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The map label for this gene is fumC

Identifier: 159184840

GI number: 159184840

Start: 1599895

End: 1601286

Strand: Direct

Name: fumC

Synonym: Atu1616

Alternate gene names: 159184840

Gene position: 1599895-1601286 (Clockwise)

Preceding gene: 159184839

Following gene: 15888930

Centisome position: 56.3

GC content: 61.21

Gene sequence:

>1392_bases
ATGACAGCCACACGGACAGAAACCGATACATTTGGCCCTATTGAAGTTCAGGCCGATCGCTACTGGGGCGCGCAGGCGCA
GCGCTCGCTCGGCAACTTCAAGATCGGCTGGGAAAAGCAGCCCGCCTCTGTCGTTCGTGCGCTCGGCATCGTCAAGCAGG
CCGCTGCCCGCGCCAACATGGCGCTTGCAGGTCTCGACCCCAAGGTGGGAGATGCCATCATCGCCGCCGCGCAGGAAGTC
ATCGACGGCAAGCTGACCGAGCATTTCCCGCTCGTCGTCTGGCAGACCGGCTCCGGCACCCAGTCCAACATGAATGCCAA
CGAGGTGATTTCCAACCGCGCGATCGAAATGCTCGGCGGCGAAATGGGCACCAAGAAGCCTGTTCACCCGAATGACCACG
TCAATATGAGCCAGTCCTCGAACGACACCTACCCGACGGCGATGCACATCGCCTGCGTGGAAGAGATCGTTCACCACCTG
TTGCCGGCCCTCAAGCACCTGCACACGGCGCTGGAAGCCAAGGTCAAGCAGTTCGAAAAGATCATCAAGATCGGCCGTAC
CCACACGCAGGACGCGACCCCGCTGACGCTCGGCCAGGAATTCTCCGGTTACGCCGCTCAGGTCGCCTCGGCGATCGCCA
ATATCGAACTCACACTGCCCGCACTGTCGAAGCTCGCCCAGGGCGGTACGGCGGTTGGCACGGGCCTCAATGCCCCTGTT
GGTTTTGCCGAAAAGGTCGCCGAGGAAATCTCTGAGATTACCGGCCTTTCCTTCGTCACCGCGCCGAACAAGTTCGAAGC
GCTTGCCTCGCATGATTCCATGGTCTTCTCGCACGGCGCGATCAACGCCGCTGCCGCTGCACTCTTCAAGATCGCCAACG
ACATCCGCTTCCTCGGTTCCGGCCCGCGCGCCGGTCTCGGCGAATTGTCGCTGCCGGAAAACGAGCCCGGCTCGTCGATC
ATGCCGGGCAAGGTCAACCCGACGCAGTCGGAGGCACTGACGCAGGTTTGCGCCCATATCTTCGGCAACAATGCAGCGCT
TTCCTTCGCAGGCTCGCAGGGCCACTTCGAACTCAACGTCTATAATCCGATGATGGCCTACAACTTTCTGCAGTCGGTCC
AGCTTCTGGGCGATGCGGCCGTGTCCTTCACCGACAACTGCGTCGTCGGCATCGAGGCGCGCGAAGACAATATCCGGAAG
GGCGTCGAGAACTCGCTGATGCTCGTCACGGCGCTCAACGGCAAGCTCGGCTACGACATCTGCGCCAAGATCGCCAAGAC
CGCCCACAAGAACGGCACGACGCTGCGCGAAGAAGCCGTTGGTGGTGGATACCTCACCAACGAGGAATTCGACCAGTATG
TGCGCCCCGAAAACATGATCGGCCCGAAGTAA

Upstream 100 bases:

>100_bases
GCAGCGCTTTCATTGCCGGCGCGATGATTCTATATATCGGCCGCGCAAGGCGGGCGAAGTGCCGTTTTGGCGGAGGAAAA
CGAGTAAAAAGGCAAGATTG

Downstream 100 bases:

>100_bases
GCCGGTTTGGAATTTGTGGGAATTGGGAACGGGCCTTCGGGCCCGTTTTTGTTTGCCCGATTGACAGCTGGGTAATGAGA
CCGGGATAGGGCCGGAACAT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MTATRTETDTFGPIEVQADRYWGAQAQRSLGNFKIGWEKQPASVVRALGIVKQAAARANMALAGLDPKVGDAIIAAAQEV
IDGKLTEHFPLVVWQTGSGTQSNMNANEVISNRAIEMLGGEMGTKKPVHPNDHVNMSQSSNDTYPTAMHIACVEEIVHHL
LPALKHLHTALEAKVKQFEKIIKIGRTHTQDATPLTLGQEFSGYAAQVASAIANIELTLPALSKLAQGGTAVGTGLNAPV
GFAEKVAEEISEITGLSFVTAPNKFEALASHDSMVFSHGAINAAAAALFKIANDIRFLGSGPRAGLGELSLPENEPGSSI
MPGKVNPTQSEALTQVCAHIFGNNAALSFAGSQGHFELNVYNPMMAYNFLQSVQLLGDAAVSFTDNCVVGIEAREDNIRK
GVENSLMLVTALNGKLGYDICAKIAKTAHKNGTTLREEAVGGGYLTNEEFDQYVRPENMIGPK

Sequences:

>Translated_463_residues
MTATRTETDTFGPIEVQADRYWGAQAQRSLGNFKIGWEKQPASVVRALGIVKQAAARANMALAGLDPKVGDAIIAAAQEV
IDGKLTEHFPLVVWQTGSGTQSNMNANEVISNRAIEMLGGEMGTKKPVHPNDHVNMSQSSNDTYPTAMHIACVEEIVHHL
LPALKHLHTALEAKVKQFEKIIKIGRTHTQDATPLTLGQEFSGYAAQVASAIANIELTLPALSKLAQGGTAVGTGLNAPV
GFAEKVAEEISEITGLSFVTAPNKFEALASHDSMVFSHGAINAAAAALFKIANDIRFLGSGPRAGLGELSLPENEPGSSI
MPGKVNPTQSEALTQVCAHIFGNNAALSFAGSQGHFELNVYNPMMAYNFLQSVQLLGDAAVSFTDNCVVGIEAREDNIRK
GVENSLMLVTALNGKLGYDICAKIAKTAHKNGTTLREEAVGGGYLTNEEFDQYVRPENMIGPK
>Mature_462_residues
TATRTETDTFGPIEVQADRYWGAQAQRSLGNFKIGWEKQPASVVRALGIVKQAAARANMALAGLDPKVGDAIIAAAQEVI
DGKLTEHFPLVVWQTGSGTQSNMNANEVISNRAIEMLGGEMGTKKPVHPNDHVNMSQSSNDTYPTAMHIACVEEIVHHLL
PALKHLHTALEAKVKQFEKIIKIGRTHTQDATPLTLGQEFSGYAAQVASAIANIELTLPALSKLAQGGTAVGTGLNAPVG
FAEKVAEEISEITGLSFVTAPNKFEALASHDSMVFSHGAINAAAAALFKIANDIRFLGSGPRAGLGELSLPENEPGSSIM
PGKVNPTQSEALTQVCAHIFGNNAALSFAGSQGHFELNVYNPMMAYNFLQSVQLLGDAAVSFTDNCVVGIEAREDNIRKG
VENSLMLVTALNGKLGYDICAKIAKTAHKNGTTLREEAVGGGYLTNEEFDQYVRPENMIGPK

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=65.7266811279826, Blast_Score=609, Evalue=1e-174,
Organism=Escherichia coli, GI1787896, Length=461, Percent_Identity=55.7483731019523, Blast_Score=524, Evalue=1e-150,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=38.8286334056399, Blast_Score=324, Evalue=9e-90,
Organism=Caenorhabditis elegans, GI17553882, Length=465, Percent_Identity=67.9569892473118, Blast_Score=636, Evalue=0.0,
Organism=Caenorhabditis elegans, GI32565146, Length=328, Percent_Identity=68.2926829268293, Blast_Score=454, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6324993, Length=464, Percent_Identity=63.5775862068966, Blast_Score=594, Evalue=1e-170,
Organism=Drosophila melanogaster, GI24640179, Length=462, Percent_Identity=64.0692640692641, Blast_Score=600, Evalue=1e-172,
Organism=Drosophila melanogaster, GI24640177, Length=462, Percent_Identity=64.0692640692641, Blast_Score=600, Evalue=1e-172,
Organism=Drosophila melanogaster, GI24662684, Length=463, Percent_Identity=59.6112311015119, Blast_Score=569, Evalue=1e-162,
Organism=Drosophila melanogaster, GI78710009, Length=463, Percent_Identity=59.8272138228942, Blast_Score=563, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24583245, Length=464, Percent_Identity=50.4310344827586, Blast_Score=471, Evalue=1e-133,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FUMC_AGRT5 (Q8UEY7)

Other databases:

- EMBL:   AE007869
- PIR:   AD2775
- PIR:   B97555
- RefSeq:   NP_354610.2
- ProteinModelPortal:   Q8UEY7
- SMR:   Q8UEY7
- STRING:   Q8UEY7
- GeneID:   1133654
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1616
- eggNOG:   COG0114
- HOGENOM:   HBG284369
- OMA:   RIEKDTM
- PhylomeDB:   Q8UEY7
- ProtClustDB:   PRK00485
- BioCyc:   ATUM176299-1:ATU1616-MONOMER
- HAMAP:   MF_00743
- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00979

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.2.1.2

Molecular weight: Translated: 49244; Mature: 49113

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: BINDING 100-100

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATRTETDTFGPIEVQADRYWGAQAQRSLGNFKIGWEKQPASVVRALGIVKQAAARANM
CCCCCCCCCCCCCEEEECCCCCCHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHCE
ALAGLDPKVGDAIIAAAQEVIDGKLTEHFPLVVWQTGSGTQSNMNANEVISNRAIEMLGG
EEECCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
EMGTKKPVHPNDHVNMSQSSNDTYPTAMHIACVEEIVHHLLPALKHLHTALEAKVKQFEK
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIKIGRTHTQDATPLTLGQEFSGYAAQVASAIANIELTLPALSKLAQGGTAVGTGLNAPV
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEHHHHHHHHCCCCEECCCCCCCC
GFAEKVAEEISEITGLSFVTAPNKFEALASHDSMVFSHGAINAAAAALFKIANDIRFLGS
CHHHHHHHHHHHHCCCEEEECCCHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCC
GPRAGLGELSLPENEPGSSIMPGKVNPTQSEALTQVCAHIFGNNAALSFAGSQGHFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEE
YNPMMAYNFLQSVQLLGDAAVSFTDNCVVGIEAREDNIRKGVENSLMLVTALNGKLGYDI
CCHHHHHHHHHHHHHHHHHHHEECCCEEEEEECCCCHHHHCCCCCEEEEEECCCCCCHHH
CAKIAKTAHKNGTTLREEAVGGGYLTNEEFDQYVRPENMIGPK
HHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TATRTETDTFGPIEVQADRYWGAQAQRSLGNFKIGWEKQPASVVRALGIVKQAAARANM
CCCCCCCCCCCCEEEECCCCCCHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHCE
ALAGLDPKVGDAIIAAAQEVIDGKLTEHFPLVVWQTGSGTQSNMNANEVISNRAIEMLGG
EEECCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
EMGTKKPVHPNDHVNMSQSSNDTYPTAMHIACVEEIVHHLLPALKHLHTALEAKVKQFEK
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIKIGRTHTQDATPLTLGQEFSGYAAQVASAIANIELTLPALSKLAQGGTAVGTGLNAPV
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEHHHHHHHHCCCCEECCCCCCCC
GFAEKVAEEISEITGLSFVTAPNKFEALASHDSMVFSHGAINAAAAALFKIANDIRFLGS
CHHHHHHHHHHHHCCCEEEECCCHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCC
GPRAGLGELSLPENEPGSSIMPGKVNPTQSEALTQVCAHIFGNNAALSFAGSQGHFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEE
YNPMMAYNFLQSVQLLGDAAVSFTDNCVVGIEAREDNIRKGVENSLMLVTALNGKLGYDI
CCHHHHHHHHHHHHHHHHHHHEECCCEEEEEECCCCHHHHCCCCCEEEEEECCCCCCHHH
CAKIAKTAHKNGTTLREEAVGGGYLTNEEFDQYVRPENMIGPK
HHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194