Click here to switch to the map view.

The map label for this gene is argC

Identifier: 159184681

GI number: 159184681

Start: 1233946

End: 1234878

Strand: Reverse

Name: argC

Synonym: Atu1244

Alternate gene names: 159184681

Gene position: 1234878-1233946 (Counterclockwise)

Preceding gene: 15888576

Following gene: 15888574

Centisome position: 43.46

GC content: 61.74

Gene sequence:

>933_bases
ATGACAGCGAAGATCTTCATCGATGGCGAACACGGCACCACGGGTCTGCAGATCCGCACGCGCCTTGCCGGTCGCCGCGA
TATCGAGCTGCTGTCCATTCCAGAGACCGAGCGCCGCAACGCGGCGATGCGCGAGGATTTGCTCAACAACGCCGACATTT
CGATCCTCTGCCTGCCGGATGATGCCTCGAAGGAGGCTGTCTCCATGGTGGCCGGCAACAATAATGTCCGCATTATCGAC
ACCTCCACCGCCTATCGCGTCCATCAGGACTGGGCTTACGGTTTTGCCGAAATGGACCGGGACCAGGGCGAGAAGGTTCG
CTCGGCCCGTTTCGTCGCCAATCCCGGCTGCTACCCGACCGGCGCAATCGGCCTCATCCGTCCGCTGCGCGCTAGCGGCA
TCCTGCCCGACGGTTATCCGGTCAGTGTCAATGCGGTCTCCGGTTACACCGGCGGTGGCAAGCAGATGATCGCGCAGATG
GAGGACCAAAGCCGCGACGATGCGATCAGCGCCAATAATTTCCTGTATGGCCTGACGCTGAAGCACAAGCACGTGCCGGA
AATGACCATTCACGGTCAGCTCGACCGCGCACCGCTGTTTGCGCCCTCCGTCGGGCGTTTCCCGCAGGGCATGATCGTGC
AGGTTCCGCTGTTTGCAGCGGACCTTGCGGAAGGCACCACGATCGAAACCATCCATGCGGCGCTGACCGCCCATTATGCG
GGCCAGGACATCGTCAGCGTCGTGCCGCTTGCCGAAAGCAAGGGGATTTCCCGCATCGACGCTGAGGAGCTGGCGGGCAA
GGACACGATGAAGCTCTTCGTTTTCGGTACGCCGGGCGGTGAGCATATCAATCTCGTGGCGCTGCTCGACAATCTCGGCA
AGGGTGCCTCCGGCGCTGCGGTACAGAACATGGAGTTGATGCTCTCGGCATGA

Upstream 100 bases:

>100_bases
CGTGCCGAACGGCTGGCGAAGGCTGGCTGACGAATAAAACGGCACTTGCCGAACTGATTCCGAATACCCTCGCAACCCTT
TGAAAAGGCAGGACAAGGAC

Downstream 100 bases:

>100_bases
TCAGCAATACGCCGTCTTTTCCGGCCTCGTGGAATATCGAGGCCGCAAAACGCATCGCCGATACACCGGCCGGCATCGTT
TACGAACTGACGCGCAAGGA

Product: N-acetyl-gamma-glutamyl-phosphate reductase

Products: NA

Alternate protein names: AGPR; N-acetyl-glutamate semialdehyde dehydrogenase; NAGSA dehydrogenase

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MTAKIFIDGEHGTTGLQIRTRLAGRRDIELLSIPETERRNAAMREDLLNNADISILCLPDDASKEAVSMVAGNNNVRIID
TSTAYRVHQDWAYGFAEMDRDQGEKVRSARFVANPGCYPTGAIGLIRPLRASGILPDGYPVSVNAVSGYTGGGKQMIAQM
EDQSRDDAISANNFLYGLTLKHKHVPEMTIHGQLDRAPLFAPSVGRFPQGMIVQVPLFAADLAEGTTIETIHAALTAHYA
GQDIVSVVPLAESKGISRIDAEELAGKDTMKLFVFGTPGGEHINLVALLDNLGKGASGAAVQNMELMLSA

Sequences:

>Translated_310_residues
MTAKIFIDGEHGTTGLQIRTRLAGRRDIELLSIPETERRNAAMREDLLNNADISILCLPDDASKEAVSMVAGNNNVRIID
TSTAYRVHQDWAYGFAEMDRDQGEKVRSARFVANPGCYPTGAIGLIRPLRASGILPDGYPVSVNAVSGYTGGGKQMIAQM
EDQSRDDAISANNFLYGLTLKHKHVPEMTIHGQLDRAPLFAPSVGRFPQGMIVQVPLFAADLAEGTTIETIHAALTAHYA
GQDIVSVVPLAESKGISRIDAEELAGKDTMKLFVFGTPGGEHINLVALLDNLGKGASGAAVQNMELMLSA
>Mature_309_residues
TAKIFIDGEHGTTGLQIRTRLAGRRDIELLSIPETERRNAAMREDLLNNADISILCLPDDASKEAVSMVAGNNNVRIIDT
STAYRVHQDWAYGFAEMDRDQGEKVRSARFVANPGCYPTGAIGLIRPLRASGILPDGYPVSVNAVSGYTGGGKQMIAQME
DQSRDDAISANNFLYGLTLKHKHVPEMTIHGQLDRAPLFAPSVGRFPQGMIVQVPLFAADLAEGTTIETIHAALTAHYAG
QDIVSVVPLAESKGISRIDAEELAGKDTMKLFVFGTPGGEHINLVALLDNLGKGASGAAVQNMELMLSA

Specific function: Arginine biosynthesis; third step. [C]

COG id: COG0002

COG function: function code E; Acetylglutamate semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAGSA dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Escherichia coli, GI1790396, Length=222, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320913, Length=272, Percent_Identity=28.3088235294118, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGC_AGRT5 (Q8UG00)

Other databases:

- EMBL:   AE007869
- PIR:   AG2729
- PIR:   H97510
- RefSeq:   NP_354256.2
- ProteinModelPortal:   Q8UG00
- STRING:   Q8UG00
- GeneID:   1133282
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1244
- eggNOG:   COG0002
- HOGENOM:   HBG294213
- OMA:   PIFVPSV
- ProtClustDB:   PRK11863
- BioCyc:   ATUM176299-1:ATU1244-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01110
- InterPro:   IPR023013
- InterPro:   IPR010136
- InterPro:   IPR016040
- InterPro:   IPR000534
- Gene3D:   G3DSA:3.40.50.720
- SMART:   SM00859
- TIGRFAMs:   TIGR01851

Pfam domain/function: PF01118 Semialdhyde_dh

EC number: =1.2.1.38

Molecular weight: Translated: 33271; Mature: 33140

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS01224 ARGC

Important sites: ACT_SITE 117-117

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKIFIDGEHGTTGLQIRTRLAGRRDIELLSIPETERRNAAMREDLLNNADISILCLPD
CEEEEEEECCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECC
DASKEAVSMVAGNNNVRIIDTSTAYRVHQDWAYGFAEMDRDQGEKVRSARFVANPGCYPT
CCCCHHEEEEECCCCEEEEECCCEEEEEHHHHHHHHHHCHHHCHHHHHEEEEECCCCCCC
GAIGLIRPLRASGILPDGYPVSVNAVSGYTGGGKQMIAQMEDQSRDDAISANNFLYGLTL
CCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEE
KHKHVPEMTIHGQLDRAPLFAPSVGRFPQGMIVQVPLFAADLAEGTTIETIHAALTAHYA
ECCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEHHHCCCCCHHHHHHHHHHHCC
GQDIVSVVPLAESKGISRIDAEELAGKDTMKLFVFGTPGGEHINLVALLDNLGKGASGAA
CCCCEEEEECCCCCCCCCCCHHHHCCCCEEEEEEEECCCCCEEEEEEEEHHCCCCCCCCE
VQNMELMLSA
EECEEEEEEC
>Mature Secondary Structure 
TAKIFIDGEHGTTGLQIRTRLAGRRDIELLSIPETERRNAAMREDLLNNADISILCLPD
EEEEEEECCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECC
DASKEAVSMVAGNNNVRIIDTSTAYRVHQDWAYGFAEMDRDQGEKVRSARFVANPGCYPT
CCCCHHEEEEECCCCEEEEECCCEEEEEHHHHHHHHHHCHHHCHHHHHEEEEECCCCCCC
GAIGLIRPLRASGILPDGYPVSVNAVSGYTGGGKQMIAQMEDQSRDDAISANNFLYGLTL
CCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEE
KHKHVPEMTIHGQLDRAPLFAPSVGRFPQGMIVQVPLFAADLAEGTTIETIHAALTAHYA
ECCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEHHHCCCCCHHHHHHHHHHHCC
GQDIVSVVPLAESKGISRIDAEELAGKDTMKLFVFGTPGGEHINLVALLDNLGKGASGAA
CCCCEEEEECCCCCCCCCCCHHHHCCCCEEEEEEEECCCCCEEEEEEEEHHCCCCCCCCE
VQNMELMLSA
EECEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194