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The map label for this gene is gcp

Identifier: 159185308

GI number: 159185308

Start: 2634510

End: 2635607

Strand: Reverse

Name: gcp

Synonym: Atu2651

Alternate gene names: 159185308

Gene position: 2635607-2634510 (Counterclockwise)

Preceding gene: 159185311

Following gene: 15889906

Centisome position: 92.75

GC content: 63.48

Gene sequence:

>1098_bases
ATGCCCCCCTTTCTTCGTATTCTCGGCATAGAGACAAGCTGTGACGAAACCGCTGCATCCATTGTGGTTCGGCATGCGGA
CGGGCGTGGCGAGATCGTCTCCGATGTCGTTTTGTCGCAGCTTGAGGAACACAGTGCCTATGGCGGTGTGGTGCCGGAAA
TTGCTGCGCGCGCCCATGTCGAGGCGCTGGACACGCTGGTGGAAGAAGCGCTGGATCAGGCGGGCGTCAAGCTTGCCGAT
GTCGACGCCATTGCAGCCACCTCCGGCCCTGGGCTCATCGGTGGGCTACTGGTGGGGCTGATGACCGGCAAGGCCATCGC
CAAGGCGGCCGGCAAACCGCTCTACGCCATCAATCATCTGGAAGGCCACGCGCTGACGGCGCGACTGACCGATGGTCTGT
CTTTTCCCTATCTGATGTTGCTCGTCTCCGGCGGTCACACCCAACTGGTGCTGGTGCGCGGGGTGGGGGAATACGAGCGC
TGGGGCACCACCATCGACGACGCGCTCGGCGAGGCCTTCGACAAGACCGCCAAACTTCTCGGGCTGCCCTATCCCGGTGG
GCCTGCCGTCGAGAACGCGGCGGCGAAGGGTGACCCGGACCGTTTTCCGCTCCCGCGCCCGATGGTTGGGGAAGCACGGC
TCGATTTTTCCTTCTCGGGCTTGAAGACAGCGGTGCGGCAGGCTGCGACCGCCATCGCGCCGCTTTCGGAGCAGGATATT
GCCGATATCTGCGCCTCCTTCCAGAAGGCGGTGTCGCGCACCCTGAAAGACCGTATCGGCCGTGGCCTTGCGCGTTTCAA
AGTAGAATTTCCGCATATCAATGGAGAACCGGCTCTTGTGGTGGCCGGCGGCGTAGCCGCCAACCAGGAAATCCGCCAGA
CCCTGCAGGCACTTTGCGATACACACGGCTTCCGCTTCGTCGCGCCGCCGCACCGGCTTTGCACCGATAATGCTGCGATG
ATCGCCTGGGCGGGTCTGGAGCGCATGGCGGAAGGCAGGCAAGCCGATGCGCTTGAGGTCGCGCCGCGCTCTCGCTGGCC
GCTTGACGGTAGCGCGGAGACATTGATTGGTTTCGGTAAAAGGGGAGCCAAGGCCTGA

Upstream 100 bases:

>100_bases
GCCGATTCGGAAAGGTTTTGTTTGCATCCGCGTCTATCCATTGTTACCGGAGTTGTCTTAGACCAACTCAGCGCATGATC
GCAATGAACGAACAGATTTG

Downstream 100 bases:

>100_bases
TGCAGCGGGAAAAAATCGTCGTCATCGGCGCCGGTGCCTTCGGAACCGCGCTTGCCGTCGTCATCGCGCTGGAAAACCGG
CATGATGTGACCCTGCTCGG

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MPPFLRILGIETSCDETAASIVVRHADGRGEIVSDVVLSQLEEHSAYGGVVPEIAARAHVEALDTLVEEALDQAGVKLAD
VDAIAATSGPGLIGGLLVGLMTGKAIAKAAGKPLYAINHLEGHALTARLTDGLSFPYLMLLVSGGHTQLVLVRGVGEYER
WGTTIDDALGEAFDKTAKLLGLPYPGGPAVENAAAKGDPDRFPLPRPMVGEARLDFSFSGLKTAVRQAATAIAPLSEQDI
ADICASFQKAVSRTLKDRIGRGLARFKVEFPHINGEPALVVAGGVAANQEIRQTLQALCDTHGFRFVAPPHRLCTDNAAM
IAWAGLERMAEGRQADALEVAPRSRWPLDGSAETLIGFGKRGAKA

Sequences:

>Translated_365_residues
MPPFLRILGIETSCDETAASIVVRHADGRGEIVSDVVLSQLEEHSAYGGVVPEIAARAHVEALDTLVEEALDQAGVKLAD
VDAIAATSGPGLIGGLLVGLMTGKAIAKAAGKPLYAINHLEGHALTARLTDGLSFPYLMLLVSGGHTQLVLVRGVGEYER
WGTTIDDALGEAFDKTAKLLGLPYPGGPAVENAAAKGDPDRFPLPRPMVGEARLDFSFSGLKTAVRQAATAIAPLSEQDI
ADICASFQKAVSRTLKDRIGRGLARFKVEFPHINGEPALVVAGGVAANQEIRQTLQALCDTHGFRFVAPPHRLCTDNAAM
IAWAGLERMAEGRQADALEVAPRSRWPLDGSAETLIGFGKRGAKA
>Mature_364_residues
PPFLRILGIETSCDETAASIVVRHADGRGEIVSDVVLSQLEEHSAYGGVVPEIAARAHVEALDTLVEEALDQAGVKLADV
DAIAATSGPGLIGGLLVGLMTGKAIAKAAGKPLYAINHLEGHALTARLTDGLSFPYLMLLVSGGHTQLVLVRGVGEYERW
GTTIDDALGEAFDKTAKLLGLPYPGGPAVENAAAKGDPDRFPLPRPMVGEARLDFSFSGLKTAVRQAATAIAPLSEQDIA
DICASFQKAVSRTLKDRIGRGLARFKVEFPHINGEPALVVAGGVAANQEIRQTLQALCDTHGFRFVAPPHRLCTDNAAMI
AWAGLERMAEGRQADALEVAPRSRWPLDGSAETLIGFGKRGAKA

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=368, Percent_Identity=36.6847826086957, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI8923380, Length=304, Percent_Identity=32.5657894736842, Blast_Score=139, Evalue=4e-33,
Organism=Escherichia coli, GI1789445, Length=350, Percent_Identity=47.1428571428571, Blast_Score=278, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17557464, Length=380, Percent_Identity=31.8421052631579, Blast_Score=164, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI71995670, Length=349, Percent_Identity=30.6590257879656, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320099, Length=372, Percent_Identity=32.7956989247312, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6322891, Length=299, Percent_Identity=28.0936454849498, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI20129063, Length=348, Percent_Identity=36.2068965517241, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI21357207, Length=313, Percent_Identity=29.7124600638978, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_AGRT5 (Q8UC47)

Other databases:

- EMBL:   AE007869
- PIR:   AB2902
- PIR:   D97677
- RefSeq:   NP_355588.2
- ProteinModelPortal:   Q8UC47
- SMR:   Q8UC47
- STRING:   Q8UC47
- MEROPS:   M22.001
- GeneID:   1134689
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu2651
- eggNOG:   COG0533
- HOGENOM:   HBG304663
- OMA:   PLYGVNH
- PhylomeDB:   Q8UC47
- ProtClustDB:   PRK09604
- BioCyc:   ATUM176299-1:ATU2651-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 38433; Mature: 38302

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPFLRILGIETSCDETAASIVVRHADGRGEIVSDVVLSQLEEHSAYGGVVPEIAARAHV
CCCCEEEEECCCCCHHHHHHEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
EALDTLVEEALDQAGVKLADVDAIAATSGPGLIGGLLVGLMTGKAIAKAAGKPLYAINHL
HHHHHHHHHHHHHHCCEEEECHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
EGHALTARLTDGLSFPYLMLLVSGGHTQLVLVRGVGEYERWGTTIDDALGEAFDKTAKLL
CCCEEEEEHHCCCCHHHHHHEECCCCEEEEEEECCCCHHHHCCCHHHHHHHHHHHHHHHH
GLPYPGGPAVENAAAKGDPDRFPLPRPMVGEARLDFSFSGLKTAVRQAATAIAPLSEQDI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHCCCCHHHH
ADICASFQKAVSRTLKDRIGRGLARFKVEFPHINGEPALVVAGGVAANQEIRQTLQALCD
HHHHHHHHHHHHHHHHHHHCCCHHHEEEECCCCCCCCCEEEECCCCCCHHHHHHHHHHHH
THGFRFVAPPHRLCTDNAAMIAWAGLERMAEGRQADALEVAPRSRWPLDGSAETLIGFGK
CCCCEEECCCHHHHCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCHHHHHHCCC
RGAKA
CCCCC
>Mature Secondary Structure 
PPFLRILGIETSCDETAASIVVRHADGRGEIVSDVVLSQLEEHSAYGGVVPEIAARAHV
CCCEEEEECCCCCHHHHHHEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
EALDTLVEEALDQAGVKLADVDAIAATSGPGLIGGLLVGLMTGKAIAKAAGKPLYAINHL
HHHHHHHHHHHHHHCCEEEECHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
EGHALTARLTDGLSFPYLMLLVSGGHTQLVLVRGVGEYERWGTTIDDALGEAFDKTAKLL
CCCEEEEEHHCCCCHHHHHHEECCCCEEEEEEECCCCHHHHCCCHHHHHHHHHHHHHHHH
GLPYPGGPAVENAAAKGDPDRFPLPRPMVGEARLDFSFSGLKTAVRQAATAIAPLSEQDI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHCCCCHHHH
ADICASFQKAVSRTLKDRIGRGLARFKVEFPHINGEPALVVAGGVAANQEIRQTLQALCD
HHHHHHHHHHHHHHHHHHHCCCHHHEEEECCCCCCCCCEEEECCCCCCHHHHHHHHHHHH
THGFRFVAPPHRLCTDNAAMIAWAGLERMAEGRQADALEVAPRSRWPLDGSAETLIGFGK
CCCCEEECCCHHHHCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCHHHHHHCCC
RGAKA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194