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The map label for this gene is dac [H]

Identifier: 159184788

GI number: 159184788

Start: 1494021

End: 1495520

Strand: Direct

Name: dac [H]

Synonym: Atu1505

Alternate gene names: 159184788

Gene position: 1494021-1495520 (Clockwise)

Preceding gene: 15888829

Following gene: 15888831

Centisome position: 52.58

GC content: 60.8

Gene sequence:

>1500_bases
ATGCGATTGAAGAGTTCAGCAGTGTTGAAAAGTCTATCTGGAGCACATTCGCGCAAAGCGGGTGCAACGTCTTTCGTGAG
GTTTGTTGCGTTGACCCTTGCTGCGGCGTTCATAGCCGCAACATCCGTTCAGACCGCAAAGGCCGACCCGAAATATGCGG
GTATCGTCATCGACGCAAAGTCTGGCAAGGTCCTGTATGGTGAGGATCCTGACGGTCTGCGTTATCCGGCATCGTTGACG
AAGATGATGACGCTTTATCTGACATTCGAGGCACTCAACAGCGGACGCATTTCGCTTGATTCCAGGGTGACTGTTTCGGC
CAATGCCGCAAAGGAGCCGCCGTCGAAGCTCGGCGTGCGCGCCGGCGGCAGCGTTACCGTGGAACAGGCTATCCTTGCCC
TCGTTACCCGGTCCGCAAACGATATGGCGACCGCGCTCGGCGAACATCTCGGCGGCTCGGAAGACCGTTTTGCCAGAATG
ATGACGGCAAAGGCCCGTGCACTTGGCATGACCCGCACGACCTATCGCAATGCCAACGGCCTGCCCAACACGGCGCAGAT
GACGACGGCACGCGACCAGGCCCGTCTCGGCATCGCGCTTCGCCAGCATTTTCCGCAATATTACGGTTATTTCAGCACCC
GAACCTTCAATTTCGGCAAGCAGGTGATTGGCAATCACAATCGCCTCGTCGGAACCGTGAAGGGCGTGGATGGCATCAAG
ACCGGTTACACCCGCGCAGCCGGCAGCAATCTGGCGACATCAGCGCAGCTCGATGGCCGCTCTATCGTCGCCGTCGTTCT
CGGCGGACGCTCCAGCGCTGCCCGTGATGCCACCATGCGCAAGCTCGTCGCAACCTATCTGCCGCAGGCATCGCGCGGCG
GCAACAGCAACCTGATCGCACAGACGCGTTCTGGCCCGGTCGAAGAACCCGTTACCGTGGCGGCAGCCGCGCCTTATCCT
TCCGTGGCAGTCGCCGCAACCGATTCCGGCCTGCCCAACGCCGGTCCCGTTCCGCAGACCCGTTACGAAGAAGCACCCGT
CACAGCCTTTGCAGGCTCTTCTTCCAATGCCGCCGTCAAGGCCATGGAAGCCGCCACCTGGCAGAAGGGCAAAGATCCGA
TCGTTCGCGCACCGGTCGCTCCCGATCGTAAGCTGATCACCAACTCGACCAAGGTGGACAATATCGTCACGGCATCGACG
GCAGCATCCGCATCCGCCGCACCTTCCGTCTCACCCAGGGCAGAGGCGCCGCAGGGTGGCTGGGTCATCCAGATCGGCGC
ATCGCCGGACGAAAACTCCGCCCGTGGCCTGCTGCAGAACGCACAGGAAAAAGGCGGCGCGGCACTGCGCTCCGCAAAAC
CCTTCACGGTCGCCTTCAGCAAGGACGGCTCCCAGATCTACCGCGCCCGTTTCGGCGGCTTTGACGGCCAGAACGCTGCG
GTAAATGCATGTAACGTATTGAAAAAGAAAGGCGTGAGCTGCTGGGCGTCACTCCAGTAA

Upstream 100 bases:

>100_bases
TATGGAAGGCGGATACCTTTCATAAACCACTTGGTAACGCCATCCCGATAAAGTTTCTTGCCGGAGCATCGGGCGGGGCG
TGTCCGAGCGGAACAGAAAT

Downstream 100 bases:

>100_bases
CTGATGTTTCCGCAGGCGGTGCTTCATTGTCGAAACATCGCCTGTCTCCTCGAATTGTGTAATGAGTAGCGAGGCTTTCG
AAGATGGCAGTCAACGAGAA

Product: penicillin-binding protein

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MRLKSSAVLKSLSGAHSRKAGATSFVRFVALTLAAAFIAATSVQTAKADPKYAGIVIDAKSGKVLYGEDPDGLRYPASLT
KMMTLYLTFEALNSGRISLDSRVTVSANAAKEPPSKLGVRAGGSVTVEQAILALVTRSANDMATALGEHLGGSEDRFARM
MTAKARALGMTRTTYRNANGLPNTAQMTTARDQARLGIALRQHFPQYYGYFSTRTFNFGKQVIGNHNRLVGTVKGVDGIK
TGYTRAAGSNLATSAQLDGRSIVAVVLGGRSSAARDATMRKLVATYLPQASRGGNSNLIAQTRSGPVEEPVTVAAAAPYP
SVAVAATDSGLPNAGPVPQTRYEEAPVTAFAGSSSNAAVKAMEAATWQKGKDPIVRAPVAPDRKLITNSTKVDNIVTAST
AASASAAPSVSPRAEAPQGGWVIQIGASPDENSARGLLQNAQEKGGAALRSAKPFTVAFSKDGSQIYRARFGGFDGQNAA
VNACNVLKKKGVSCWASLQ

Sequences:

>Translated_499_residues
MRLKSSAVLKSLSGAHSRKAGATSFVRFVALTLAAAFIAATSVQTAKADPKYAGIVIDAKSGKVLYGEDPDGLRYPASLT
KMMTLYLTFEALNSGRISLDSRVTVSANAAKEPPSKLGVRAGGSVTVEQAILALVTRSANDMATALGEHLGGSEDRFARM
MTAKARALGMTRTTYRNANGLPNTAQMTTARDQARLGIALRQHFPQYYGYFSTRTFNFGKQVIGNHNRLVGTVKGVDGIK
TGYTRAAGSNLATSAQLDGRSIVAVVLGGRSSAARDATMRKLVATYLPQASRGGNSNLIAQTRSGPVEEPVTVAAAAPYP
SVAVAATDSGLPNAGPVPQTRYEEAPVTAFAGSSSNAAVKAMEAATWQKGKDPIVRAPVAPDRKLITNSTKVDNIVTAST
AASASAAPSVSPRAEAPQGGWVIQIGASPDENSARGLLQNAQEKGGAALRSAKPFTVAFSKDGSQIYRARFGGFDGQNAA
VNACNVLKKKGVSCWASLQ
>Mature_499_residues
MRLKSSAVLKSLSGAHSRKAGATSFVRFVALTLAAAFIAATSVQTAKADPKYAGIVIDAKSGKVLYGEDPDGLRYPASLT
KMMTLYLTFEALNSGRISLDSRVTVSANAAKEPPSKLGVRAGGSVTVEQAILALVTRSANDMATALGEHLGGSEDRFARM
MTAKARALGMTRTTYRNANGLPNTAQMTTARDQARLGIALRQHFPQYYGYFSTRTFNFGKQVIGNHNRLVGTVKGVDGIK
TGYTRAAGSNLATSAQLDGRSIVAVVLGGRSSAARDATMRKLVATYLPQASRGGNSNLIAQTRSGPVEEPVTVAAAAPYP
SVAVAATDSGLPNAGPVPQTRYEEAPVTAFAGSSSNAAVKAMEAATWQKGKDPIVRAPVAPDRKLITNSTKVDNIVTAST
AASASAAPSVSPRAEAPQGGWVIQIGASPDENSARGLLQNAQEKGGAALRSAKPFTVAFSKDGSQIYRARFGGFDGQNAA
VNACNVLKKKGVSCWASLQ

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=263, Percent_Identity=35.7414448669202, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1786851, Length=273, Percent_Identity=33.3333333333333, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI87082022, Length=267, Percent_Identity=32.9588014981273, Blast_Score=122, Evalue=8e-29,
Organism=Escherichia coli, GI87082054, Length=247, Percent_Identity=27.9352226720648, Blast_Score=82, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 51930; Mature: 51930

Theoretical pI: Translated: 10.78; Mature: 10.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLKSSAVLKSLSGAHSRKAGATSFVRFVALTLAAAFIAATSVQTAKADPKYAGIVIDAK
CCCCHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCEEEEEEECC
SGKVLYGEDPDGLRYPASLTKMMTLYLTFEALNSGRISLDSRVTVSANAAKEPPSKLGVR
CCEEEECCCCCCCCCCHHHHHHHHHHHEEECCCCCCEEECCEEEEECCCCCCCHHHCCCC
AGGSVTVEQAILALVTRSANDMATALGEHLGGSEDRFARMMTAKARALGMTRTTYRNANG
CCCCEEHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCC
LPNTAQMTTARDQARLGIALRQHFPQYYGYFSTRTFNFGKQVIGNHNRLVGTVKGVDGIK
CCCCHHHHHHHHHHHHHHHHHHHCHHHHCCCCEEEECCCHHHHCCCCEEEEEECCCCCCC
TGYTRAAGSNLATSAQLDGRSIVAVVLGGRSSAARDATMRKLVATYLPQASRGGNSNLIA
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEE
QTRSGPVEEPVTVAAAAPYPSVAVAATDSGLPNAGPVPQTRYEEAPVTAFAGSSSNAAVK
ECCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEE
AMEAATWQKGKDPIVRAPVAPDRKLITNSTKVDNIVTASTAASASAAPSVSPRAEAPQGG
HHHHHHHCCCCCCEEECCCCCCCCEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCC
WVIQIGASPDENSARGLLQNAQEKGGAALRSAKPFTVAFSKDGSQIYRARFGGFDGQNAA
EEEEECCCCCCHHHHHHHHHHHHHCCCHHHCCCCEEEEECCCCHHHHHHHHCCCCCCCHH
VNACNVLKKKGVSCWASLQ
HHHHHHHHHCCCCEEEECC
>Mature Secondary Structure
MRLKSSAVLKSLSGAHSRKAGATSFVRFVALTLAAAFIAATSVQTAKADPKYAGIVIDAK
CCCCHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCEEEEEEECC
SGKVLYGEDPDGLRYPASLTKMMTLYLTFEALNSGRISLDSRVTVSANAAKEPPSKLGVR
CCEEEECCCCCCCCCCHHHHHHHHHHHEEECCCCCCEEECCEEEEECCCCCCCHHHCCCC
AGGSVTVEQAILALVTRSANDMATALGEHLGGSEDRFARMMTAKARALGMTRTTYRNANG
CCCCEEHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCC
LPNTAQMTTARDQARLGIALRQHFPQYYGYFSTRTFNFGKQVIGNHNRLVGTVKGVDGIK
CCCCHHHHHHHHHHHHHHHHHHHCHHHHCCCCEEEECCCHHHHCCCCEEEEEECCCCCCC
TGYTRAAGSNLATSAQLDGRSIVAVVLGGRSSAARDATMRKLVATYLPQASRGGNSNLIA
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEE
QTRSGPVEEPVTVAAAAPYPSVAVAATDSGLPNAGPVPQTRYEEAPVTAFAGSSSNAAVK
ECCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEE
AMEAATWQKGKDPIVRAPVAPDRKLITNSTKVDNIVTASTAASASAAPSVSPRAEAPQGG
HHHHHHHCCCCCCEEECCCCCCCCEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCC
WVIQIGASPDENSARGLLQNAQEKGGAALRSAKPFTVAFSKDGSQIYRARFGGFDGQNAA
EEEEECCCCCCHHHHHHHHHHHHHCCCHHHCCCCEEEEECCCCHHHHHHHHCCCCCCCHH
VNACNVLKKKGVSCWASLQ
HHHHHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]