Click here to switch to the map view.

The map label for this gene is livH [H]

Identifier: 159185205

GI number: 159185205

Start: 2382267

End: 2383880

Strand: Reverse

Name: livH [H]

Synonym: Atu2413

Alternate gene names: 159185205

Gene position: 2383880-2382267 (Counterclockwise)

Preceding gene: 159185206

Following gene: 15889683

Centisome position: 83.89

GC content: 62.02

Gene sequence:

>1614_bases
ATGACGATCCGATCTTTTCTCGGAGCCATCTTCCTCTGGTTCACCATGGGGATCGCAGCCCACGCCGTCGCGCAGAGCGA
TCCGAAGGCGCTGATTGACCAGCTTGGCACGGCTGATTTCAAGCAGGCCGAAGTGCTGATCGGGCAGATCGCCGCAACGG
GCGATGCGCGCGTCGTTCCAGCGCTGGAGGCTTTCGCGGCGGGCGATCTTTACGTGCGCAAATCCGACAATCTCGTCTTC
ATGACCAAGCCCGCCGGCTCCGATTTCACGCTGATCGACCCGCTGACGGGTGAAAGCGCCGGCTCGGCGCCCAAGGCTGC
CGTCACCAAGATCAGGGTCAACAATAATCTTCGCCGCGTCATTCGCGCCGCGATGGGTGGCCTGACGCTGCTCAGCCCGG
AACGCGCGGTGCGGCTTTCCGCCGCCGATGCGGTTCTGAAAGCCCCCAGCGCCGAAAATCTGGAATTGCTGGAAGCGGCC
ATATCAAAGGAAACCGACAATGAGGTGCGGACCCGGATGGAGGAGGCGCGGGCTGTCTCGCTGCTCTCCTCCGACCGCCC
CCTCGAGGTGAAGAAAGAAGCGATCGCCACCATCAAGAAGCTCGGTGGGCGCGATGCGATCAGCATTCTCATGGCGGCGA
CGCCCTCGGTCGATCCGAGCCTGAAGCCTGATGTGGACGAGGCGATTTCCAGCATCGAGAGCGCACTGGCCTTCTGGGAT
TATGCGCAGAATGTCTGGTATGGCCTGTCGCTCGGTTCCGTGCTGCTGCTGGCCGCCATCGGCCTTGCCATCACCTTCGG
CGTGATGGGCATCATCAACATGGCACATGGCGAGATGGTGATGATCGGCGCTTACTCCACCTTCATGGTGCAGGAAGTGA
TCCGCAGTCACTTCCCCGGCCTGTTCGACTGGTCGCTGGCGATTGCCTTGCCAGTCGCCTTTCTGGTGACAGGTTTTGTC
GGCCTCGTGATGGAACGAGGCGTCATCCGCTTCCTCTACGGGCGGCCTTTGGAAACGCTGCTCGCCACCTGGGGCATCTC
GCTGATGTTGCAACAGGGCGTACGCTCCATTTTCGGCCCCACCAACCGGGAGGTTGGCAGCCCCGGCTGGATGTCCGGCT
CCTTCAGCGTCGGTTATCTCAATTTCACCTGGAACCGGGTGTGGATCGTCTGCTTCTCGCTGTCGGTGTTCTTCGCGCTG
CTGGTGCTTCTGAAGCGCTCCGCCTTCGGTCTGCAGATGCGCGCCGTGACTCAGAACCGCCGCATGGCCTCCTCCATGGG
CATTCGCACGCCCTGGGTGGATGCCTTCACCTTCGCGCTCGGTTCAGGCGTTGCCGGGCTTGCCGGCGTTGCGCTATCGC
AGATCGACAATGTCTCGCCCAATCTCGGCCAGAGCTACATCATCGACAGTTTCATGGTGGTGGTGTTCGGCGGCGTCGGC
AATCTCTGGGGAACGCTGGTGGGTGCATTGTCGCTCGGCGTGCTCAACAAGTTCCTCGAGCCGACGGTGGGCGCCGTGCT
CGGCAAGATCCTCGTGCTCGTTCTCATCATCCTGTTCATCCAGAAGCGGCCGCGCGGTCTCTTCGCACTCAAGGGAAGGG
CGATCGAAGCATGA

Upstream 100 bases:

>100_bases
CCTTGTGGGGGAGATGCCCGGCAGGACAGAGGGGGTGAGCCGCATATTCCAGCAGCGCCAAAATAAACGCCCCATCGCAA
ACCGCTCCAAGGACCCTGAC

Downstream 100 bases:

>100_bases
TTACCGGCTTCCTCCTGCGCGCGCTCGATCGCCGCATTTCCATCGCCATCGGCATCATCCTGGCCATCGCCGTCCTGGTG
CCCGCCTCCAACCTGCTTTT

Product: ABC transporter, membrane spanning protein (urea/amide)

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MTIRSFLGAIFLWFTMGIAAHAVAQSDPKALIDQLGTADFKQAEVLIGQIAATGDARVVPALEAFAAGDLYVRKSDNLVF
MTKPAGSDFTLIDPLTGESAGSAPKAAVTKIRVNNNLRRVIRAAMGGLTLLSPERAVRLSAADAVLKAPSAENLELLEAA
ISKETDNEVRTRMEEARAVSLLSSDRPLEVKKEAIATIKKLGGRDAISILMAATPSVDPSLKPDVDEAISSIESALAFWD
YAQNVWYGLSLGSVLLLAAIGLAITFGVMGIINMAHGEMVMIGAYSTFMVQEVIRSHFPGLFDWSLAIALPVAFLVTGFV
GLVMERGVIRFLYGRPLETLLATWGISLMLQQGVRSIFGPTNREVGSPGWMSGSFSVGYLNFTWNRVWIVCFSLSVFFAL
LVLLKRSAFGLQMRAVTQNRRMASSMGIRTPWVDAFTFALGSGVAGLAGVALSQIDNVSPNLGQSYIIDSFMVVVFGGVG
NLWGTLVGALSLGVLNKFLEPTVGAVLGKILVLVLIILFIQKRPRGLFALKGRAIEA

Sequences:

>Translated_537_residues
MTIRSFLGAIFLWFTMGIAAHAVAQSDPKALIDQLGTADFKQAEVLIGQIAATGDARVVPALEAFAAGDLYVRKSDNLVF
MTKPAGSDFTLIDPLTGESAGSAPKAAVTKIRVNNNLRRVIRAAMGGLTLLSPERAVRLSAADAVLKAPSAENLELLEAA
ISKETDNEVRTRMEEARAVSLLSSDRPLEVKKEAIATIKKLGGRDAISILMAATPSVDPSLKPDVDEAISSIESALAFWD
YAQNVWYGLSLGSVLLLAAIGLAITFGVMGIINMAHGEMVMIGAYSTFMVQEVIRSHFPGLFDWSLAIALPVAFLVTGFV
GLVMERGVIRFLYGRPLETLLATWGISLMLQQGVRSIFGPTNREVGSPGWMSGSFSVGYLNFTWNRVWIVCFSLSVFFAL
LVLLKRSAFGLQMRAVTQNRRMASSMGIRTPWVDAFTFALGSGVAGLAGVALSQIDNVSPNLGQSYIIDSFMVVVFGGVG
NLWGTLVGALSLGVLNKFLEPTVGAVLGKILVLVLIILFIQKRPRGLFALKGRAIEA
>Mature_536_residues
TIRSFLGAIFLWFTMGIAAHAVAQSDPKALIDQLGTADFKQAEVLIGQIAATGDARVVPALEAFAAGDLYVRKSDNLVFM
TKPAGSDFTLIDPLTGESAGSAPKAAVTKIRVNNNLRRVIRAAMGGLTLLSPERAVRLSAADAVLKAPSAENLELLEAAI
SKETDNEVRTRMEEARAVSLLSSDRPLEVKKEAIATIKKLGGRDAISILMAATPSVDPSLKPDVDEAISSIESALAFWDY
AQNVWYGLSLGSVLLLAAIGLAITFGVMGIINMAHGEMVMIGAYSTFMVQEVIRSHFPGLFDWSLAIALPVAFLVTGFVG
LVMERGVIRFLYGRPLETLLATWGISLMLQQGVRSIFGPTNREVGSPGWMSGSFSVGYLNFTWNRVWIVCFSLSVFFALL
VLLKRSAFGLQMRAVTQNRRMASSMGIRTPWVDAFTFALGSGVAGLAGVALSQIDNVSPNLGQSYIIDSFMVVVFGGVGN
LWGTLVGALSLGVLNKFLEPTVGAVLGKILVLVLIILFIQKRPRGLFALKGRAIEA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=312, Percent_Identity=30.4487179487179, Blast_Score=96, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 57535; Mature: 57404

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRSFLGAIFLWFTMGIAAHAVAQSDPKALIDQLGTADFKQAEVLIGQIAATGDARVVP
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHH
ALEAFAAGDLYVRKSDNLVFMTKPAGSDFTLIDPLTGESAGSAPKAAVTKIRVNNNLRRV
HHHHHHCCCEEEEECCCEEEEECCCCCCCEEECCCCCCCCCCCCHHHHEEEEECHHHHHH
IRAAMGGLTLLSPERAVRLSAADAVLKAPSAENLELLEAAISKETDNEVRTRMEEARAVS
HHHHHCCCEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
LLSSDRPLEVKKEAIATIKKLGGRDAISILMAATPSVDPSLKPDVDEAISSIESALAFWD
HHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
YAQNVWYGLSLGSVLLLAAIGLAITFGVMGIINMAHGEMVMIGAYSTFMVQEVIRSHFPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHCCC
LFDWSLAIALPVAFLVTGFVGLVMERGVIRFLYGRPLETLLATWGISLMLQQGVRSIFGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
TNREVGSPGWMSGSFSVGYLNFTWNRVWIVCFSLSVFFALLVLLKRSAFGLQMRAVTQNR
CCCCCCCCCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
RMASSMGIRTPWVDAFTFALGSGVAGLAGVALSQIDNVSPNLGQSYIIDSFMVVVFGGVG
HHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCH
NLWGTLVGALSLGVLNKFLEPTVGAVLGKILVLVLIILFIQKRPRGLFALKGRAIEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
TIRSFLGAIFLWFTMGIAAHAVAQSDPKALIDQLGTADFKQAEVLIGQIAATGDARVVP
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHH
ALEAFAAGDLYVRKSDNLVFMTKPAGSDFTLIDPLTGESAGSAPKAAVTKIRVNNNLRRV
HHHHHHCCCEEEEECCCEEEEECCCCCCCEEECCCCCCCCCCCCHHHHEEEEECHHHHHH
IRAAMGGLTLLSPERAVRLSAADAVLKAPSAENLELLEAAISKETDNEVRTRMEEARAVS
HHHHHCCCEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
LLSSDRPLEVKKEAIATIKKLGGRDAISILMAATPSVDPSLKPDVDEAISSIESALAFWD
HHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
YAQNVWYGLSLGSVLLLAAIGLAITFGVMGIINMAHGEMVMIGAYSTFMVQEVIRSHFPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHCCC
LFDWSLAIALPVAFLVTGFVGLVMERGVIRFLYGRPLETLLATWGISLMLQQGVRSIFGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
TNREVGSPGWMSGSFSVGYLNFTWNRVWIVCFSLSVFFALLVLLKRSAFGLQMRAVTQNR
CCCCCCCCCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
RMASSMGIRTPWVDAFTFALGSGVAGLAGVALSQIDNVSPNLGQSYIIDSFMVVVFGGVG
HHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCH
NLWGTLVGALSLGVLNKFLEPTVGAVLGKILVLVLIILFIQKRPRGLFALKGRAIEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]