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The map label for this gene is gph

Identifier: 159184839

GI number: 159184839

Start: 1596625

End: 1597326

Strand: Direct

Name: gph

Synonym: Atu1614

Alternate gene names: 159184839

Gene position: 1596625-1597326 (Clockwise)

Preceding gene: 159184836

Following gene: 159184840

Centisome position: 56.19

GC content: 60.83

Gene sequence:

>702_bases
GTGACATCCCGCCCGCTCTCCCCGCTCGCTATTTTCGATCTTGACGGCACGCTCGTCGATACCGCCGCCGATCTGGTCTC
CAGCCTCAACCACACCATCGCCGCAGCCGGGCTTGCCCCCGTCACCTATGACGATCTGACCCACCTCGTTGGCCAAGGCG
CGCGGGTGATGATCAAGCGCGCCTTCGCGTTGCGCGAGACGGAATTGCCGGAAGCCGATATCGATCCCCTTTACGAACGC
TTCATCACCCATTACCGCGCTGAAATGCCCGGCGAAAGCCGCCCCTATCCGGGCATCATCGAGACGCTGGATGCGCTCTC
GCAAGCCGGCATCACGCTTGCTGTCTGCACCAACAAGACCGAAATCCTCGCTGTGCCGCTGCTCGAAAAACTCGGCCTGA
CGCGTTATTTCGCGGCGATTACCTGCGGCGACACCTTCGCCTTCCGCAAGCCCGATGCCCGCCATATTCTCGGCACCATC
GAAAAGGCCGGGGGCGACGTGCAGCGCTCCATAATGGTCGGCGACAGCATCAACGACATTCTCGCCGCCAGGAATGCAGC
AGTACCATCAATCGGCGTGACCTTCGGTTATACGGATGTGCCGATGGTAGAACTTGAGCCGGATGTCGTGATTGATGATT
TCGCCGCTCTAACGCCGGCGCTCTTTGAGAAGCTGGTTTCCAAGGGTGCAGCGGCAGCCTGA

Upstream 100 bases:

>100_bases
CGTTGTGACGCGGTTGCAAAGACAGGCCCGTTTGCCTAGGCTTGGCGTCAATGAAAGCGCAGATCGTTCAGCACCCGCAT
TCCCCAAGAGGCCCGTTCCC

Downstream 100 bases:

>100_bases
GAGGCTGGACGACATAAAAGCAGGAATGGGGCGAATGAGGATGACATTTCCTCACTCTCGACGTCATCCTCGGCCTTGCG
CCGAGGATCTAATCACATCC

Product: phosphoglycolate phosphatase

Products: NA

Alternate protein names: PGP; PGPase

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MTSRPLSPLAIFDLDGTLVDTAADLVSSLNHTIAAAGLAPVTYDDLTHLVGQGARVMIKRAFALRETELPEADIDPLYER
FITHYRAEMPGESRPYPGIIETLDALSQAGITLAVCTNKTEILAVPLLEKLGLTRYFAAITCGDTFAFRKPDARHILGTI
EKAGGDVQRSIMVGDSINDILAARNAAVPSIGVTFGYTDVPMVELEPDVVIDDFAALTPALFEKLVSKGAAAA

Sequences:

>Translated_233_residues
MTSRPLSPLAIFDLDGTLVDTAADLVSSLNHTIAAAGLAPVTYDDLTHLVGQGARVMIKRAFALRETELPEADIDPLYER
FITHYRAEMPGESRPYPGIIETLDALSQAGITLAVCTNKTEILAVPLLEKLGLTRYFAAITCGDTFAFRKPDARHILGTI
EKAGGDVQRSIMVGDSINDILAARNAAVPSIGVTFGYTDVPMVELEPDVVIDDFAALTPALFEKLVSKGAAAA
>Mature_232_residues
TSRPLSPLAIFDLDGTLVDTAADLVSSLNHTIAAAGLAPVTYDDLTHLVGQGARVMIKRAFALRETELPEADIDPLYERF
ITHYRAEMPGESRPYPGIIETLDALSQAGITLAVCTNKTEILAVPLLEKLGLTRYFAAITCGDTFAFRKPDARHILGTIE
KAGGDVQRSIMVGDSINDILAARNAAVPSIGVTFGYTDVPMVELEPDVVIDDFAALTPALFEKLVSKGAAAA

Specific function: Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stres

COG id: COG0546

COG function: function code R; Predicted phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family

Homologues:

Organism=Escherichia coli, GI1789787, Length=228, Percent_Identity=32.0175438596491, Blast_Score=110, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPH_AGRT5 (Q8UEY9)

Other databases:

- EMBL:   AE007869
- PIR:   AB2775
- PIR:   H97554
- RefSeq:   NP_354608.2
- ProteinModelPortal:   Q8UEY9
- SMR:   Q8UEY9
- STRING:   Q8UEY9
- GeneID:   1133652
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1614
- eggNOG:   COG0546
- HOGENOM:   HBG742904
- OMA:   ERFITHY
- PhylomeDB:   Q8UEY9
- ProtClustDB:   PRK13222
- BioCyc:   ATUM176299-1:ATU1614-MONOMER
- HAMAP:   MF_00495
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR006346
- InterPro:   IPR023198
- Gene3D:   G3DSA:3.40.50.1000
- Gene3D:   G3DSA:1.10.150.240
- TIGRFAMs:   TIGR01549
- TIGRFAMs:   TIGR01509
- TIGRFAMs:   TIGR01449

Pfam domain/function: PF00702 Hydrolase; SSF56784 SSF56784

EC number: =3.1.3.18

Molecular weight: Translated: 24886; Mature: 24755

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: NA

Important sites: ACT_SITE 13-13

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRPLSPLAIFDLDGTLVDTAADLVSSLNHTIAAAGLAPVTYDDLTHLVGQGARVMIKR
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHH
AFALRETELPEADIDPLYERFITHYRAEMPGESRPYPGIIETLDALSQAGITLAVCTNKT
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCC
EILAVPLLEKLGLTRYFAAITCGDTFAFRKPDARHILGTIEKAGGDVQRSIMVGDSINDI
EEEEHHHHHHHCHHHHHHHHEECCCCEECCCCHHHHHHHHHHCCCCCEEEEEECCCHHHH
LAARNAAVPSIGVTFGYTDVPMVELEPDVVIDDFAALTPALFEKLVSKGAAAA
HHHHCCCCCCCCEEECCCCCCEEEECCCEEHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TSRPLSPLAIFDLDGTLVDTAADLVSSLNHTIAAAGLAPVTYDDLTHLVGQGARVMIKR
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHH
AFALRETELPEADIDPLYERFITHYRAEMPGESRPYPGIIETLDALSQAGITLAVCTNKT
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCC
EILAVPLLEKLGLTRYFAAITCGDTFAFRKPDARHILGTIEKAGGDVQRSIMVGDSINDI
EEEEHHHHHHHCHHHHHHHHEECCCCEECCCCHHHHHHHHHHCCCCCEEEEEECCCHHHH
LAARNAAVPSIGVTFGYTDVPMVELEPDVVIDDFAALTPALFEKLVSKGAAAA
HHHHCCCCCCCCEEECCCCCCEEEECCCEEHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194