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The map label for this gene is ilvD

Identifier: 159184978

GI number: 159184978

Start: 1895477

End: 1897312

Strand: Reverse

Name: ilvD

Synonym: Atu1918

Alternate gene names: 159184978

Gene position: 1897312-1895477 (Counterclockwise)

Preceding gene: 15889217

Following gene: 15889211

Centisome position: 66.77

GC content: 61.38

Gene sequence:

>1836_bases
ATGCCAGCCTATCGCTCCAGAACGACAACCCACGGCCGCAACATGGCGGGCGCGCGCGGCCTTTGGCGCGCCACCGGCAT
GAAGGACAGCGATTTCGGCAAGCCGATCATCGCGGTGGTCAATTCCTTCACGCAGTTCGTACCGGGCCATGTGCATCTAA
AGGATCTCGGCCAGCTCGTTGCCCGCGAAATCGAGGCGGCCGGCGGCGTTGCCAAGGAATTCAACACGATTGCGGTCGAT
GATGGTATCGCCATGGGCCATGACGGCATGCTCTATTCGCTGCCGTCGCGCGAGATCATCGCTGACTCGGTCGAATATAT
GGTCAATGCCCATTGCGCCGATGCGATGGTCTGCATTTCCAACTGCGACAAGATCACGCCCGGCATGCTGAATGCCGCGA
TGCGCCTCAACATTCCCGCCGTTTTCGTGTCCGGTGGTCCAATGGAAGCGGGCAAGGTGGTTCTGCACGGCAAGACCGTT
GCGCTCGATCTGGTCGACGCGATGGTGGCTGCTGCCGACGACAAGATTTCCGATGAGGACGTCAAGATCATCGAGCGCTC
CGCCTGCCCGACCTGCGGTTCCTGTTCCGGCATGTTCACGGCCAATTCCATGAACTGTCTGACCGAGGCGCTCGGCCTGT
CATTGCCCGGCAACGGCTCGACGCTTGCCACCCACTCCGATCGCAAGCGCCTGTTCGTTGAAGCCGGTCACCTGATCGTC
GATCTGGCCCGCCGTTATTACGAGCAGGACGACGAAACCGTTCTGCCGCGCACCATCGCCAACAAGGCGGCGTTCGAAAA
CGCCATGTCGCTGGATATTGCCATGGGCGGCTCCACCAACACGGTTCTGCATATTCTGGCGGCAGCCCACGAGGGCGGCG
TCGATTTCGGTATGGAGGACATCGACCGGCTTTCCCGCAAGGTTCCCTGCCTTTCCAAGGTTGCGCCTGCGAAGCAGGAT
GTGCACATGGAAGACGTGCATCGCGCCGGCGGCATCATGCGTATTCTCGGTGAGCTGGAGCGTGGCGGTCTCATCAACCG
CGATACCTATACCGTACACGAAGCGACGCTTGGCGATGCCATCGACCGCTGGGACATCACGCGCACCAACAGCGAAATGG
TGCGGCAGTTCTTCAAGGCCGCTCCGGGCGGCGTACCGACACAGGTGGCCTTCAGCCAGTCCTCGCGCTGGGATGATCTG
GACACCGACAGCGACAACGGCGTCATTCGTTCGGTCGAGAAGCCTTTCTCCAAGGATGGCGGTCTGGCCGTTCTTTACGG
CAACATCGCGCTCGATGGCTGCATCGTGAAGACGGCGGGTGTTGATGAATCCATCCTGAAATTCAACGGATCGGCAGTCG
TTTACGAAAGCCAGGACGCGGCCGTGAAGGGCATTCTCGGCAACGAGGTCAAGGCGGGCGACGTCGTCGTCATCCGCTAT
GAAGGACCGAAGGGCGGCCCGGGCATGCAGGAAATGCTCTATCCGACCAGCTACCTCAAGTCCAAGGGCCTCGGTAAAGC
CTGCGCGCTCATCACCGATGGTCGCTTCTCCGGTGGCACGTCAGGCCTTTCCATCGGTCATGCCTCGCCGGAAGCGGCGC
AGGGCGGTGCCATCGGCCTCGTGCGTCAGGGCGACCTGATTGAGATCGATATTCCGAACCGCACGATCAATCTCAAGGTT
TCGGATGCGGAACTGGCCGCGCGCCGGGCCGAGCAGGAAGAAAAGGGCTGGAAGCCGGAAGCACCGCGCAAGCGTAATGT
CACGACGGCGCTCAAGGCCTATGCGGCCTTTGCGTCGAGCGCGGACAAGGGTGCTGTGCGGATTCTGCCGGAGTAA

Upstream 100 bases:

>100_bases
ACAGCGTGTGCGGTTTGCGCTAGAAAAACTGCAAAATGGGGAAAGGCGGTTTGTCTGTGTTGTGGACAAACGCCTTCGCC
GAGAGATCGAGGAAAACACC

Downstream 100 bases:

>100_bases
GCTGTCGCAGAGTGGGGTGGGGAGTTAATTAACCGTCCCGTCGCGCGGTGGCTGCAGCTTACTGATCAAGGTCGGAAAAC
GCTCACCCGTCATGCTCGGG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 611; Mature: 610

Protein sequence:

>611_residues
MPAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCISNCDKITPGMLNAAMRLNIPAVFVSGGPMEAGKVVLHGKTV
ALDLVDAMVAAADDKISDEDVKIIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHSDRKRLFVEAGHLIV
DLARRYYEQDDETVLPRTIANKAAFENAMSLDIAMGGSTNTVLHILAAAHEGGVDFGMEDIDRLSRKVPCLSKVAPAKQD
VHMEDVHRAGGIMRILGELERGGLINRDTYTVHEATLGDAIDRWDITRTNSEMVRQFFKAAPGGVPTQVAFSQSSRWDDL
DTDSDNGVIRSVEKPFSKDGGLAVLYGNIALDGCIVKTAGVDESILKFNGSAVVYESQDAAVKGILGNEVKAGDVVVIRY
EGPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHASPEAAQGGAIGLVRQGDLIEIDIPNRTINLKV
SDAELAARRAEQEEKGWKPEAPRKRNVTTALKAYAAFASSADKGAVRILPE

Sequences:

>Translated_611_residues
MPAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCISNCDKITPGMLNAAMRLNIPAVFVSGGPMEAGKVVLHGKTV
ALDLVDAMVAAADDKISDEDVKIIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHSDRKRLFVEAGHLIV
DLARRYYEQDDETVLPRTIANKAAFENAMSLDIAMGGSTNTVLHILAAAHEGGVDFGMEDIDRLSRKVPCLSKVAPAKQD
VHMEDVHRAGGIMRILGELERGGLINRDTYTVHEATLGDAIDRWDITRTNSEMVRQFFKAAPGGVPTQVAFSQSSRWDDL
DTDSDNGVIRSVEKPFSKDGGLAVLYGNIALDGCIVKTAGVDESILKFNGSAVVYESQDAAVKGILGNEVKAGDVVVIRY
EGPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHASPEAAQGGAIGLVRQGDLIEIDIPNRTINLKV
SDAELAARRAEQEEKGWKPEAPRKRNVTTALKAYAAFASSADKGAVRILPE
>Mature_610_residues
PAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCISNCDKITPGMLNAAMRLNIPAVFVSGGPMEAGKVVLHGKTVA
LDLVDAMVAAADDKISDEDVKIIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHSDRKRLFVEAGHLIVD
LARRYYEQDDETVLPRTIANKAAFENAMSLDIAMGGSTNTVLHILAAAHEGGVDFGMEDIDRLSRKVPCLSKVAPAKQDV
HMEDVHRAGGIMRILGELERGGLINRDTYTVHEATLGDAIDRWDITRTNSEMVRQFFKAAPGGVPTQVAFSQSSRWDDLD
TDSDNGVIRSVEKPFSKDGGLAVLYGNIALDGCIVKTAGVDESILKFNGSAVVYESQDAAVKGILGNEVKAGDVVVIRYE
GPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHASPEAAQGGAIGLVRQGDLIEIDIPNRTINLKVS
DAELAARRAEQEEKGWKPEAPRKRNVTTALKAYAAFASSADKGAVRILPE

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=610, Percent_Identity=74.0983606557377, Blast_Score=931, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=566, Percent_Identity=30.565371024735, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1786464, Length=535, Percent_Identity=31.4018691588785, Blast_Score=184, Evalue=2e-47,
Organism=Escherichia coli, GI1788157, Length=540, Percent_Identity=28.8888888888889, Blast_Score=182, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6322476, Length=609, Percent_Identity=36.9458128078818, Blast_Score=344, Evalue=3e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_AGRT5 (Q8UE43)

Other databases:

- EMBL:   AE007869
- PIR:   AD2812
- PIR:   E97590
- RefSeq:   NP_354893.2
- STRING:   Q8UE43
- GeneID:   1133956
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1918
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- PhylomeDB:   Q8UE43
- ProtClustDB:   PRK12448
- BioCyc:   ATUM176299-1:ATU1918-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 65025; Mature: 64894

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCIS
HHHHHHCCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLNAAMRLNIPAVFVSGGPMEAGKVVLHGKTVALDLVDAMVAAADDKISDED
CCCCCCCHHHHHEEEECCCEEEEECCCCCCCEEEEECCEEHHHHHHHHHHHCCCCCCCCH
VKIIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHSDRKRLFVEAGHLIV
HHHHHHCCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEHHHHHHH
DLARRYYEQDDETVLPRTIANKAAFENAMSLDIAMGGSTNTVLHILAAAHEGGVDFGMED
HHHHHHHCCCCCEECCHHHHHHHHHHCCCEEEEEECCCCHHHHHEEHHHCCCCCCCCHHH
IDRLSRKVPCLSKVAPAKQDVHMEDVHRAGGIMRILGELERGGLINRDTYTVHEATLGDA
HHHHHHCCCHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEHHHHHHH
IDRWDITRTNSEMVRQFFKAAPGGVPTQVAFSQSSRWDDLDTDSDNGVIRSVEKPFSKDG
HHHCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCC
GLAVLYGNIALDGCIVKTAGVDESILKFNGSAVVYESQDAAVKGILGNEVKAGDVVVIRY
CEEEEECCEEECCEEEEECCCCHHHHEECCCEEEEECCCCEEECCCCCCCCCCCEEEEEE
EGPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHASPEAAQGGAIGL
CCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEE
VRQGDLIEIDIPNRTINLKVSDAELAARRAEQEEKGWKPEAPRKRNVTTALKAYAAFASS
EECCCEEEEECCCEEEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
ADKGAVRILPE
CCCCEEEECCC
>Mature Secondary Structure 
PAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCIS
HHHHHHCCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLNAAMRLNIPAVFVSGGPMEAGKVVLHGKTVALDLVDAMVAAADDKISDED
CCCCCCCHHHHHEEEECCCEEEEECCCCCCCEEEEECCEEHHHHHHHHHHHCCCCCCCCH
VKIIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHSDRKRLFVEAGHLIV
HHHHHHCCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEHHHHHHH
DLARRYYEQDDETVLPRTIANKAAFENAMSLDIAMGGSTNTVLHILAAAHEGGVDFGMED
HHHHHHHCCCCCEECCHHHHHHHHHHCCCEEEEEECCCCHHHHHEEHHHCCCCCCCCHHH
IDRLSRKVPCLSKVAPAKQDVHMEDVHRAGGIMRILGELERGGLINRDTYTVHEATLGDA
HHHHHHCCCHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEHHHHHHH
IDRWDITRTNSEMVRQFFKAAPGGVPTQVAFSQSSRWDDLDTDSDNGVIRSVEKPFSKDG
HHHCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCC
GLAVLYGNIALDGCIVKTAGVDESILKFNGSAVVYESQDAAVKGILGNEVKAGDVVVIRY
CEEEEECCEEECCEEEEECCCCHHHHEECCCEEEEECCCCEEECCCCCCCCCCCEEEEEE
EGPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHASPEAAQGGAIGL
CCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEE
VRQGDLIEIDIPNRTINLKVSDAELAARRAEQEEKGWKPEAPRKRNVTTALKAYAAFASS
EECCCEEEEECCCEEEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
ADKGAVRILPE
CCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194