGFGPSVEGPVAMGYVPVSYAAPGTAIFAEVRGKYLPVTVAALPFIKPTYKR

Sequences:

>Translated_379_residues
MDDTAALKTTPLHSLHTSLGARMVPFAGYDMPVQYPAGVLKEHLQTRTSAGLFDVSHMGQVILKARSGNNEDAARALEKL
VPVDIFGLKEGRQRYGFFTDDNGNILDDLMITNRGDHLFVVVNASCKDADVAHMKAHLSDTCEITLLVDRALIALQGPRA
EAVLAELWAGVSEMKFMDVQGVPLHDVPCIVSRSGYSGEDGFEISVPADKAEEIAKALLEHPDCEPIGLGARDSLRLEAG
LCLYGNDIDTTTSPIEASLEWAIQKARRAGGEREGGFPGAERILRELKDGTSRRRVGLKPEGKAPVRGHSKLFADAEGVT
EIGEVTSGGFGPSVEGPVAMGYVPVSYAAPGTAIFAEVRGKYLPVTVAALPFIKPTYKR
>Mature_379_residues
MDDTAALKTTPLHSLHTSLGARMVPFAGYDMPVQYPAGVLKEHLQTRTSAGLFDVSHMGQVILKARSGNNEDAARALEKL
VPVDIFGLKEGRQRYGFFTDDNGNILDDLMITNRGDHLFVVVNASCKDADVAHMKAHLSDTCEITLLVDRALIALQGPRA
EAVLAELWAGVSEMKFMDVQGVPLHDVPCIVSRSGYSGEDGFEISVPADKAEEIAKALLEHPDCEPIGLGARDSLRLEAG
LCLYGNDIDTTTSPIEASLEWAIQKARRAGGEREGGFPGAERILRELKDGTSRRRVGLKPEGKAPVRGHSKLFADAEGVT
EIGEVTSGGFGPSVEGPVAMGYVPVSYAAPGTAIFAEVRGKYLPVTVAALPFIKPTYKR

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=382, Percent_Identity=45.0261780104712, Blast_Score=284, Evalue=9e-77,
Organism=Homo sapiens, GI257796258, Length=363, Percent_Identity=45.4545454545455, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI257796256, Length=317, Percent_Identity=45.7413249211356, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI257796254, Length=376, Percent_Identity=41.4893617021277, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI24797151, Length=361, Percent_Identity=23.5457063711911, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI197927446, Length=329, Percent_Identity=24.0121580547112, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI21361378, Length=329, Percent_Identity=24.0121580547112, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1789272, Length=377, Percent_Identity=35.0132625994695, Blast_Score=184, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17560118, Length=387, Percent_Identity=39.0180878552972, Blast_Score=227, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6320222, Length=394, Percent_Identity=38.5786802030457, Blast_Score=256, Evalue=3e-69,
Organism=Drosophila melanogaster, GI20129441, Length=382, Percent_Identity=40.0523560209424, Blast_Score=261, Evalue=5e-70,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40709; Mature: 40709

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDTAALKTTPLHSLHTSLGARMVPFAGYDMPVQYPAGVLKEHLQTRTSAGLFDVSHMGQ
CCCCCCEECCCHHHHHHHHCCEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHH
VILKARSGNNEDAARALEKLVPVDIFGLKEGRQRYGFFTDDNGNILDDLMITNRGDHLFV
EEEEECCCCCHHHHHHHHHHCCCEEEECCCCHHHCCEEECCCCCEEHHHEEECCCCEEEE
VVNASCKDADVAHMKAHLSDTCEITLLVDRALIALQGPRAEAVLAELWAGVSEMKFMDVQ
EEECCCCCCHHHHHHHHCCCCEEEEEEEEEEHHEECCCCHHHHHHHHHCCHHHCEEEECC
GVPLHDVPCIVSRSGYSGEDGFEISVPADKAEEIAKALLEHPDCEPIGLGARDSLRLEAG
CCCCCCCCEEEECCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCEECCCCCCCEEEECC
LCLYGNDIDTTTSPIEASLEWAIQKARRAGGEREGGFPGAERILRELKDGTSRRRVGLKP
EEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCC
EGKAPVRGHSKLFADAEGVTEIGEVTSGGFGPSVEGPVAMGYVPVSYAAPGTAIFAEVRG
CCCCCCCCCHHHEECCCCHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCEEHHHHCC
KYLPVTVAALPFIKPTYKR
CEEEEEEHHHCCCCCCCCC
>Mature Secondary Structure
MDDTAALKTTPLHSLHTSLGARMVPFAGYDMPVQYPAGVLKEHLQTRTSAGLFDVSHMGQ
CCCCCCEECCCHHHHHHHHCCEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHH
VILKARSGNNEDAARALEKLVPVDIFGLKEGRQRYGFFTDDNGNILDDLMITNRGDHLFV
EEEEECCCCCHHHHHHHHHHCCCEEEECCCCHHHCCEEECCCCCEEHHHEEECCCCEEEE
VVNASCKDADVAHMKAHLSDTCEITLLVDRALIALQGPRAEAVLAELWAGVSEMKFMDVQ
EEECCCCCCHHHHHHHHCCCCEEEEEEEEEEHHEECCCCHHHHHHHHHCCHHHCEEEECC
GVPLHDVPCIVSRSGYSGEDGFEISVPADKAEEIAKALLEHPDCEPIGLGARDSLRLEAG
CCCCCCCCEEEECCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCEECCCCCCCEEEECC
LCLYGNDIDTTTSPIEASLEWAIQKARRAGGEREGGFPGAERILRELKDGTSRRRVGLKP
EEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCC
EGKAPVRGHSKLFADAEGVTEIGEVTSGGFGPSVEGPVAMGYVPVSYAAPGTAIFAEVRG
CCCCCCCCCHHHEECCCCHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCEEHHHHCC
KYLPVTVAALPFIKPTYKR
CEEEEEEHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA