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The map label for this gene is nuoN [H]

Identifier: 159184691

GI number: 159184691

Start: 1270546

End: 1271988

Strand: Direct

Name: nuoN [H]

Synonym: Atu1283

Alternate gene names: 159184691

Gene position: 1270546-1271988 (Clockwise)

Preceding gene: 15888611

Following gene: 15888613

Centisome position: 44.71

GC content: 58.7

Gene sequence:

>1443_bases
ATGACCGCTGAAATCCTTTTTGCCAGTCTGCACATCGCGACGCCCGAGCTGATCCTTGCGGTCGGCGCGCTGGCGCTGCT
CATGATTGGCGTCTTCTCGGGCGACAAGTCGACAACGACGGTGACCGGCCTTGCCGTTGCCCTCCTGCTCGTCGTCGGTC
TCTGGATCATCTTTGCCCCCGCATCGGGCGTGGCCTTCGGCGGTGTTTACATCGCCGATGCATTCGGCAATTTCATGAAG
GTGCTGGCGCTGATCGGCTCCATCACCGCCATGATCCTCGCCGTCGGCCAGGGCCGTTTCGAGCCGATCGGTCGTTTCGA
ATATCCGGTGCTGCTGGTTCTGGCCACTCTCGGCATCTTGCTGATGATCTCGGCCAACAACATGATCTCGCTCTACATGG
CGCTAGAACTGCAGTCGCTGGCCCTCTACGTCGTCTGCGCCATCAACCGCGAGAGCCTGCGCTCCACGGAAGCTGGCCTG
AAATACTTCGTTCTCGGCGCGCTCTCCTCCGGCATGCTGCTTTACGGCATGTCGCTGGTTTACGGCTTCACCGGCAATAC
CGGCTTCACCGAAATCGCGCAGGTTCTGGCGTCGGAAACGCGCTCGCTCGGCCTCGTCTTTGGTCTGGTCTTCGTTCTCG
CCGGTCTTGCGTTCAAGATTTCCGCCGTGCCGTTCCACATGTGGACGCCTGATGTTTATGAAGGTGCGCCGACCCCAGTC
ACCGCCTTCCTGTCGGCTGCACCGAAGATCGGCGCCATGGCGATCCTCGTGCGTATCGTCGTCGAGGCTTTCCAGCCGGT
CTTTGCCGACTGGCAGCAGATCGTCGTCTTCATCTCCATCGCTTCGATGCTGCTCGGCTCCTTCGCAGCAATCGGCCAGA
AGAACATCAAGCGCCTGATGGCCTATTCCTCCATCGGTCACATGGGTTATGCGCTGGTCGGTCTTGCGGCCGGCACCGAA
GCCGGTATTTCGGGCGTCATTCTTTACATGACCATCTACATGGTCATGACGCTTGGCACCTTCGCCTGCATTCTCTCCAT
GCGCCGCAAGGAAATCGGCAATGTCGAAAATGTTGAGGATCTTGCCGGGCTTTCCTCCACCAATCCCTTCATGGCGGTTG
TGTTGACGATCCTGATGTTCTCGCTTGCCGGTATTCCGCCGCTCGCCGGCTTCTTCGGCAAATATTACGTCTTCCTTGCC
GCCATCGAAGCGAAGCTTTATCCGCTCGCCATCATCGGTGTGATCGGCTCGGTTGTCGGCGCCTATTATTATATCCGCGT
CGTCAAGGTCATGTGGTTCGATGAGGCCAAGGACAAGTTCGAACGTCCGGCCGGTGAACTGAAAGTCGTTTATGCGCTTT
CGGCCCTGTTCGTTGTCGCCTTCGTCGTCTTTGGCGGTGCACTTGGCAACGCGGTGACTGTTGCGGCGAAGACCTTCTTT
TGA

Upstream 100 bases:

>100_bases
AGCCGCATCGGTCGATCTTCTGGTAAACAACTATACGGCTGCATTGCAGGCGGCGCAAAATGTTGCGCTCACTATGAATT
GACGACAGGACCCGTTGGAC

Downstream 100 bases:

>100_bases
GCAGCACACACAAGCATACGGGCCGGATGTCCATTGATGACTTCCGGCACGAGGCGATGGCGGAGACGCCATCGACCAAT
CTGGAATGTTTCGCCCGGGC

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N 1; NDH-1 subunit N 1 [H]

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MTAEILFASLHIATPELILAVGALALLMIGVFSGDKSTTTVTGLAVALLLVVGLWIIFAPASGVAFGGVYIADAFGNFMK
VLALIGSITAMILAVGQGRFEPIGRFEYPVLLVLATLGILLMISANNMISLYMALELQSLALYVVCAINRESLRSTEAGL
KYFVLGALSSGMLLYGMSLVYGFTGNTGFTEIAQVLASETRSLGLVFGLVFVLAGLAFKISAVPFHMWTPDVYEGAPTPV
TAFLSAAPKIGAMAILVRIVVEAFQPVFADWQQIVVFISIASMLLGSFAAIGQKNIKRLMAYSSIGHMGYALVGLAAGTE
AGISGVILYMTIYMVMTLGTFACILSMRRKEIGNVENVEDLAGLSSTNPFMAVVLTILMFSLAGIPPLAGFFGKYYVFLA
AIEAKLYPLAIIGVIGSVVGAYYYIRVVKVMWFDEAKDKFERPAGELKVVYALSALFVVAFVVFGGALGNAVTVAAKTFF

Sequences:

>Translated_480_residues
MTAEILFASLHIATPELILAVGALALLMIGVFSGDKSTTTVTGLAVALLLVVGLWIIFAPASGVAFGGVYIADAFGNFMK
VLALIGSITAMILAVGQGRFEPIGRFEYPVLLVLATLGILLMISANNMISLYMALELQSLALYVVCAINRESLRSTEAGL
KYFVLGALSSGMLLYGMSLVYGFTGNTGFTEIAQVLASETRSLGLVFGLVFVLAGLAFKISAVPFHMWTPDVYEGAPTPV
TAFLSAAPKIGAMAILVRIVVEAFQPVFADWQQIVVFISIASMLLGSFAAIGQKNIKRLMAYSSIGHMGYALVGLAAGTE
AGISGVILYMTIYMVMTLGTFACILSMRRKEIGNVENVEDLAGLSSTNPFMAVVLTILMFSLAGIPPLAGFFGKYYVFLA
AIEAKLYPLAIIGVIGSVVGAYYYIRVVKVMWFDEAKDKFERPAGELKVVYALSALFVVAFVVFGGALGNAVTVAAKTFF
>Mature_479_residues
TAEILFASLHIATPELILAVGALALLMIGVFSGDKSTTTVTGLAVALLLVVGLWIIFAPASGVAFGGVYIADAFGNFMKV
LALIGSITAMILAVGQGRFEPIGRFEYPVLLVLATLGILLMISANNMISLYMALELQSLALYVVCAINRESLRSTEAGLK
YFVLGALSSGMLLYGMSLVYGFTGNTGFTEIAQVLASETRSLGLVFGLVFVLAGLAFKISAVPFHMWTPDVYEGAPTPVT
AFLSAAPKIGAMAILVRIVVEAFQPVFADWQQIVVFISIASMLLGSFAAIGQKNIKRLMAYSSIGHMGYALVGLAAGTEA
GISGVILYMTIYMVMTLGTFACILSMRRKEIGNVENVEDLAGLSSTNPFMAVVLTILMFSLAGIPPLAGFFGKYYVFLAA
IEAKLYPLAIIGVIGSVVGAYYYIRVVKVMWFDEAKDKFERPAGELKVVYALSALFVVAFVVFGGALGNAVTVAAKTFF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831108, Length=210, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI145693160, Length=456, Percent_Identity=35.3070175438597, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI1788831, Length=394, Percent_Identity=26.6497461928934, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788614, Length=375, Percent_Identity=24.2666666666667, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788613, Length=239, Percent_Identity=24.2677824267782, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788827, Length=297, Percent_Identity=26.2626262626263, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788829, Length=239, Percent_Identity=25.1046025104602, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 50971; Mature: 50839

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAEILFASLHIATPELILAVGALALLMIGVFSGDKSTTTVTGLAVALLLVVGLWIIFAP
CCHHHEEHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCC
ASGVAFGGVYIADAFGNFMKVLALIGSITAMILAVGQGRFEPIGRFEYPVLLVLATLGIL
CCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
LMISANNMISLYMALELQSLALYVVCAINRESLRSTEAGLKYFVLGALSSGMLLYGMSLV
HHCCCCCHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
YGFTGNTGFTEIAQVLASETRSLGLVFGLVFVLAGLAFKISAVPFHMWTPDVYEGAPTPV
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHCCCCCCHH
TAFLSAAPKIGAMAILVRIVVEAFQPVFADWQQIVVFISIASMLLGSFAAIGQKNIKRLM
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYSSIGHMGYALVGLAAGTEAGISGVILYMTIYMVMTLGTFACILSMRRKEIGNVENVED
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LAGLSSTNPFMAVVLTILMFSLAGIPPLAGFFGKYYVFLAAIEAKLYPLAIIGVIGSVVG
HHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYYYIRVVKVMWFDEAKDKFERPAGELKVVYALSALFVVAFVVFGGALGNAVTVAAKTFF
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
>Mature Secondary Structure 
TAEILFASLHIATPELILAVGALALLMIGVFSGDKSTTTVTGLAVALLLVVGLWIIFAP
CHHHEEHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCC
ASGVAFGGVYIADAFGNFMKVLALIGSITAMILAVGQGRFEPIGRFEYPVLLVLATLGIL
CCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
LMISANNMISLYMALELQSLALYVVCAINRESLRSTEAGLKYFVLGALSSGMLLYGMSLV
HHCCCCCHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
YGFTGNTGFTEIAQVLASETRSLGLVFGLVFVLAGLAFKISAVPFHMWTPDVYEGAPTPV
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHCCCCCCHH
TAFLSAAPKIGAMAILVRIVVEAFQPVFADWQQIVVFISIASMLLGSFAAIGQKNIKRLM
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYSSIGHMGYALVGLAAGTEAGISGVILYMTIYMVMTLGTFACILSMRRKEIGNVENVED
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LAGLSSTNPFMAVVLTILMFSLAGIPPLAGFFGKYYVFLAAIEAKLYPLAIIGVIGSVVG
HHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYYYIRVVKVMWFDEAKDKFERPAGELKVVYALSALFVVAFVVFGGALGNAVTVAAKTFF
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]