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The map label for this gene is hflx [H]

Identifier: 159184763

GI number: 159184763

Start: 1446573

End: 1447907

Strand: Direct

Name: hflx [H]

Synonym: Atu1451

Alternate gene names: 159184763

Gene position: 1446573-1447907 (Clockwise)

Preceding gene: 17935350

Following gene: 159184766

Centisome position: 50.91

GC content: 60.67

Gene sequence:

>1335_bases
ATGCGCGCGGTCGTTCTTGTACCCTTCCTCAAGCAGCAGCGCGAAAATCGTGACGCGGCATCAGCCCCGGCTGCTCCCGG
CCGTTCCGTCGAAGCCAAGCTTGAGGAAGCGAAGGGTCTGGCGCTTGCCATCGATCTCGAGGTGACCCAGGGGCTCGTCG
TTCCCGTCAACCAGCCGCGTCCCGCAACCCTGTTCGGAACCGGCAAGATCGAGGAAATCGGTCATCTCTTGGATGAAACC
AATTCCGGCCTGGTGATTGTCGATCATCCGCTCACCCCGGTGCAGCAGCGCAATCTCGAAAAGCAGTGGAACGCCAAGGT
TATCGACCGCACCGGTCTGATCCTTGAAATCTTCGGCCGCCGCGCCTCCACCAAGGAAGGCACGCTGCAGGTCGATCTTG
CGCATCTGAACTACCAGAAGGGCCGCCTCGTCAGAAGCTGGACCCACCTTGAACGCCAGCGCGGTGGTGCAGGCTTCATG
GGTGGCCCGGGTGAAACCCAGATCGAGGCCGACAGACGATTGCTGCAGGATCGCATCGTCAAGCTCGAGAAGGAGCTGGA
GCAGGTGGTGCGCACCCGCCAGCTTCACCGCGCCAAGCGCCGCAAAGTGCCGCATCCGATCGTGGCACTTGTTGGCTATA
CCAATGCTGGCAAATCCACGCTGTTCAACCGCATCACGGGTGCGGGTGTTCTGGCCGAAGACATGCTGTTCGCTACACTC
GACCCGACCCTGCGCCGTATGAAACTGCCGCATGGCCGAACCGTCATCCTGTCGGATACGGTGGGCTTTATTTCCGACCT
GCCGACGCATCTCGTCGCCGCTTTCCGCGCAACGCTGGAAGAGGTGCTGGAAGCCGATCTTGTTCTGCACGTGCGTGACA
TGTCCGATCCGGACAATGCCGCCCAGTCTGCTGATGTGCTGCGCATTCTTGGCGACCTCGGCATTGACGAGAAGGAAGCC
GAAAAGCGCATCATCGAGGTCTGGAACAAGGTCGACCGTCTGGAGCCCGAAGCACACGACGCCATCATGCAGCGCGCCGA
AGGCCGCTCAGATATCCGCGCCGTTTCGGCCATCACGGGCGAGGGCGTCGATGCCCTGATGGAAGAGATTTCAAAACGCC
TGTCCGGTGTGCTGACGGAAACGACCGTGGTGCTTTCTGTCGAGCAATTGCCGCTGATCTCCTGGGTCTACAGCAATTCC
ATCGTCGACAATCGTGAAGATCACGAAGACGGATCGGTTGCGCTGGATGTGCGCCTGTCGGAAGCGCAGGCTGTGGAACT
CGAACGGAAGCTTGGAAAGACGGCTGGTCGCGAGCGGGAAGACTGGGAACGCTGA

Upstream 100 bases:

>100_bases
AACATTCTTTACATTCTTTCTGGATAAGGCCGAACCCATTTCAACACGCGACACCTCGAGCGAATCGATCATTCCGGAGC
AGGAAAAACGCCGCGACGAC

Downstream 100 bases:

>100_bases
GCGCTTCTTGAAGGTACAAATTCCGTCAGATGCGACGTCATCCTCGGGCTTGTCCCGAGGATCCGCTACGGTATTCAAAA
TCGATAGGCAGCAGATGCCC

Product: GTP-binding protein HFLX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MRAVVLVPFLKQQRENRDAASAPAAPGRSVEAKLEEAKGLALAIDLEVTQGLVVPVNQPRPATLFGTGKIEEIGHLLDET
NSGLVIVDHPLTPVQQRNLEKQWNAKVIDRTGLILEIFGRRASTKEGTLQVDLAHLNYQKGRLVRSWTHLERQRGGAGFM
GGPGETQIEADRRLLQDRIVKLEKELEQVVRTRQLHRAKRRKVPHPIVALVGYTNAGKSTLFNRITGAGVLAEDMLFATL
DPTLRRMKLPHGRTVILSDTVGFISDLPTHLVAAFRATLEEVLEADLVLHVRDMSDPDNAAQSADVLRILGDLGIDEKEA
EKRIIEVWNKVDRLEPEAHDAIMQRAEGRSDIRAVSAITGEGVDALMEEISKRLSGVLTETTVVLSVEQLPLISWVYSNS
IVDNREDHEDGSVALDVRLSEAQAVELERKLGKTAGREREDWER

Sequences:

>Translated_444_residues
MRAVVLVPFLKQQRENRDAASAPAAPGRSVEAKLEEAKGLALAIDLEVTQGLVVPVNQPRPATLFGTGKIEEIGHLLDET
NSGLVIVDHPLTPVQQRNLEKQWNAKVIDRTGLILEIFGRRASTKEGTLQVDLAHLNYQKGRLVRSWTHLERQRGGAGFM
GGPGETQIEADRRLLQDRIVKLEKELEQVVRTRQLHRAKRRKVPHPIVALVGYTNAGKSTLFNRITGAGVLAEDMLFATL
DPTLRRMKLPHGRTVILSDTVGFISDLPTHLVAAFRATLEEVLEADLVLHVRDMSDPDNAAQSADVLRILGDLGIDEKEA
EKRIIEVWNKVDRLEPEAHDAIMQRAEGRSDIRAVSAITGEGVDALMEEISKRLSGVLTETTVVLSVEQLPLISWVYSNS
IVDNREDHEDGSVALDVRLSEAQAVELERKLGKTAGREREDWER
>Mature_444_residues
MRAVVLVPFLKQQRENRDAASAPAAPGRSVEAKLEEAKGLALAIDLEVTQGLVVPVNQPRPATLFGTGKIEEIGHLLDET
NSGLVIVDHPLTPVQQRNLEKQWNAKVIDRTGLILEIFGRRASTKEGTLQVDLAHLNYQKGRLVRSWTHLERQRGGAGFM
GGPGETQIEADRRLLQDRIVKLEKELEQVVRTRQLHRAKRRKVPHPIVALVGYTNAGKSTLFNRITGAGVLAEDMLFATL
DPTLRRMKLPHGRTVILSDTVGFISDLPTHLVAAFRATLEEVLEADLVLHVRDMSDPDNAAQSADVLRILGDLGIDEKEA
EKRIIEVWNKVDRLEPEAHDAIMQRAEGRSDIRAVSAITGEGVDALMEEISKRLSGVLTETTVVLSVEQLPLISWVYSNS
IVDNREDHEDGSVALDVRLSEAQAVELERKLGKTAGREREDWER

Specific function: Unknown

COG id: COG2262

COG function: function code R; GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI310133118, Length=297, Percent_Identity=35.6902356902357, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI310133116, Length=286, Percent_Identity=36.013986013986, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI310124269, Length=267, Percent_Identity=36.3295880149813, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI310124267, Length=267, Percent_Identity=36.3295880149813, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI310124171, Length=267, Percent_Identity=36.3295880149813, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI310124169, Length=267, Percent_Identity=36.3295880149813, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1790615, Length=386, Percent_Identity=45.5958549222798, Blast_Score=290, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI17561038, Length=419, Percent_Identity=31.5035799522673, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24650079, Length=427, Percent_Identity=31.8501170960187, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR016496
- InterPro:   IPR006073
- InterPro:   IPR002917 [H]

Pfam domain/function: PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 49300; Mature: 49300

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVVLVPFLKQQRENRDAASAPAAPGRSVEAKLEEAKGLALAIDLEVTQGLVVPVNQPR
CCEEEEEHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEEEEECCCEEEECCCCC
PATLFGTGKIEEIGHLLDETNSGLVIVDHPLTPVQQRNLEKQWNAKVIDRTGLILEIFGR
CCEEEECCCHHHHHHHHHCCCCCEEEECCCCCCHHHHCCHHHCCCEEECCCCHHHEECCC
RASTKEGTLQVDLAHLNYQKGRLVRSWTHLERQRGGAGFMGGPGETQIEADRRLLQDRIV
CCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
KLEKELEQVVRTRQLHRAKRRKVPHPIVALVGYTNAGKSTLFNRITGAGVLAEDMLFATL
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHC
DPTLRRMKLPHGRTVILSDTVGFISDLPTHLVAAFRATLEEVLEADLVLHVRDMSDPDNA
CHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHH
AQSADVLRILGDLGIDEKEAEKRIIEVWNKVDRLEPEAHDAIMQRAEGRSDIRAVSAITG
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCC
EGVDALMEEISKRLSGVLTETTVVLSVEQLPLISWVYSNSIVDNREDHEDGSVALDVRLS
CCHHHHHHHHHHHHHHHHHHHEEEEEHHHCCHHHHHHHCCCCCCCCCCCCCCEEEEEEEC
EAQAVELERKLGKTAGREREDWER
CHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRAVVLVPFLKQQRENRDAASAPAAPGRSVEAKLEEAKGLALAIDLEVTQGLVVPVNQPR
CCEEEEEHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEEEEECCCEEEECCCCC
PATLFGTGKIEEIGHLLDETNSGLVIVDHPLTPVQQRNLEKQWNAKVIDRTGLILEIFGR
CCEEEECCCHHHHHHHHHCCCCCEEEECCCCCCHHHHCCHHHCCCEEECCCCHHHEECCC
RASTKEGTLQVDLAHLNYQKGRLVRSWTHLERQRGGAGFMGGPGETQIEADRRLLQDRIV
CCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
KLEKELEQVVRTRQLHRAKRRKVPHPIVALVGYTNAGKSTLFNRITGAGVLAEDMLFATL
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHC
DPTLRRMKLPHGRTVILSDTVGFISDLPTHLVAAFRATLEEVLEADLVLHVRDMSDPDNA
CHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHH
AQSADVLRILGDLGIDEKEAEKRIIEVWNKVDRLEPEAHDAIMQRAEGRSDIRAVSAITG
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCC
EGVDALMEEISKRLSGVLTETTVVLSVEQLPLISWVYSNSIVDNREDHEDGSVALDVRLS
CCHHHHHHHHHHHHHHHHHHHEEEEEHHHCCHHHHHHHCCCCCCCCCCCCCCEEEEEEEC
EAQAVELERKLGKTAGREREDWER
CHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8248183; 7610040; 9278503; 2020545; 3040675 [H]