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The map label for this gene is ilvA [H]

Identifier: 159184664

GI number: 159184664

Start: 1198612

End: 1199886

Strand: Direct

Name: ilvA [H]

Synonym: Atu1205

Alternate gene names: 159184664

Gene position: 1198612-1199886 (Clockwise)

Preceding gene: 159184662

Following gene: 159184665

Centisome position: 42.18

GC content: 59.06

Gene sequence:

>1275_bases
ATGAATTTCAATGGATTGACTATCGTGGACAAGCAGCTTGTGGAAGCAGCGCGGCGGGAAGTGCGGGAGATATTCCCGGA
AACGCCGCTGCAGTTGAATGAACATCTCAGCCGTCGCTATGGCGCATCGATTTGGCTGAAGCGTGAGGATCTGTCCCCGG
TTCGTTCCTACAAGATTAGAGGCGCATTCAATTTTCTCCGCAAGGCGGTGGCCAAGGCTGGCAAGGACAAGGTTTTCGTC
TGCGCGTCCGCCGGCAACCACGCCCAGGGCTTTGCTTTCGCCTGCCGCCATTTCGGCGTTCACGGCGTCGTTTTCATGCC
GGTGACGACACCGCAGCAGAAGATCGAAAAAACCCGCATCTTTGGCGGAGAGTTCATCAAGATCCGTCTGGTGGGCGATA
TCTTCGACCAGTGTTACGCCGCTGCGCGTCAGCATGTGCAGGACCATGACGGCTACATGGTTCCGCCCTTTGACCATGAG
GATATTATCGAAGGCCAGGCGACGGTCGCCGCCGAGATCATGGACCAGCTGCCCGAAGGCACCAAACCTGACATCGTCGT
GATGCCTGTCGGTGGTGGCGGTCTTTCGGCCGGCCTGACCGGGTTTCTGGCCGGCACGGTGAAGAAGGAGAACTTCGTGT
TCTGCGAGCCGGAAGGCGCGCCCAGCCTGAAAAAGAGCCTGGAACGTGGCGAACCGGTGACGCTGAACAAGGTCGACAAT
TTTGTCGATGGTGCCGCCGTTGCCCGCATCGGCGACCTGAACTTCAAGGCGCTGAAGGATTTTCCGGCCGAGCAGGTGAT
GCTCATCCCGGAAAATGCGATCTGCGTGACGATCATCGAGATGCTGAACCTAGAAGGCGTGGTGCTGGAGCCTGCGGGCG
CCCTGTCCATCGCCGCGCTGGAAAGGCTCGGCCGCGAGAGGCTGGAAGGCAAGACGGTCATCGCCGTGGTCTCCGGCGGT
AATTTCGATTTCGAGCGCCTGCCGGACGTCAAGGAACGCGCCATGCGTTACACCGGCGTGAAGAAGTACTTCATCCTGCG
CCTGCCGCAGCGCCCCGGCGCGCTGCGCGATTTCCTCAATCTGCTCGGTCCGGACGACGATATCGCCCGTTTCGAATATC
TGAAGAAATCCGCCCGCAATTTCGGCTCGATCCTGATCGGCATCGAGACCAATGCGCAGGAAAACTTCGCCGGGTTGCTG
GAGCGCTTCGAGGCAGCCGGTCTCGGCTATGAGGATATTACCGAAAACGACATCTTGTCGAACCTGATCATCTGA

Upstream 100 bases:

>100_bases
CGCAGGAGGTTGCTGTTCAAGAAATGAAACCCAGAGTTCGTGGCCGCGCTGAAATGAGTCTTTGTCTCCGACGCCTTCCT
ATGGCATAGCGGGTGCCATT

Downstream 100 bases:

>100_bases
TCGGGAACGAACGACAGGGAAGGGCGGATCACCTCCGCCCTTCAAACGTGATATTGATTGAGGGAGTGAAAGCCATGGCA
TCGTTTTTTTCCAAAATCCT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MNFNGLTIVDKQLVEAARREVREIFPETPLQLNEHLSRRYGASIWLKREDLSPVRSYKIRGAFNFLRKAVAKAGKDKVFV
CASAGNHAQGFAFACRHFGVHGVVFMPVTTPQQKIEKTRIFGGEFIKIRLVGDIFDQCYAAARQHVQDHDGYMVPPFDHE
DIIEGQATVAAEIMDQLPEGTKPDIVVMPVGGGGLSAGLTGFLAGTVKKENFVFCEPEGAPSLKKSLERGEPVTLNKVDN
FVDGAAVARIGDLNFKALKDFPAEQVMLIPENAICVTIIEMLNLEGVVLEPAGALSIAALERLGRERLEGKTVIAVVSGG
NFDFERLPDVKERAMRYTGVKKYFILRLPQRPGALRDFLNLLGPDDDIARFEYLKKSARNFGSILIGIETNAQENFAGLL
ERFEAAGLGYEDITENDILSNLII

Sequences:

>Translated_424_residues
MNFNGLTIVDKQLVEAARREVREIFPETPLQLNEHLSRRYGASIWLKREDLSPVRSYKIRGAFNFLRKAVAKAGKDKVFV
CASAGNHAQGFAFACRHFGVHGVVFMPVTTPQQKIEKTRIFGGEFIKIRLVGDIFDQCYAAARQHVQDHDGYMVPPFDHE
DIIEGQATVAAEIMDQLPEGTKPDIVVMPVGGGGLSAGLTGFLAGTVKKENFVFCEPEGAPSLKKSLERGEPVTLNKVDN
FVDGAAVARIGDLNFKALKDFPAEQVMLIPENAICVTIIEMLNLEGVVLEPAGALSIAALERLGRERLEGKTVIAVVSGG
NFDFERLPDVKERAMRYTGVKKYFILRLPQRPGALRDFLNLLGPDDDIARFEYLKKSARNFGSILIGIETNAQENFAGLL
ERFEAAGLGYEDITENDILSNLII
>Mature_424_residues
MNFNGLTIVDKQLVEAARREVREIFPETPLQLNEHLSRRYGASIWLKREDLSPVRSYKIRGAFNFLRKAVAKAGKDKVFV
CASAGNHAQGFAFACRHFGVHGVVFMPVTTPQQKIEKTRIFGGEFIKIRLVGDIFDQCYAAARQHVQDHDGYMVPPFDHE
DIIEGQATVAAEIMDQLPEGTKPDIVVMPVGGGGLSAGLTGFLAGTVKKENFVFCEPEGAPSLKKSLERGEPVTLNKVDN
FVDGAAVARIGDLNFKALKDFPAEQVMLIPENAICVTIIEMLNLEGVVLEPAGALSIAALERLGRERLEGKTVIAVVSGG
NFDFERLPDVKERAMRYTGVKKYFILRLPQRPGALRDFLNLLGPDDDIARFEYLKKSARNFGSILIGIETNAQENFAGLL
ERFEAAGLGYEDITENDILSNLII

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=339, Percent_Identity=27.4336283185841, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI33469958, Length=321, Percent_Identity=29.595015576324, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI19923959, Length=324, Percent_Identity=25.3086419753086, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790207, Length=403, Percent_Identity=32.5062034739454, Blast_Score=178, Evalue=6e-46,
Organism=Escherichia coli, GI1789505, Length=319, Percent_Identity=31.3479623824451, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789235, Length=219, Percent_Identity=25.5707762557078, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71991565, Length=337, Percent_Identity=30.2670623145401, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17537387, Length=395, Percent_Identity=29.3670886075949, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17508781, Length=288, Percent_Identity=28.125, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320930, Length=414, Percent_Identity=31.4009661835749, Blast_Score=186, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6322631, Length=310, Percent_Identity=28.0645161290323, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319788, Length=285, Percent_Identity=27.3684210526316, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6322024, Length=181, Percent_Identity=30.3867403314917, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355833, Length=326, Percent_Identity=29.7546012269939, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24645328, Length=257, Percent_Identity=29.9610894941634, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR001721
- InterPro:   IPR011820 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 46797; Mature: 46797

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFNGLTIVDKQLVEAARREVREIFPETPLQLNEHLSRRYGASIWLKREDLSPVRSYKIR
CCCCCEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHEEHH
GAFNFLRKAVAKAGKDKVFVCASAGNHAQGFAFACRHFGVHGVVFMPVTTPQQKIEKTRI
HHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHC
FGGEFIKIRLVGDIFDQCYAAARQHVQDHDGYMVPPFDHEDIIEGQATVAAEIMDQLPEG
CCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHCCHHHHHHHHHHHCCCC
TKPDIVVMPVGGGGLSAGLTGFLAGTVKKENFVFCEPEGAPSLKKSLERGEPVTLNKVDN
CCCCEEEEECCCCCHHHHHHHHHHHCEECCCEEEECCCCCHHHHHHHHCCCCEEHHHHHH
FVDGAAVARIGDLNFKALKDFPAEQVMLIPENAICVTIIEMLNLEGVVLEPAGALSIAAL
HHCCHHHHEECCCCHHHHHCCCCCCEEEECCCCHHHHHHHHHCCCCEEECCCCCHHHHHH
ERLGRERLEGKTVIAVVSGGNFDFERLPDVKERAMRYTGVKKYFILRLPQRPGALRDFLN
HHHHHHHCCCCEEEEEEECCCCCHHHCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHH
LLGPDDDIARFEYLKKSARNFGSILIGIETNAQENFAGLLERFEAAGLGYEDITENDILS
HHCCCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCCHHHCCHHHHHH
NLII
HHCC
>Mature Secondary Structure
MNFNGLTIVDKQLVEAARREVREIFPETPLQLNEHLSRRYGASIWLKREDLSPVRSYKIR
CCCCCEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHEEHH
GAFNFLRKAVAKAGKDKVFVCASAGNHAQGFAFACRHFGVHGVVFMPVTTPQQKIEKTRI
HHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHC
FGGEFIKIRLVGDIFDQCYAAARQHVQDHDGYMVPPFDHEDIIEGQATVAAEIMDQLPEG
CCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHCCHHHHHHHHHHHCCCC
TKPDIVVMPVGGGGLSAGLTGFLAGTVKKENFVFCEPEGAPSLKKSLERGEPVTLNKVDN
CCCCEEEEECCCCCHHHHHHHHHHHCEECCCEEEECCCCCHHHHHHHHCCCCEEHHHHHH
FVDGAAVARIGDLNFKALKDFPAEQVMLIPENAICVTIIEMLNLEGVVLEPAGALSIAAL
HHCCHHHHEECCCCHHHHHCCCCCCEEEECCCCHHHHHHHHHCCCCEEECCCCCHHHHHH
ERLGRERLEGKTVIAVVSGGNFDFERLPDVKERAMRYTGVKKYFILRLPQRPGALRDFLN
HHHHHHHCCCCEEEEEEECCCCCHHHCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHH
LLGPDDDIARFEYLKKSARNFGSILIGIETNAQENFAGLLERFEAAGLGYEDITENDILS
HHCCCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCCHHHCCHHHHHH
NLII
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA