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The map label for this gene is fdhA [H]

Identifier: 159184819

GI number: 159184819

Start: 1553545

End: 1554741

Strand: Direct

Name: fdhA [H]

Synonym: Atu1567

Alternate gene names: 159184819

Gene position: 1553545-1554741 (Clockwise)

Preceding gene: 159184816

Following gene: 15888887

Centisome position: 54.67

GC content: 62.24

Gene sequence:

>1197_bases
ATGGATATGAGCAGGAACAGAGGCGTCGTTTACCTGAAACCAGGCCAGGTCGAAGTCCGCGACATCGACGACCCGAAGCT
TGAGGCGCCGGATGGCCGCCGCATCGAGCACGGCGTCATTCTCAAGGTGATTTCCACGAATATCTGCGGCTCCGACCAGC
ACATGGTGCGCGGCCGCACCACCGCGATGCCGGGCCTCGTCCTTGGCCATGAAATCACCGGCGAAGTCATCGAAAAAGGC
ATCGACGTCGAAATGCTGCAGGTCGGCGACATCGTCTCCGTGCCGTTCAACGTCGCCTGCGGCCGTTGCCGCTGCTGCAA
GTCGCAGGATACCGGCGTCTGCCTGACGGTGAACCCGTCACGCGCCGGCGGCGCTTACGGTTATGTCGATATGGGCGGCT
GGATCGGCGGACAGGCCCGTTATGTCACGATCCCTTATGCCGATTTCAACCTTCTGAAATTCCCCGATCGCGACAAGGCG
ATGTCGAAGATCCGCGACCTTACCATGCTATCAGACATTCTGCCGACCGGCTTCCATGGCGCGGTCAAGGCAGGCGTCGG
CGTCGGCTCCACGGTTTATGTCGCCGGCGCCGGCCCGGTCGGTCTTGCCGCCGCCGCCTCCGCCCGCATTCTGGGTGCGG
CCGTTGTCATGGTCGGCGATTTCAACAAGGATCGTCTCGCCCATGCGGCAAGAGTCGGTTTTGAACCCGTCGATCTTTCC
AAGGGCGACCGGCTGGGCGACATGATCGCTGAGATCGTCGGCACCAATGAGGTGGACAGCGCCATCGACGCCGTCGGCTT
CGAAGCCCGCGGCCATTCCGGCGGCGAACAGCCGGCCATCGTTCTTAACCAGATGATGGAGATTACCCGCGCCGCCGGCT
CCATCGGCATTCCCGGTCTCTACGTCACCGAAGACCCCGGCGCGGTTGACAATGCGGCAAAGCAGGGCGCCCTGTCGCTG
CGCTTCGGCCTTGGCTGGGCGAAGGCGCAATCCTTCCACACCGGCCAGACACCGGTGCTGAAATATAATCGTCAGCTGAT
GCAGGCCATCCTGCACGACCGCCTGCCGATTGCCGATATCGTCAACGCCAAGATCATCGCCCTTGATGATGCCGTGCAGG
GATATGAAAGCTTTGATCAGGGCGCGGCCACCAAGTTCGTGCTTGATCCGCATGGCGATCTGCTGAAGGCAGCCTGA

Upstream 100 bases:

>100_bases
CTTCGACGCGGGATTTCGCGTCGGAACGGTTGAAGTGCATTTCGATAAAATTATGCCCGCGGAGGAGCGGGCCGGCATTG
ATGTTCAAACCACGGAGGAG

Downstream 100 bases:

>100_bases
TATAACCGACAATTTTTCCAGGGAATGAAGGCACCCGCGGCAATCTCGCCGCGGGTGTTTTTTGTCTCCTGTCTCCGACT
GGAGATATTACGCTTCGCTT

Product: glutathione-independent formaldehyde dehydrogenase

Products: NA

Alternate protein names: FALDH; FDH [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MDMSRNRGVVYLKPGQVEVRDIDDPKLEAPDGRRIEHGVILKVISTNICGSDQHMVRGRTTAMPGLVLGHEITGEVIEKG
IDVEMLQVGDIVSVPFNVACGRCRCCKSQDTGVCLTVNPSRAGGAYGYVDMGGWIGGQARYVTIPYADFNLLKFPDRDKA
MSKIRDLTMLSDILPTGFHGAVKAGVGVGSTVYVAGAGPVGLAAAASARILGAAVVMVGDFNKDRLAHAARVGFEPVDLS
KGDRLGDMIAEIVGTNEVDSAIDAVGFEARGHSGGEQPAIVLNQMMEITRAAGSIGIPGLYVTEDPGAVDNAAKQGALSL
RFGLGWAKAQSFHTGQTPVLKYNRQLMQAILHDRLPIADIVNAKIIALDDAVQGYESFDQGAATKFVLDPHGDLLKAA

Sequences:

>Translated_398_residues
MDMSRNRGVVYLKPGQVEVRDIDDPKLEAPDGRRIEHGVILKVISTNICGSDQHMVRGRTTAMPGLVLGHEITGEVIEKG
IDVEMLQVGDIVSVPFNVACGRCRCCKSQDTGVCLTVNPSRAGGAYGYVDMGGWIGGQARYVTIPYADFNLLKFPDRDKA
MSKIRDLTMLSDILPTGFHGAVKAGVGVGSTVYVAGAGPVGLAAAASARILGAAVVMVGDFNKDRLAHAARVGFEPVDLS
KGDRLGDMIAEIVGTNEVDSAIDAVGFEARGHSGGEQPAIVLNQMMEITRAAGSIGIPGLYVTEDPGAVDNAAKQGALSL
RFGLGWAKAQSFHTGQTPVLKYNRQLMQAILHDRLPIADIVNAKIIALDDAVQGYESFDQGAATKFVLDPHGDLLKAA
>Mature_398_residues
MDMSRNRGVVYLKPGQVEVRDIDDPKLEAPDGRRIEHGVILKVISTNICGSDQHMVRGRTTAMPGLVLGHEITGEVIEKG
IDVEMLQVGDIVSVPFNVACGRCRCCKSQDTGVCLTVNPSRAGGAYGYVDMGGWIGGQARYVTIPYADFNLLKFPDRDKA
MSKIRDLTMLSDILPTGFHGAVKAGVGVGSTVYVAGAGPVGLAAAASARILGAAVVMVGDFNKDRLAHAARVGFEPVDLS
KGDRLGDMIAEIVGTNEVDSAIDAVGFEARGHSGGEQPAIVLNQMMEITRAAGSIGIPGLYVTEDPGAVDNAAKQGALSL
RFGLGWAKAQSFHTGQTPVLKYNRQLMQAILHDRLPIADIVNAKIIALDDAVQGYESFDQGAATKFVLDPHGDLLKAA

Specific function: Catalyzes the oxidation of long-chain alcohols but is inactive against ethanol [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=227, Percent_Identity=29.5154185022026, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI4501929, Length=236, Percent_Identity=29.2372881355932, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI34577061, Length=230, Percent_Identity=30.4347826086957, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI262073058, Length=289, Percent_Identity=25.6055363321799, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI71743840, Length=275, Percent_Identity=25.8181818181818, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI4501939, Length=282, Percent_Identity=26.241134751773, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI156523966, Length=282, Percent_Identity=26.241134751773, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI71565154, Length=253, Percent_Identity=26.8774703557312, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786825, Length=401, Percent_Identity=34.1645885286783, Blast_Score=188, Evalue=4e-49,
Organism=Escherichia coli, GI1790045, Length=359, Percent_Identity=27.8551532033426, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790718, Length=263, Percent_Identity=25.0950570342205, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI226510992, Length=267, Percent_Identity=30.3370786516854, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1788073, Length=203, Percent_Identity=29.064039408867, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI87082125, Length=238, Percent_Identity=30.2521008403361, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1787863, Length=250, Percent_Identity=28.8, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=287, Percent_Identity=27.8745644599303, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=255, Percent_Identity=29.0196078431373, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319955, Length=276, Percent_Identity=30.4347826086957, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322619, Length=276, Percent_Identity=30.4347826086957, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6323099, Length=308, Percent_Identity=25, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=255, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17737897, Length=256, Percent_Identity=30.859375, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17137530, Length=260, Percent_Identity=31.1538461538462, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR014184
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.2.1.46 [H]

Molecular weight: Translated: 42081; Mature: 42081

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00059 ADH_ZINC ; PS00862 OX2_COVAL_FAD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMSRNRGVVYLKPGQVEVRDIDDPKLEAPDGRRIEHGVILKVISTNICGSDQHMVRGRT
CCCCCCCCEEEECCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHCCCC
TAMPGLVLGHEITGEVIEKGIDVEMLQVGDIVSVPFNVACGRCRCCKSQDTGVCLTVNPS
CCCCCEEECCHHHHHHHHCCCCEEEEEECCEEECCCCCCCCCCEECCCCCCCEEEEECCC
RAGGAYGYVDMGGWIGGQARYVTIPYADFNLLKFPDRDKAMSKIRDLTMLSDILPTGFHG
CCCCCEEEEECCCCCCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCH
AVKAGVGVGSTVYVAGAGPVGLAAAASARILGAAVVMVGDFNKDRLAHAARVGFEPVDLS
HHHHCCCCCCEEEEECCCCHHHHHHHHHHHEEEEEEEEECCCHHHHHHHHHCCCCCCCCC
KGDRLGDMIAEIVGTNEVDSAIDAVGFEARGHSGGEQPAIVLNQMMEITRAAGSIGIPGL
CCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEE
YVTEDPGAVDNAAKQGALSLRFGLGWAKAQSFHTGQTPVLKYNRQLMQAILHDRLPIADI
EEECCCCCCCHHHHCCCEEEEECCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHH
VNAKIIALDDAVQGYESFDQGAATKFVLDPHGDLLKAA
CCCEEEEECHHHHHHHHHCCCCCEEEEECCCCHHHCCC
>Mature Secondary Structure
MDMSRNRGVVYLKPGQVEVRDIDDPKLEAPDGRRIEHGVILKVISTNICGSDQHMVRGRT
CCCCCCCCEEEECCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHCCCC
TAMPGLVLGHEITGEVIEKGIDVEMLQVGDIVSVPFNVACGRCRCCKSQDTGVCLTVNPS
CCCCCEEECCHHHHHHHHCCCCEEEEEECCEEECCCCCCCCCCEECCCCCCCEEEEECCC
RAGGAYGYVDMGGWIGGQARYVTIPYADFNLLKFPDRDKAMSKIRDLTMLSDILPTGFHG
CCCCCEEEEECCCCCCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCH
AVKAGVGVGSTVYVAGAGPVGLAAAASARILGAAVVMVGDFNKDRLAHAARVGFEPVDLS
HHHHCCCCCCEEEEECCCCHHHHHHHHHHHEEEEEEEEECCCHHHHHHHHHCCCCCCCCC
KGDRLGDMIAEIVGTNEVDSAIDAVGFEARGHSGGEQPAIVLNQMMEITRAAGSIGIPGL
CCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEE
YVTEDPGAVDNAAKQGALSLRFGLGWAKAQSFHTGQTPVLKYNRQLMQAILHDRLPIADI
EEECCCCCCCHHHHCCCEEEEECCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHH
VNAKIIALDDAVQGYESFDQGAATKFVLDPHGDLLKAA
CCCEEEEECHHHHHHHHHCCCCCEEEEECCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]