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The map label for this gene is gpsA

Identifier: 15889906

GI number: 15889906

Start: 2633527

End: 2634510

Strand: Reverse

Name: gpsA

Synonym: Atu2650

Alternate gene names: 15889906

Gene position: 2634510-2633527 (Counterclockwise)

Preceding gene: 159185308

Following gene: 15889905

Centisome position: 92.71

GC content: 64.23

Gene sequence:

>984_bases
ATGCAGCGGGAAAAAATCGTCGTCATCGGCGCCGGTGCCTTCGGAACCGCGCTTGCCGTCGTCATCGCGCTGGAAAACCG
GCATGATGTGACCCTGCTCGGCCGCGATCCGTCGCTGATGGCCGATCTAAGGAACGAACGCGTACACGAGGCCGCCCTAC
CGGGTGTGGAGTTGCCGGATGCACTTGGATTCTCGGCCGAGCCTGACGTGCTGGCTGGCGCCAGTATCGTGTTGTTCGCC
ATGCCTTCGCAGGCCCATGCCGACGCGGCCCAACACTATGGCCCTTATCTGGCCAGTGACTCTATCATCGTCACCTGCGC
GAAAGGTATCGACCGCAACTCCGGTCGTCTGCTGACGGAACTTCTGGAGACGGAACTGCCGCATCATCCCATTGCTGTTC
TGTCCGGGCCGGGCTTTGCTGCCGATATCGCGCGCGGCTTGCCGACCGCCATGGCGATTGCGGCGGAGGACGCCACGGTT
GCCGAACGGCTGGCGACCACGATTTCGGGCAAGACCTTCCGGCTTTATGCCTCGACGGACCGCATCGGCGTGCAGCTTGG
CGGTGCGCTGAAGAATGTTCTCGCCATTGCCGCCGGCATTGTCGAAGGAGCGGGGCTCGGCGATTCCGCCCGGGCGGCGC
TGATTTCGCGTGGGCTTGCCGAAATGTCTCGTCTCATCGTCGCCATGGGCGGCAAGGCCGATACGGTGCGCGGTCTTTCC
GGCCTCGGCGATCTGGTGCTGACCGCCACCAGCCACCAGTCGCGCAACCTGCGTTTCGGCATCGCGCTTGGCCGGGGTGA
GGGCAAGGACATGTCCGGCGGGCTGGTGGAGGGTGCCTTTGCGGCAGCCGTTGCCGCTCGGCTCGGCGAACACCACGCAA
TCGACATGCCGGTGACCGAGGCGGTGGCCGCCATTATTGATGGCAATCTGGATGTGGCGAGCGCCATGCAACAATTGATG
ACACGGCCGATCACCACCGAATGA

Upstream 100 bases:

>100_bases
GGCAAGCCGATGCGCTTGAGGTCGCGCCGCGCTCTCGCTGGCCGCTTGACGGTAGCGCGGAGACATTGATTGGTTTCGGT
AAAAGGGGAGCCAAGGCCTG

Downstream 100 bases:

>100_bases
GGTGAGGCGGTCGAATAATATTTTACGCATGTCCTGGTCCCAAACCGCTGACCCATTTGGGAGACATGCTCTAGCAAGGA
GACGACAATGCTGTTTGCCT

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MQREKIVVIGAGAFGTALAVVIALENRHDVTLLGRDPSLMADLRNERVHEAALPGVELPDALGFSAEPDVLAGASIVLFA
MPSQAHADAAQHYGPYLASDSIIVTCAKGIDRNSGRLLTELLETELPHHPIAVLSGPGFAADIARGLPTAMAIAAEDATV
AERLATTISGKTFRLYASTDRIGVQLGGALKNVLAIAAGIVEGAGLGDSARAALISRGLAEMSRLIVAMGGKADTVRGLS
GLGDLVLTATSHQSRNLRFGIALGRGEGKDMSGGLVEGAFAAAVAARLGEHHAIDMPVTEAVAAIIDGNLDVASAMQQLM
TRPITTE

Sequences:

>Translated_327_residues
MQREKIVVIGAGAFGTALAVVIALENRHDVTLLGRDPSLMADLRNERVHEAALPGVELPDALGFSAEPDVLAGASIVLFA
MPSQAHADAAQHYGPYLASDSIIVTCAKGIDRNSGRLLTELLETELPHHPIAVLSGPGFAADIARGLPTAMAIAAEDATV
AERLATTISGKTFRLYASTDRIGVQLGGALKNVLAIAAGIVEGAGLGDSARAALISRGLAEMSRLIVAMGGKADTVRGLS
GLGDLVLTATSHQSRNLRFGIALGRGEGKDMSGGLVEGAFAAAVAARLGEHHAIDMPVTEAVAAIIDGNLDVASAMQQLM
TRPITTE
>Mature_327_residues
MQREKIVVIGAGAFGTALAVVIALENRHDVTLLGRDPSLMADLRNERVHEAALPGVELPDALGFSAEPDVLAGASIVLFA
MPSQAHADAAQHYGPYLASDSIIVTCAKGIDRNSGRLLTELLETELPHHPIAVLSGPGFAADIARGLPTAMAIAAEDATV
AERLATTISGKTFRLYASTDRIGVQLGGALKNVLAIAAGIVEGAGLGDSARAALISRGLAEMSRLIVAMGGKADTVRGLS
GLGDLVLTATSHQSRNLRFGIALGRGEGKDMSGGLVEGAFAAAVAARLGEHHAIDMPVTEAVAAIIDGNLDVASAMQQLM
TRPITTE

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=349, Percent_Identity=24.0687679083095, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI24307999, Length=347, Percent_Identity=23.6311239193084, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1790037, Length=308, Percent_Identity=42.8571428571429, Blast_Score=233, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI32564399, Length=354, Percent_Identity=24.5762711864407, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32564403, Length=363, Percent_Identity=24.7933884297521, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI193210136, Length=363, Percent_Identity=24.7933884297521, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17507425, Length=278, Percent_Identity=24.1007194244604, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193210134, Length=350, Percent_Identity=24.5714285714286, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324513, Length=358, Percent_Identity=26.8156424581006, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320181, Length=346, Percent_Identity=24.2774566473988, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136204, Length=270, Percent_Identity=28.1481481481481, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17136202, Length=270, Percent_Identity=28.8888888888889, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17136200, Length=270, Percent_Identity=28.1481481481481, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI45551945, Length=277, Percent_Identity=25.9927797833935, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281362270, Length=277, Percent_Identity=25.9927797833935, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_AGRT5 (Q8UC48)

Other databases:

- EMBL:   AE007869
- PIR:   AI2901
- PIR:   C97677
- RefSeq:   NP_355587.1
- ProteinModelPortal:   Q8UC48
- SMR:   Q8UC48
- STRING:   Q8UC48
- GeneID:   1134688
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu2650
- eggNOG:   COG0240
- HOGENOM:   HBG586392
- OMA:   AKGIEHG
- PhylomeDB:   Q8UC48
- ProtClustDB:   PRK00094
- BioCyc:   ATUM176299-1:ATU2650-MONOMER
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 33601; Mature: 33601

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 191-191 BINDING 108-108 BINDING 108-108 BINDING 140-140 BINDING 255-255 BINDING 277-277

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQREKIVVIGAGAFGTALAVVIALENRHDVTLLGRDPSLMADLRNERVHEAALPGVELPD
CCCCEEEEEECCHHHHHEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCH
ALGFSAEPDVLAGASIVLFAMPSQAHADAAQHYGPYLASDSIIVTCAKGIDRNSGRLLTE
HCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCEECCCCEEEEEECCCCCCCCHHHHH
LLETELPHHPIAVLSGPGFAADIARGLPTAMAIAAEDATVAERLATTISGKTFRLYASTD
HHHHHCCCCCEEEEECCCHHHHHHHCCCHHEEEECCCHHHHHHHHHHHCCCEEEEEECCC
RIGVQLGGALKNVLAIAAGIVEGAGLGDSARAALISRGLAEMSRLIVAMGGKADTVRGLS
CCEEEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
GLGDLVLTATSHQSRNLRFGIALGRGEGKDMSGGLVEGAFAAAVAARLGEHHAIDMPVTE
CCCCEEEEECCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCHHH
AVAAIIDGNLDVASAMQQLMTRPITTE
HHHHHHCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQREKIVVIGAGAFGTALAVVIALENRHDVTLLGRDPSLMADLRNERVHEAALPGVELPD
CCCCEEEEEECCHHHHHEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCH
ALGFSAEPDVLAGASIVLFAMPSQAHADAAQHYGPYLASDSIIVTCAKGIDRNSGRLLTE
HCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCEECCCCEEEEEECCCCCCCCHHHHH
LLETELPHHPIAVLSGPGFAADIARGLPTAMAIAAEDATVAERLATTISGKTFRLYASTD
HHHHHCCCCCEEEEECCCHHHHHHHCCCHHEEEECCCHHHHHHHHHHHCCCEEEEEECCC
RIGVQLGGALKNVLAIAAGIVEGAGLGDSARAALISRGLAEMSRLIVAMGGKADTVRGLS
CCEEEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
GLGDLVLTATSHQSRNLRFGIALGRGEGKDMSGGLVEGAFAAAVAARLGEHHAIDMPVTE
CCCCEEEEECCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCHHH
AVAAIIDGNLDVASAMQQLMTRPITTE
HHHHHHCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194