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The map label for this gene is hflK [H]

Identifier: 159185025

GI number: 159185025

Start: 2004069

End: 2005187

Strand: Reverse

Name: hflK [H]

Synonym: Atu2045

Alternate gene names: 159185025

Gene position: 2005187-2004069 (Counterclockwise)

Preceding gene: 15889333

Following gene: 15889331

Centisome position: 70.57

GC content: 61.93

Gene sequence:

>1119_bases
ATGCCCTGGAGCAATCAGAATGGCGGCGGCGGCCCATGGGGCGGCGGCGGTGGAGGAAACAACCAGGGCGGCGGTGGCGG
CCCATGGGGGCAGGGGCCTAACCGGCCTCGCGGCGGTGGCGGCGGCAATGGCGGCCCACCCGATCTGGAAGAGATCATCC
GGCGCAGCCAGGACCGTTTCAAGAATGTGCTGCCCGGCGGCTTCAATGGCGGCGTGGTCGCCATCGTGGTTCTCGTCGTT
CTGGTTTTCCTCGGCATCCAGTCCATCTACACCGTCCAGCCGGATGAGCGCGGCGTCGAGCTGCGTTTCGGCCGTCCGAA
GGACGAAATCTCGATGCCTGGCCTGCATTTCCATCTGTGGCCGATCGAGACGGTGGAAATCGTCAAGGTGACCGAGCAGC
AGCAGAATATCGGCTCGCGCGCCTCGTCGTCTTCGTCGAGCGGCGTGATGCTGACCGGCGACCAGAACATCGTCAACGTT
CAGTTCTCGGTGCTTTATACGGTCTCCGATCCGAAATCCTATCTCTTCAACGTCGACGCCCCGGCGGAAACGCTGCAGCA
GGTTTCCGAAAGCGCCATGCGCGAAGTCGTTGGCCGTCGTCCGGCGCAGGATATCTTCCGCGATAACCGACAGGCGATTG
CGGCGGATGTGCGCAGCATCATCCAGTCCACCATGGACGGTTATGGCGCGGGCATCTCCATCAATGCAGTGGCCATCGAA
GATGCGGCTCCGCCGCGCGAAGTGGCCGATGCCTTCGACGAAGTGCAGCGTGCCGAACAGGATGAAGACCGCTTCGTTCA
GGAAGCCAATCAATACGCCAACCAGAAGCTCGGTGCCGCACGCGGTCAGGCCGCGCAGATCGTCGAAGAGGCGAACGCCT
ACAAGTCGCGTGTCGTCAACGAGGCGGAAGGTGAGGCGCAGCGCTTCATTTCCATCTATGACCAGTATCGCACGGCGCCT
GAGGTAACCCGTCAGCGCATGTTCCTGGAAACGATGGAGCAGGTCCTGAAGGGTTCCAACAAGATCATCATCGACGAGAA
ACAGGGCGTGGTGCCTTATCTGCCTCTGAACGAGATCATGCGCAACAATCCGGGCGCAGCACAGCAGGGAGGCAACTGA

Upstream 100 bases:

>100_bases
AAACAGGCGCTTCTCCTTCCTATAACGGGTCGATATTCCCGCCGCACGCGAGCAATCGCTTACGAACGGAACCGGGAGAG
GCTTTTATAAAGAGGTATTG

Downstream 100 bases:

>100_bases
TATGGGTAACCGTCTTACGGCCGTTCTTGTCGGTCTCGCCGTCCTGCTTTTCCTCGGTTATTCGTCGATCTTCGTCGTCA
ACGAGCGCCAGCAGGCCATC

Product: HFLK protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MPWSNQNGGGGPWGGGGGGNNQGGGGGPWGQGPNRPRGGGGGNGGPPDLEEIIRRSQDRFKNVLPGGFNGGVVAIVVLVV
LVFLGIQSIYTVQPDERGVELRFGRPKDEISMPGLHFHLWPIETVEIVKVTEQQQNIGSRASSSSSSGVMLTGDQNIVNV
QFSVLYTVSDPKSYLFNVDAPAETLQQVSESAMREVVGRRPAQDIFRDNRQAIAADVRSIIQSTMDGYGAGISINAVAIE
DAAPPREVADAFDEVQRAEQDEDRFVQEANQYANQKLGAARGQAAQIVEEANAYKSRVVNEAEGEAQRFISIYDQYRTAP
EVTRQRMFLETMEQVLKGSNKIIIDEKQGVVPYLPLNEIMRNNPGAAQQGGN

Sequences:

>Translated_372_residues
MPWSNQNGGGGPWGGGGGGNNQGGGGGPWGQGPNRPRGGGGGNGGPPDLEEIIRRSQDRFKNVLPGGFNGGVVAIVVLVV
LVFLGIQSIYTVQPDERGVELRFGRPKDEISMPGLHFHLWPIETVEIVKVTEQQQNIGSRASSSSSSGVMLTGDQNIVNV
QFSVLYTVSDPKSYLFNVDAPAETLQQVSESAMREVVGRRPAQDIFRDNRQAIAADVRSIIQSTMDGYGAGISINAVAIE
DAAPPREVADAFDEVQRAEQDEDRFVQEANQYANQKLGAARGQAAQIVEEANAYKSRVVNEAEGEAQRFISIYDQYRTAP
EVTRQRMFLETMEQVLKGSNKIIIDEKQGVVPYLPLNEIMRNNPGAAQQGGN
>Mature_371_residues
PWSNQNGGGGPWGGGGGGNNQGGGGGPWGQGPNRPRGGGGGNGGPPDLEEIIRRSQDRFKNVLPGGFNGGVVAIVVLVVL
VFLGIQSIYTVQPDERGVELRFGRPKDEISMPGLHFHLWPIETVEIVKVTEQQQNIGSRASSSSSSGVMLTGDQNIVNVQ
FSVLYTVSDPKSYLFNVDAPAETLQQVSESAMREVVGRRPAQDIFRDNRQAIAADVRSIIQSTMDGYGAGISINAVAIED
AAPPREVADAFDEVQRAEQDEDRFVQEANQYANQKLGAARGQAAQIVEEANAYKSRVVNEAEGEAQRFISIYDQYRTAPE
VTRQRMFLETMEQVLKGSNKIIIDEKQGVVPYLPLNEIMRNNPGAAQQGGN

Specific function: HflC and HflK govern the stability of phage lambda cII protein and have been proposed to encode or regulate a cII- specific protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=394, Percent_Identity=33.756345177665, Blast_Score=202, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 40196; Mature: 40065

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPWSNQNGGGGPWGGGGGGNNQGGGGGPWGQGPNRPRGGGGGNGGPPDLEEIIRRSQDRF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
KNVLPGGFNGGVVAIVVLVVLVFLGIQSIYTVQPDERGVELRFGRPKDEISMPGLHFHLW
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEECCCHHHCCCCCCEEEEC
PIETVEIVKVTEQQQNIGSRASSSSSSGVMLTGDQNIVNVQFSVLYTVSDPKSYLFNVDA
CCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEEEEEEECCCHHHEEECCC
PAETLQQVSESAMREVVGRRPAQDIFRDNRQAIAADVRSIIQSTMDGYGAGISINAVAIE
HHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEC
DAAPPREVADAFDEVQRAEQDEDRFVQEANQYANQKLGAARGQAAQIVEEANAYKSRVVN
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
EAEGEAQRFISIYDQYRTAPEVTRQRMFLETMEQVLKGSNKIIIDEKQGVVPYLPLNEIM
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHH
RNNPGAAQQGGN
CCCCCCCCCCCC
>Mature Secondary Structure 
PWSNQNGGGGPWGGGGGGNNQGGGGGPWGQGPNRPRGGGGGNGGPPDLEEIIRRSQDRF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
KNVLPGGFNGGVVAIVVLVVLVFLGIQSIYTVQPDERGVELRFGRPKDEISMPGLHFHLW
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEECCCHHHCCCCCCEEEEC
PIETVEIVKVTEQQQNIGSRASSSSSSGVMLTGDQNIVNVQFSVLYTVSDPKSYLFNVDA
CCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEEEEEEECCCHHHEEECCC
PAETLQQVSESAMREVVGRRPAQDIFRDNRQAIAADVRSIIQSTMDGYGAGISINAVAIE
HHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEC
DAAPPREVADAFDEVQRAEQDEDRFVQEANQYANQKLGAARGQAAQIVEEANAYKSRVVN
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
EAEGEAQRFISIYDQYRTAPEVTRQRMFLETMEQVLKGSNKIIIDEKQGVVPYLPLNEIM
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHH
RNNPGAAQQGGN
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]